Clinical trials: Substance Related Disorders
Voiding Dysfunction, Substance Abuse
Treatment Outcomes Under a Standardized Treatment Protocol in Patients Suffered Substance Abuse Related Voiding Dysfunction
With the increase of substance abuse over the world, substance abuse e.g. ketamine and methamphetamine related voiding dysfunction is becoming an important medical problem.
- Trial name
- NCT03913819
- Testing
- First line treatment: oral NSAID and anticholinergic agents, Second line treatment: additional treatment for pain control, Third line treatment: A course of intravesical hyaluronate will be given.
- Where
- Hong Kong
- Volunteers
- 1,500 people
- Sponsor
- Chinese University of Hong Kong
Chronic Insomnia, Chronic Pain
Lemborexant vs Clonidine vs Sedatives to Treat Insomnia in Chronic Pain Patients
Prospective observational crossover study of 250 adults undergoing chronic pain management. For insomnia treatment, patients alternate their usual prescribed sedative versus Lemborexant or Clonidine; on alternate nights.
- Conditions
- Chronic Insomnia, Chronic Pain, Restless Leg Syndrome (RLS), Substance Abuse
- Trial name
- NCT05618002
- Testing
- Lemborexant
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- Salem Anaesthesia Pain Clinic
Alcohol Use, Adolescent
Evaluating Caregiver Involvement in Primary Care-Based Brief Interventions for Adolescent Alcohol Use Problems
Intervention for mild severity alcohol use among U.S. teens is crucial, as alcohol is the most commonly used substance in this age group, yet few receive the necessary interventions.
- Conditions
- Alcohol Use, Adolescent, Mild Alcohol Use Disorder, Mild Substance Use Disorder
- Trial name
- NCT06593652
- Testing
- Teen Intervene - Adolescent Only, Teen Intervene with Caregiver Session, Family Check Up
- Where
- United States
- Volunteers
- 615 people
- Sponsor
- Indiana University
Alcoholism, Substance-Related Disorders
SMART-r: Substance Monitoring and Active Relapse Tracking Repository
Background: About 1.5 million adults in the US enter alcohol or substance use treatment programs each year. Unfortunately, more than half of patients do not finish their program.
- Trial name
- NCT06676059
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Healthy Volunteers
Phase I Trial of High-Density Theta Burst Stimulation (hdTBS)
Background: Transcranial magnetic stimulation (TMS) uses magnetic pulses to affect brain activity. A type of TMS called theta burst stimulation (TBS) is approved to treat people with major depression.
- Trial name
- NCT06868914
- Testing
- TMS (MagVenture MagPro 100 with MagOption)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use Disorders (SUDs)
Development of an Interview-Informed Timeline Follow-Back (TLFB) for Opioid Use in the Era of Fentanyl
Background: A Timeline Follow-Back (TLFB) is a tool that helps researchers track how much of a substance a person uses. Different versions of the tool are used to track the use of alcohol, cigarettes, and cannabis.
- Trial name
- NCT06995885
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use Disorders, Mental Health Disorders
Validation of the Behavioral Activation for Depression Scale in Individuals With Substance Use Disorders
This cross-sectional observational study evaluates the psychometric properties, structural validity, item response characteristics, and concurrent criterion validity of the Behavioral Activation for Depression Scale (BADS) in…
- Conditions
- Substance Use Disorders, Mental Health Disorders, Substance-related Disorders, Depression Scale Score
- Trial name
- BADS-SUD (NCT07395700)
- Where
- Mexico
- Volunteers
- 289 people
- Sponsor
- Lauro Gutiérrez Castro
HIV, Substance Use Disorder
Olfactory Function and Model-Based Behavior in People Living With HIV and SUD
Background: Human immunodeficiency virus (HIV) infection can affect areas of the brain that control thinking ability. These same areas of the brain also control the sense of smell.
- Trial name
- NCT07637669
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Stress, Drug Abuse
Developing Field Tools for Real-Time Assessment of Exposure to Psychosocial Stress and Drug Use in an Outpatient Treatment Population
Background: Researchers are interested in developing more accurate methods to assess environmental influences on psychological stress and drug use.
