Clinical trials: Suicide
Depression and Suicide
Effects of Transcranial Direct Current Stimulation (tDCS) in the Management of Suicidal Ideation
The main objective of this study is to demonstrate that 15 transcranial direct current stimulation (tDCS) sessions of 30 minutes at 2 mA intensity are effective to reduce suicidal ideation
- Trial name
- tDCS-IDSDEP (NCT06009523)
- Testing
- Transcranial direct current stimulation
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Henri Laborit
Suicide Attempt, Suicidal and Self-injurious Behavior
Suicide Preventive Psychosocial Treatment for Youths
Suicide is the leading cause of death amongst 10-18-year-olds in Sweden. Suicide attempts are the strongest predictor of subsequent death by suicide, often lead to inpatient care, and are associated with substantial societal…
- Conditions
- Suicide Attempt, Suicidal and Self-injurious Behavior, Suicide Attempted, Suicide, Attempted
- Trial name
- NCT06931639
- Testing
- Safe Alternatives for Teens and Youth (SAFETY), Enhanced Treatment As Usual
- Where
- 5 sites in Sweden
- Volunteers
- 282 people
- Sponsor
- Karolinska Institutet
Clinical High Risk for Psychosis (CHR), Suicidal Ideation
Developing a Recovery-Oriented Suicide Prevention Program for Young People at Clinical High Risk for Psychosis
Young people at clinical high risk for psychosis are more likely to experience suicide thoughts than the general population, but there are few suicide prevention programs designed specifically for them.
- Conditions
- Clinical High Risk for Psychosis (CHR), Suicidal Ideation, Psychosis, Suicidal Behavior
- Trial name
- NCT07756567
- Testing
- Suicide Prevention Intervention, Standard Care (in control arm)
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of California, San Diego
Suicidal Ideation, Suicidal Behavior
Intravenous Ketamine for Acute Suicidal Crisis and Psychiatric Hospital Length of Stay
This randomized, double-blind, active placebo-controlled superiority trial will evaluate whether intravenous esketamine reduces time to psychiatric hospital discharge in adults hospitalized because of acute suicide risk.
- Trial name
- NCT07888933
- Testing
- Esketamine, Midazolam (Intravenous)
- Where
- Brazil
- Volunteers
- 106 people
- Sponsor
- University of Sao Paulo
Suicide and Self-harm
Suicide Prevention for Criminal Legal Involved Managed Care Subscribers
The goal of this clinical trial is to test the effects of a suicide prevention intervention for individuals released from jail. The main question it aims to answer is: Does the use of Caring Contacts improve subscriber engagement…
- Trial name
- NCT05579600
- Testing
- Caring Contacts letters
- Where
- United States
- Volunteers
- 45,155 people
- Sponsor
- Butler Hospital
Depressive Disorder, Major Depressive Disorder, Suicidal Ideation
Evaluation of a Multi-Layered Digital Phenotyping, Digital Safety Plan, and Pharmacogenomic Intervention for Suicide Prevention in Adults With Depression
The goal of this clinical trial is to learn if a multi-layered digital and pharmacogenomic intervention works to prevent suicide re-attempts in adults with depression.
- Conditions
- Depressive Disorder, Major Depressive Disorder, Suicidal Ideation, Suicide, Attempted, Suicide Prevention
- Trial name
- SMARTomicS (NCT07885722)
- Testing
- Digital Monitoring (Active/Passive EMA), Ecological Momentary Intervention (EMI) via Digital Safety Plan, Pharmacogenetic-Guided Care and Therapeutic Drug Monitoring
- Where
- Spain
- Volunteers
- 525 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Suicide, Suicide Prevention
Suicide Prevention Integration Into Task-shifted Mental Health Interventions
Investigators will conduct a pilot clinical trial to assess the feasibility and acceptability of implementing a Suicide Prevention Package (SuPP) within an existing task-shifted depression intervention in rural Pakistan.
- Conditions
- Suicide, Suicide Prevention, Suicidal Ideation
- Trial name
- KPZ (NCT06208293)
- Testing
- KPZ Program (KPZ), Enhanced Usual Care (EUC)
- Where
- Pakistan
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Yale University
Suicide
THRIVE: A Recovery-Focused Suicide Prevention Intervention in Crisis Stabilization Centers
Suicide is a major public health concern in the United States, with more than 1.4 million adults attempting suicide and nearly 50,000 adults dying by suicide each year.
- Trial name
- THRIVE (NCT07784634)
- Testing
- Toward Hope, Recovery, Interpersonal Growth, Values, and Engagement (THRIVE), Center Care as Usual
- Where
- 3 sites in United States
- Volunteers
- 552 people
- Sponsor
- University of Alabama at Birmingham
Suicide, Attempted
DBT Skills Groups for Veterans at High Risk for Suicide Attempt
Veteran suicide death is a national crisis. Risk factors include emotion dysregulation, which occurs across mental health disorders.
