Clinical trials: Surgery in Elderly Patients
Cystic Echinococcosis
Surgical Treatment of Hepatic Hydatidosis in Elderly Patients
Cystic echinococcosis is a clinically complex chronic parasitic disease and a major socioeconomic problem in endemic areas. The safety of liver resection in elderly patients is often debated among medical professionals.
- Trial name
- ELDHIDA (NCT05113550)
- Testing
- Surgical remove
- Where
- 2 sites in Spain
- Volunteers
- 279 people
- Sponsor
- Universidad de Extremadura
Postoperative Delirium (POD), Postoperative Sleep Disturbance
Effects of Esketamine on the Incidence of Postoperative Delirium and Postoperative Sleep Disturbance in Elderly Patients After Major Non-cardiac Surgery
Postoperative delirium (POD) is a common surgical complication.It is associated with a range of negative outcomes such as delayed postoperative recovery,prolonged hospitalization,additional medical expenditures and higher…
- Trial name
- EPISODE (NCT06900205)
- Testing
- Esketamine, 0.9 % saline
- Where
- China
- Sponsor
- RenJi Hospital
Endometrial Serous Adenocarcinoma, Fallopian Tube Carcinoma
Comprehensive Patient Questionnaires in Predicting Complications in Older Patients With Gynecologic Cancer Undergoing Surgery
This research trial studies comprehensive patient questionnaires in predicting complications in older patients with gynecologic cancer undergoing surgery.
- Conditions
- Endometrial Serous Adenocarcinoma, Fallopian Tube Carcinoma, Malignant Female Reproductive System Neoplasm, Ovarian Carcinoma
- Trial name
- NCT02315469
- Testing
- Comprehensive Geriatric Assessment, Questionnaire Administration
- Where
- 393 sites in United States, Canada
- Volunteers
- 190 people
- Sponsor
- NRG Oncology
Anesthesia, Covert Stroke
A Prospective Cohort Study of Perioperative Covert Stroke and Postoperative Cognitive Dysfunction
With the development of population aging, the incidence of covert stroke gradually increased. Currently, there is still lack of prospective cohort study with large sample size on the relationship between perioperative covert…
- Trial name
- PRECISION (NCT03081429)
- Where
- 2 sites in China
- Volunteers
- 934 people
- Sponsor
- Beijing Tiantan Hospital
Postoperative Cognitive Dysfunction
The Influence of Postoperative Analgesia on Systemic Inflammatory Response and POCD After Femoral Fractures Surgery
The purpose of this study is to determine whether epidural levobupivacaine applied for the purpose of post-operative analgesia compared to systemic analgesia with morphine leads to better pain control, stronger suppression of the…
- Trial name
- NCT02848599
- Testing
- morphine, levobupivacaine
- Where
- Croatia
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Osijek University Hospital
Dexamethasone, Urologic Endoscopic Surgery
Effect of Intrathecal Dexamethasone on Intra-operative Hemodynamic in Elderly Patients Undergoing Urologic Endoscopic Surgery
Correction of Post-spinal anesthesia hypotension by fluids pose the risk of volume overload or compromising cardiac conditions. Intravenous Dexamethasone in some studies is used to treat conditions manifested by decrease of…
- Trial name
- NCT05549895
- Testing
- Dexamethasone, Bupivacaine Hydrochloride
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Injection, Non-cardiac Surgery
A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery
To observe and study the clinical effect of Huperzine A Injection on reducing postoperative delirium in elderly patients undergoing non-cardiac surgery
- Conditions
- Injection, Non-cardiac Surgery, Delirium in Old Age, Post Operative Delirium
- Trial name
- NCT05242419
- Testing
- Sodium Chloride Injection, Huperzine A Injection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Transversus Abdominis Block
Dexmedetomidine Versus Fentanyl Added to Levobupivacaine for Transversus Abdominis Plane (TAP) Block
The perioperative management of pain following lower abdominal surgery can pose a challenge to anesthesia providers. Conventional practice has involved the use of opioids as well as neuraxial analgesic techniques.
- Trial name
- NCT03778671
- Testing
- Levobupivacaine, Dexmedetomidine Injection [Precedex], fentanyl
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Caudal Epidural Anesthesia, Erector Spinae Plane Block
Comparison of Erector Spinae Plane Block and Caudal Block in Pediatric Patients Aged 1 to 8 Years Undergoing Lower Abdominal Surgery
In routine pediatric surgical practice, lower abdominal surgeries are commonly performed. Inadequate control of postoperative pain can hinder functional recovery and may lead to negative behavioral changes as well as parental…
- Conditions
- Caudal Epidural Anesthesia, Erector Spinae Plane Block, Pediatric
- Trial name
- NCT07426939
- Testing
- caudal block, Erector Spinae Plane Block
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Caregiver, Head and Neck Carcinoma
Geriatric and Quality of Life Assessments in Older Patients With Non-metastatic or Metastatic Head and Neck or Lung Cancer Undergoing Surgery or Chemoradiation and Their Caregivers
This trial studies comprehensive geriatric and quality of life assessments in older patients with head and neck or lung cancer that has or has not spread to other parts of the body who are undergoing standard surgery or…
- Conditions
- Caregiver, Head and Neck Carcinoma, Lung Carcinoma, Metastatic Head and Neck Carcinoma
- Trial name
- NCT03902535
- Testing
- Comprehensive Geriatric Assessment, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Proximal Humeral Fractures, AO/OTA (2007) Group B2 and C2
Displaced Proximal Humeral Fractures: Delta Prothesis or Philos Plate?
To investigate the assumption that reversed shoulder prosthetic replacement will give a better functional outcome compared to open reduction and internal fixation with an angular stable plate in displaced proximal humeral…
- Trial name
- DELPHI (NCT01737060)
- Testing
- Reverse total shoulder arthroplasty
- Where
- Norway
- Volunteers
- 124 people
- Sponsor
- Oslo University Hospital
Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery
PCO₂ Gap and Lactate as Predictors of POCD After Cardiac Surgery
This prospective observational study aims to evaluate whether intraoperative venous-to-arterial carbon dioxide partial pressure difference (PCO₂ gap) and arterial lactate levels can serve as early predictors of postoperative…
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT07843186
- Volunteers
- 185 people
- Sponsor
- Ain Shams University
Delirium on Emergence
Ketofol for Preventing Postoperative Delirium in Elderly Patients
Delirium is a cognitive disturbance characterized by acute and fluctuating impairment in attention and awareness. Although its incidence in the general surgical population is 2-3%, it has been reported to occur in up to 10-80% of…
- Trial name
- NCT04816162
- Testing
- ketofol, dexmedetomidine, normal saline
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University
Postoperative Pulmonary Infection in Elderly Patients
Predicting Postoperative Pulmonary Infection in Elderly Patients Undergoing Major Surgery: a Study Based on Logistic Regression and Machine Learning Models
Although a number of clinical predictive models were developed to predict postoperative pulmonary infection, few predictive models have been used in elderly patients.
- Trial name
- NCT06491459
- Where
- China
- Volunteers
- 9,481 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Postoperative Infection, Geriatrics
Machine Learning Prediction of Multiple Infections in Elderly Surgical Patients
Utilizing machine learning techniques, investigators developed the geriatric infection assessment model, leveraging domestic databases to predict multiple postoperative infections in elderly patients.
- Conditions
- Postoperative Infection, Geriatrics, Prediction
- Trial name
- NCT06547281
- Where
- China
- Volunteers
- 42,540 people
- Sponsor
- Weidong Mi
Depression, Anxiety
Postoperative Anxiety and Depression Among Chinese Elderly Patients
The goal of this observational study is to learn about the prevalence of postoperative anxiety and depression symptoms and identify the related risk factors in elderly patients aged 65 and older who undergo non-cardiac surgery in…
- Trial name
- NCT07532122
- Where
- China
- Volunteers
- 7,568 people
- Sponsor
- Chinese PLA General Hospital
Delirium, Postoperative
Dexmedetomidine on Postoperative Delirium and Quality of Recovery in Geriatric Patients
Postoperative agitation (hyperactive delirium) is common following major surgery(incidence was about 20% in our pilot study). Dexmedetomidine was related to a reduced delirium rate when comparing with midazolam in many clinical…
- Trial name
- NCT01283412
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Huazhong University of Science and Technology
Acute Postoperative Pain, Trajectory
Pain Trajectories and Predictors After Noncardiac Surgery in Elderly Patients
This study will use group-based trajectory modeling to identify the different postoperative pain trajectory groups that exist in a mixed surgical population (non-cardiac surgery) of elderly patients during the first seven days…
- Trial name
- NCT05865366
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Feng Gao
Surgery
The Effects of Anesthetic Method on Cerebral Oxygen Saturation in Geriatric Patients Undergoing Transurethral Surgery
The effects of anesthetic method on cerebral oxygen saturation in geriatric patients undergoing transurethral surgery.
- Trial name
- NCT01147146
- Testing
- propofol, fentanyl, atracurium, bupivacaine, bupivacaine, Midazolam
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Yonsei University
Non-small Cell Lung Cancer
A Study to Evaluate Effectiveness and Safety of Surgeries in Elderly NSCLC Patients
The trial was designed to compare effectiveness and safety of surgeries in the patients with non-small cell lung cancer
- Trial name
- NCT03429673
- Testing
- Surgeries
- Where
- 10 sites in China
- Volunteers
- 10,885 people
- Sponsor
- China-Japan Friendship Hospital