Clinical trials: Structural Heart Disease
Structural Heart Disease
NHLBI-Emory Advanced Cardiac CT Reconstruction
Background: Doctors use computed tomography (CT) to get detailed pictures of the heart. CT uses x-rays to gather raw data. Computers assemble this data to make the images doctors look at.
- Trial name
- NCT05372627
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Structural Heart Abnormality, Structural Heart Disease
Harnessing ECG Artificial Intelligence for Rapid Treatment and Accurate Interpretation
HEART-AI is a pragmatic randomized trial currently active at Montreal Heart Institute, with planned multicenter expansion testing whether an artificial intelligence (AI) score from a routine 12-lead electrocardiogram (ECG) helps…
- Trial name
- HEART-AI (NCT06462989)
- Testing
- ECHONEXT
- Where
- Canada
- Volunteers
- 5,700 people
- Sponsor
- Montreal Heart Institute
Advanced Heart Failure, Acquired Heart Disease
TORCH-LATAM-004: Regional Advanced-Therapy Pathways for Adults With Acquired or Structural Heart Disease
TORCH-LATAM-004 is a pragmatic stepped-wedge cluster randomized trial evaluating a regional pathway for adults with advanced heart failure secondary to acquired or structural heart disease who may require heart or combined…
- Conditions
- Advanced Heart Failure, Acquired Heart Disease, Structural Heart Disease, Heart Transplantation
- Trial name
- TORCH-004 (NCT07826078)
- Testing
- TORCH Adult Advanced Therapies Pathway (TORCH-AATP)
- Volunteers
- 360 people
- Sponsor
- CardioVision International Tech, S.A.S. de C.V.
Primary Care Provider, Structural Heart Disease
Deployment and Evaluation of Artificial Intelligence Software for Electrocardiogram Analysis and Management in Primary Care
The DAISEA-ECG project aims to improve the diagnosis of heart diseases in primary care through the DeepECG platform, which combines ECG-AI and ECHONeXT algorithms.
- Trial name
- DAISEA-ECG (NCT06637293)
- Testing
- DeepECG plateform diagnosis & recommendations
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Structural Heart Abnormality, Valve Heart Disease
Capitalizing on AI to CapTure Undiagnosed Structural Heart Disease
Doctors are testing a new tool called EchoNext to see if it can help find heart problems earlier. EchoNext looks at the heart's electrical test, called an ECG, and uses artificial intelligence (AI) to check for signs of…
- Conditions
- Structural Heart Abnormality, Valve Heart Disease, Heart Diseases, Cardiovascular Diseases
- Trial name
- CACTUS (NCT07843004)
- Testing
- EHR Alert
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- Pierre Elias
Structural Heart Disease, Mitral Valve Regurgitation
The Asia-Pacific Mitral & Tricuspid Valve-in-Valve/Valve-in-Ring Registry
A significant number of patients with severe mitral and tricuspid valve disease have been previously treated with either valve repair with annuloplasty rings or valve replacement with bioprosthetic/mechanical valves.
- Trial name
- AP ViV (NCT07296016)
- Where
- Hong Kong
- Volunteers
- 15 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Aortic Valve Stenosis, Heart Valve Diseases
ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation
The objective of ENVISION is to evaluate the safety and effectiveness of the Navitor Transcatheter Aortic Valve Implantation (TAVI) System for treating patients with symptomatic, severe native aortic stenosis who are considered…
- Conditions
- Aortic Valve Stenosis, Heart Valve Diseases, Aortic Valve Disease, Heart Disease Structural Disorder
- Trial name
- ENVISION (NCT05932615)
- Testing
- Navitor Transcatheter Aortic Valve Implantation (TAVI) System, Any Commercially Available Transcatheter Aortic Valve (CAV) System
- Where
- 107 sites in United States, Australia and 11 more
- Volunteers
- 1,500 people
- Sponsor
- Abbott Medical Devices
Ventricular Tachycardia (VT), Structural Heart Disease
Ventricular Tachycardia：A Registry Study
Structural heart disease-related ventricular tachycardia (SHD-VT) is associated with substantial morbidity and mortality. Although catheter ablation, ICD therapy, antiarrhythmic drugs, and other treatment strategies are widely…
- Trial name
- NCT07149701
- Testing
- Standard Clinical Care
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
Pulmonary Artery Hypertension, Congenital Heart Disease
Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive Guidewires
Background: A heart catheterization is a diagnostic heart procedure used to measure pressures and take pictures of the blood flow through the heart chambers.
- Conditions
- Pulmonary Artery Hypertension, Congenital Heart Disease, Structural Heart Disease
- Trial name
- NCT03152773
- Testing
- MRI Heart guidewire catheterization
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Structural Heart Disease
Improvement of an Algorithm to Detect Structural Heart Murmurs in Adult Patients Using Electronic Stethoscopes
The main objective of this study is to evaluate a machine learning model's ability to detect murmurs indicative of structural heart disease ("structural murmur") by analyzing phonocardiogram waveforms-and simultaneous…
- Trial name
- NCT07202104
- Testing
- Eko digital stethoscopes
- Where
- United States
- Sponsor
- Eko Devices, Inc.
