Clinical trials: Substance-related Disorders
Tobacco Use Disorder
Innovative Interventions for Smoking Cessation
The purpose of this study is to evaluate the effect of a combination of the 21 mg nicotine patch and very low nicotine content (VLNC) cigarettes compared to 21 mg nicotine patch only and very low nicotine content cigarette only…
- Trial name
- NCT01050569
- Testing
- Nicotine Patch, VLNC Cigarette, VLNC Cigarette Plus Nicotine Patch
- Where
- 2 sites in United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Nicotine Dependence
Smoking Treatment in HIV Clinical Care Settings
The study is designed to evaluate and compare the efficacy and cost effectiveness of 3 smoking cessation treatments with HIV-positive cigarette smokers.
- Trial name
- NCT00297453
- Testing
- Internet-based smoking treatment, Individual Counseling, self-help
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Addiction
A Study to Assess 18-Methoxycoronaridine (18-MC HCl) in Healthy Volunteers
The primary objective of this study is to assess the safety and tolerability of a single day dosing and a separate multiple day dosing of 18-MC HCl administered orally, each part of the study having a different set of healthy…
- Trial name
- NCT04292197
- Testing
- 18-MC Compound
- Where
- Australia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Definium Therapeutics US, Inc.
Alcohol Dependence, Alcohol-Related Disorders
Remote Alcohol Monitoring and Episodic Thinking
Nearly 18% of United States adults meet criteria for alcohol dependence sometime in their lifetime, with only 24% of those individuals ever receiving any treatment for their disorder (Hasin et al., 2007).
- Trial name
- RMET (NCT03340051)
- Testing
- Episodic Future Thinking (EFT), Episodic Recent Thinking (ERT)
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Cocaine Related Disorders
The Effect of Yohimbine on Cocaine Cue Reactivity
Stress and cues reminiscent of cocaine use promote craving and relapse in cocaine dependent individuals. In addition, there appears to be gender differences in determinants of relapse to drug use following abstinence in…
- Trial name
- NCT00535002
- Testing
- Yohimbine
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Opioid-use Disorder
Intervention to Expand Opioid Use Disorder Treatment Pharmacotherapy Prescribers
This is a cluster-randomized controlled trial designed to increase the availability of buprenorphine and extended-release naltrexone treatment capacity for opioid use disorder (OUD).
- Trial name
- NCT02926482
- Testing
- Prescriber Recruitment Bundle (PRB)
- Where
- 3 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Anxiety, Relapse
"The Evaluation of Stimulant Withdrawal"
The purpose of this research study is to determine whether Carvedilol, an FDA approved beta blocker, when administered for an 8-week period to veterans currently undergoing treatment for methamphetamine dependence (1) improves…
- Conditions
- Anxiety, Relapse, Substance Addiction
- Trial name
- MARC (NCT00442923)
- Testing
- Coreg
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aaron J. Janowsky
Binge Drinking
The Brain, the Bug, and the Binge: the Interplay Between Binge Drinking, Gut Microbiota, and Brain Functioning
Adolescence and youth are periods of significant maturational changes which seems to involve greater susceptibility to disruptive events in the brain such as binge drinking (BD).
- Trial name
- NCT05946083
- Testing
- Inulin Intervention, Maltodextrin Intervention
- Where
- Portugal
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Minho
Alcohol Consumption, Alcohol Use Disorder
Step Away: Comparing a Chatbot-delivered Alcohol Intervention With a Smartphone App
A wide gap exists between the number of people needing alcohol treatment and those actually receiving it. This study builds on a previous one that indicated that smartphone-based intervention can help increase the number of…
- Trial name
- NCT04447794
- Testing
- Step Away Chatbot, Step Away App
- Where
- United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- University of Alaska Anchorage
Healthy
Testing the Interactive Effects of Delta-9-Tetrahydrocannabinol and Pregnenolone
The overall purpose of this study is to examine the effect of pregnenolone (PREG) on the acute psychosis-like and cognitive effects of Delta-9-tetrahydrocannabinol (THC).
- Trial name
- THC-Preg (NCT02576912)
- Testing
- Active Delta-9-THC, Active Pregnenolone
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Yale University
Schizophrenia, Tobacco Use Disorder
Effect of Bupropion on Smoking Behavior in Smokers With Schizophrenia
Many individuals with schizophrenia smoke cigarettes but little is known about the factors that control smoking in people with schizophrenia.
- Trial name
- NCT00218231
- Testing
- 300 mg/day bupropion-sr, 0 mg/day bupropion-sr
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Dependence
Nicotine Lozenge or Tobacco-Free Snuff for Smokeless Tobacco Reduction
Smokeless tobacco (ST) is a known human carcinogen. Long-term ST use is known to increase the risk for oropharyngeal cancer. Extant literature on cigarette smokers suggests that smoking reduction increases smoking abstinence…
- Trial name
- NCT01018394
- Testing
- nicotine lozenges, tobacco-free snuff
- Where
- 2 sites in United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tobacco Use Disorder
Fresh Lime Alone for Smoking Cessation
The purpose of this study is to determine whether fresh lime alone is effective for smoking cessation.
- Trial name
- LIM (NCT01333202)
- Testing
- Fresh lime
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Thai Health Professional Alliance Against Tobacco
Amphetamine Addiction
The Application of Cognitive Rehabilitation Therapy for Amphetamine-type Stimulants Addiction
The computerized cognitive rehabilitation therapy will be used to treat amphetamine-type stimulant (ATS) addiction.
- Trial name
- NCT03318081
- Testing
- cognitive function rehabilitation and bias modification
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Hepatitis C, Substance Use Disorders
Eliminating HCV in Rural South Carolina Utilizing NP Led Mobile Clinics and Virtual Care Coordination
Up to 150 individuals with current hepatitis C (HCV) will be recruited from mobile health clinics in rural South Carolina - sites will be selected based on HCV prevalence rates and lack of current HCV screening/treatment…
- Trial name
- STAT-C (NCT05369507)
- Testing
- Virtual Care Coordination
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate
Mood Disorder, Substance-Related Disorders
Pharmacological Interaction Between Doxazosin and Methylenedioxymethamphetamine (MDMA)
The purpose of this study is to determinate the effect of a pre-treatment with doxazosin, a alpha1-adrenergic receptor blocker, on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").
- Conditions
- Mood Disorder, Substance-Related Disorders, Amphetamine-Related Disorders
- Trial name
- NCT01386177
- Testing
- 3,4-Methylenedioxymethamphetamine, Doxazosin
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Marijuana
Helping Eliminate Marijuana Use Through Pediatric Practice
This study adapts the Public Health Service (PHS) 5As model for use with adolescent marijuana users and pilot the intervention to test feasibility and acceptability in pediatric primary care settings.
- Trial name
- HEMPP (NCT02744118)
- Testing
- 5A's Model, Healthy Internet Use Model
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- American Academy of Pediatrics
Cannabis, Psychotic Disorders
Cannabinoids, Learning, and Memory
The overarching goal of this study is to characterize the effects of cannabinoids on working and episodic memory.
- Trial name
- THC-Memory (NCT02407808)
- Testing
- THC
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yale University
Social Isolation or Loneliness, Anxiety
Health Surveillance at Constructor University Bremen (CUB)
The aim of Health Surveillance is to analyze and describe the state of health of students at Constructor University, key influencing factors and individual resources by using mixed-method design.
- Conditions
- Social Isolation or Loneliness, Anxiety, Anxiety Depression (Mild or Not Persistent), Health Behavior
- Trial name
- CUB-HS2025 (NCT06899308)
- Testing
- questionnaire
- Where
- 2 sites in Germany
- Volunteers
- 373 people, healthy volunteers welcome
- Sponsor
- Jacobs University Bremen gGmbH
Behavior, Health
Train Your Brain 2.0 - Improving Memory and Decision Making Among Youth
The goal of this clinical trial is to deliver a computer-based working memory training program to improve delay discounting (DD) and prevent substance misuse among at-risk adolescents in a traditionally underserved area.
- Trial name
- NCT06242704
- Testing
- Working Memory Training, Working Memory
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Wayne State University