Clinical trials: Surgical Anesthesia, open to volunteers
Anesthesia, Surgery With General Anesthesia
The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient…
- Conditions
- Anesthesia, Surgery With General Anesthesia, Noncardiac Surgery, Hypotension During Surgery
- Trial name
- VEGA-2 (NCT06802224)
- Testing
- Norepinephrine, Phenylephrine
- Where
- 10 sites in United States, Canada
- Volunteers
- 18,000 people
- Sponsor
- University of California, San Francisco
Lung Cancer (Diagnosis)
Effect of Apneic Oxygenation of the Non-ventilated Lung During Lung Cancer Surgery.
This study investigates the effect of apneic oxygenation of the non-ventilated lung on local and systemic inflammatory response during lung cancer surgery.
- Trial name
- NCT07393490
- Testing
- Apnoeic Oxygenation, Standard Ventilation
- Where
- Croatia
- Volunteers
- 56 people
- Sponsor
- Osijek University Hospital
Surgical Stress Response, Inflammation
CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy
This randomized controlled trial evaluates whether intraoperative guidance using the CoreSys monitor reduces the surgical stress response in patients undergoing elective open abdominal hysterectomy.
- Conditions
- Surgical Stress Response, Inflammation, Anesthesia, Perioperative Care
- Trial name
- CORESTRESS (NCT07571473)
- Testing
- propofol, CoreSys Monitor, Remifentanil (Target-Controlled Infusion)
- Where
- Argentina
- Volunteers
- 30 people
- Sponsor
- Hospital Provincial de Rosario
Acute Kidney Injury, Surgery Complications
Real-Time Acute Kidney Injury Perioperative Prediction Clinical Trial
This investigator-initiated, pragmatic trial evaluates whether displaying a machine learning (ML)- derived perioperative AKI risk score-alone or paired with an interruptive Best/Our Practice Advisory (BPA/OPA)-improves…
- Conditions
- Acute Kidney Injury, Surgery Complications, Anesthesia
- Trial name
- ML-AKI (NCT07604662)
- Testing
- EHR-Embedded AKI Risk Score, EHR-Embedded AKI Risk Score with Best Practice Advisory
- Where
- United States
- Volunteers
- 25,518 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Postoperative Pain, Hemidiaphragmatic Paresis
Combined Suprascapular and PECS I Blocks Versus Interscalene Block for Shoulder Arthroscopy
Shoulder arthroscopy can cause moderate to severe pain after surgery. An interscalene block is commonly used to reduce this pain, but it may temporarily weaken movement of the diaphragm on the treated side.
- Trial name
- NCT07852754
- Testing
- suprascapular nerve block, PECS I Block, Interscalene Brachial Plexus Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Cansu Ofluoğlu
Perioperative Care, Hemodynamics
ImPortance of Arterial Measurement Sites (IPAMS) on Intraoperative Hemodynamic Management
The goal of this clinical trial is to demonstrate the importance of arterial pressure measurement sites during major abdominal surgeries.
- Conditions
- Perioperative Care, Hemodynamics, Monitoring Blood Pressure, Arterial Lines
- Trial name
- IPAMS (NCT06982001)
- Testing
- Brachial line guided hemodynamic management, Radial line guided hemodynamic management, Radial line catheterization
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Orthopedic Procedure, Anesthesia
Evaluation of the Impact of Virtual Reality on Sedation Use in Patients Undergoing Regional Anesthesia for Scheduled Orthopedic Surgery
The VIRTUALR study evaluates the effect of virtual reality combined with hypnosis on anxiety in patients undergoing orthopedic surgery under regional anesthesia.
- Conditions
- Orthopedic Procedure, Anesthesia, Sedation
- Trial name
- VIRTUALR (NCT07013695)
- Testing
- Virtual reality headset, Standard Care (in control arm)
- Where
- France
- Volunteers
- 164 people
- Sponsor
- Centre Hospitalier Eure-Seine
Perioperative Care, EEG Power Spectra
Extended Emergence Strategy on Post-Anesthesia Care Unit Events After Outpatient Orthopedic Surgery
The goal of this clinical trial is to learn if an extended emergence from anesthesia can improve recovery room (Post-Anesthesia Care Unit or PACU) outcomes in lower-leg or foot surgery with nerve blocks.
- Conditions
- Perioperative Care, EEG Power Spectra, Delirium - Postoperative
- Trial name
- PACU-EMERGE (NCT07533370)
- Testing
- Standard of Care EEG-Guided Emergence, Extended EEG Emergence Trajectory
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Harrison Shong-Wen Chow
Cardiac Surgery, Peri Operative Medicine
Risk Factors of Atrial Fibrillation After Cardiac Surgery
Supraventricular arrhythmias complicate more than 40% of cardiac surgeries and are associated with an increased risk of bleeding, stroke, heart failure, and death.