Structural Heart Disease
Optimised Decrement Evoked Potential (DeEP) Mapping to Guide Ventricular Tachycardia (VT) Ablation in Patients With Structural Heart Disease VT
Ventricular tachycardia (VT) is a life-threatening heart rhythm disorder. Special pacemakers called implantable cardiac defibrillators (ICDs) help treat VT episodes, however they do not prevent the VT episodes from occurring.
- Trial name
- Opto-DeEP (NCT06937983)
- Testing
- Optimised DeEP-guided ablation
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Ventricular Tachycardia, Myocardial Infarction
Cohort Study - SBRT for VT Radioablation
Ventricular tachycardia (VT) contributes to over 350,000 sudden deaths each year in the US. Malignant VTs involve an electrical "short circuit" in the heart, formed by narrow channels of surviving tissue inside myocardial scar.
- Conditions
- Ventricular Tachycardia, Myocardial Infarction, Heart Disease Structural Disorder
- Trial name
- NCT04162171
- Testing
- Stereotactic Body Radiotherapy (SBRT) ablation of VT
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- John Sapp
Heart Disease Structural Disorder, Ventricular Tachycardia
Catheter Ablation Versus Anti-arrhythmic Drugs for Ventricular Tachycardia
Sudden cardiac death (SCD) due to recurrent ventricular tachycardia (VT) is an important clinical sequela in patients with structural heart disease.
- Conditions
- Heart Disease Structural Disorder, Ventricular Tachycardia, Cardiomyopathy, Dilated, Sarcoidosis
- Trial name
- CAAD-VT (NCT05524077)
- Testing
- Ablation, Anti-arrhythmic Drugs (AADs)
- Where
- 9 sites in Australia
- Volunteers
- 162 people
- Sponsor
- Western Sydney Local Health District
Structural Heart Disease
AI-Assisted Smart Stethoscope Screening for Structural Heart Disease in School Students in Ruyang County
The goal of this observational diagnostic study is to evaluate whether an artificial intelligence (AI)-enabled smart stethoscope can accurately detect structural heart disease in school-aged children and adolescents (10-18 years)…
- Trial name
- RY-CHD Screen (NCT07194785)
- Testing
- AI-Assisted Cardiac Auscultation using the HearTech Smart Stethoscope
- Where
- China
- Volunteers
- 6,614 people, healthy volunteers welcome
- Sponsor
- Heart Health Research Center
Tricuspid Regurgitation, Heart Failure
Biventricular Remodeling in Transcatheter Tricuspid Valve Replacement - Acute Hemodynamic Instability Study
TTVR-AHI is a multicenter, retrospective registry including heart failure patients displaying a severe and symptomatic tricuspid regurgitation (TR), deemed non-eligible to cardiac surgery and therefore treated with transcatheter…
- Conditions
- Tricuspid Regurgitation, Heart Failure, Structural Heart Disease, Interventional Cardiology
- Trial name
- TTVR-AHI (NCT06954792)
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Columbia University
Heart Failure, Structural Heart Disease
Pressure-Volume Loop Assessment in Valvular Heart Disease
The VHD PV loop study intends to assess invasive right ventricular to pulmonary artery (RV-PA) coupling in patients with valvular heart disease (VHD).
- Conditions
- Heart Failure, Structural Heart Disease, Interventional Cardiology
- Trial name
- VHD-PV-loop (NCT07112391)
- Testing
- Observational Invasive Hemodynamic Assessment
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Nantes University Hospital
Mitral Valve Disease, Heart Valve Diseases
Autonomous Robotics for Transcatheter Cardiac Procedures
Cardiovascular diseases represent the most common cause of death worldwide. Percutaneous approaches with intravascular catheters are pivotal, since they allow to treat patients with high perioperative risks.
- Conditions
- Mitral Valve Disease, Heart Valve Diseases, Structural Heart Abnormality
- Trial name
- ARTERY (NCT04787757)
- Testing
- Percutaneous cardiac procedure
- Where
- Italy
- Volunteers
- 401 people
- Sponsor
- Università Vita-Salute San Raffaele
Congenital Heart Disease (CHD), Structural Heart Disease
Artificial Intelligence-assisted Diagnosis
This study aims to investigate whether an AI-assisted decision support can improve the diagnosis of congenital heart diseases on Chest X-ray.
- Trial name
- AID (NCT06783933)
- Testing
- surgical or interventional validation
- Where
- China
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Structural Heart Disease
Interventional Structural Registry - LuEbeck
The aim of the registry is to investigate the effect of catheter-assisted procedures in the context of structural heart disease on clinical morbidity and mortality.
- Trial name
- INSTYLE (NCT06977139)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Prof. Dr. med. Ingo Eitel
Premature Ventricular Complexes, Ventricular Arythmias
WHEN DO WE HAVE to PERFORM CARDIAC MAGNETIC RESONANCE in PATIENTS REFERRED for PREMATURE VENTRICULAR COMPLEXES by THEIR CARDIOLOGISTS
Premature ventricular complexes (PVC) are a common entity affecting approximatively 20% of the general population. It can be discovered incidentally on electrocardiogram (ECG) or associated with symptoms with a wide spectrum from…
- Conditions
- Premature Ventricular Complexes, Ventricular Arythmias, Cardiac Magnetic Resonance Imaging, Focal or Diffuse Fibrosis
- Trial name
- IRMESV (NCT06801743)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens