Clinical trials: Spine Disorder
Analgesia, Patient-controlled, Spinal Stenosis
The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal Midazolam
Introduction Ketamine is an old and generally well accepted analgesic used in the intra- and perioperative setting. Several studies demonstrated the effectiveness of ketamine in the postoperative setting.
- Trial name
- NASKEMI (NCT01275547)
- Testing
- s-ketamine & midazolam, Morphine PCA
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Basel, Switzerland
Ankylosing Spondylitis, Rheumatic Arthritis
Biomarkers in Inflammatory Rheumatic Diseases Diagnosis
Ankylosing spondylitis (AS), Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) are three diseases where early diagnosis remains a major challenge.
- Conditions
- Ankylosing Spondylitis, Rheumatic Arthritis, Systemic Lupus Erythematosus
- Trial name
- BIRDD (NCT06778343)
- Where
- Portugal
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Leg Length Inequality, Cerebral Palsy
Spine Biomechanics During Gait Following Lower Extremity Treatment in Different Patient Groups
Measuring spine dynamics is a necessity in order to better understand gait deviations throughout the whole body and to evaluate treatment effects on spinal movement during gait.
- Trial name
- NCT01803243
- Testing
- Ankle foot orthosis, Shoe insole, Modified shoe with sole lift
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Children's Hospital Basel
Radiating Leg Pain, Disc Protrusion
A Randomized, Controlled Trial of Treatment for Disc Herniation With Radiating Leg Pain
Hypothesis - This study is designed to evaluate the results of using the Orthotrac Pneumatic Vest versus an EZ form brace in patients with radiating leg pain from disc bulge / protrusion / herniation.
- Trial name
- NCT00220935
- Testing
- Orthotrac Pneumatic Vest
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Texas Back Institute
Opioid Use, Lumbar Spinal Stenosis
Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression
This study seeks to evaluate the impact of intra-operative topical epidural steroid usage in patients undergoing 1-2 level lumbar laminectomy.
- Conditions
- Opioid Use, Lumbar Spinal Stenosis, Pain, Postoperative, Pain, Back
- Trial name
- NCT05058287
- Testing
- Depo-Medrol 40Mg/Ml Suspension for Injection
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Hospital for Special Surgery, New York
Evaluate Bone Changes in Patients With PsA
Abatacept Bone Effects in Psoriatic Arthritis With Bone Biomarker
Observation has pointed out, that osteitis present in the MRI scans, predicts bone erosion and that this in accordance with the concept by underlining the importance of bone marrow involvement in arthritis [Krabben A, 2013].
- Trial name
- NCT04106804
- Testing
- Abatacept 125 MG/ML
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Low Back Pain, Spondylosis
Back in the Game: An Immediate Functional Progression Program in Athletes With a Spondylolysis.
Half of all adolescents report experiencing low back pain (LBP), and adolescents who are active in sport report an even higher rate.
- Trial name
- NCT03237104
- Testing
- Immediate PT
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Nationwide Children's Hospital
Cervical Spondylosis
Effectiveness of Pressure Biofeedback-Assisted Deep Cervical Flexor Training With and Without Scapular Stabilization Exercises on Pain, Range of Motion and Neck Disability in Cervical Spondylosis
This randomized controlled trial will evaluate the effectiveness of pressure biofeedback-assisted deep cervical flexor training with and without scapular stabilization exercises in patients with cervical spondylosis.
- Trial name
- NCT07814833
- Testing
- Pressure Biofeedback-Assisted Deep Cervical Flexor Training, Scapular Stabilization Exercises, Standard Physiotherapy
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Ibadat International University, Islamabad
Lumbar Spondylosis
Study Evaluating the Safety and Feasibility of Platelet-rich Plasma to Treat Facetogenic Low Back Pain
This study is being done to assess the safety of using the Angel Concentrated Platelet Rich Plasma System to process Platelet Rich Plasma (PRP) to treat arthritis of the low back (lumbar spondylosis).
- Trial name
- NCT05250947
- Testing
- Angel® Concentrated Platelet Rich Plasma System, Platelet Rich Plasma
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Matthew Pingree
Scoliosis, Kyphosis
Postoperative and Chronic Pain Genetic Spine and Pectus Surgery Study
This will be an open label, prospective study to determine the association between specific genotypes, epigenetics and behavioral factors, with the phenotypes, defined by pain perception, postoperative pain, analgesic and side…
- Conditions
- Scoliosis, Kyphosis, Kyphoscoliosis, Pectus Excavatum
- Trial name
- NCT02998138
- Where
- 5 sites in United States
- Volunteers
- 880 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Arthritis, Psoriatic, Arthritis, Rheumatoid
Stepping Up For Inflammatory Arthritis
This study will examine the benefits of a monitored physical activity program for participants with rheumatoid arthritis (RA) or psoriatic arthritis (PsA) using a wearable activity device (e.g.fitbit).
- Trial name
- SUFIA (NCT02912221)
- Testing
- Incentive
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Pennsylvania
Postoperative Pain, Lumbar Disc Surgery
Efficacy and Safety of Ultrasound-guided Lateral Thoracolumbar Interfascial Plane Block (TLIPB) for Postoperative Pain in Patients Undergoing Herniated Lumbar Disc Surgery
Surgery of the lumbar spine is characterized by diffuse and severe postoperative pain. In recent years, some case reports indicate that the thoracolumbar interfascial plane block (TLIPB) can reduce postoperative pain after spinal…
- Trial name
- NCT03951038
- Testing
- PCIA group, Lateral TLIPB group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Spondyloarthritis, Rheumatoid Arthritis
Nutrition in Rheumatic Diseases
Background: Patients with inflammatory rheumatic diseases (IRD) are prone to malnutrition for several reasons. The diseases and treatment can cause reduced intake and absorption of nutrients and the inflammatory processes may…
- Conditions
- Spondyloarthritis, Rheumatoid Arthritis, Polyarthritis
- Trial name
- EROM (NCT04586933)
- Testing
- Omega-3, Dietary guidance
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Haukeland University Hospital
Crohn Disease, Ulcerative Colitis
The Evaluation of Injection Site Pain and Adherence in Patients Switching From a Low To High Concentration Adalimumab (AVT-02) Across Multiple Indications.
The purpose of the Phase IV study is to investigate the effects of both Volume and Citrate on Injection Site Pain (ISP), adherence, patient satisfaction, Quality of Life, and Disease Assessment in the Canadian Adalimumab Market.
- Conditions
- Crohn Disease, Ulcerative Colitis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- EASE PAIN (NCT05913817)
- Testing
- AVT02 (Alvotech Biosimilar to Adalimumab)
- Where
- Canada
- Volunteers
- 324 people
- Sponsor
- Jamp Pharma Corporation
Adolescent Idiopathic Scoliosis (AIS)
Relationship Between Spinopelvic Parameters and Plantar Pressure in Adolescents With Lenke Type I and V Scoliosis
Adolescent idiopathic scoliosis (AIS) affects the alignment of the spine and body posture, which can influence balance and the way body weight is distributed through the feet.
- Trial name
- AIS-PLANTAR (NCT07810140)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Aslıhan içer
Ankylosing Spondylitis
Alexithymia in Ankylosing Spondylitis
The study included 55 patients having Ankylosing Spondylitis (AS) for at least 1 year diagnosed according to the ASAS classification criteria who presented to our hospital's outpatient clinic and 55 healthy subjects.
- Trial name
- NCT04320459
- Testing
- Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI)
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Ankylosing Spondylitis, Sexual Dysfunction
Sexual Dysfunction in Partner of Patients With Ankylosing Spondylitis
The adverse effects of rheumatologic diseases, especially Ankylosing Spondylitis (AS), on sexual functions are known. The causes of sexual dysfunction in rheumatologic diseases are due to factors such as pain, weakness, fatigue…
- Trial name
- NCT04411485
- Testing
- Sexual dysfunction
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Antalya Training and Research Hospital
Psoriatic Arthritis
Safety and Effectiveness and Effect on Quality of Life and Work Productivity of Humira in Patients With Psoriatic Arthritis in Clinical Routine
Safety and effectiveness, quality of life and work productivity of Humira in patients with psoriatic arthritis in clinical routine.
- Trial name
- ELAN (NCT01078610)
- Testing
- adalimumab (Humira)
- Sponsor
- Abbott
Lumbar Disc Herniation
Effect of Electromagnetic Field in Lumbar Disc Prolapse Patients
to investigate the effect of electromagnetic field therapy on sciatica and postural control in lumbar disc prolapse patients BACKGROUND: lumbar disc prolapse is a clinical condition resulting from compression of lumbar nerve…
- Trial name
- NCT05559723
- Testing
- electromagnetic field therapy, selected physical therapy program, Therapeutic ultrasound therapy
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- October 6 University
Stroke, Hemiplegia
Brain-controlled Spinal Cord Stimulation in Participants With Chronic Stroke for Lower and Upper Limb Rehabilitation
The purpose of this clinical study is to evaluate the preliminary safety and effectiveness of using a cortical recording device (ECoG) combined with cervical and lumbar targeted epidural electrical stimulation (EES) of the spinal…
- Trial name
- Stroke-BSI (NCT07610850)
- Testing
- ARC-BSI Stroke system
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne