Clinical trials: Stroke, completed
Chronic Disease, Frail
Functional Exercise and Nutrition Education Program for Older Adults
There is strong evidence that specific types of exercise can improve health and physical function in older adults. While community exercise classes exist, many older adults with chronic conditions may need guidance from…
- Conditions
- Chronic Disease, Frail, Diabetes Mellitus, Cancer
- Trial name
- MoveStrong (NCT04037436)
- Testing
- Strength and Balance Training & Nutrition Education, Usual Care
- Where
- 5 sites in Canada
- Volunteers
- 44 people
- Sponsor
- University of Waterloo
Chronic Stroke
Post-Stroke Walking Speed and Community Ambulation Conversion Study
The purpose of this randomized, controlled study is to collect performance data on the ability of an investigational device designed to digitally deliver Rhythmic Auditory Stimulation to improve walking speed in people who…
- Trial name
- NCT04121754
- Testing
- MR-001, Active Walking
- Where
- 8 sites in United States
- Volunteers
- 87 people
- Sponsor
- MedRhythms, Inc.
Stroke, Brain Diseases
Spinal Cord Stimulation for Restoration of Arm and Hand Function in People With Subcortical Stroke
The goal of this study is to verify whether electrical stimulation of the cervical spinal cord can activate muscles of the arm and hand in people with hemiplegia following stroke.
- Conditions
- Stroke, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases
- Trial name
- NCT04512690
- Testing
- Epidural electrical stimulation (EES) of the cervical spinal cord
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Lee Fisher, PhD
Cerebral Palsy, Stroke
Spinal Stimulation and Mobility Devices
This research study will combine non-invasive spinal stimulation with an ankle exoskeleton to examine the acute impact of the stimulation on gait in children with cerebral palsy.
- Conditions
- Cerebral Palsy, Stroke, Premature Birth, Hypoxic-Ischemic Encephalopathy
- Trial name
- NCT05520359
- Testing
- Mobility Device, Spinal Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Stroke
Cognitive Control Functions of the Human Thalamus
The goal of this research project is to investigate how brain lesions affect our ability to generate goal-directed behaviors - a cognitive function commonly referred to as cognitive control.
- Trial name
- NCT06920992
- Testing
- measuring cognitive flexibility including working memory and set-switching
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Kai Hwang
Stroke
Phase-dependent Evaluation of Motor Cortex Excitability With TMS in Stroke
The purpose of this study is to investigate the effects of transcranial magnetic stimulation (TMS) on motor cortex excitability in individuals who have suffered stroke and to study the influence of the phase of the oscillatory…
- Trial name
- NCT04968743
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Stroke, Healthy Adult
tVNS Responsiveness Testing With Pupil Size
The goal of this study is to learn about the acute pupil response to transcutaneous vagus nerve stimulation (tVNS) in stroke survivors and healthy adults.
- Trial name
- NCT06335199
- Testing
- Unilateral Left tVNS stimulation, Bilateral tVNS stimulation, Unilateral Right tVNS stimulation
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Stroke
Neuromodulation and Dynamic Balance in Stroke
Portable Neuromodulation Stimulator (PoNS) is non-invasive stimulation device placed on the tongue to stimulate those brain regions understood to be important for maintaining balance.
- Trial name
- NCT05135533
- Testing
- Portable Neuromodulation Stimulation, Gait and balance training
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Medical University of South Carolina
Stroke, Stroke, Ischemic
At-Home taVNS - Stroke Rehab
Early evidence suggests the benefits of post-stroke motor rehabilitation may be enhanced by applying electrical stimulation to the ear.
- Conditions
- Stroke, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- NCT06616831
- Testing
- Remote Transcutaneous Auricular Vagal Nerve Stimulation Paired with Task-Specific Training
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Stroke, Hemiparesis
Fully Remote Use of IpsiHand Device in Hemiparetic Stroke
BCI-REHAB was a randomized clinical trial comparing an at-home brain-computer interface therapy system versus an at-home exercise program for upper-extremity rehabilitation in the chronic phases of stroke.
- Conditions
- Stroke, Hemiparesis, Spasticity as Sequela of Stroke, Brain Computer Interface
- Trial name
- NCT05965713
- Testing
- Neurolutions IpsiHand Upper Extremity Rehabilitation System, Home Exercise rehabilitation regimen Program (HEP)
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Neurolutions, Inc.
Cerebrovascular Disorders, Smoking Cessation
Efficacy and Cost-Effectiveness of Cost-free Pharmacotherapy for Smoking Cessation for High-risk Smokers With Cerebrovascular Disease
Research Aims The aims of this research study are to determine whether cost-free smoking cessation pharmacotherapy: 1. Helps smokers with Transient Ischemic Attack (TIA) or stroke to quit smoking over the long-term, compared to…
- Trial name
- NCT00962988
- Testing
- Cost-Free Pharmacotherapy Group, Prescription Only Group
- Where
- 2 sites in Canada
- Volunteers
- 194 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Stroke
A TargEted MAnageMent Intervention for Reducing Stroke Risk Factors in High Risk Ugandans
The proposed 2-phase project will first refine the TargetEd MAnageMent (TEAM) intervention to ensure acceptability across a broad range of Ugandans at risk for stroke and then test the effects of TEAM in reducing stroke risk in a…
- Trial name
- TEAM-U (NCT04685408)
- Testing
- TEAM, ETAU
- Where
- 3 sites in Uganda
- Volunteers
- 276 people
- Sponsor
- Case Western Reserve University
Stroke
Optimizing Parameters of Low-Intensity Focused Ultrasound for Cortical Modulation in Stroke Patients
The purpose of this research study is to find out the optimal intensity and frequency of Low Intensity Focused Ultrasound (LIFU) that is safe and tolerable in people who have had a stroke.
- Trial name
- LIFU (NCT05016531)
- Testing
- Low Intensity Focused Ultrasonic Stimulation, Low Intensity Focused Ultrasonic Stimulation Frequency
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Ischemic Stroke
Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy Pilot Trial
Prospective, single center, non-randomized, pilot study to assess the feasibility of IA TNK following standard of care mechanical thrombectomy (MT) in patients with AIS.
- Trial name
- ALLY (NCT05172934)
- Testing
- intra-arterial tenecteplase
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- ProMedica Health System
Chronic Pain, Post Stroke Pain
Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain
Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but current technology is unable to reliably achieve long-term pain symptom relief.
- Conditions
- Chronic Pain, Post Stroke Pain, Phantom Limb Pain, Spinal Cord Injuries
- Trial name
- NCT03029884
- Testing
- Open-Loop DBS, Closed-Loop DBS
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Prasad Shirvalkar, MD, PhD
Myocardial Infarction, Stroke
Women's Health Initiative Strong and Healthy Study
The WHISH trial applies state-of-the science behavioral principles and currently available technologies to deliver a physical activity intervention without face-to-face contact to ~25,000 older U.S. women expected to consent.
- Conditions
- Myocardial Infarction, Stroke, Cardiovascular Mortality, Hip Fractures
- Trial name
- WHISH (NCT02425345)
- Testing
- Physical Activity
- Volunteers
- 49,331 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Stroke
Zambia Stroke Unit Study
The goal of this clinical trial is to evaluate the impact of a locally adapted stroke unit on outcomes of adults with stroke in Zambia.
- Trial name
- ZASUS (NCT06457048)
- Testing
- Stroke Unit
- Where
- Zambia
- Volunteers
- 300 people
- Sponsor
- Johns Hopkins University
Stroke, Healthy Adult
Tracking Post-stroke Walking Improvements From the Clinic Into the Home
The purpose of this proposal is to use novel video-based movement tracking technology to measure gait quality after stroke - in the home.
- Trial name
- NCT05454007
- Testing
- Step length asymmetry training
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Western University of Health Sciences
Cardiovascular Diseases, Myocardial Infarction
Improving How Older Adults at Risk for Cardiovascular Outcomes Are Selected for Care Coordination
This pragmatic clinical trial embedded in an accountable care organization will determine the comparative effectiveness of two approaches for assigning care coordinators to older adults at risk for cardiovascular outcomes.
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Atrial Fibrillation, Diabetes Mellitus
- Trial name
- NCT05820295
- Testing
- Care coordination delivered based on perceived need, Care coordination delivered based on usual care (e.g. discharge from hospital)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Weill Medical College of Cornell University
Acute Ischemic Stroke (AIS)
Safety and Pharmacokinetics of MCI-186 in Subjects With Acute Ischemic Stroke
The objectives of this study are to assess the safety, tolerability and local tolerance, and to investigate the plasma levels and terminal elimination half life of MCI-186, and to review the routine clinical and neurological…
- Trial name
- NCT00821821
- Testing
- MCI-186
- Where
- 3 sites in Finland, Netherlands and 1 more
- Volunteers
- 36 people
- Sponsor
- Shionogi