Clinical trials: Status Asthmaticus
Asthma, Status Asthmaticus
Study Evaluating the Safety and Effects of MN-221 in Subjects Experiencing an Acute Exacerbation of Asthma
The objective of this clinical study is to examine the safety and effectiveness of intravenous MN-221 compared to placebo when administered as an adjunct to standard therapy in subjects experiencing an acute exacerbation of…
- Trial name
- NCT00683449
- Testing
- Dose Group 1, Dose Group 2, Dose Group 3
- Where
- 9 sites in United States
- Volunteers
- 29 people
- Sponsor
- MediciNova
Asthma Exacerbation, Emergency Department
Efficacy of High-Dose Continuous Intravenous Magnesium Sulfate Infusion vs Standard Intravenous Magnesium Sulfate Therapy in Status Asthmaticus in the ED
The goal of this clinical is to compare treatment outcomes between high dose continuous IV Magnesium and standard therapy in the management of acute exacerbation of asthma in the emergency department.
- Conditions
- Asthma Exacerbation, Emergency Department, Magnesuim Sulfate, High Dose
- Trial name
- HIMAG-ED-STAT (NCT07795970)
- Testing
- ้High-dose Magnesium sulphate, standard-dose Magnesium Sulfate
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Bronchial Asthma, Status Asthmaticus
NiPPV in the Treatment of Acute Asthma Exacerbations
Study Summary: Title: A Randomized Controlled Trial of Noninvasive Positive Airway Pressure in the Pediatric Emergency Department for the Treatment of Acute Asthma Exacerbations Principal Investigator: Thomas J.
- Trial name
- NCT03219736
- Testing
- Standard of Care therapies, NiPPV Therapy, Routine Respiratory Care
- Where
- United States
- Sponsor
- Arkansas Children's Hospital Research Institute
Childhood Asthma With Status Asthmaticus
Status Asthmaticus on the PICU; Intravenous Salbutamol
Although IV salbutamol is frequently used in children in a wide range, pharmacodynamic data are scarce. To date, there is an insufficient evidence base to guide initial and subsequent dosing recommendation for its IV use in…
- Trial name
- STATIC IV (NCT03493503)
- Testing
- Salbutamol, Sodium Chloride 0.9%
- Where
- Netherlands
- Volunteers
- 58 people
- Sponsor
- Erasmus Medical Center
Status Asthmaticus
A Prospective Trial of BiPAP Administration vs. Non-positive Pressure Therapy for Pediatric Status Asthmaticus
Though BiPAP is an increasingly common tool used by pediatric critical care physicians and there is promising data suggesting a role for BiPAP in the management of status asthmaticus, more information is needed to more…
- Trial name
- NCT02539420
- Testing
- BiPAP treatment
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Status Asthmaticus
High Flow Nasal Cannula in Children With Status Asthmaticus
In France, over 2.5 million people suffer from asthma, including one-third of children. This is the chronic respiratory disease leading to the highest rate of hospitalization.
- Trial name
- CANULASTHM (NCT03157102)
- Testing
- HFNC, Standard Oxygen Treatment
- Where
- 14 sites in France
- Volunteers
- 272 people
- Sponsor
- Hospices Civils de Lyon
Status Asthmaticus
Trial of Terbutaline for the Treatment of Status Asthmaticus in Children
Although widely used for the treatment of pediatric status asthmaticus, intravenous terbutaline has potentially significant side effects; may not improve outcomes; and may increase Intensive Care Unit (ICU) length of stay.
- Trial name
- NCT00124995
- Testing
- terbutaline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Connecticut Children's Medical Center
Status Asthmaticus
Pleth Variability and Asthma Severity in Children
Research has shown that pleth variability can be used to assess asthma severity in children with status asthmaticus. The investigators would like to use an FDA-cleared monitor (Masimo Radical 7) which measures Pleth Variability…
- Trial name
- NCT02302261
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Northwell Health
Status Asthmaticus
Phase I, Placebo-Controlled, Blinded Pilot Study of Ipratropium in Children Admitted to the ICU With Status Asthmaticus
This study is a Phase I study to investigate the addition of inhaled Ipratropium bromide to standard therapy in the treatment of severe asthma attacks in children admitted to the Pediatric Intensive Care Unit.
- Trial name
- NCT02872597
- Testing
- Ipratropium, 0.9% Sodium Chloride, Albuterol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University Hospitals Cleveland Medical Center
Asthma Childhood
Ideal Steroids for Asthma Treatment in the PICU
Determine if differences in (1) pediatric intensive care unit length of stay, (2) continuous nebulized albuterol duration, and (3) a composite outcome of advanced asthma therapy incidence including use of non-invasive ventilation…
- Trial name
- iSTAT PICU (NCT03900624)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Johns Hopkins All Children's Hospital
Respiratory Failure, Status Epilepticus
Pilot Simulation RCT of Telemedical Support for Paramedics
This study evaluates the impact of video communication via telemedicine on the quality of emergency care provided to children by paramedic teams supported by a remote physician in a simulated out-of-hospital setting.
- Conditions
- Respiratory Failure, Status Epilepticus, Status Asthmaticus, Cardiopulmonary Arrest
- Trial name
- NCT03742167
- Testing
- Telemedicine
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Boston Medical Center
Acute Asthma Exacerbation
Acute Montelukast in Asthma
Patients presenting to hospital with an acute asthma exacerbation severe enough to require admission would receive full standard treatment according to British Thoracic Society guidelines in addition they would be offered the…
- Trial name
- AcMk (NCT01011452)
- Testing
- Montelukast
- Where
- United Kingdom
- Volunteers
- 87 people
- Sponsor
- University of East Anglia
Asthma Acute
Comparison Of Efficacy Of Hydrocortisone And Methyl Prednisolone In Acute Severe Asthma
COMPARISON OF EFFICACY OF HYDROCORTISONE AND METHYLPREDNISOLONE IN ACUTE SEVERE ASTHMA In this study Investigator will compare the efficacy of hydrocortisone and methyl prednisolone in acute severe asthma that will lead to final…
- Trial name
- NCT06171932
- Testing
- Methylprednisolone,
- Where
- 4 sites in Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Karachi
Acute Severe Asthma
Compare Efficacy Nebulized and Intravenous Magnesium Sulphate in Thai Children
The purpose of this study is to determine whether nebulized magnesium sulphate is effective in the treatment of acute severe asthma when comparison with intravenous magnesium sulphate
- Trial name
- NCT02112305
- Testing
- isotonic magnesium sulphate, 50% magnesium sulphate
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Queen Sirikit National Institute of Child Health
Asthma
Intramuscular Epinephrine as an Adjunctive Treatment for Severe Pediatric Asthma Exacerbation
Project Aim: To determine if intramuscular epinephrine is an effective adjunct to inhaled bronchodilators (β2 agonists) for children with severe asthma exacerbation.
- Trial name
- NCT01705964
- Testing
- IM epinephrine 1:1000, No intervention
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Louisville
Asthma, Asthmatic Crisis
Extra-fine Formoterol/Beclomethasone in Asthmatic Crisis
The purpose of this study is to determine whether extra fine formoterol/beclomethasona are more effective in the treatment of asthmatic crisis when added to conventional treatment compared with conventional treatment alone.
- Trial name
- NCT02345993
- Testing
- Extra fine Formoterol/Beclomethasone
- Where
- Mexico
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Respiratory Diseases, Mexico
Status Asthmaticus
Non Invasive Positive Pressure Ventilation in Status Asthmaticus
Status Asthmaticus is recognized as a common cause of morbidity in children in the United States (CDC). In recent years, hospitalization rates have reached an all time high.
- Trial name
- NCT01403428
- Testing
- Noninvasive positive pressure ventilation
- Where
- United States
- Sponsor
- Southern Illinois University
Asthma (Diagnosis)
Pediatric Asthma Trial of Corticosteroid Heterogeneity (PATCH): Trial of Dexamethasone Versus Methylprednisolone for Pediatric Critical Asthma
Acute asthma exacerbation is caused by dysregulated pulmonary inflammatory pathways such that standard treatment includes prompt administration of exogenous systemic corticosteroids (SCs), but there remains an ongoing dialogue…
- Trial name
- PATCH (NCT07455396)
- Testing
- Dexamethasone (0.6mg/kg; Max 16mg) Once Daily, Dexamethasone (0.25 mg/kg/dose, Max dose 16mg) every 6-hours, Methylprednisolone
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Johns Hopkins All Children's Hospital
Asthma
Continuous Levalbuterol for Treatment of Status Asthmaticus in Children
This study will use a randomized, double-blind, controlled trial design in order to assess the safety and efficacy of levalbuterol (LEV) compared to racemic albuterol (RAC) when delivered continuously in a high-dose regimen for…
- Trial name
- NCT00124176
- Testing
- Racemic albuterol (R+S albuterol), Levalbuterol (R albuterol)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Children's Hospital of Philadelphia
Asthma
Oral Glucocorticosteroid in the Treatment of Severe Asthma Exacerbation in Hospitalized Patients
A comparison of oral prednisolone administration with intravenous methylprednisolone infusion in the treatment of acute asthma exacerbation in hospitalized patients.
- Trial name
- NCT00627731
- Testing
- methylprednisolone sodium succinate (mPSL), prednisolone (PSL)
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Hamamatsu University