Clinical trials: Spinal Cord Compression
Metastatic Epidural Spinal Cord Compression
Phase I Study of Feasibility of Single Session Spine Stereotactic Radiosurgery (SSRS) in the Primary Management in Patients With Inoperable, Previously Unirradiated Metastatic Epidural Spinal Cord Compression (MESCC)
The goal of this clinical study is to learn the feasibility of using a single session of radiation, known as spine stereotactic radiosurgery (SSRS), to treat metastatic epidural spinal cord compression.
- Trial name
- NCT01254903
- Testing
- Stereotactic Radiosurgery (SSRS)
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- M.D. Anderson Cancer Center
Neoplasm Metastasis, Spinal Cord Diseases
Laser Interstitial Thermal Ablation and Stereotactic Radiosurgery for Patients With Spine Metastases
The purpose of this research is to combine two complementary modes of treatment, spinal interstitial laser ablation and stereotactic spine radiosurgery (SSRS) for the treatment for spinal tumors near the spinal cord with an…
- Conditions
- Neoplasm Metastasis, Spinal Cord Diseases, Spinal Cord Compression, Spinal Cord Tumor
- Trial name
- NCT05023772
- Testing
- Stereotactic Laser Ablation, Stereotactic Radiosurgery, MRI guided laser ablation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Henry Ford Health System
Metastatic Spinal Cord Compression, Radiation Toxicity
Esophagus-sparing Radiotherapy for Metastatic Spinal Cord Compression.
Metastatic spinal cord compression (MSCC) is a serious complication to metastatic cancer and when diagnosed life expectancy is short. Treatment is palliative radiotherapy (RT).
- Conditions
- Metastatic Spinal Cord Compression, Radiation Toxicity, Esophagitis, Patient Reported Outcome Measures
- Trial name
- ESO-SPARE (NCT05109819)
- Testing
- Esophagus sparring radiotherapy treatment
- Where
- 2 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Herlev Hospital
Myelopathy, Non-Compressive
Evaluation of Non-Compressive Myelopathy in a Sample of Egyptian Patients
An observational study will be conducted in the Department of Neurology at AlAzhar University Hospitals To study the etiological factors of non-compressive myelopathy in a sample of Egyptian patients
- Trial name
- NCT05257330
- Testing
- CSF Examination
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Al-Azhar University
Tethered Spinal Cord, Brain Tumor
Dexmedetomidine on Intraoperative Somatosensory and Motor Evoked Potential Monitoring During Neurosurgery in Pediatric Patients
The investigators want to know if using the study drug dexmedetomidine will improve nerve wave readings during neurosurgery. These readings are done many times during surgery while the patient is asleep.
- Conditions
- Tethered Spinal Cord, Brain Tumor, Cranio Cervical Compression
- Trial name
- NCT01512147
- Testing
- Isoflurane, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Metastatic Epidural Spinal Cord Compression, Spinal Cord Compression
Miami "RADAR" Trial
The purpose of this study is to see if treating cancer with radiation therapy administered by the Varian Ethos system can control patient's tumor and eliminate the need for surgery used to treat nerves in the spine flattened by…
- Trial name
- RADAR (NCT06077071)
- Testing
- Stereotactic Radiosurgery (SRS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Miami
Cervical Spinal Cord Injury, Spinal Cord Injuries
Restoring Hand Function Utilizing Nerve Transfers in Persons With Cervical Spinal Cord Injuries
The primary objective of this study is to evaluate the safety and efficacy of nerve transfer surgery for restoring hand function as a therapy for patients with cervical spinal cord injury.
- Conditions
- Cervical Spinal Cord Injury, Spinal Cord Injuries, Traumatic Spinal Cord Compression
- Trial name
- NCT03451474
- Testing
- Upper extremity nerve transfer surgery
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas Health Science Center, Houston
Metastatic Spinal Tumors, Spinal Cord Compression
Postoperative Neurological Recovery and Risk Factor Analysis in Patients With Paralysis Due to Spinal Metastases
Metastatic spinal tumors represent a common and devastating complication in patients with advanced solid malignancies. Up to 40% of cancer patients may develop spinal metastases during the course of their disease, often resulting…
- Conditions
- Metastatic Spinal Tumors, Spinal Cord Compression, Paralysis, Neurological Deficits
- Trial name
- NCT07527728
- Volunteers
- 150 people
- Sponsor
- Shanghai Changzheng Hospital
Spinal Cord Compression, Spondylosis
UNiD 3D VBR Register
Multicenter study allowing to include the first sixty patients implanted with a custom-made corpectomy implant (UNiD 3D VBR): 30 patient implanted in cervical region and 30 patients implanted in thoracolumbar region.
- Conditions
- Spinal Cord Compression, Spondylosis, Ossification of Posterior Longitudinal Ligament, Spinal Neoplasms
- Trial name
- NCT02926391
- Testing
- UNiD 3D VBR
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Medicrea International
Spinal Metastases, Metastatic Epidural Spinal Cord Compression
Postoperative Edge (RapidArc) Stereotactic Body Radiotherapy for Spinal Metastases
This study observes the effectiveness of high-precision radiation therapy using the Edge system after surgery for patients with spinal metastases.
