Clinical trials: Stroke Ischemic
Ischemic Stroke, Depressive Symptoms
Combined tDCS and Cognitive Neurorehabilitation in Post-Stroke Depression
This study evaluates a multimodal intervention pathway for affective and cognitive symptoms after ischemic stroke. Patients undergo an initial screening of depressive symptoms, cognitive function, and quality of life.
- Trial name
- CACTUS (NCT07848919)
- Testing
- Active transcranial direct current stimulation, Cognitive neurorehabilitation using Guttmann NeuroPersonalTrainer
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida)
Stroke
Neopterin Effects on Ischemic Stroke
Ischemic stroke accounts for the majority of stroke cases and constitutes a major cause of death and disability in industrial world. Inflammation has been reported to constitute a major component of ischemic stroke pathology.
- Trial name
- NCT02974192
- Testing
- Neopterin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Stroke, Acute Ischemic, Stroke, Acute
CHemical OptImization of Cerebral Embolectomy 2 (CHOICE 2).
Multi-center, randomized, parallel-group, superiority study to compare the efficacy of adjunct intra-arterial rt-PA versus not adjunct intra-arterial rt-PA in the improvement of the efficacy of mechanical thrombectomy in patients…
- Trial name
- CHOICE2 (NCT05797792)
- Testing
- Intraarterial alteplase
- Where
- 14 sites in Spain
- Volunteers
- 440 people
- Sponsor
- Hospital Clinic of Barcelona
Ischemic Stroke, Transient Ischemic Attack
Platelet Aggregation Function-Guided De-Escalation Antiplatelet Therapy in Patients With Acute Ischemic Stroke
This multicenter, prospective, open-label, randomized controlled trial will evaluate whether platelet aggregation function-guided de-escalation of antiplatelet therapy is non-inferior in efficacy and superior in safety compared…
- Trial name
- PATH STROKE D (NCT07644234)
- Testing
- Clopidogrel, Aspirin
- Where
- China
- Volunteers
- 3,836 people
- Sponsor
- Sichuan Provincial People's Hospital
Ischemic Stroke, Acute
Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-B )
To compare the door-to-puncture time of patients with hyperacute ischemic stroke (between 4.5-6 hours after the onset of symptoms) treated in a standard stroke unit adherent to guidelines versus treated in Emergency Stroke Unit…
- Trial name
- NCT06492265
- Testing
- Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit adherent to guidelines
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yongjun Wang
Cerebral Infarction, Stenosis Artery
The Effect and Safety of Combined Anti-platelet Treatment in Acute Ischemic Stroke Due to Large Artery Atherosclerosis
Currently, aspirin plus clopidogrel is considered as a standard acute treatment of ischemic stroke, based on results of CHANCE and POINT trial.
- Trial name
- CHANGE (NCT06757764)
- Testing
- Aspirin, Clopidogrel, Cilostazol
- Where
- 24 sites in South Korea
- Volunteers
- 2,340 people
- Sponsor
- Asan Medical Center
Ischemic Stroke, Transient Ischemic Attack
European Blood Pressure Intensive Control After Stroke
Stroke is the third most common cause of death worldwide and the leading cause of disability. High blood pressure is an important risk factor for stroke.
- Trial name
- EPICS-Pilot (NCT04647292)
- Testing
- anti-hypertensive, home blood pressure measurement, telemonitoring and medication titration, Standard of Care Blood Pressure Management with Antihypertensives
- Where
- Ireland
- Volunteers
- 142 people
- Sponsor
- University College Dublin
Ischemic Stroke
Individual Alpha Frequency-Based rTMS for Post-Stroke Motor Recovery: Efficacy and Neurophysiological Mechanisms
The goal of this clinical trial is to evaluate the efficacy of a personalized brain stimulation technique, Individual Alpha Frequency (IAF)-based rTMS, for motor function recovery in adult patients with a first-ever ischemic…
- Trial name
- NCT07498777
- Testing
- Active Individual Alpha Frequency-based Repetitive Transcranial Magnetic Stimulation (IAF-rTMS)
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- National Taiwan University Hospital
Stroke, Inflammation
Combinating Fingolimod With Alteplase Bridging With Thrombectomy in Acute Ischemic Stroke
Proof-of concept clinical trials have indicated that the sphingosine-1-phosphate receptor modulator fingolimod may be efficacious in attenuating brain inflammation and improving clinical outcomes in patients with AIS as a single…
- Trial name
- NCT04675762
- Testing
- Fingolimod
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Middle Cerebral Artery Infarction
Intravenous Autologous Mesenchymal Stem Cells Transplantation to Treat Middle Cerebral Artery Infarct
This study aims to determine the efficacy of intravenous transplantation of autologous bone marrow-derived mesenchymal stem cells in patients with acute middle cerebral artery infarct.
