Clinical trials: Spine Degeneration
Spondylolisthesis, Scoliosis
A Prospective Study of Instrumented, Posterolateral Lumbar Fusions (PLF) With OsteoAMP®
OsteoAMP is a novel allograft bone graft substitute (BGS) that has been processed to retain multiple endogenous growth factors for use in spinal fusion.
- Conditions
- Spondylolisthesis, Scoliosis, Intervertebral Disc Disease
- Trial name
- NCT02225444
- Testing
- OsteoAMP
- Where
- 9 sites in United States
- Volunteers
- 42 people
- Sponsor
- Bioventus LLC
Lower Back Pain, Disc Degeneration
Isolation and Authentication of Mesenchymal Stem Cell-like Progenitor Cells From the Degenerated Intervertebral Disc of Lumbar Spine
The study is designed for evaluating the presence of mesenchymal stem cells of vertebral disc. Isolation and authentication of these cells may be applied for the vertebral disc regeneration and the research tissue engineering.
- Trial name
- NCT01213953
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Medical University WanFang Hospital
Lumbar Degenerative Disc Disease
Radiostereometric Analysis of Spine Arthrodesis
The primary objective of this pilot study is to determine the precision of post-operative radiostereometric measurements for the assessment of lumbar spinal fusion.
- Trial name
- NCT01721889
- Testing
- Radiostereometric Analysis
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- OAD Orthopaedics
Lumbar Spine Degeneration
Development of a Patient-reported Outcome Instrument for Patients With Lumbar Degenerative Disease After Lumbar Fusion
The commonly used scales (ODI+JOA-29+VAS) lack the assessment of lumbar stiffness, and there is no scale for evaluating lumbar stiffness in China.Based on the Delphi method and the analytic hierarchy process, this study will…
- Trial name
- DPROIPLDDALF (NCT04781517)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Intervertebral Disc Degeneration, Intervertebral Disc Displacement
Dose Responsiveness as a Measure of Clinical Effectiveness During Neuromonitored Spine Surgery
Intraoperative Neuromonitoring (IONM) is a tool used by neurophysiologists during spine surgery to prevent irreversible damage to the spinal cord during procedures through a system of alerts.
- Conditions
- Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Curvatures, Spinal Stenosis
- Trial name
- IONM (NCT05110833)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Allina Health System
Cervical Spondylosis, Degenerative Intervertebral Discs
An ACDF Multi-Center Study Using ViviGen Cellular Bone Matrix
The purpose of this post-market study is to collect data on ViviGen and how its use affects fusion rates in the cervical spine when used as additional grafting material to fill the cervical spacer.
- Conditions
- Cervical Spondylosis, Degenerative Intervertebral Discs, Herniated Disc
- Trial name
- NCT02814825
- Testing
- ViviGen
- Volunteers
- 100 people
- Sponsor
- DePuy Spine
Lumbar Spine Degeneration, Physical Activity
Physical Activity, Disability and Quality of Life Before and After Lumbar Spine Surgery
To date it is unknown how physical activity levels in adults is limited before and after lumbar spine surgery and if physical activity level is associated with disability and limitations of quality of life.
- Conditions
- Lumbar Spine Degeneration, Physical Activity, Quality of Life, Disability Physical
- Trial name
- PA-LSS (NCT03452449)
- Testing
- planned lumbar spine surgery
- Where
- 2 sites in Switzerland
- Volunteers
- 29 people
- Sponsor
- University Hospital, Basel, Switzerland
Degenerative Spinal Disease, Deformity of Spine
Fenestrated Screw Study
The primary objective of this post-market study is to demonstrate that Oswestry disability index (ODI) score improved significantly at 12 months post-operatively as compared to baseline for each indication (degenerative spinal…
- Trial name
- FNS (NCT03797144)
- Testing
- CD HORIZON® Fenestrated Screw System with Fenestrated Screw Cement
- Where
- 6 sites in Belgium, Finland and 3 more
- Volunteers
- 27 people
- Sponsor
- Medtronic Spinal and Biologics
Cervical Vertebrae, Single
The Comparison Between the Stand-alone Cage and the Autologous Iliac Bone Graft/Anterior Plating in the Single-level Surgical Treatment of the Cervical Spine
The use of plate in addition to autologous bone is better then stand alone cage fusion regarding fusion rate and segmental lordosis.
- Conditions
- Cervical Vertebrae, Single, Degenerative Disease
- Trial name
- CAP_2014 (NCT02030899)
- Testing
- Cage fusion, Plate fusion
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Low Back Pain, Herniation, Disc
Non-surgical Spinal Decompression Therapy and Outcomes
This project will determine the clinical utility of non-surgical spine decompression for chronic low back pain (LBP). LBP is one of the highest incidence medical conditions that contributes to disability, decreased activities of…
- Conditions
- Low Back Pain, Herniation, Disc, Sciatic Radiculopathy, Intervertebral Disc Stenosis of Neural Canal
- Trial name
- RESTORE (NCT06525896)
- Testing
- NSSD
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of South Florida
Exercise Training, Adherence, Treatment
Adherence to Home-Based Exercises in Musculoskeletal Disorders
Home exercise program is recommended by physicians to patients and their relatives to do at home and It is a treatment option in which the physician describes how to do it.
- Conditions
- Exercise Training, Adherence, Treatment, Musculoskeletal Disease, Rehabilitation Exercise
- Trial name
- NCT07261553
- Testing
- Home exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 252 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Degenerative Disc Disease, Spondylolisthesis
Quintex® Follow-up After One Year Minimum
Prospective study, not randomised, non-interventional, monocentric, investigating an intended patient cohort of 60 patients already operated on the cervical spine due to degenerative disc disease of the cervical spine down to the…
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Trauma, Spinal Stenosis
- Trial name
- Quintex (NCT04489394)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Aesculap AG
Lumbar Spine Degeneration
Mini-invasive Lumbar Arthrodesis in Ambulatory
Degenerative lumbar pathologies are characterised by functional impairment and the occurrence of severe chronic pain and disability Arthrodesis of the lumbar spine is a common surgery for the treatment of degenerative lumbar…
- Trial name
- ALAMBU (NCT04914728)
- Testing
- mini-invasive lumbar arthrodesis
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Elsan
Disc Degeneration
Lumbar Spine on MRI and Low Back Pain in Elite Cross-country Skiers
The investigators will examine the prevalence of low-back pain and disc degeneration among Finnish elite skiers between 16 and 35 years of age and compare these findings with the data collected among healthy volunteers studied…
- Trial name
- NCT05641857
- Where
- Finland
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Orton Orthopaedic Hospital
Lumbar Spine Degeneration, Arthrosis; Spine
Postoperative Bracing Patterns After Lumbar Surgery
A variety of postoperative bracing are routinely applied after spinal procedures but there are limited data regarding their efficacy, especially with the increasing use of internal fixation.Currently, no data are available…
- Conditions
- Lumbar Spine Degeneration, Arthrosis; Spine, Surgery
- Trial name
- NCT03427281
- Testing
- questionnaire
- Where
- Belgium
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Degenerative Lumbar Spinal Stenosis
Segmental Decompression Versus Wide Decompression With Fixation for Degenerative Lumbar Canal Stenosis
The purpose of this study is to compare two different surgical techniques for treating degenerative lumbar canal stenosis, a condition where the lower spinal canal narrows and puts pressure on the spinal nerves.
- Trial name
- NCT07542054
- Testing
- Segmental Decompression, Wide Decompression with Fixation
- Volunteers
- 56 people
- Sponsor
- Assiut University
Degenerative Disc Disease, Grade 1 Spondylolisthesis
Comparison of Complication Rates Between Lateral Approaches to the Lumbar Spine
An evaluation of the incidence of complications resulting from far lateral spine surgery utilizing the K2M RAVINE® Lateral Access System (RAVINE) with ALEUTIAN® Lateral Interbody Spacer System versus literature reported results…
- Trial name
- RAVINE (NCT02068729)
- Volunteers
- 131 people
- Sponsor
- K2M, Inc.
Radius; Deformity, Hip Osteoarthritis
Clinical Evaluation and Cost-effectiveness Analysis of 3D Digital Surgery in Traumatology
Digital surgery, in combination with patient specific instrumentation (PSI) is being used more and more in traumatology due to its proven benefits and applications.
- Conditions
- Radius; Deformity, Hip Osteoarthritis, Hip Arthritis, Hip Arthropathy
- Trial name
- NCT06603831
- Testing
- patients treated using 3D technology and Patient-Specific Instrumentation, Patients treated with conventional surgery, without using 3D technology
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Corporacion Parc Tauli
Cervical Myelopathy
The Characteristic of Axial Pain and EEG Analysis of Patients After Laminoplasty
The characteristic of axial pain and EEG analysis of patients after laminoplasty
- Trial name
- NCT04968639
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital