Clinical trials: Stimulant Dependence
Amphetamine-Related Disorders, Tobacco Use Disorder
Effects of Stimulant Dependence on Human Striatal Dopamine System - 15
The purpose of this study is to determine whether DAT availability, assessed by WIN binding, in the striatum is altered in cocaine or methamphetamine dependence.
- Trial name
- NCT00000350
- Testing
- radioactive substance
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Pemoline in the Treatment of Stimulant Dependence - 5
The purpose of this study is to assess the efficacy of pemoline in treating cocaine and/or methamphetamine dependent adults with comorbid Adult Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- NCT00000340
- Testing
- Pemoline
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
Effects of Progesterone on Smoked Nicotine Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effects
The clinical studies propose to study the abuse-related effects of nicotine after progesterone administration during the follicular phase in women of reproductive age.
- Trial name
- NCT01636336
- Testing
- Nicotine, Progesterone
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Cocaine Dependence, Methamphetamine Dependence
Smoking-Cessation and Stimulant Treatment (S-CAST)
The primary objective of this study is to evaluate the impact of substance-abuse treatment as usual plus smoking-cessation treatment (TAU+SCT), relative to substance-abuse treatment as usual (TAU), on drug-abuse outcomes.
- Conditions
- Cocaine Dependence, Methamphetamine Dependence, Nicotine Dependence
- Trial name
- S-CAST (NCT01077024)
- Testing
- Smoking-cessation treatment
- Where
- 12 sites in United States
- Volunteers
- 538 people
- Sponsor
- University of Cincinnati
Stimulant Dependence, Methamphetamine-dependence
Pilot TMS for Methamphetamine Use Disorder
This is a pilot study to test the feasibility of a recruitment strategy and study protocol to examine the effects of a dual target transcranial magnetic stimulation treatment in methamphetamine use disorder.
- Conditions
- Stimulant Dependence, Methamphetamine-dependence, Addiction, Drug
- Trial name
- NCT04449055
- Testing
- Transcranial Magnetic Stimulation--DPFC first, MPFC second, Transcranial Magnetic Stimulation--MPFC first, DPFC second
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Ryan M. Carnahan
Stimulant Dependence
Mindfulness Based Relapse Prevention for Stimulant Users
The broad, long-term objective of the current research is to improve treatment for stimulant use disorders by augmenting traditional relapse prevention therapy with innovative meditation-based strategies to promote affect…
- Trial name
- MBRP (NCT01094223)
- Testing
- Mindfulness Based Relapse Prevention, Health Education
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, Los Angeles
Alcohol Abuse, Cannabis Abuse
Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse
The purpose of this study is to determine whether Integrated Cognitive Behavioral Therapy or Twelve Step Facilitation Therapy is most effective for treatment of dually diagnosed veterans with depressive and substance use…
- Conditions
- Alcohol Abuse, Cannabis Abuse, Major Depressive Disorder, Substance-Related Disorders
- Trial name
- NCT00108407
- Testing
- Integrated Cognitive Behavioral Therapy, Twelve Step Facilitation Therapy
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders
Safety, Tolerability and Abuse Liability Study of Intravenous NRP104 in Adults With Stimulant Abuse Histories
This research is being done to evaluate if NRP 104 is a safe drug. The other purpose is to learn if NRP104, when injected into a vein, produces a high and any other effects like amphetamine and other stimulant drugs that are…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00247572
- Testing
- NRP104
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- New River Pharmaceuticals
Heroin Dependence, Amphetamine Dependence
An Open Label Study of Oral Minocycline for the Treatment of Patients With Co-occurring Opioid and ATS Dependence
The proposed study will evaluate the tolerability, acceptability and potential efficacy of minocycline for the treatment of co-occurring opioid and amphetamine-type stimulant (ATS) dependence.
- Trial name
- NCT02541500
- Testing
- Minocycline
- Where
- Malaysia
- Volunteers
- 40 people
- Sponsor
- Universiti Sains Malaysia
Opioid Dependence, Cocaine Dependence
Effects of Glucocorticoids on Craving During Detoxification Treatment of Heroin and/or Stimulants
The purpose of this study is to evaluate whether prednisolone lowers intensity and frequency of craving in heroin-addicted subjects undertaking a detoxification of cocaine and/or heroin.
- Trial name
- Goliath (NCT02935101)
- Testing
- Prednisolone
- Where
- Switzerland
- Volunteers
- 4 people
- Sponsor
- Prof. Dominique de Quervain, MD
Methamphetamine Abuse, Methamphetamine-dependence
Feasibility of Long-term, High-dose Stimulant for Methamphetamine Use Disorder
Methamphetamine use disorder (MUD) is becoming an increasing public health concern in Canada. While the evidence on the efficacy and safety of prescription psychostimulants for the treatment of MUD is promising, the knowledge on…
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance Abuse
- Trial name
- NCT06788587
- Testing
- LDX-01 plus TAU
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cocaine Dependence, Substance Use Disorders
Transcranial Magnetic Stimulation for Cocaine Addiction
Background: Cocaine use disorders (CUD) is a complex brain disorder, involving several brain areas and neurocircuits. Effective treatments for CUD are still needed.
- Conditions
- Cocaine Dependence, Substance Use Disorders, Chemical Addiction, Mental Disorder
- Trial name
- BRAINSWITCH (NCT03333460)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Bipolar Disorder, Cocaine Dependence
A Randomized Control Trial Comparing Quetiapine to Risperidone in Bipolar Disorder With Stimulant Dependence
The purpose of this study is to determine whether quetiapine or risperidone are effective in treating mood symptoms, drug cravings and use in bipolar disorder with concurrent cocaine or methamphetamine dependence.
- Conditions
- Bipolar Disorder, Cocaine Dependence, Methamphetamine Dependence
- Trial name
- NCT00227123
- Testing
- quetiapine, risperidone
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- University of Texas Southwestern Medical Center
Methamphetamine Abuse, Substance Use Disorders
rTMS for Craving in Methamphetamine Use Disorder
The primary aim of this project is to use a randomized single-blind sham-controlled study to investigate if high frequency repetitive transmagnetic stimulation (HF-rTMS) can modulate cue-induced craving in adult methamphetamine…
- Conditions
- Methamphetamine Abuse, Substance Use Disorders, Stimulant Dependence, Methamphetamine-dependence
- Trial name
- NCT03470480
- Testing
- Real Repetitive transcranial magnetic stimulation, Methamphetamine visual cues, Neutral visual cues
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
Methamphetamine Abuse, Methamphetamine-dependence
Clinical Trial of High Dose Lisdexamfetamine and Contingency Management in MA Users
The goal of this clinical trial is to learn if administering a high dose stimulant with Contingency Management reduces days of use in adults who use methamphetamine better than the usual treatment provided by the clinic.
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance, Addiction
- Trial name
- NCT05854667
- Testing
- Treatment as Usual plus lisdexamfetamine (LDX-01), Treatment as Usual plus lisdexamfetamine (LDX-01) plus Contingency Management
- Where
- 4 sites in Canada
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Opioid Abuse, Opioid Addiction
The Discriminative Effects of Tramadol in Humans
This research is part of a set of studies whose purpose is to test whether tramadol can be used for the treatment of opioid addiction. Tramadol is already available in the United States as a pain medicine marketed as Ultram.
- Conditions
- Opioid Abuse, Opioid Addiction, Stimulant Abuse, Stimulant Addiction
- Trial name
- NCT00499746
- Testing
- tramadol, Hydromorphone, Methylphenidate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Heroin Dependence, Amphetamine Dependence
Mirtazapine as a Treatment for Co-Occurring Opioid and ATS Dependence in Malaysia
The purpose of this study is to evaluate tolerability, acceptability and potential efficacy of 4 months of maintenance treatment with Mirtazapine as compared to placebo for patients with co-occurring amphetamine-type stimulant…
- Trial name
- NCT02541526
- Testing
- Mirtazapine
- Where
- Malaysia
- Volunteers
- 80 people
- Sponsor
- Universiti Sains Malaysia
Cannabis Dependence, Psychostimulant Dependence
Evaluation of the Effects of Treatment of Psycho-stimulant and Cannabis-dependent Users in Israel
This study evaluates the effects of psychological and pharmacological treatment of regular users of cannabis and psychostimulants in a treatment center (Kfar Izun) in Israel.
- Trial name
- NCT01510015
- Testing
- Risperidone
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
HIV Infections, Methamphetamine-dependence
Stimulant Use and Methylation in HIV
This study will leverage extracted leukocyte DNA specimens from a completed NIH-funded project to examine the efficacy of a behavioral intervention model that reduced stimulant use on DNA methylation over 6 months.
- Conditions
- HIV Infections, Methamphetamine-dependence, Methamphetamine Abuse
- Trial name
- NCT05916989
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Florida International University
HIV Infections, Cocaine Dependence
Pharmacotherapy for HIV+ Stimulant Dependent Individuals
The hypotheses of this study are: 1. Ondansetron will show a decrease in cocaine use from baseline in individuals with HIV who are cocaine using. 2.
- Trial name
- NCT00599573
- Testing
- ondansetron
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia