Clinical trials: Spine
Erythema
Effect of Thoracic Spine Mobilization on Sympathetic Nervous Systems
This pilot study aims to i) represents the feasibility of the study design and ii) to point out acute effects of thoracic spine mobilization on skin-blood flow, erythema and the sympathetic nervous system.
- Trial name
- NCT02832141
- Testing
- Mobilization anterior, Mobilization posterior
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bern University of Applied Sciences
Spine Fusion
Steroids After Spine Fusion Surgery
This trial studies how well low-dose postoperative corticosteroids (FDA approved) affect patient outcomes (patient reported outcomes, pain medication use, length of stay, major complications, and time to first bowel movement)…
- Trial name
- NCT04568837
- Testing
- Prednisone 20 Mg
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Erector Spinae Block
Erector Spinae Plane (ESP) Block For Postoperative Pain Management In Lumbar Spine Surgery
Lumbar vertebra surgery is one of the most common surgical procedures. After lumbar veretebra surgery, patients complain of excessive pain.
- Trial name
- NCT03997227
- Testing
- Erector spinae Block
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Aydin Adnan Menderes University
Spine Degeneration, Hip Arthritis
Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation
This study aims to evaluate the effectiveness of a mobile application in improving postoperative rehabilitation outcomes among patients undergoing orthopedic surgery.
- Conditions
- Spine Degeneration, Hip Arthritis, Knee Osteoarthritis, Hip Fractures
- Trial name
- NCT06407427
- Testing
- App for in-bed conditioning exercises, Usual care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Intervertebral Disc Herniation, Stiffness; Spine
Cervical Changes by 4h of Hyper-buoyancy Flotation and Followed by 15 Mins 1g Re-loading
Study with the aim to see the effect on a space ground anaologue, Hyperbuoyancy Floatation (HBF) on cervical column.
- Trial name
- NCT05296200
- Testing
- Hyperbuoyancy Floatation
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Universidad Autonoma de Madrid
Spine Degeneration, Spine Disorder
Rate of Bone Union After Surgery With Stand-alone Fibergraft
Some people have back problems caused by degenerative conditions or instability of the spine (eg. Spondylolisthesis). These problems can lead to pain, nerve issues, or difficulties in walking.
- Conditions
- Spine Degeneration, Spine Disorder, Spine Pain, Spine Fusion
- Trial name
- Fibergraft (NCT07199075)
- Testing
- Questionnaires, Computer Tomography
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- AO Innovation Translation Center
Spinal Deformity
Supplemental Anterior Lumbar Interbody Fusion (ALIF) in Spinal Deformity
Within the last decade there has been an increase in the number of surgical procedures for deformities of the spine. This is caused by the increase in the elderly population, improved surgical techniques and an increased number…
- Trial name
- SALIF (NCT01601054)
- Testing
- Tantalum cage from Zimmer
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Back Pain
Evaluation of How Different Dosages of Spinal Manipulation Modulate Spinal Stiffness in Participants With Back Pain
This study evaluate the relationships between spinal manipulative therapy dosage (speed and peak force), the resulting modulation of thoracic spinal stiffness and changes in the clinical status in participants with chronic…
- Trial name
- NCT03063177
- Testing
- Spinal manipulative therapy
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- Université du Québec à Trois-Rivières
Lumbar Spine Degeneration
MOTUS Total Joint Replacement Investigational Device Exemption Study
This study is designed to collect safety and efficacy data on patients who plan to undergo a single-level total joint replacement of the lumbar spine using the MOTUS device (MOTUS Total Joint Replacement procedure) to demonstrate…
- Trial name
- NCT05438719
- Testing
- MOTUS Total Joint Replacement
- Where
- 14 sites in United States
- Volunteers
- 158 people
- Sponsor
- 3Spine
Spinal Muscular Atrophy, Spine Deformity
Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy
The primary objective of the clinical investigation is to demonstrate successful clinical use of the ThecaFlex DRx™ System in delivering nusinersen in subjects with spinal muscular atrophy (SMA).
- Conditions
- Spinal Muscular Atrophy, Spine Deformity, Scoliosis
- Trial name
- PIERRE (NCT05866419)
- Testing
- ThecaFlex DRx System
- Where
- 21 sites in United States, Germany and 3 more
- Volunteers
- 90 people
- Sponsor
- Alcyone Therapeutics, Inc
Degenerative Disc Disease, Discogenic Low Back Pain
A Comparative Study Between Mechanical and a Viscoelastic Disc Prosthesis in the Lumbar Spine
TDR implants for the lumbar spine are currently most 2- or 3-piece devices with a purely mechanical function that provide/restore mobility.