- Trial name
- NCT05000749
- Testing
- DBT-SG, VHA treatment as usual
- Where
- 5 sites in United States
- Volunteers
- 156 people
- Sponsor
- VA Office of Research and Development
Suicide
Army-SPRING Army-Suicide Prevention Research
Every unit in the Connecticut Army National Guard has a Suicide Intervention Officer to provide suicide intervention education awareness for their unit, monitor for soldiers in crisis and connect soldiers with helping resources…
- Trial name
- NCT06547008
- Testing
- Army-SPRING, Risk Reduction Group (Control)
- Where
- 3 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy Volunteers, Depression
Neurobiology of Suicide
Background: There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies.
- Trial name
- NCT02543983
- Testing
- Magnetic Resonance Imaging scanner, 3T, NeurOptics PLRTM-3000 Pupillometer, Experimental Anxiety Devices
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Suicide, Adolescent Behavior
Wearable Suicidal Early Warning System for Adolescents
This study is prospectively enrolling a cohort of adolescent patients who present to the Emergency Department and an inpatient psychiatric adolescent unit with acute suicidality.
- Trial name
- NCT03030924
- Testing
- Solace
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Oregon Health and Science University
Suicide, Mental Health Issue
Proximal Risk for Suicide in Adolescents
The central hypothesis is that biometric data can continuously monitor and allow for early identification/intervention of escalating suicidal symptoms.
- Trial name
- NCT06400810
- Testing
- Analog Devices Inc.
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Oregon Health and Science University
Skin Cancer, Melanoma (Skin Cancer)
Digital Phenotyping of Psychological Distress in Skin Cancer Patients
This prospective observational study enrolls 500 skin cancer patients across five Chinese tertiary care centers. The investigators use natural language processing and a hierarchical transformer model to analyse 1.2 million social…
- Conditions
- Skin Cancer, Melanoma (Skin Cancer), Squamous Cell Carcinoma Head and Neck Cancer (HNSCC), Basal Cell Carcinoma of Skin
- Trial name
- DP-SKIN (NCT07670403)
- Where
- China
- Sponsor
- West China Hospital
Suicide, Attempted, Suicide and Depression
Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents
This project aims to examine the signal of efficacy of ketamine, a rapidly acting medication shown to decrease suicidality in adults in as short as hours or days, as opposed to weeks.
- Conditions
- Suicide, Attempted, Suicide and Depression, Suicide Threat
- Trial name
- TASK (NCT04592809)
- Testing
- Ketamine Hydrochloride, Midazolam Hydrochloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Borderline Personality Disorder (BPD), Dialectical Behavior Therapy
Effectiveness of Enhanced Dialectical Behavior Therapy Skills Training Group for Borderline Personality Disorder
Dialectical Behavior Therapy (DBT) holds the strongest empirical support for the treatment of Borderline Personality Disorder (BPD).
- Conditions
- Borderline Personality Disorder (BPD), Dialectical Behavior Therapy, Public Health, Suicide Behavior
- Trial name
- ANDES (NCT07875166)
- Testing
- Enhanced Dialectical Behavior Therapy Skills Training, Dialectical Behavior Therapy, Treatment as Usual (TAU)
- Where
- 7 sites in Chile
- Volunteers
- 360 people
- Sponsor
- Hospital Dr Sotero del Rio
Suicide
CAMS Relational Agent System (CAMS-RAS) for Suicide Prevention
This Phase II study is a continuation of the Phase I feasibility study where the investigators fully met and exceeded project aims to design, build, and test the usability and acceptability of an avatar-based system, Jaspr Health…
- Trial name
- V-CAMS (NCT03584386)
- Testing
- Jaspr, Jaspr-at-Home (JAH)
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Evidence-Based Practice Institute, Seattle, WA
HIV - Human Immunodeficiency Virus, Suicide Prevention
IDEAS for Hope to Reduce Suicide Risk and Improve HIV Care Engagement in Tanzania
In this project, the investigators will conduct a clinical trial to test the effectiveness and implementation of IDEAS for Hope, a 3-session telehealth counseling intervention delivered by nurses, to reduce suicidality and…
- Trial name
- NCT07459218
- Testing
- IDEAS for Hope, Safety Planning Intervention
- Where
- Tanzania
- Volunteers
- 600 people
- Sponsor
- Duke University
Lethal Means Counseling Skill
Pathways 2 Safety: AI-Simulated Clients for Experiential Learning in Behavioral Health Education
The goal of this study was to compare the effectiveness of practicing lethal means counseling skills with an artificial intelligence (AI)-powered client compared to practice with a live actor.
- Trial name
- NCT07873658
- Testing
- Lethal means counseling training and skills practice
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Washington
Suicide Mortality
The Developmental Origins of Suicide Mortality
Background: Suicide rates are rising. In 2013, it was the third leading cause of death in children ages 10-14. It was the second leading cause of death for ages 15-24. Many risk factors for suicide have been found.
- Trial name
- NCT03027440
- Where
- United States
- Volunteers
- 52,966 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)