Clinical trials: Sudden Death
Arrhythmia, Cardiovascular Diseases
Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)
To compare conventional treatment of congestive heart failure (CHF) with two experimental interventions: amiodarone and an implantable cardioverter-defibrillator (ICD).
- Conditions
- Arrhythmia, Cardiovascular Diseases, Death, Sudden, Cardiac, Heart Diseases
- Trial name
- NCT00000609
- Testing
- amiodarone, defibrillators, implantable
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Out-of-Hospital Cardiac Arrest, Sudden Cardiac Death
The Effect of Chest Compression and Ventilation Coordination During Cardiopulmonary Resuscitation.
Airway management and maintaining adequate ventilation during cardiopulmonary resuscitation (CPR) are important. The rule of 30:2 compression-to-ventilation ratios before endotracheal intubation and keeping 1 breath every 6-8…
- Trial name
- NCT02056509
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Sudden Cardiac Arrest
HeartStart FRx Defibrillator Event Registry
This post market clinical follow-up study is a multi-center, non-randomized, unblinded, observational registry of the performance of the FRx Automated external defibrillator (AED) used in conjunction with electrodes with or…
- Trial name
- NCT04250857
- Testing
- HeartStart FRX
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- Heartstream US LLC
Myocardial Infarction, Dilated Cardiomyopathy
Arrhythmia Prediction Trial
Patients with Ischaemic and Dilated Cardiomyopathy, face an increased risk for Arrhythmic Sudden Cardiac Death. The purpose of this study is to estimate the performance of Modern Non-Invasive Indices and the performance of…
- Conditions
- Myocardial Infarction, Dilated Cardiomyopathy, Heart Failure
- Trial name
- APRET (NCT02175836)
- Where
- Greece
- Volunteers
- 500 people
- Sponsor
- University of Athens
Arrhythmogenic Cardiomyopathy, PKP2-ACM
Gene Therapy for ACM Due to a PKP2 Pathogenic Variant
This is a Phase 1/2, first-in-human, open-label, intravenous, dose-escalating, multicenter trial that is designed to assess the safety and tolerability of LX2020 in adult patients with PKP2-ACM
- Conditions
- Arrhythmogenic Cardiomyopathy, PKP2-ACM, PKP2-ARVC
- Trial name
- NCT06109181
- Testing
- LX2020
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Lexeo Therapeutics
Bradycardia, Sudden Cardiac Arrest
Feasibility Study of Remote Support for Implantable Pulse Generator (IPG)/Implantable Cardioverter Defibrillator (ICD) Implant
The purpose of this study is to gain real world, live implant experience with the remote implant support system. This system is intended to provide the technical support for device implants from a remote location through…
- Trial name
- NCT01809652
- Testing
- Remote Implant Support Capability
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Mucopolysaccharidosis II
Safety and Efficacy of HMI-203 in ERT-Treated Adults With MPS II
Phase 1, open-label, sequential ascending dose-escalation study. Designed to evaluate the safety and efficacy of a single IV infusion of investigational gene therapy HMI-203.
- Trial name
- NCT05238324
- Testing
- Genetic HMI-203
- Where
- 6 sites in United States, Canada
- Sponsor
- Homology Medicines, Inc
Cardiovascular Diseases, Heart Diseases
Epidemiology of Long QTand Asian Sudden Death in Sleep
To conduct a cross-sectional epidemiologic study of the determinants of prolonged heart rate corrected QT interval (QTc) among 300 men and 300 woman in the population with the highest known risk of SUDS: Southeast Asian refugees…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Arrhythmia, Death, Sudden, Cardiac
- Trial name
- NCT00005367
- Sponsor
- Utah State University
Prevention of Sudden Death
Training Mothers of Infants in Infant Cardiopulmonary Resuscitation (CPR)
This research will be a prospective, cohort study to determine if mothers of infants/newborns are more willing to complete CPR training using a 22-minute instructional DVD and infant manikin versus traditional four hour didactic…
- Trial name
- NCT00570869
- Testing
- CPR Anytime
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Lehigh Valley Hospital
Acute Myocardial Infarction, Ventricular Tachycardia
Acute Cardiovascular Events Triggered by COVID-19-Related Stress
The current COVID19 pandemic has afflicted almost the whole globe. The stress related to the pandemic, not the direct virus-related injury, can be potentially associated with acute cardiovascular events due to a large list of…
- Conditions
- Acute Myocardial Infarction, Ventricular Tachycardia, Sudden Cardiac Death, Stroke, Acute
- Trial name
- JoCORE (NCT04368637)
- Where
- 5 sites in Jordan
- Volunteers
- 50 people
- Sponsor
- Jordan Collaborating Cardiology Group
Sudden Death
The Significance of Arrhythmias in Athletes
Athletes with complex ventricular arrhythmias are potentially at risk of sudden death. The aim of the study is to investigate the relevance of ventricular tachyarrhythmias induced by an exercise test in a retrospectively…
- Trial name
- Athlete (NCT00469794)
- Testing
- stress test
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Assaf-Harofeh Medical Center
Sudden Death, Sudden Cardiac Arrest
Impact of an Intensive Care Diary on Post-traumatic Stress Disorder After a Resuscitated Sudden Death
Sudden death is a public health problem with more than 300,000 cases per year in USA and 40,000 cases per year in France. Moreover, despite all recent therapeutic improvements (therapeutic hypothermia, new techniques of…
- Trial name
- COREABOR (NCT02874469)
- Testing
- Diary
- Where
- France
- Volunteers
- 173 people
- Sponsor
- University Hospital, Lille
Sudden Unexpected Death in Epilepsy, Near-Sudden Unexpected Death in Epilepsy
Electroclinical Features of Sudden Unexpected Death in Epilepsy (SUDEP) : a Multi-center Observational Study
Sudden unexpected death in epilepsy (SUDEP) is regarded as a leading cause of premature death in epilepsy patients. We aim to capture the whole process of SUDEP and near-SUDEP occurrence in patients with epilepsy, and expolre…
- Trial name
- NCT05423990
- Testing
- Video-Electroencephalography
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Liu Yonghong
Sudden Cardiac Arrest
HeartStart HS1 Defibrillator* Event Registry
A Prospective study on the performance and safety of the HeartStart OnSite (Model M5066A) \& HeartStart Home (Model M5068A) Defibrillator device data.
- Trial name
- NCT04840797
- Testing
- HeartStart HS1
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- Heartstream US LLC
Chronic Stable Angina, Unstable Angina
The Role of Alcohol Consumption in the Aetiology of Different Cardiovascular Disease Phenotypes: a CALIBER Study
The association between alcohol consumption and cardiovascular disease (CVD) has mostly been examined using broad endpoints or cause-specific mortality.
- Conditions
- Chronic Stable Angina, Unstable Angina, Coronary Heart Disease Not Otherwise Specified, Acute Myocardial Infarction
- Trial name
- NCT01864031
- Where
- United Kingdom
- Volunteers
- 2,240,000 people
- Sponsor
- University College, London
Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation
PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)
The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation, Death, Sudden, Cardiac, Therapeutic Hypothermia
- Trial name
- PRECEDENCE (NCT07421882)
- Testing
- CarbonCool® Cooling Vest
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore General Hospital
Sudden Cardiac Arrest
HS Students Mandatory Universal Student Instruction in CPR Appraised Learning- Is the Mandate Working?
This study will help to provide better input to state health and education departments to improve the processes for CPR education.
- Trial name
- NCT04493970
- Testing
- High School Students Survey
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Cardiac Arrest, Out-Of-Hospital, Sudden Cardiac Arrest
Epinephrine Dose: Optimal Versus Standard Evaluation Trial
The objective of this randomized controlled trial is to evaluate whether a low cumulative dose of epinephrine ("low dose") is non-inferior to a standard cumulative dose of epinephrine ("standard dose") with respect to survival to…
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Sudden Cardiac Arrest, Ventricular Fibrillation, Ventricular Tachycardia-Pulseless
- Trial name
- EpiDOSE (NCT03826524)
- Testing
- Epinephrine
- Where
- 9 sites in Canada
- Volunteers
- 1,250 people
- Sponsor
- Unity Health Toronto
Sudden Death, Out-Of-Hospital Cardiac Arrest
Head-to-pelvis Computed Tomography Evaluation of Sudden Death Survivors
Out-of-hospital arrest can occur from multiple etiologies. In patients without an obvious reason for the sudden-death event, diagnostic evaluation is not clear.
- Trial name
- NCT03111043
- Testing
- Head to pelvis CT scan
- Where
- 2 sites in United States
- Volunteers
- 104 people
- Sponsor
- University of Washington
Acute Myocardial Infarction (AMI)
Risk Stratification After Acute Myocardial Infarction With Cardiac MRI
Given the existing controversy regarding the appropriate determination time for placement of implantable cardioverter-defibrillator (ICD) in patients at risk for sudden cardiac death (SCD) following acute myocardial infarction…
- Trial name
- CR-2280 (NCT03725826)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Montefiore Medical Center