Clinical trials: Stomatitis (Oral Mucositis)
Acute Leukemia, Acute Myeloid Leukemia
Prevention of Oral Mucositis in Adults in With Hematologic Malignancy
The goal of this quasiexperimental cohort controlled intervention study is to learn if aloe vera mouthwash works better than usual care in the prevention and treatment of oral mucositis.
- Conditions
- Acute Leukemia, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Oral Mucositis
- Trial name
- NCT07809984
- Testing
- Aloe Vera Mouthwash, Standard of Care
- Where
- 3 sites in United States
- Volunteers
- 206 people
- Sponsor
- Wake Forest University Health Sciences
Oral Ulcer, Oral Mucositis
A Study of Phenytoin Mucoadhesive Film for Oral Ulcers in Healthy Volunteers
The goal of this clinical trial is to learn if a new 1% Phenytoin mucoadhesive film is safe and works to treat oral ulcers in healthy adult volunteers and patients with oral ulcers.
- Conditions
- Oral Ulcer, Oral Mucositis, Aphthous Stomatitis
- Trial name
- PHENO-FILM (NCT07890428)
- Testing
- 1% Phenytoin Mucoadhesive Film, Blank Mucoadhesive Film
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Head and Neck Cancer (H&N), Oral Mucositis (Ulcerative) Due to Radiation
Oral Care Program for Mouth Side Effects During Head and Neck Radiation Therapy
People having radiation therapy to the head and neck often develop painful mouth problems - mouth sores, dry mouth, mouth pain, trouble eating and drinking, and changes in taste.
- Conditions
- Head and Neck Cancer (H&N), Oral Mucositis (Ulcerative) Due to Radiation, Stomatitis (Oral Mucositis), Xerostomia Due to Radiotherapy
- Trial name
- OSEM (NCT07885033)
- Testing
- ORAL CARE PRODUCT KIT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- UNCANCER LLC
Mucositis Oral, Head and Neck Cancer
Photobiomodulation for the Prevention of Radiation Induced Oral Mucositis
Radiotherapy for head and neck cancer can cause severe mucositis (ulcers in the mouth) and pain. Photobiomodulation (Light therapy) will be used before and during radiotherapy to try to reduce the occurence and severity of…
- Conditions
- Mucositis Oral, Head and Neck Cancer, Radiation Dermatitis
- Trial name
- NCT04671862
- Testing
- Photobiomodulation
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Ottawa Hospital Research Institute
Oral Mucosa Discomfort, Pediatric Cancer
Music Therapy for Oral Mucositis Pain in Pediatric Patients
This mixed-methods pilot study will examine the effect of music therapy on oral mucositis pain in pediatric oncology patients. Oral mucositis, characterized by painful ulcerative lesions in the mouth, is a common side effect of…
- Conditions
- Oral Mucosa Discomfort, Pediatric Cancer, Mucositis Oral
- Trial name
- NCT07653360
- Testing
- Semi-Structured Interviews
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Head and Neck Neoplasms, Mucositis Oral
Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy
This study aims to propose an alternative and auxiliary methodology for the prevention and treatment of Oral Mucositis (OM) in patients undergoing radiotherapy or radio and chemotherapy for head and neck neoplasms through the use…
- Conditions
- Head and Neck Neoplasms, Mucositis Oral, Radiotherapy; Complications
- Trial name
- NCT05308732
- Testing
- Copaiba
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Head & Neck Cancer, Oral Mucositis
A Clinical Study to Compare BupiZenge With Lidocaine for Pain Due to Oral Mucositis in Patients With Head and Neck Cancer.
Most patients who receive radiation therapy for head and neck cancer develop painful sores in the mouth called oral mucositis. For many of them, these sores are severe and result in debilitating pain.
- Trial name
- BEAM-Pain (NCT07672236)
- Testing
- BupiZenge 25 mg, Lidocaine viscous 2%
- Where
- 11 sites in Denmark, Germany and 2 more
- Volunteers
- 150 people
- Sponsor
- OncoZenge AB
Oral Mucositis, Oral Mucositis (Ulcerative) Due to Radiation
Copaíba-based Mouthwash in Oral Mucotitis Prevention and Treatment in Oral Cancer Patients During Radioteraphy
Oral mucositis is the most significant acute toxicity of oral cavity radiotherapy. The available scientific evidence supports its preventive and therapeutic approach with low-level laser; however, this is unsuitable for tumor…
- Conditions
- Oral Mucositis, Oral Mucositis (Ulcerative) Due to Radiation, Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy, Oral Mucositis Due to Radiation
- Trial name
- NCT06708702
- Testing
- Copaíba mouthwash
- Where
- 2 sites in Brazil
- Sponsor
- Instituto Nacional de Cancer, Brazil
Mucositis Oral, Head & Neck Cancer
Photobiomodulation Alone Versus Photobiomodulation Combined With Topical Oral Oxygen Therapy for Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Randomized Clinical Trial
Oral mucositis is the inflammation and ulceration of the mucous membranes within the oral cavity, characterized by atrophy, edema, and erythema (1), and it occurs in nearly all patients with advanced head and neck cancer (HNC)…
- Trial name
- NCT07865780
- Testing
- sirolase xtent laser, blue m gel
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Assiut University
Mucositis Oral
A Clinical Trial of the Administration of Light Therapy to Prevent Mouth Sores in Children With Cancer
The goal of this clinical trial is to learn if light therapy can prevent mouth sores in children with cancer. The main questions it aims to answer are: Is it reasonable and acceptable to provide light therapy for children with…
- Trial name
- PBM (NCT06623305)
- Testing
- Photobiomodulation for prevention arm, Photobiomodulation for exploratory arm
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical College of Wisconsin
Oral Mucositis, Chemotherapy Effect
Effect of Sodium Bicarbonate, Saline and Black Mulberry Syrup on Degree of Oral Mucositis in Children Receiving Chemotherapy
This study was planned as a randomized controlled experimental study in order to compare the effects of oral care with saline and black mulberry syrup in addition to sodium bicarbonate on oral mucositis level in children aged…
- Trial name
- NCT06525402
- Testing
- Sodium Bicarbonate Group (Usual care), Saline Group, Black Mulberry Syrup Group
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
Radiation-induced Oral Mucositis, Head and Neck Cancer
Citrus Sinensis Peel Gel for Radiation-Induced Oral Mucositis
This randomized controlled clinical trial aims to evaluate the efficacy of Citrus sinensis peel extract gel in the treatment of radiation-induced oral mucositis in head and neck cancer patients.
- Trial name
- NCT07813923
- Testing
- Citrus sinensis peel extract gel, Conventional supportive treatment
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Oral Mucositis, Stem Cell Transplant Complications
Study of a New Medical Device for Oral Mucositis
This is a single-center randomized controlled trial of a new medical device (Bocaliner™) that has been designed to improve the treatment of chemotherapy-induced oral mucositis in patients undergoing cancer treatment.
- Trial name
- MDOM (NCT05104268)
- Testing
- Bocaliner
- Where
- Armenia
- Sponsor
- E2Bio Life Sciences, LLC
Oral Mucositis
Lactobacillus Rhamnosus GG Alleviates Oral Mucositis in Patients Undergoing Radiotherapy
Radiation therapy is a common treatment modality in the management of head and neck malignancies. However, head and neck tumors often have some adverse reactions when receiving radiation therapy, such as dry mouth, change of…
- Trial name
- NCT06390176
- Testing
- Lactobacillus rhamnosus GG, Radiotherapy
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Oral Mucositis, Hematopoietic Stem Cell Transplantation (HSCT)
Effect of a Standardized Oral Care Program on Oral Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation: A Randomized Controlled Trial(SOC-HSCT)
Oral mucositis is one of the most common and debilitating complications in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT).
- Trial name
- SOC-HSCT (NCT07809451)
- Testing
- Standardized Oral Care Intervention, Routine Oral Care
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Oral Mucositis, Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy
Study of a Copaiba-Based Mouthwash Combined With Low-Level Laser Therapy in the Prevention of Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation
Oral mucositis (OM) one of the most significant acute toxicity of Hematopoietic Stem Cell Transplantation (HSCT). There is already scientific evidence suporting OM the use of: low-level laser therapy (LLLT), cryotherapy (in…
- Conditions
- Oral Mucositis, Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy, Oral Mucositis Due to Chemotherapy, Oral Mucositis in Patients Undergoing HSCT
- Trial name
- NCT07810530
- Testing
- Copaíba
- Where
- Brazil
- Volunteers
- 76 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Peri-implant Mucositis, Mucositis Oral
Treatment of Peri-implant Mucositis by Application of a Spermidine-based Gel
The aim of the study is to evaluate the potential of a spermidine-based topical gel as an adjuvant to non-surgical treatment of peri-implant mucositis.
- Trial name
- NCT05926557
- Testing
- Spermidine gel, NSMD
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Oral Mucositis, Quality of Life
Retrospective Observational Study of Oral Complications and Quality of Life in Head and Neck Cancer Patients Treated With Radiotherapy or Chemoradiotherapy.
Head and Neck cancer patients receiving radiation therapy (with or without chemotherapy) suffer several oral complications, such as oral mucositis, which impairs quality of life of patients during radiotherapy and in the…
- Conditions
- Oral Mucositis, Quality of Life, Mucositis, Pain
- Trial name
- NCT07739771
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Mucosa Innovations, S.L.
Oral Mucositis, Total Body Irradiation
Chlorophyllin for Reducing Oral Mucositis in Total Body Irradiation Prior to Transplant
The goal of this phase II, single-arm interventional clinical trial is to evaluate whether oral sodium copper chlorophyllin (CHL) can reduce the frequency and severity of oral mucositis in patients aged 12-65 years undergoing…
- Conditions
- Oral Mucositis, Total Body Irradiation, Hematological Malignancies, Hematopoietic Stem Cell Transplantation (HSCT)
- Trial name
- ChROMME-TBI (NCT07709195)
- Testing
- Sodium Copper Chlorophyllin
- Where
- India
- Volunteers
- 17 people
- Sponsor
- Tata Memorial Centre
Oral Mucositis
Laser Therapy Versus Ozone Therapy for Oral Mucositis in Patients With Cancer
This retrospective observational study will compare laser therapy and ozone therapy for the management of oral mucositis in adults with head and neck cancer.
- Trial name
- LOMUC-RETRO (NCT07724444)
- Testing
- Laser Therapy, Ozone therapy
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia