Clinical trials: Spontaneous Abortion
Ultrasound-guided Manual Vacuum Aspiration, First Trimester Spontaneous Abortion
Ultrasound-guided Manual Vacuum Aspiration (USG-MVA)
This is a retrospective study to review the current experience of USG-MVA in Hong Kong and also evaluate the effectiveness of USG-MVA in cytological analysis in the management of first trimester miscarriage.
- Trial name
- NCT05413525
- Testing
- ultrasound-guided manual vacuum aspiration (USG- MVA)
- Where
- 2 sites in Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Obesity, Inflammation
Inflammasome Activation and Cortisol Metabolism in Obese Women With Recurrent Miscarriage
The prevalence of obesity among women of reproductive age is increasing. Obesity represents a chronic low-grade inflammatory state and NLRP3 inflammasome plays a pivotal role in obesity-induced inflammation.
- Trial name
- NCT04275674
- Where
- Taiwan
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Miscarriage in First Trimester, Missed Miscarriage
Letrozole Plus Misoprostol Versus Misoprostol Alone for Treating Women With Missed Miscarriage
The goal of this clinical trial is to learn whether adding the medicine letrozole to Misoprostol helps women have a complete abortion more often than using Misoprostol alone for the treatment of missed miscarriage (when a…
- Trial name
- NCT07160855
- Testing
- Misoprostol (given vaginally), Letrozole 5 mg
- Where
- Pakistan
- Volunteers
- 92 people
- Sponsor
- Nishtar Medical University
Miscarriage
Remnants of Conception After Suction Evacuation of Missed Abortion
All women admitted for surgical evacuation of missed abortion after failure of medical treatment from June 2016 underwent transvaginal sonography immediately after completion of the procedure as judged by the operator to ensure…
- Trial name
- NCT03813849
- Testing
- Sonographic examination of uterus after surgical evacuation
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- University of Alexandria
Infertility
Pregnancy/Implantation Rates Using a Day 3 Score Versus Graduated Embryo Score Plus a Biochemical Marker (sHLA-G)
Objective: To compare pregnancy rates and implantation rates when embryos are selected based on a single Day 3 (D.3) score vs. a GES score plus sHLA-G expression.
- Trial name
- NCT00680238
- Testing
- Human derived FSH
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Stellenbosch
Miscarriage
Serum Kisspeptin: a Predictive Marker of Miscarriage or Not?
This is a prospective observational study. Eligible women undergo ART treatment in our centre will be recruited for the study and each woman will only be included in the study once. Informed written consent will be obtained.
- Trial name
- NCT03940495
- Where
- China
- Volunteers
- 182 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Abortion, Spontaneous, Abortion in First Trimester
Application of Lactobacillus Salivarius CECT5713 in Infertility of Unknown Origin
In this study, we aimed to assess the cervicovaginal environment (pH, Nugent score, soluble immune factors and bacterial profile) in women with reproductive failure because of either repetitive abortion or infertility of unknown…
- Conditions
- Abortion, Spontaneous, Abortion in First Trimester, Infertility Unexplained
- Trial name
- NCT04446572
- Testing
- Lactobacillus salivarius CECT5713
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Universidad Complutense de Madrid
Spontaneous Abortion
Composition of the Intestinal Microbiome in Patients With Recurrent Spontaneous Abortions.
Up to 50% of all women suffer of a spontaneous abortion. Having two/three or more spontaneous abortions is one of the main reasons of unwanted childlessness.
- Trial name
- NCT07246486
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Dr. Natascha Köstlin-Gille
Recurrent Miscarriage
Walking and Dietary Modification for Recurrent Early Miscarriages
This study is part of a big one aiming to evaluate how lifestyle interventions during pregnancy affect obstetric results, neonatal metabolism and the intelligence of the offspring (study not yet completed).
- Trial name
- W&D (NCT03023137)
- Testing
- Walking & dietary modification
- Where
- Brazil
- Volunteers
- 480 people
- Sponsor
- Hospital dos Servidores do Estado do Rio de Janeiro
Post-traumatic Stress Disorder, Miscarriage
Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task
This is a randomised controlled trial designed to investigate the impact of a brief-cognitive task based intervention on intrusive memories, mental health symptoms and daily functioning, in women following an early pregnancy loss.
- Conditions
- Post-traumatic Stress Disorder, Miscarriage, Ectopic Pregnancy, Pregnancy Loss
- Trial name
- IMPREL (NCT05039853)
- Testing
- Brief cognitive task-based intervention
- Where
- United Kingdom
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Early Pregnancy
Conversational AI Platform for Early Pregnancy Care City-wide Recruitment: A Feasibility Study
This study seeks to determine pregnant patients in the Philadelphia area can be recruited to a conversational AI texting platform.