- Trial name
- NCT01461720
- Testing
- Standard medical care, Autologous bone marrow-derived mesenchymal stem cells
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- National University of Malaysia
Stroke, Acute, Neurological Impairment
A Study on the Use of Tanakan® for Recovery of Neurological Impairment Following Ischaemic Stroke
The purpose of this study is to evaluate the effectiveness of Tanakan® 240mg in association with Acetylsalicylic acid (325mg/day) in the recovery of neurological impairment following ischemic stroke.
- Trial name
- NCT00276380
- Testing
- EGb761, Acetylsalicylic acid
- Where
- 10 sites in Czechia, Poland and 2 more
- Volunteers
- 204 people
- Sponsor
- Ipsen
Restless Legs Syndrome, Stroke
Restless Legs Syndrome in Stroke Patients
Our study aimed to examine a possible association between Restless legs syndrome and cerebrovascular disease, by examining patients during hospitalization for acute stroke or transient ischemic attack, in a matched case-control…
- Conditions
- Restless Legs Syndrome, Stroke, Transient Ischemic Attack
- Trial name
- NCT01967303
- Volunteers
- 447 people
- Sponsor
- Rambam Health Care Campus
Acute Ischemic Stroke
Ultrasound for Acute Field Triage of Stroke
Acute ischemic stroke (AIS) is responsible for considerable morbidity and mortality worldwide and has serious medico-economic and psychosocial consequences.
- Trial name
- USTRAFAST (NCT05845203)
- Testing
- perform a simultaneous bilateral DTC acquisition of 20 seconds per hemisphere
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Atrial Fibrillation, Stroke
Transient Electrocardiogram Assessment in Stroke Evaluation
In stroke survivors, atrial fibrillation is typically detected with short-term electrocardiogram (ECG) monitoring in the stroke unit.
- Trial name
- TEASE (NCT03301662)
- Testing
- chest and thumb- ECG
- Volunteers
- 100 people
- Sponsor
- Region Gävleborg
Stroke Hemorrhagic, Stroke, Ischemic
The Role of Cognition in Motor Learning After Stroke
Stroke leads to lasting problems in using the upper limb (UL) for everyday life activities. While rehabilitation programs depend on motor learning, UL recovery is less than ideal.
- Conditions
- Stroke Hemorrhagic, Stroke, Ischemic, Cognitive Impairment
- Trial name
- NCT05268861
- Testing
- Error Augmentation Feedback, No Error Augmentation Feedback
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McGill University
Stenosis
Effects of Intense Aerobic Exercise on the Cerebrovascular Reserve Capacity in Patients With Hemodynamically Relevant Intra- and Extracranial Stenoses
The purpose of this trial is to study the improvement of cerebral hemodynamics in high risk stroke patients with impaired Cerebrovascular Reserve (CVR) due to high grade stenosis of the internal carotid (ICA) or middle cerebral…
- Trial name
- Exercise (NCT00912561)
- Testing
- Intense aerobic exercise
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Gerhard Jan Jungehuelsing
Prevention & Control
Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease
The primary objectives of this study are: To determine whether rivaroxaban 2.5 mg twice daily (bid) + aspirin 100 mg once daily (od) compared with aspirin 100 mg od reduces the risk of a composite of myocardial infarction…
- Trial name
- COMPASS (NCT01776424)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Aspirin, Pantoprazole
- Where
- 565 sites in United States, Argentina and 31 more
- Volunteers
- 27,395 people
- Sponsor
- Bayer
Stroke, Hypothermia Treatment
Prognostic Biomarkers for Selective Intra-Arterial Cooling Infusion Combined with Endovascular Thrombectomy in Acute Ischemic Stroke Based on Proteomics and Metabolomics.
Endovascular Thrombectomy has emerged as a pivotal treatment modality for acute ischemic stroke. However, despite successful thrombus removal, a substantial proportion of patients still experience poor outcomes.
- Trial name
- NCT06665386
- Testing
- hypothermia
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Capital Medical University
Stroke, Ischemic
Implementation of New Multimodal MRI Sequences by Fingerprint to Improve Ischemic Stroke Examination.
Currently, standard brain MRI takes 20 to 25 minutes, but in the case of ischemic stroke, every minute counts to limit the extension of the necrotic core, with the possibility of recanalizing the occluded artery (intravenous…
- Trial name
- INDEX (NCT07199920)
- Testing
- Achieva 3.0T dStream Philips
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Grenoble
Stroke, Rehabilitation
Virtual Reality-Based Upper Limb Rehabilitation in Chronic Stroke
This randomized controlled study aims to evaluate the effectiveness of non-immersive virtual reality-based rehabilitation using the MindMotion™ GO system compared with conventional occupational therapy for improving upper limb…
- Conditions
- Stroke, Rehabilitation, Upper Limb Paresis, Chronic Stroke Patient
- Trial name
- NCT07534124
- Testing
- Non-Immersive Virtual Reality Rehabilitation, Occupational Therapy
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Universidad Complutense de Madrid
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