- Trial name
- NCT03716947
- Testing
- Device: ZACK, Device: ORBIT, Device: SASCA
- Where
- Sweden
- Volunteers
- 246 people
- Sponsor
- Karolinska Institutet
Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy
Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
This prospective, observational, non-randomized clinical study aims to evaluate the intraoperative and postoperative effects of opioid-free multimodal anesthesia compared with opioid-containing anesthesia methods in adult…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis, Lumbar Disc Degeneration
- Trial name
- NCT07489001
- Testing
- Opioid-free Anesthesia, Erector Spinae Plane Block, Opioid based Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Marmara University
Spine Surgery
Radiological and Clinical Efficacy of a Hybrid Spinal Implant ("Topping Off"): a Mono-center, Prospective Clinical Trial
The study aim is to show the effectiveness of a hybrid system (DTO) regarding clinical outcome and radiological alteration in a single-center prospective setting.
- Trial name
- NCT03404232
- Testing
- Dynesys DTO device (Zimmer Spine, Inc.)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital, Aachen
Blood Loss
Salient Aquamantys Spine Trial
The purpose of this study is to compare standard of care hemostasis techniques with and without the use of Aquamantys in reducing peri-operative blood loss.
- Trial name
- NCT01331499
- Testing
- Bipolar Sealer (Aquamantys), Standard of Care
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Salient Surgical Technologies
Spondylolisthesis, Scoliosis
A Prospective Study of Instrumented, Posterolateral Lumbar Fusions (PLF) With OsteoAMP®
OsteoAMP is a novel allograft bone graft substitute (BGS) that has been processed to retain multiple endogenous growth factors for use in spinal fusion.
- Conditions
- Spondylolisthesis, Scoliosis, Intervertebral Disc Disease
- Trial name
- NCT02225444
- Testing
- OsteoAMP
- Where
- 9 sites in United States
- Volunteers
- 42 people
- Sponsor
- Bioventus LLC
Spondyloarthrosis, Spondylosis
Study Confirms or Refutes the Hypothesis That the Autologous Bone Marrow Concentrate Together With the Allograft is a Better Alternative for the Posterolateral Fusion in Spine Surgery Than the Allograft Alone
The use of autologous mesenchymal stem cell (MSCs) in form of the BMC in combination with allograft is an effective option how to enhance the Posterolateral Fusion (PLF) healing.
- Trial name
- NCT01603836
- Testing
- bone allogaft with bone marrow concentrate
- Volunteers
- 80 people
- Sponsor
- Hospital Znojmo
Marrow Adiposity Lumbar Spine
Mapping the Lumbar Spine Marrow Adiposity
The objective of this study is to describe the change in the percentage of fat in the lumbar spine.
- Trial name
- FATFRAC (NCT02887716)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
Erector Spina Plan Block
The Effect of bılateral Erector spına Plan Block on postoperatıve paın ın spınal Surgery
Patients undergoing lumbar spinal stabilization surgery may experience severe postoperative pain lasting at least three days. Analgesia after lumbar stabilization surgery is beneficial for early recovery and is therefore…
- Trial name
- ESPB (NCT07537647)
- Testing
- UNDER ULTRASOUND GUİDANCE ESPB BLOCK, PROCEDURE/SURGERY: ERECTOR SPİNAE (ESP) BLOCK WİTH BUPİVACAİNE
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Low Back Pain, Manual Therapy
A Randomized Placebo Controlled Trial on the Efficacy of Sustained Natural Apophyseal Glide (SNAG) in Low Back Pain Patients
Objectives: Determine the efficacy of the SNAG technique (Mulligan) applied to a subgroup of people with non-specific low back pain (LBP) on two new kinematic-algorythms, on pain, functional disability and kinesiophobia.
- Conditions
- Low Back Pain, Manual Therapy, Sustained Natural Apophyseal Glide (SNAG)
- Trial name
- NCT02128607
- Testing
- SNAG
- Where
- Belgium
- Volunteers
- 32 people
- Sponsor
- Université Catholique de Louvain
Hypotension
Vasopressor Outcomes in Spine Surgery
This is a prospective, randomized control trial comparing norepinephrine versus phenylephrine for vasopressor support in patients undergoing elective spinal fusion surgery.
- Trial name
- V-SPINE (NCT06053398)
- Testing
- Phenylephrine, Norepinephrine
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of Texas Southwestern Medical Center