- Trial name
- CIRCA (NCT07197892)
- Testing
- CIRCA Texting Platform
- Where
- United States
- Volunteers
- 2,637 people
- Sponsor
- University of Pennsylvania
Recurrent Miscarriage, First Trimester Abortion
Hydroxychloroquine for Prevention of Recurrent Miscarriage.
Recurrent miscarriage (RM) defined by >=3 consecutive losses affects 1% of fertile couples. Most women have recurrent early loss with a failure of development before 10 weeks' gestation.
- Trial name
- BBQ (NCT03165136)
- Testing
- Hydroxychloroquine
- Where
- 18 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Recurrent Implantation Failure, Recurrent Pregnancy Loss
Study of Endometrial Immune and Microbiological Modifications in Cases of Recurrent Implantation Failure and/or Recurrent Pregnancy Loss
The IMERR study aims to improve understanding of certain causes of infertility related to recurrent implantation failure (RIF) and/or recurrent pregnancy loss (RPL), conditions that affect many women undergoing assisted…
- Conditions
- Recurrent Implantation Failure, Recurrent Pregnancy Loss, Infertility, Female, Endometrial Diseases
- Trial name
- IMERR (NCT07265505)
- Testing
- Endometrial Biopsy, Vaginal Swab, Blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Abortion, Missed, Infertility Unexplained
Autologous Decidual-like Natural Killer Cells Therapy for Reproductive Failure
The aim of this study is to verify the efficacy of in vitro induction of autologous decidual-like NK cells therapy for reproductive failure associated with uterine NK cells abnormalities.
- Conditions
- Abortion, Missed, Infertility Unexplained, Reproductive Disorder
- Trial name
- NCT07230574
- Testing
- NK cell perfusion group
- Volunteers
- 159 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Recurrent Early Pregnancy Loss, Thyroid Diseases
Thyroxine Therapy for Recurrent Pregnancy Loss in Hypothyroid Women
The goal of this clinical trial is to investigate the influence of thyroxine supplementation on pregnancy outcomes in women with varying levels of Thyroid-Stimulating Hormone (TSH), who have experienced recurrent pregnancy loss…
- Trial name
- NCT06036576
- Testing
- Levothyroxine Pill
- Where
- Iraq
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Al-Kindy College of Medicine
Pregnancy Loss
ACTRAMAT-D: Impact of Post-Traumatic Stress Disorder After Pregnancy Loss After 12 Weeks of Gestation
In France The prevalence of Pregnancy Loss after 12 weeks of gestation is around 3%. This situation is probably associated to a risk of post-traumatic stress disorder.
- Trial name
- ACTRAMAT-D (NCT03433989)
- Testing
- telephone interview
- Where
- France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Missed Abortion
Oxytocin Effectiveness in First Trimester Dilatation and Curettage
The aim of this study is to investigate the impact of oxytocin on perioperative blood loss during the D\&C procedure, as well as to assess early and late complications associated with it's use.
- Trial name
- NCT06469203
- Testing
- Oxytocin, Sodium Chloride 0.9% Inj
- Volunteers
- 160 people
- Sponsor
- Assuta Ashdod Hospital
Missed Miscarriage
Mifepristone and Misoprostol Versus Misoprostol Alone in the Medical Management of Missed Miscarriage
Miscarriage is the most common complication of pregnancy. As many as 15-25% of pregnancies end in miscarriage, and the number of miscarriages in England is estimated to be approximately 125,000 per year.
- Trial name
- MifeMiso (NCT03065660)
- Testing
- Mifepristone, Oral, 200 Mg
- Where
- 28 sites in United Kingdom
- Volunteers
- 711 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Early Pregnancy, Early Pregnancy Loss
EARLY-PREG: A Preconception Cohort Study Based on Counterfactuals to Study Maternal-Embryonic Molecular Interactions
EARLY-PREG is an open-cohort clinical study with a preconception, longitudinal, bidirectional and counterfactual design. The aim of this cohort is to investigate the proteomic signatures of maternal-embryonic communication by…
- Conditions
- Early Pregnancy, Early Pregnancy Loss, Childbirth, Healthy
- Trial name
- EARLY-PREG (NCT07358026)
- Testing
- EMBRYO EXPOSURE
- Where
- Chile
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- MELISA Institute Genomics & Proteomics Research SpA
Polycystic Ovary Syndrome, Miscarriage
The Effects of Metformin on Pregnancy and Miscarriage Rates in Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine whether metformin may improve pregnancy rates, and decrease miscarriage rates and complications of pregnancy, such as toxemia and gestational diabetes, in women with polycystic ovary…
- Conditions
- Polycystic Ovary Syndrome, Miscarriage, Infertility, Toxemia
- Trial name
- NCT00994812
- Testing
- metformin
- Where
- 5 sites in Finland
- Volunteers
- 326 people
- Sponsor
- University of Oulu