- Conditions
- Spinal Metastases, Metastatic Epidural Spinal Cord Compression, Spinal Cord Compression
- Trial name
- NCT07801274
- Testing
- Stereotactic Body Radiotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Spinal Cord Compression, Spinal Cord Injuries
Enhancing Recovery in Non-Traumatic Spinal Cord Injury
The investigators have spent the last decade uncovering unique metabolic and functional abnormalities in the brains of patients with spinal cord compression.
- Conditions
- Spinal Cord Compression, Spinal Cord Injuries, Cervical Spondylosis, Myelopathy Cervical
- Trial name
- NCT03320759
- Testing
- Occupational therapy rehabilitation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Western University, Canada
Spinal Metastases
Surgical Spinal Decompression of Metastatic Spinal Cord Compression, Minimal Access Versus Open Surgery
The investigators wish to evaluate the effect of minimal access spinal surgery compared to traditional open surgery spinal surgery in patients with metastatic spinal cord compression.
- Trial name
- NCT01865942
- Testing
- open surgery, Minimal access surgery
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Spinal Cord Compression Due to Metastasis to Spine
High-precision Radiotherapy of Motor Deficits Due to Metastatic Spinal Cord Compression
The major goal of this clinical study is to investigate to which extent high-precision radiotherapy (RT) with modern techniques can prevent progression or recurrence of motor deficits (weakness) of the legs following RT.
- Trial name
- PRE-MODE (NCT03070431)
- Testing
- High-precision RT 5x5 Gy in 1 week
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University Hospital Schleswig-Holstein
Metastatic Spinal Cord Compression, Metastasis Spine
Carbon Fiber Transpedicular Screws in Treatment of Spinal Metastatic Disease
Background: Spinal metastatic disease constitute a serious clinical problem in oncology. Bones are the third most common organ where metastases are located, and the spine is the place where they are most often located.
- Trial name
- CarboMetaspine (NCT06293157)
- Testing
- Transpedicular spinal stabilization - carbon fibers-based implants, Transpedicular spinal stabilization - titanium implants, Stereotactic body radiotherapy
- Where
- 5 sites in Poland
- Volunteers
- 226 people
- Sponsor
- Copernicus Memorial Hospital
Degenerative Cervical Myelopathy, Non-myelopathic Degenerative Cervical Cord Compression
A Multicenter Registry-Based Study Across the Spectrum of Degenerative Cervical Myelopathy
This is a multicenter, prospective, longitudinal, observational registry-based study of degenerative cervical myelopathy (DCM) across the full disease spectrum, linked to a disease-specific biobank.
- Conditions
- Degenerative Cervical Myelopathy, Non-myelopathic Degenerative Cervical Cord Compression, Asymptomatic Degenerative Cervical Cord Compression, Cervical Spinal Cord Compression
- Trial name
- DCM-RB (NCT07641699)
- Testing
- Registry-based observation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wangjing Hospital, China Academy of Chinese Medical Sciences
Cauda Equina Syndrome
Brief ES for Recovery of Autonomic Function in CES
BESCES is a study that aims to explore the feasibility of intraoperative brief epidural electrical stimulation (ES) for patients undergoing routine decompression for cauda equina syndrome.
- Trial name
- BESCES (NCT06416878)
- Testing
- Brief ES at the time of decompression for cauda equina syndrome, Brief ES to facilitate mcturition/removal of catheter
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Liverpool
Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma
Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord
This phase II clinical trial studies how well thermal ablation and spine stereotactic radiosurgery work in treating patients with cancer that has spread to the spine (spine metastases) and is at risk for compressing the spinal…
- Conditions
- Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma, Metastatic Kidney Carcinoma, Metastatic Malignant Neoplasm in the Spine
- Trial name
- NCT02713269
- Testing
- Computed Tomography, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Hypertension
Cervical Cord Compression and Hypertension
Myelopathy from cervical cord compression may induce hypertension and sympathetic hyperactivity. Anesthesia may suppress sympathetic activity and lead to hypotension that require vasopressor treatment.
- Trial name
- NCT04345822
- Testing
- Decompression surgery
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB)
Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries
Sleep-disordered breathing (SDB) is common in individuals with cervical spinal cord injuries, with studies suggesting prevalence rates ranging from 27% to 62%.
- Conditions
- Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB), Sleep Apnea, Cervical Spinal Cord Injruy
- Trial name
- NCT06818604
- Testing
- CPAP, BiPAP
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Spinal Cord Compression, Cauda Equina Syndrome
Stereotactic Body Radiotherapy Boost After Palliative Radiotherapy for Spinal Cord Compression
Spinal cord compression (SCC) is a devastating complication of advanced malignancy, and can cause significant deterioration in function and quality of life (QoL).
- Conditions
- Spinal Cord Compression, Cauda Equina Syndrome, Stereotactic Body Radiotherapy
- Trial name
- CRUSSH (NCT03529708)
- Testing
- 3D CRT plus SBRT boost
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Juravinski Cancer Center