- Conditions
- Cardiac Surgery, Peri Operative Medicine, Thoracic Surgery, Cardiopulmonary Bypass
- Trial name
- PFAS (NCT07625033)
- Where
- France
- Volunteers
- 918 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Postoperative Pain, Opioid Consumption
Comparison of TAP Block and Umbilical Paramedian Linea Semilunaris Block in Pediatric Laparoscopic Surgery
The aim of this prospective randomized controlled trial is to compare the postoperative analgesic efficacy of ultrasound-guided transversus abdominis plane (TAP) block and umbilical paramedian linea semilunaris block in pediatric…
- Trial name
- NCT07801794
- Testing
- Ultrasound-Guided Transversus Abdominis Plane Block, Ultrasound-Guided Linea Semilunaris Block
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Pain Management, Regional Anesthesia
Revision of Deep Brain Stimulator in Patients With Parkinson's Disease
Parkinson's disease is a chronic and progressive neurodegenerative disease that affects the central nervous system, particularly impairing movement control.
- Conditions
- Pain Management, Regional Anesthesia, Deep Brain Stimulation, Parkinsons Disease
- Trial name
- NCT07176494
- Testing
- Patients who underwent surgery under general anesthesia, Patients who underwent surgery under regional anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara Etlik City Hospital
Inguinal Hernia Unilateral, Postoperative Pain Management
Transversalis Fascia Plane Block Versus Surgical Wound Infiltration for Postoperative Analgesia in Open Inguinal Hernia Repair
The purpose of this clinical trial is to evaluate whether two different analgesic techniques - ultrasound-guided Transversalis Fascia Plane Block (TFPB) and surgical wound infiltration - can improve postoperative pain control in…
- Conditions
- Inguinal Hernia Unilateral, Postoperative Pain Management, Regional Anaesthesia, Transversalis Fascia Plane Block
- Trial name
- TFPB-WIN (NCT07238829)
- Testing
- Ultrasound-Guided Transversalis Fascia Plane Block (TFPB), Surgical Wound Infiltration
- Volunteers
- 104 people
- Sponsor
- Ondokuz Mayıs University
Caudal Epidural Anesthesia, Erector Spinae Plane Block
Comparison of Erector Spinae Plane Block and Caudal Block in Pediatric Patients Aged 1 to 8 Years Undergoing Lower Abdominal Surgery
In routine pediatric surgical practice, lower abdominal surgeries are commonly performed. Inadequate control of postoperative pain can hinder functional recovery and may lead to negative behavioral changes as well as parental…
- Conditions
- Caudal Epidural Anesthesia, Erector Spinae Plane Block, Pediatric
- Trial name
- NCT07426939
- Testing
- caudal block, Erector Spinae Plane Block
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Stress, Stress and Burnout
Deep Relaxation Using Virtual Reality Intervention Before Surgery for Healthcare Professionals Working in the Operating Room
The goal of this clinical trials is to primary learn if deep relaxation using Virtual Reality (VR) compared to a low stimulus environment can lower perceived and measured stress in healthcare professionals working in the…
- Conditions
- Stress, Stress and Burnout, Stress Biomarkers
- Trial name
- DEEP_VR (NCT07470697)
- Testing
- Virtual Reality intervention, Low Stimulus Environment
- Where
- 2 sites in Denmark, Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
PONV
Risk Factors for Postoperative Nausea and Vomiting After Nasal Surgery Under General Anesthesia
The goal of this observational study is to learn how often postoperative nausea and vomiting occur in adults undergoing nasal surgery under general anesthesia and to identify factors associated with these events.
- Trial name
- N-PONV (NCT07749079)
- Volunteers
- 1,000 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Anesthesia, Surgical Patients
Effect of Visual Aids Added to Informed Consent on Patient Understanding and Anesthesia Awareness
This prospective cluster-randomized controlled study aims to evaluate whether visual support material provided in addition to the standard written informed consent form improves patients' comprehension of informed consent and…
- Trial name
- NCT07461480
- Testing
- Standard Informed Consent, Visual Support Supplemented Informed Consent
- Volunteers
- 236 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Post Operative Pain, Analgesia
Evaluation of Postoperative Pain Control in Ear Surgery
Middle ear surgery is the most popular procedure in ear, nose and throat surgery. Increased sympathetic stimulation after surgery can activate the sympathetic system, causing hypertension and increased heart rate.
- Trial name
- NCT06869967
- Testing
- Auricularis Magnus Nerve Block, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Kocaeli University
Low-flow Anesthesia, Hemodynamics
Low-Flow Anesthesia and Open-Heart Surgery
Low-flow anesthesia (LFA) is a technique in which at least 50% of the exhaled air, after carbon dioxide absorption, is mixed with a certain amount of fresh gas and returned to the patient during the next inspiration. In 1974, R.
- Conditions
- Low-flow Anesthesia, Hemodynamics, Open-heart Surgery
- Trial name
- NCT07040735
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Çağrı Özdemir
Pain Management
Local Anesthesia for Facial Fractures
The study is a double-blind randomized, placebo controlled trial examining the impact of perioperative bupivacaine nerve block on PACU recovery metrics.
- Trial name
- LAFF (NCT06429501)
- Testing
- Bupivacaine/Epinephrine, Saline
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Brain Tumor Adult, Processed EEG
Processed EEG for Monitoring of Anesthetic Depth in Intracranial Tumor Surgery
An important feature of neurosurgical anesthesia is early postoperative recovery of consciousness with minimal residual sedation.
- Conditions
- Brain Tumor Adult, Processed EEG, Total Intravenous Anesthesia
- Trial name
- NCT06922500
- Testing
- depth of anesthesia
- Where
- Sweden
- Volunteers
- 126 people
- Sponsor
- Region Skane