Clinical trials: Stomatitis (Oral Mucositis)
Cryotherapy Effect
Cryoprotection of Chemotherapy-induced Oral Mucositis After Autologous Stem Cell Transplantation, a Randomized Study
This study evaluates, among study patients with lymphoma or myeloma undergoing autologous SCT, whether cooling oral mucosa with a cooling device compared with ice cubes/crushed ice or ice pop succeeds in reducing the degree of…
- Trial name
- NCT03203733
- Testing
- Cooral™, cryotherapy
- Where
- 5 sites in Norway, Sweden
- Volunteers
- 182 people
- Sponsor
- Uppsala University
Cancer of the Head and Neck, Xerostomia
The Effectiveness of a Thyme and Honey Spray for Oral Toxicities
Aim: To evaluate the effectiveness of thymus honey on radiation induced-oral mucositis and xerostomia. Background: Oral mucositis and xerostomia are two of the most severe side effects that head and neck cancer patients confront…
- Conditions
- Cancer of the Head and Neck, Xerostomia, Oral Mucositis, Radiation Toxicity
- Trial name
- HONEY (NCT04880148)
- Testing
- Thyme and Honey-based oral spray
- Where
- 2 sites in Cyprus
- Volunteers
- 200 people
- Sponsor
- Cyprus University of Technology
Oral Mucositis
A Study to Describe the Effect of Photobiomodulation (Low Level Laser Therapy) in Reducing the Severity and Incidence of Oral Mucositis (Oral Ulceration) in Oral Cancer Patients Undergoing Radiation Treatment
The goal of this study is to describe the effect of photobiomodulation (PBM) on the incidence and severity of oral mucositis in post-operative oral cancer patients receiving radiotherapy +/- chemotherapy.
- Trial name
- PBM (NCT07387978)
- Testing
- photobiomodulation
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Drug/Agent Toxicity by Tissue/Organ, Leukemia
Growth Factor to Prevent Oral Mucositis in Patients With Hematologic Cancer
RATIONALE: Keratinocyte growth factor may prevent symptoms of mucositis in patients receiving radiation therapy and chemotherapy.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00004132
- Testing
- filgrastim, palifermin, cyclophosphamide
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Childhood Oncology, Mucositis Oral
Oral Mucositis Management in Pediatric Oncology Patients
This study evaluated the impact of an oral mucositis care protocol on the severity of mucositis. The main questions it aims to answer are: -What is the severity of mucositis in parents and children who receive oral mucositis…
- Trial name
- NCT06711315
- Testing
- Oral Mucosit Care Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Zubeyde Ezgi Ercelik
Quality of Life, Oral Mucositis
Efficacy of a Probiotic and Microbiological Analysis on Oral Complications in Patients With HNC
The study is a Clinical Trial and the main objective is to Evaluate the effects of probiotics on oral complications induced by antineoplastic therapies in patients with head and neck cancer, attended at the radiotherapy service…
- Conditions
- Quality of Life, Oral Mucositis, Dental Plaque, Periodontal Diseases
- Trial name
- HNC (NCT06122636)
- Testing
- The probiotic to be used in the intervention corresponds to PRODEFEN Plus manufactured by ITALFARMACO S.A. laboratory
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- University of Barcelona
Oral Mucositis (Ulcerative)
Randomized Trial of Curcumin to Reduce Mucositis in Autologous Transplant Setting
Mucositis is a very common complication in bone marrow transplant setting. It is a result of injury to the gut caused by high dose chemotherapy.
- Trial name
- NCT04896164
- Testing
- Curcumin Lozenges
- Where
- India
- Volunteers
- 190 people
- Sponsor
- Tata Memorial Centre
Rare Diseases, Toxic Epidermal Necrolyses
Severe Bullous Drug Eruption and Filgrastim
Toxic epidermal necrolysis (TEN) including Stevens Johnson (SJS) and Lyell syndromes represent the most severe drug eruptions. It is an allergic disorder caused by cytotoxic T lymphocytes, specific of drugs, responsible for the…
- Trial name
- GNET (NCT04651439)
- Testing
- Filgrastim
- Where
- 3 sites in France
- Volunteers
- 42 people
- Sponsor
- Hospices Civils de Lyon
Oral Mucositis
Laser Therapy Versus Ozone Therapy for Oral Mucositis in Patients With Cancer
This retrospective observational study will compare laser therapy and ozone therapy for the management of oral mucositis in adults with head and neck cancer.
- Trial name
- LOMUC-RETRO (NCT07724444)
- Testing
- Laser Therapy, Ozone therapy
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Stomatitis
Laser for Oral Mucositis in Pediatric Onco-hematology
Children with cancer undergoing intensive chemotherapy (CT) regimens experience many side effects among which oral mucositis (OM) is one of the most debilitating.
