Clinical trials: Spleen Injury
Asplenia
Immunologic Response to Pneumococcal Polysaccharide Vaccine in Splenic Injury Patients
Persons without a spleen are susceptible to potentially lethal infections from certain bacteria, with pneumococcus being the most prevalent.
- Trial name
- NCT02232191
- Testing
- Pneumovax-23
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, Davis
Spleen Injury, Machine Learning
Deep Learning Algorithm for Traumatic Splenic Injury Detection and Sequential Localization
Spleen laceration is a lethal abdominal trauma and usually be diagnosed by medical images such as computed tomography. Deep learning had been proved its usage in detect abnormalities in medical images.
- Trial name
- NCT05643612
- Testing
- Deep learning algorithm
- Where
- Taiwan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Grade III Traumatic Splenic Injury in Hemodynamically Stable Patients
Traumatic Injury of Spleen:Laparoscopic Splenectomy Vs Splenic Artery Embolization
The goal of this clinical trial is selection of the best method in management of grade 3 traumatic Splenic Injury in Hemodynamically Stable Patients thus improving the quality of life and clinical outcome.
- Trial name
- NCT07274007
- Testing
- Laparoscopic Splenectomy vs splenic Artery Embolization
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zagazig University
High-grade Splenic Injuries
Embolization of the Splenic Artery After Trauma
Our aim is to conduct a multi-center, Bayesian, randomized clinical trial to evaluate the primary technical success of coils and vascular plugs for proximal splenic artery embolization in the setting of high-grade splenic trauma.
- Trial name
- ELSA-2 (NCT05128955)
- Testing
- Splenic artery embolization with vascular embolic coils or plugs
- Where
- 5 sites in United States
- Volunteers
- 180 people
- Sponsor
- Andrew J. Gunn
Blunt Injuries
Nonoperative Management Protocol in Patients With Blunt Splenic Injuries
This study was designed to explore the adverse events and associated risk factors before and after protocol-based NOM of BSI over a 12-year period in our institution.
- Trial name
- NCT03943355
- Testing
- Patient before cohort (2005-2010), Patient after cohort (2011-2016)
- Volunteers
- 399 people
- Sponsor
- Chang Gung Memorial Hospital
Trauma to the Spleen
Embolization in Splenic Trauma
Randomized, prospective, feasibility study to begin evaluating the efficacy, safety, and cost of using either coils or vascular plugs (VPs) for proximal splenic artery embolization in the setting of traumatic splenic injury.
- Trial name
- ELSA (NCT03613454)
- Testing
- Splenic artery embolization with vascular embolic coils, Splenic artery embolization with vascular embolic plugs
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Alabama at Birmingham
Thrombosis of Portal Venous System.
Evaluation of Portal Venous System Thrombosis After Blunt Splenic Trauma Utilizing Doppler Ultrasound
The true incidence of thrombosis in the portal venous system after blunt splenic trauma is unknown and has not been elucidated in the medical literature.
- Trial name
- NCT01906983
- Testing
- Doppler Ultrasound
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rambam Health Care Campus
Trauma, Spleen Injury
Splenic Embolisation Decisions
The spleen is often injured when the body sustains trauma. This leads to bleeding. The bleeding can be stopped by a big operation cutting open the belly or a small hole in your groin where a blood vessel can be accessed and…
- Trial name
- SPEED (NCT06334263)
- Where
- United Kingdom
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust
Radiofrequency Can be Used to Treat Splenic Trauma Because of Its Excellent Coagulation Hemostasis
RF-assisted Splenic Preservation VS Conventional Treatment of Blunt Splenic Injury.
Radiofrequency (RF) can be used to treat splenic trauma because of its excellent coagulation hemostasis. This study aimed to compare the efficacy of RF-assisted spleen-preserving surgery with that of conventional…
- Trial name
- NCT03890328
- Testing
- radiofrequency ablation
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Southwest Hospital, China
End Stage Liver Disease, Jaundice
SSM Predicts Outcomes of CLD Inpatients With Acute Liver Injury
In this study, a single non-invasive tool, spleen stiffness measurement (SSM), was used to monitor the disease regression of inpatients with chronic liver disease (CLD) and acute liver injury.
- Conditions
- End Stage Liver Disease, Jaundice, Liver Dysfunction, Portal Hypertension
- Trial name
- NCT06173947
- Testing
- FibroScan® Expert 630
- Where
- China
- Volunteers
- 411 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Spleen Injury
Observation vs Embolization in Severe Splenic Injury: A Randomized Controlled Trial
Nonoperative management (NOM) of blunt splenic injuries has been the standard of care for decades. While many splenic injuries can be successfully observed, studies have demonstrated increased failure rates for higher grade…
- Trial name
- NCT05008172
- Testing
- Splenic Artery Embolization
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Medical College of Wisconsin
Laparoscopic Surgery
Laparoscopic Splenectomy in Isolated High Grades Splenic Injuries
Background: Trauma laparoscopic splenectomy has no defined reasons. Compared trauma patient characteristics and results with laparoscopic and open splenectomies.
- Trial name
- NCT04329845
- Testing
- open splenectomy, laparoscopic splenectomy for splenic injury in trauma
- Volunteers
- 2 people
- Sponsor
- Zagazig University
Small-For-Size Liver Syndrome, Ligation
Splenic Artery Ligation and Portocaval Shunt in Small-for-size Syndrome
Our study aimed at assessing the changes of portal vein pressure, portal vein flow and hepatic arterial flow (HAF) in liver remnants ≤ 30% of the standard liver volume by reducing portal vein overflow via ligation of the splenic…
- Conditions
- Small-For-Size Liver Syndrome, Ligation, Liver Regeneration, Splenic Artery
- Trial name
- splen ligation (NCT05459883)
- Testing
- splenic artery ligation
- Where
- Greece
- Volunteers
- 13 people
- Sponsor
- Aretaieion University Hospital
Trauma Splenic, Trauma Abdomen
The Role of Prehospital eFAST in Accelerating Time to Diagnostics or Definitive Treatment in the Emergency Department
Actual literature has demonstrated that prehospital extended focused assessment sonography for trauma (eFAST) could impact on logistic and treatment decisions such as mode of transportation and choice of hospital destination.
- Conditions
- Trauma Splenic, Trauma Abdomen, Liver Injury
- Trial name
- NCT04934384
- Testing
- prehospital extended focused assessment sonography for trauma
- Where
- Italy
- Volunteers
- 199 people
- Sponsor
- Azienda Usl di Bologna
Quality of Life, Spleen Injury
Traumatic Splenic Injury and Management (SPLENIQ Study)
OBJECTIVE: To determine the quality of life (QOL) and clinical outcome after conservative therapy, embolization (proximal versus distal) or surgery in patients with traumatic splenic injury.
- Conditions
- Quality of Life, Spleen Injury, Trauma, Splenic Artery Embolization
- Trial name
- SPLENIQ (NCT03099798)
- Testing
- Questionnaires, MRI abdomen
- Where
- 10 sites in Netherlands
- Volunteers
- 106 people
- Sponsor
- Elisabeth-TweeSteden Ziekenhuis
Gut Microbiota, Spleen Injury
Microbiota is Related With Increasing Infection Rates After Splenectomy
Studies has shown an increasingly infection rate after splenectomy, and there is a potential correlation between microbiota and immune system.
- Conditions
- Gut Microbiota, Spleen Injury, Infection
- Trial name
- NCT03420599
- Testing
- splenectomy
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Splenic Rupture, Abdominal Injuries
Outcome After Conservative and Surgical Treatment of Splenic Injuries After Blunt Abdominal Trauma.
Retrospective study in order to investigate the outcome after conservative (with or without transcatheter arterial embolization) and surgical treatment of splenic injuries.
- Trial name
- NCT00910182
- Testing
- splenorrhaphy
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Splenic Injury
Treatment of Splenic Trauma: a Retrospective Cohort Study
In blunt trauma, the spleen is most frequent injured organ in the abdomen and the most frequent source of bleeding in the abdomen. Historically, splenectomy was the treatment of choice for splenic bleeding.
- Trial name
- NCT01965548
- Testing
- Treatment of splenic injury
- Where
- Norway
- Volunteers
- 109 people
- Sponsor
- University Hospital of North Norway
Trauma Splenic
Long Term Effect of Splenectomy on Metabolism
Metabolic status of patients who had gone through trauma splenectomy between July 2008 and July 2013 were compared to patients who had gone through bowel resection due to obstruction in the same period of time.
- Trial name
- NCT03648307
- Testing
- Blood sample
- Volunteers
- 154 people
- Sponsor
- Imam Hossein General Hospital
Trauma
Prospective Evaluation of Spleen Injury Treatments in Languedoc Roussillon
Descriptive, prospective, multicenter evaluation of spleen injury treatment in the Languedoc Roussilon region according to trauma severity, morbi-mortality and length of hospitalization.
- Trial name
- NCT01103999
- Where
- 12 sites in France
- Volunteers
- 93 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes