Clinical trials: Spontaneous Breathing, active
Mechanical Ventilation, Spontaneous Breathing Trial
Trial of Spontaneous Breathing Test
The hypothesis is that the Spontaneous Breathing Test (SBT) without pressure support (PS) is not inferior to the SBT with pressure support in relation to the following outcomes: a) extubation failure; b) time on MV.
- Conditions
- Mechanical Ventilation, Spontaneous Breathing Trial, Extubation Readiness, Extubation Failures
- Trial name
- NCT06593288
- Testing
- Pressure Support Ventilation, continuous positive airway pressure (CPAP)
- Where
- Brazil
- Volunteers
- 170 people
- Sponsor
- University of Sao Paulo
Ventilator Weaning, Airway Extubation
Can a Pain Monitor Predict When Postoperative Intensive Care Unit Patients Are Ready to Breathe on Their Own? A Pilot Study
The goal of this observational study is to learn if a chest monitor that tracks heart rhythm can help predict whether adults on a breathing machine after surgery will be able to breathe on their own once the breathing tube is…
- Conditions
- Ventilator Weaning, Airway Extubation, Respiration, Artificial
- Trial name
- NCT07771101
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Weaning-induced Pulmonary Edema, Mechanical Ventilation Weaning
Detecting Early Weaning-induced Pulmonary Oedema Using Lung Impedance Negative Trend During Spontaneous Breathing Trials
Critically ill patients who require a breathing machine are routinely assessed with a spontaneous breathing trial (SBT) to determine if they can safely breathe on their own.
- Conditions
- Weaning-induced Pulmonary Edema, Mechanical Ventilation Weaning, Spontaneous Breathing Trial
- Trial name
- DEWPOINT (NCT07886671)
- Where
- Canada
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Mechanical Ventilation, Extubation
Spontaneous Breathing Trials Using Pressure Support or T-Piece in Overweight and Obese Patients
This study aims to find out which method of spontaneous breathing trial (SBT) better helps overweight and obese ICU patients prepare for extubation, which is the removal of the breathing tube.
- Conditions
- Mechanical Ventilation, Extubation, Obesity &Amp; Overweight, Respiratory Failure
- Trial name
- NCT07114289
- Testing
- Spontaneous breathing trial using pressure support ventilation, Spontaneous breathing trial using T-Piece
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University Hospital
ARDS (Acute Respiratory Distress Syndrome)
International Survey for EXTubation Evaluation and Respiratory Dynamics in Acute Respiratory Distress Syndrome
EXTEND ARDS study is an international survey for ventilator weaning and extubation among ARDS patients. This study will be conducted on behalf of the Japanese ARDS Clinical Practice Guideline 2024 Committee as well as endorsement…
- Trial name
- EXTEND ARDS (NCT06598709)
- Where
- Japan
- Volunteers
- 1,000 people
- Sponsor
- Hiroshima University
Lung Cancer, OLV
Spontaneous Breathing Mode: A Risk for Hypoxemia During OLV?
Patients undergoing thoracic surgery with one-lung ventilation (OLV) are prone to hypoxemia, which is primarily attributable to pulmonary ventilation-perfusion (V/Q) mismatch.
- Conditions
- Lung Cancer, OLV, Hypoxemia During Surgery
- Trial name
- OLV (NCT07494006)
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Peking University People's Hospital
Weaning From Mechanical Ventilation in Care Unit
Prediction of the Spontaneous Breathing Test Success Using Biosignal and Biomarker in Critical Care Unit by a Machine Learning Approach
Context: Several authors have been interested in applying Artificial Intelligence (AI) to medicine, using various Machine Learning (ML) techniques: managing septic shock, predicting renal failure...
- Trial name
- NCT05886803
- Testing
- Spontaneous ventilation test
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Spontaneous Breathing Trial in ICU
Effect of High-Flow Humidified Oxygen on Ventilatory Work During the Spontaneous Breathing Trial
Weaning from mechanical ventilation (MV) accounts for a significant portion of the total MV duration, and failure to extubate or delayed extubation increases complications (particularly Ventilator-Associated Pneumonia (VAP)) and…
- Trial name
- OTRAVAIL (NCT07724392)
- Testing
- T piece, PSV, HFO
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Mechanical Ventilation Weaning, Chronic Disease
Phenotype-Guided Weaning in Mechanically Ventilated Patients With Chronic Comorbidities
The goal of this clinical trial is to learn whether a phenotype-guided weaning strategy can help adults with chronic comorbidities be liberated from invasive mechanical ventilation earlier.
- Trial name
- NCT07594418
- Testing
- Phenotype-Guided Weaning Strategy, Standard Care
- Volunteers
- 1,380 people
- Sponsor
- Southeast University, China
End-stage Lung Disease
Perioperative Recovery Outcomes of a Spontaneous Breathing-Preserving Strategy in Salvage Lung Transplantation
The goal of this prospective, multicenter, single-arm clinical study is to learn whether a breathing-preserved anesthesia-surgical strategy can improve early recovery and perioperative survival in adults undergoing rescue/bridge…
- Trial name
- NCT07384533
- Testing
- Lung transplantation that preserves spontaneous breathing function
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Respiratory Mechanics, Monitoring, Physiologic
Dynamic Non-invasive Monitoring of Inspiratory Effort
This prospective, observational cohort study aims to evaluate whether the dynamic monitoring of a patient's breathing effort can predict successful liberation from invasive mechanical ventilation.
- Conditions
- Respiratory Mechanics, Monitoring, Physiologic, Respiratory Insufficiency Requiring Mechanical Ventilation, Critical Illness
- Trial name
- NCT07839949
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Cardiac Arrest (CA)
Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?
To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest…
- Trial name
- LUCASVP (NCT06824961)
- Testing
- 5-second ventilation pause duration during mechanical CPR, 3-second ventilation pause duration during mechanical CPR
- Where
- 2 sites in Netherlands
- Volunteers
- 692 people
- Sponsor
- Amsterdam UMC, location VUmc
Acute Respiratory Distress Syndrome
Effect of Spontaneous Breathing in APRV Mode on Respiratory Physiology of ARDS Patients
This is a single-center, prospective, randomized, three-period crossover physiological study in adult patients with moderate-to-severe acute respiratory distress syndrome (ARDS, PaO₂/FiO₂ ≤150 mmHg).
- Trial name
- SBA-APRV (NCT07798154)
- Testing
- APRV ventilation with low-level spontaneous breathing, APRV ventilation with high-level spontaneous breathing, APRV ventilation with fully suppressed spontaneous breathing
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Heart Transplant
Non-Intubated Anesthesia for Adult Heart Transplantation
This prospective, multicenter, randomized controlled trial aims to evaluate whether non-intubated spontaneous ventilation anesthesia (NISVA) supported by a supraglottic airway can reduce cardiopulmonary complications and promote…
- Trial name
- NISVA-HTx (NCT07758894)
- Testing
- Non-Intubated Spontaneous Ventilation Anesthesia, Conventional Anesthesia, Standardized Perioperative Anesthetic and Analgesic Medication Regimen
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Tracheoesophageal Fistula, Esophageal Atresia With Tracheo-esophageal Fistula
Camera-based Endoscopy Allows Spontaneous Breathing Diagnostic Management in Neonates With Tracheoesophageal Fistula
The investigators aim to compare rigid tracheoscopy versus flexible tracheo-video-endoscopy in neonates requiring diagnostic assessment before undergoing a congenital tracheoesophageal fistula repair.
- Trial name
- CBESB (NCT07687628)
- Testing
- tracheoscopy performed with rigid optical tracheoscopy, flexible video endoscopy of trachea
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Papa Giovanni XXIII Hospital
Acute Respiratory Distress Syndrome (ARDS), Acute Hypoxemic Respiratory Failure
Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory Failure
Acute hypoxemic respiratory failure may progress to acute respiratory distress syndrome, a life-threatening condition that often requires mechanical ventilation.
- Trial name
- SVALBARD (NCT07463885)
- Testing
- Spontaneous Ventilation Strategy, Controlled Ventilation Strategy
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Respiration, Artificial, Weaning
Optimal Timing for Spontaneous Breathing Trials
This study aims to explore how the timing of Spontaneous Breathing Trials (SBTs) affects recovery in adult patients who are on mechanical ventilation in the ICU.
- Trial name
- NCT06561295
- Testing
- Later Morning Timing of Spontaneous Breathing Trials
- Where
- United States
- Volunteers
- 348 people
- Sponsor
- Rush University Medical Center
Cardiac Arrest (CA)
PRECISION-CPR: PRecision-Controlled Ventilation in CPR
Cardiac arrest is a life-threatening emergency that requires immediate treatment with cardiopulmonary resuscitation (CPR). While chest compressions circulate blood, manual ventilation provides oxygen to the patient.
- Trial name
- NCT07088120
- Testing
- Precision-Controlled Ventilation with Real-Time Feedback, Standard Manual Ventilation During CPR
- Where
- 2 sites in United States, Mexico
- Volunteers
- 852 people
- Sponsor
- Rush University Medical Center
End-stage Lung Disease
BREATHE Study: Spontaneous Breathing-Preserved Anesthesia and Surgical Strategy for Hospital Recovery in Lung Transplantation
The goal of this study is to learn whether a spontaneous-breathing ("tubeless") anesthesia and surgery strategy can improve early recovery and remain safe for adults who receive a lung transplant.
- Trial name
- BREATHE-LTx (NCT07384546)
- Testing
- Lung transplantation that preserves spontaneous breathing function
- Volunteers
- 110 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Airway Extubation, Extubation Failure
One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial
This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to…
- Conditions
- Airway Extubation, Extubation Failure, Weaning Mechanical Ventilation
- Trial name
- GS-Wean Tpiece (NCT07324382)
- Testing
- One-hour positive pressure ventilation, Immediate extubation
- Volunteers
- 4,000 people
- Sponsor
- Hospital do Coracao