- Trial name
- NCT00787423
- Where
- United States
- Volunteers
- 373 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Pain, Abuse, Drug
Cannabis Effects as a Function of Sex
The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-related effects between men and women
- Trial name
- CanSex (NCT04385082)
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cannabis Use
An App to Reduce Cannabis Use Among Emerging Adults
This study is being completed to pilot prevention methods to promote wellness and reduce risky behaviors, including the use of substances such as cannabis.
- Trial name
- NCT05824754
- Testing
- Just-In-Time-Adaptive-Intervention (JITAI)
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of Michigan
Substance Use Disorders, Substance Use
Ketamine for Methamphetamine Use Disorder
This study aims to determine whether treatment response with IV ketamine is superior to treatment response with IV midazolam in adults with moderate to severe MUD.
- Conditions
- Substance Use Disorders, Substance Use, Methamphetamine Abuse
- Trial name
- KMD (NCT06496750)
- Testing
- Ketamine Hydrochloride, Midazolam Hydrochloride
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Texas Southwestern Medical Center
Burnout, Secondary Trauma
PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R33 Phase Clinical Trial)
The investigators propose to test the effectiveness of PATH (Peer Advanced Training for total Health) as an educational workforce intervention for improving peer recovery support specialists' (PRSS) overdose prevention (OP)…
- Conditions
- Burnout, Secondary Trauma, Compassion Fatigue, Opioid Use Disorder
- Trial name
- NCT07886944
- Testing
- PATH (Peer Advanced Training for total Health)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Chestnut Health Systems
Adolescent Health
Health Behavior in School-Age Children: NEXT Longitudinal Study 2009-2016
NEXT is a seven-year longitudinal assessment of a representative sample of U.S. adolescent and young adults starting at grade 10.
- Trial name
- NCT01031160
- Where
- United States
- Volunteers
- 4,902 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Substance Use Disorder (SUD)
Predicting Dropout and Outcome From Neuropsychological Functions in SUD Patients
The aim of this project is to gain a more specific understanding of how different cognitive profiles predict residential treatment drop-out, treatment retention and post-treatment outcome in a population with Substance Use…
- Trial name
- NCT03220373
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Opioid-Related Disorders, Drug Addiction
Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder
Background: People with addictions often find it hard to choose the long-term benefits of abstinence over the short-term effects of using drugs.
- Trial name
- NCT03745339
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Major Depressive Disorder, Substance Use Disorder
Defining Neurobiological Links Between Substance Use and Mental Illness
Background: Nicotine dependence leads to about 480,000 deaths every year in the United States. People with major depressive disorder (MDD) are twice as likely to use nicotine compared to the general population.
- Conditions
- Major Depressive Disorder, Substance Use Disorder, Normal Physiology
- Trial name
- NCT05538910
- Testing
- Nicotine Patch
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Methamphetamine Use Disorder, Substance Use Disorder
Closed-loop TBS Targeting rPO for the Core Clinical Features of Methamphetamine Use Disorder
The goal of this clinical trial is to evaluate whether closed-loop theta-burst stimulation (TBS) targeting the right parietal-occipital cortex (rPO) can improve core clinical symptoms in individuals with methamphetamine use…
- Conditions
- Methamphetamine Use Disorder, Substance Use Disorder, Cue-reactivity, Craving
- Trial name
- NCT07775807
- Testing
- Closed-loop Theta-Burst Stimulation (TBS) Targeting rPO
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shanghai Mental Health Center
Methamphetamine Use Disorder
Randomized Controlled Trial of Tirzepatide for Methamphetamine Use Disorder
This is a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial evaluating the tolerability, safety, and preliminary efficacy of tirzepatide for the treatment of individuals with moderate or severe…
- Trial name
- T-STEM (NCT07825857)
- Testing
- Tirzepatide
- Where
- 4 sites in United States
- Volunteers
- 228 people
- Sponsor
- University of Texas Southwestern Medical Center
Opioid-Related Disorders, NAS
MOms in REcovery (MORE) Study: Defining Optimal Care
Northern New England has among the highest rates of opioid dependence in the U.S. This region also has among the highest rates of opioid-related deaths in the U.S., with a disproportionate high rate among pregnant women with…
- Conditions
- Opioid-Related Disorders, NAS, Substance Use Disorders, Mental Health
- Trial name
- MORE (NCT04251208)
- Testing
- Observational Study
- Where
- 10 sites in United States
- Volunteers
- 2,510 people
- Sponsor
- Trustees of Dartmouth College