Clinical trials: Stroke Due to Basilar Artery Occlusion
Acute Ischemic Stroke, Basilar Artery Occlusion
Basilar Artery Occlusion Chinese Endovascular Trial in the Extended Time Window
A prospective, multi-center, randomized, controlled, open-label, blinded-endpoint trial to evaluate the safety and efficacy of endovascular mechanical thrombectomy for acute basilar artery occlusion in the extended time window
- Trial name
- BAOCHE2 (NCT06560203)
- Testing
- Mechanical thrombectomy
- Where
- China
- Volunteers
- 309 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Radial Versus Femoral Access For Thrombectomy in Patients With Acute Basilar Artery Occlusion
Stroke is one of the most important diseases endangering the health and quality of life of Chinese people. Acute ischemic stroke (AIS) is commonly caused by cerebrovascular stenosis or occlusion.
- Trial name
- NCT05903560
- Testing
- endovascular recanalization via radial approach, endovascular recanalization via femoral approach
- Where
- China
- Volunteers
- 386 people
- Sponsor
- Jinling Hospital, China
Basilar Artery Occlusion
OUTCOME AND SAFETY OF RECANALIZATION TREATMENTS IN ISCHEMIC STROKE DUE TO ACUTE BASILAR ARTERY OCCLUSION
Rationale: Recently, two prospective multicenter RCT reported a potential beneficial effect of endovascular thrombectomy (EVT) in patients with an acute symptomatic basilar artery occlusion (BAO).
- Trial name
- NCT05402878
- Where
- Vietnam
- Volunteers
- 150 people
- Sponsor
- 115 People's Hospital
Basilar Artery Occlusion, Posterior Circulation Brain Infarction
Cerebrolysin as an Add-On Therapy to Standard Treatment of Basilar Artery Occlusion
The standard therapy for acute ischemic posterior circulation stroke (PCS) often leads to poor functional outcomes and high mortality rates, despite all advances in reperfusion therapy.
- Trial name
- NCT06489925
- Testing
- Cerebrolysin
- Volunteers
- 20 people
- Sponsor
- University Hospital Sestre Milosrdnice
Ischemic Stroke
Cerebellar Infarct Volume in Basilar Artery Stroke
Preprocedural predictors of outcome in patients with acute basilar artery occlusion (ABAO) who underwent endovascular treatment (EVT) remain controversial.
- Trial name
- CIV-ABAO (NCT04611178)
- Testing
- Mechanical thrombectomy
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Montpellier
Basilar Artery Occlusion, Thrombectomy
Additive Effects of Intra-arterial Tenecteplase for Successful Thrombectomy Due to Acute Basilar Artery Occlusion
Recent studies revealed the safety and effectiveness of EVT in patients with acute occlusion at basilar artery, showing that up to 46% of patients receiving EVT had favorable functional outcome at 3 months (ATTENTION and BAOCHE…
- Conditions
- Basilar Artery Occlusion, Thrombectomy, Tenecteplase
- Trial name
- NCT05580822
- Testing
- Tenecteplase for Injection, Saline
- Volunteers
- 520 people
- Sponsor
- First Hospital of China Medical University
Basilar Artery Occlusion, Large Ischemic Core
EVT in Acute Basilar Artery Occlusion With Large Infarction Core
A multicenter, prospective, open-label, blinded endpoint, randomized controlled trial designed to evaluate the efficacy and safety of best medical management (BMM) combined with endovascular treatment (EVT) versus BMM alone in…
- Conditions
- Basilar Artery Occlusion, Large Ischemic Core, Large Core Infarct, Endovascular Treatments
- Trial name
- BOLT (NCT07090941)
- Testing
- Endovascular Treatment
- Where
- 2 sites in China
- Volunteers
- 372 people
- Sponsor
- The First Affiliated Hospital of Hainan Medical University
Basilar Artery Occlusion, Ischemic Stroke
Basilar Artery Occlusion Chinese Endovascular Registry in Patients With Large-Core Infarct
This multicenter retrospective registry study evaluates the safety and effectiveness of endovascular therapy versus medical therapy for acute large-core basilar artery occlusion.
- Conditions
- Basilar Artery Occlusion, Ischemic Stroke, Large Core Infarct
- Trial name
- BAOCHE-LC (NCT07345702)
- Testing
- Endovascular Therapy
- Where
- China
- Volunteers
- 518 people
- Sponsor
- Xuanwu Hospital, Beijing
Basilar Artery Occlusion, Acute Cerebrovascular Accident
Intravenous Tenecteplase Plus EVT Versus EVT Alone on 4.5 to 24 Hours After Basilar Artery Occlusion
To assess the effect of intravenous tenecteplase plus endovascular thrombectomy (EVT) compared to EVT alone on 4.5 to 24 hours after stroke due to basilar artery occlusion.
- Conditions
- Basilar Artery Occlusion, Acute Cerebrovascular Accident, Stroke Due to Basilar Artery Occlusion
- Trial name
- NCT05701956
- Testing
- Tenecteplase, Endovascular thrombectomy
- Where
- China
- Volunteers
- 330 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Acute Ischemic Stroke, Basilar Artery Occlusion
Selective Intra-Arterial Hypothermia After Endovascular Treatment for Acute Basilar Artery Occlusion
This study will examine whether cooling part of the brain through a catheter after endovascular treatment improves recovery in adults with acute basilar artery occlusion, a type of severe stroke.
- Trial name
- NCT07896655
- Testing
- Mechanical thrombectomy, Normothermic saline infusion, 4°C saline infusion
- Where
- 2 sites in China
- Volunteers
- 818 people
- Sponsor
- Guangdong Second Provincial General Hospital
Acute Mild Basilar Artery Occlusion, Basilar Artery Occlusion
The Efficacy and Safety of Endovascular Treatment for Acute Mild Basilar Artery Occlusion
This study assesses the efficacy and safety of endovascular treatment for acute mild basilar artery occlusion within a multicenter, prospective, open-label, endpoint-blinded, randomized controlled clinical trial.
- Conditions
- Acute Mild Basilar Artery Occlusion, Basilar Artery Occlusion, Endovascular Treatment
- Trial name
- NCT07390032
- Testing
- Endovascular Recanalization Strategy, Best Medical Management
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Feng Gao
Ischemic Stroke, Acute
Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events-5
The trial is a multicentre, prospective, open-label, blinded endpoint (PROBE), phase 3, randomized controlled design. Patients with acute ischemic stroke due to basilar artery occlusion presenting within 24 hours will be…
- Trial name
- TRACE-5 (NCT06196320)
- Testing
- Tenecteplase, Best Practice (which may include intravenous Alteplase)
- Where
- 59 sites in China
- Volunteers
- 452 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke, Basilar Artery Occlusion
Endovascular Therapy for Acute Basilar Artery Occlusion With Large Ischemic Core
Acute basilar artery occlusion is associated with high mortality and severe disability. Previous randomized trials have demonstrated the benefit of endovascular therapy in selected patients with basilar artery occlusion; however…
- Conditions
- Acute Ischemic Stroke, Basilar Artery Occlusion, Large Ischemic Core
- Trial name
- NCT07672795
- Testing
- Endovascular Therapy, Best Medical Management
- Where
- China
- Volunteers
- 256 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Ischemic Stroke, Acute, Minocycline
Minocycline for Acute Ischemic Stroke Undergoing Endovascular Treatment Due to Basilar Artery Occlusion (MIST-B)
This is a multi-center, evaluator-blinded, randomized, open-label, proof of concept trial to explore possible beneficial effect of adjunctive oral minocycline on acute ischemic stroke (AIS) undergoing endovascular treatment due…
- Conditions
- Ischemic Stroke, Acute, Minocycline, Endovascular Treatment, Basilar Artery Occlusion
- Trial name
- MIST-B (NCT05512910)
- Testing
- Minocycline
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Basilar Artery Occlusion, Acute Cerebrovascular Accident
Endovascular Treatment for Acute Basilar Artery Occlusion
Rationale: Recently, two prospective multicenter RCT reported a potential beneficial effect of endovascular thrombectomy (EVT) in patients with an acute symptomatic basilar artery occlusion (BAO).
- Conditions
- Basilar Artery Occlusion, Acute Cerebrovascular Accident, Stroke Due to Basilar Artery Occlusion
- Trial name
- NCT04751708
- Testing
- endovascular treatment, best medical management
- Where
- China
- Volunteers
- 340 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Basilar Artery Occlusion, Ischemic Stroke
Basilar Artery Occlusion Chinese Endovascular Trial in Patients With Large Core Infarct
This study evaluates the safety and efficacy of endovascular therapy for acute basilar artery occlusion with large core infarcts in a multicenter randomized trial.
- Conditions
- Basilar Artery Occlusion, Ischemic Stroke, Large Core Infarct
- Trial name
- BAOCHE3 (NCT07046299)
- Testing
- Endovascular Therapy Plus Best Medical Treatment, Best Medical Treatment Alone
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Capital Medical University
Ischemic Stroke
Total Posterior-circulation Infarct Volume in Basilar Artery Stroke
Preprocedural predictors of outcome in patients with acute basilar artery occlusion (ABAO) who underwent endovascular treatment (EVT) remain controversial.
- Trial name
- TPCIV-ABAO (NCT04650022)
- Testing
- Mechanical thrombectomy
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Montpellier
Acute Ischemic Stroke, Basilar Artery Occlusion
Efficacy and Safety of Endovascular Recanalization for Acute Basilar Artery Occlusion With Extended Time Window (ANGEL-BAO)
The aim of this study is to assess the efficacy and safety of endovascular treatment versus medical management in patients with acute basilar artery occlusion with extended time window of 24-72 hours from onset.
- Trial name
- ANGEL-BAO (NCT06101667)
- Testing
- Best medical management, Endovascular treatment
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Tiantan Hospital
Acute Basilar Artery Occlusion, Endovascular Therapy
The Efficacy and Safety of Endovascular Therapy for Acute Ischemic Stroke Due to Large Core Infarction
This study assesses the efficacy and safety of endovascular therapy in patients with acute basilar artery occlusion with large core infarction within a multicenter, prospective, open-label, blinded endpoint, randomized controlled…
- Conditions
- Acute Basilar Artery Occlusion, Endovascular Therapy, Large Core Infarction
- Trial name
- NCT07333950
- Testing
- Endovascular Recanalization Strategy, Best Medical Management
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Beijing Tiantan Hospital
Basilar Artery Occlusion, Acute Cerebrovascular Accident
Endovascular Thrombectomy Alone Versus Intravenous Thrombolysis Plus Thrombectomy on Acute Basilar Artery Occlusion
To assess the effect of endovascular thrombectomy alone compared to intravenous thrombolysis plus endovascular thrombectomy in acute basilar artery occlusion patients within 4.5 hours from onset on efficacy and safety outcomes.
- Conditions
- Basilar Artery Occlusion, Acute Cerebrovascular Accident, Stroke Due to Basilar Artery Occlusion
- Trial name
- NCT05827042
- Testing
- Intravenous thrombolysis, Endovascular thrombectomy
- Where
- China
- Volunteers
- 338 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China