Clinical trials: Spinal Cord Injury Cervical
Tetraplegia, Asthma
Exhaled Breath Condensate Biomarkers of Inflammation in Individuals With Chronic Cervical Spinal Cord Injury
The purpose of this study is to obtain markers of airway inflammation from the exhaled breath condensate (the moisture in exhaled air) for comparison to blood based markers.
- Trial name
- NCT02235714
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Tetraplegia, Plegia
Nerve Transfer Reconstruction in the Tetraplegic Upper Extremity
The cervical spine is most commonly injured, accounting for 53.4% of spinal injuries. More than 40% of all spinal injuries occur at either C4, C5 or C6 levels leading to variable loss of function in the upper extremities.
- Conditions
- Tetraplegia, Plegia, Paresis, Cervical Spinal Cord Injury
- Trial name
- NCT01579604
- Testing
- Nerve reconstruction
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of British Columbia
Cervical Spinal Cord Injury
Feasibility and Safety of a Combined Augmented Reality and Functional Electrical Stimulation System
Cervical spinal cord injury (cSCI) can result in substantial loss of upper-limb function, with associated socio-economic impact on affected individuals and the healthcare system.
- Trial name
- NCT07299734
- Testing
- AR + FES
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto
Cervical Spinal Cord Injury
Improving Upper Extremity Function and Trunk Stability After Cervical Spinal Cord Injury (SCI)
Ninety-nine individuals meeting the study's inclusion/exclusion criteria will be enrolled in this study. The objective of this study is to evaluate three different therapeutic approaches to synergistically retrain functional…
- Trial name
- NCT05191121
- Testing
- FTP Alone, FTP+Con-FES, FTP+WPHF-FES
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Craig Hospital
Central Cord Syndrome
The Natural History of Traumatic Spinal Cord Injury Using fMRI, MRS and DTI
Traumatic spinal cord injury is a common injury to the spine and can lead to a clinical syndrome called central cord syndrome (CCS).
- Trial name
- NCT00790361
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cervical Spinal Cord Injury, Cervical Spinal Cord Paralysis
Nerve Transfers Plus Electrical Stimulation to Improve Hand Function in Cervical Spinal Cord Injury
The goal of this prospective observational study is to determine whether brief intraoperative electrical stimulation and temporary postoperative electrical stimulation improve motor and/or pain outcomes for patients with cervical…
- Conditions
- Cervical Spinal Cord Injury, Cervical Spinal Cord Paralysis, Tetraplegia, Tetraplegia/Tetraparesis
- Trial name
- NCT06541041
- Testing
- Brief intraoperative electrical stimulation, Temporary Postoperative Peripheral Nerve Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Spinal Cord Injuries, Spinal Cord Injury Cervical
Restoring Motor and Sensory Hand Function in Tetraplegia Using a Neural Bypass System
This is a single-cohort early feasibility trial to determine whether an investigational device called the Bidirectional Neural Bypass System can lead to the restoration of movement and sensation in the hand and wrist of up to…
- Trial name
- NCT03680872
- Testing
- Bidirectional Neural Bypass System
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Chad Bouton
Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma
Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord
This phase II clinical trial studies how well thermal ablation and spine stereotactic radiosurgery work in treating patients with cancer that has spread to the spine (spine metastases) and is at risk for compressing the spinal…
- Conditions
- Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma, Metastatic Kidney Carcinoma, Metastatic Malignant Neoplasm in the Spine
- Trial name
- NCT02713269
- Testing
- Computed Tomography, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Spinal Cord Injury, Tetraparesis
Spinal Cord Neuromodulation for Spinal Cord Injury
This study is designed to assess the strategy of using spinal cord stimulation to improve the ability to move in spinal cord injured humans.
- Conditions
- Cervical Spinal Cord Injury, Tetraparesis, Tetraplegia
- Trial name
- NCT02313194
- Testing
- Epidural Stimulation, Buspirone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, Los Angeles
Spinal Cord Injury, Spinal Cord Injury at C5-C7 Level
Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury
The goal of this prospective, open-label cohort study is to assess functional outcomes in individuals with cervical spinal cord injury who have undergone nerve transfer surgery to restore upper limb function.
- Conditions
- Spinal Cord Injury, Spinal Cord Injury at C5-C7 Level, SCI - Spinal Cord Injury, Upper Extremity Paralysis
- Trial name
- NCT05638191
- Testing
- Nerve transfer surgery
- Where
- 4 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Cervical Spinal Cord Injury
ExaStim Upper Limb Home Use Clinical Validation Study
This is a multi-center, observational, single-arm, 6-week home study to evaluate the safety and efficacy of transcutaneous spinal cord stimulation via the ExaStim system for 4 consecutive weeks used in the home setting for…
- Trial name
- NCT06850363
- Testing
- ExaStim Stimulation System
- Where
- 5 sites in United States
- Volunteers
- 33 people
- Sponsor
- Niche Biomedical, Inc. dba ANEUVO
Traumatic Brain Injury, TBI (Traumatic Brain Injury)
Cervical Transcutaneous SCS for TBI
The goal of this study is to test the effects of non-invasive electrical stimulation of the spinal cord (called transcutaneous spinal cord stimulation, or tSCS) on arm and hand movement in people with motor impairments after a…
- Trial name
- NCT07147816
- Testing
- Transcutaneous electrical stimulation of the cervical spinal cord (tSCS)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Roberto de Freitas
Dysphagia
The Safety and Efficacy of the 4 Channel NMES on Swallowing
This study is a pilot study to prepare clinical trials to evaluate the safety and effectiveness of 4-channel electric stimulation therapy devices as a newly developed function for the treatment of dysphagia disorders.
- Trial name
- NCT03670498
- Testing
- 4 channel Electrical Stimulation Device, 2 channel Electrical Stimulation Device
- Where
- South Korea
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Individuals With C6-C7 Tetraplegia (AIS A or B)
Grasping Rehabilitation Using Motor Imagery With or With no Neurofeedback After Tetraplegia
Motor imagery has shown promising results to optimize tenodesis grasp in individuals with C6-C7 tetraplegia. However, efficacy of using motor imagery to improve grasping after tetraplegia requires further study with higher level…
- Trial name
- TETRAMINF (NCT03190863)
- Testing
- Motor imagery combined with neurofeedback (MINF), Motor imagery (MI), Control (C)
- Where
- 2 sites in France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon
Spinal Cord Injury Cervical
Combining Spinal Cord Transcutaneous Stimulation and Activity-based Training in Inpatient Rehabilitation to Facilitate Upper Limb Function of Individuals with Acute to Subacute Cervical Spinal Cord Injury
The purpose of this clinical trial is to understand the safety and practicality of using spinal cord transcutaneous (through the skin) stimulation in an inpatient setting as well as how the combination of activity-based training…
- Trial name
- NCT06773286
- Testing
- Active Stimulation, Training only
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Spinal Cord Injuries, Spinal Cord Injury
Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury
People with spinal cord injuries may experience muscle tightness or uncontrollable spasms. This study is being conducted to investigate whether transcutaneous spinal stimulation can improve these symptoms.
- Conditions
- Spinal Cord Injuries, Spinal Cord Injury, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic
- Trial name
- NCT06274021
- Testing
- Transcutaneous spinal stimulation at 100 Hz, Transcutaneous spinal stimulation at 50 Hz, Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Mississippi Medical Center
Spinal Cord Injuries, Tetraplegia
Random Noise Stimulation to Enhance Cortical Drive & Improve Hand Function
Cervical spinal cord injury (SCI) results in hand and arm function impairments and decreased independence in performance of daily activities such as bathing, eating, dressing, writing, or typing.
- Conditions
- Spinal Cord Injuries, Tetraplegia, Cervical Spinal Cord Injury
- Trial name
- NCT04777149
- Testing
- transcranial Random Noise Stimulation (tRNS), transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Shepherd Center, Atlanta GA
Spinal Cord Injury Cervical
Randomized Controlled Study on T-PEP Versus IPV Method for Lower Respiratory Airways Clearance in Tetraplegic Tracheotomized Spinal Cord Injured Patients
In tetraplegic patients with complete cervical spinal cord injury, respiratory complications are very frequent, especially in the sub-acute phase: the lungs often become obstructed due to the accumulation of secretions and the…
- Trial name
- T-PEP (NCT04142814)
- Testing
- T-PEP, IPV
- Where
- Italy
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.
Spinal Cord Injuries and Disorders (SCI/D), Spinal Cord Injury
Motoneuron Recruitment and Motor Evoked Potential Up-Conditioning (MEP) in Spinal Cord Injury (SCI)
The purpose of this research study is to examine the effect of a brain stimulation training to improve the function of brain-spinal cord- muscle connections.
- Trial name
- NCT07179822
- Testing
- Motor Evoked Potential (MEP) Operant Conditioning
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical University of South Carolina
Spinal Cord Injury
Autologous Mesenchymal Stem Cells Transplantation in Cervical Chronic and Complete Spinal Cord Injury
The purpose of this study is to analyze the safety and efficacy of autologous bone marrow mesenchymal stem cell transplantation in patients with cervical chronic and complete spinal cord injury.
- Trial name
- NCT02574572
- Testing
- Autologous mesenchymal cells transplantation
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital Sao Rafael