- Trial name
- LAMPO (NCT02762019)
- Testing
- Laser therapy
- Where
- 8 sites in Italy
- Volunteers
- 101 people
- Sponsor
- IRCCS Burlo Garofolo
Stomatitis (Oral Mucositis)
Low Level Laser Therapy Versus Benzydamin in Prevention and Treatment of Oral Mucositis
A prospective study will be conducted at the Department of Oral Medicine, Periodontology, Diagnosis and Oral Radiology Faculty of Dental Medicine, Assiut branch Al-Azhar University.
- Trial name
- NCT05034068
- Testing
- 0.15% bezaydamine hydrochloride., low power laser with a wavelength of 870 nm
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Al-Azhar University
Oral Mucositis
A Dose Escalating Study of SGX942 for Oral Mucositis in Patients With Head and Neck Cancer
To evaluate the safety and efficacy of SGX942 in patients receiving chemoradiation treatment for the treatment of head and neck cancer.
- Trial name
- NCT02013050
- Testing
- SGX942
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Soligenix
Oral Mucositis
Mulberry Syrup on Oral Mucositis Healing
Objective: This study was carried out to investigate the effectiveness of oral care with black mulberry syrup on oral mucositis healing in individuals with COPD.
- Trial name
- NCT04118335
- Testing
- Black Mulberry Syrup
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- TC Erciyes University
Denture Stomatitis
Ozonated Water in Treatment of Denture Stomatitis
The effect of Ozonated water on the treatment of oral stomatitis associated with complete denture wearer in comparison to Chlorhexidine mouthwash
- Trial name
- NCT06021847
- Testing
- Ozonated water, Chlorhexidine mouthwash
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- National Research Centre, Egypt
Oral Mucositis
Investigation of the Effect of Oral Care With Coconut Oil on the Degree of Oral Mucositis in Pediatric Oncology Patients
Oral mucositis is characterized by ulcerative and inflammatory changes in the oral mucosa and is frequently seen in pediatric oncology patients receiving chemotherapy.
- Trial name
- NCT05849571
- Testing
- coconut oil
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Büşra Ekinci
GM-CSF
The Effect of GM-CSF to Preventing Oral Mucositis for Patients With Nasopharyngeal Carcinoma Receiving Radiotherapy
To evaluate the efficacy of GM-CSF to preventing oral mucositis for patients with nasopharyngeal carcinoma receiving radiotherapy.
- Trial name
- NCT06472739
- Testing
- GM-CSF
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Sun Yat-sen University
Candida Albicans Infection, Cigarette Smoking
Curcumin; Rose Bengal; Denture Stomatitis
Cigarette smoking in conjugation with bad oral hygiene is considered a typical predisposing factor for many oral diseases including denture stomatitis.
- Trial name
- NCT04837664
- Testing
- Curcumin, Rose Bengal, Nystatin
- Where
- Saudi Arabia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- King Saud University
Stomatitis
Recombinant Human Keratinocyte Growth Factor to Reduce Oral Mucositis in Hematologic Malignancy Patients Undergoing Peripheral Blood Stem Cell Transplantation After Radiation and High-dose Chemotherapy
Radiotherapy and high dose chemotherapy with bone marrow transplantation or peripheral blood stem cell transplantation is frequently used as treatment for patients with cancers of the bone marrow or lymph nodes such as Hodgkin's…
- Trial name
- NCT00041665
- Testing
- Recombinant Human Keratinocyte Growth Factor
- Sponsor
- Amgen
Mucositis, Solid Tumors
Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer
The purpose of this research study is to test the safety and effectiveness of palifermin to determine if weekly doses can be safely administered to reduce the incidence (occurrence of), duration (length of time) and severity…
- Conditions
- Mucositis, Solid Tumors, Stomatitis, Head and Neck Cancer
- Trial name
- NCT00101582
- Testing
- palifermin, cisplatin chemotherapy, Radiotherapy
- Volunteers
- 188 people
- Sponsor
- Swedish Orphan Biovitrum
Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Cancer
Mucoadhesive Oral Wound Rinse in Preventing and Treating Stomatitis in Patients With ER- or PR-Positive Metastatic or Locally Recurrent Breast Cancer That Cannot be Removed by Surgery Receiving Everolimus
This randomized phase II trial studies how well mucoadhesive oral wound rinse works in preventing and treating stomatitis in patients with estrogen receptor (ER)- or progesterone receptor (PR)-positive metastatic or locally…
- Conditions
- Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Cancer, Oral Complications, Progesterone Receptor-positive Breast Cancer
- Trial name
- NCT02015559
- Testing
- mucoadhesive oral wound rinse, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Jonsson Comprehensive Cancer Center