Clinical trials: Spider Phobia
Posttraumatic Stress Disorder, Anxiety Disorder
Pilot Study of Pharmaceutical and Behavioral Interventions to Treat Anxiety Disorders
The aim of this project is to create fear conditioning paradigm within which the relative strengths of various novel pharmacological and behavioral interventions can be tested.
- Trial name
- NCT01631682
- Testing
- Propranolol, Reactivation, Mifepristone
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Specific Phobia
The Effects of Safety Seeking Behaviors During Exposure Therapy for Adults With Spider Phobia
Exposure-based cognitive-behavioral therapy (i.e., "exposure therapy"), which entails repeated and prolonged confrontation with feared situations/stimuli, is the most effective treatment for anxiety disorders (e.g.…
- Trial name
- NCT03233113
- Testing
- Exposure therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina, Chapel Hill
Spider Fear, Arachnophobia
Feasibility of an Online Modeled Exposure in Spider Fearful Individuals
The effectiveness of an optimized group exposure treatment is investigated in spider-fearful individuals. Participants will undergo an optimized standardized exposure treatment.
- Trial name
- OMEX (NCT06182709)
- Testing
- online psychoeducation video + modeled exposure, live psychoeducation video + modeled exposure, group exposure
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Philipps University Marburg
Specific Phobia, Cognitive-behavioral Therapy
Virtual Reality Exposure in Spider Phobia
While knowledge on the neurobiological signatures of fear and anxiety disorders and, in particular, their association with treatment outcome is accumulating, clinical translation still awaits empirical proof of evidence.
- Conditions
- Specific Phobia, Cognitive-behavioral Therapy, Virtual Reality
- Trial name
- NCT03208400
- Testing
- virtual reality exposure
- Where
- 2 sites in Germany
- Volunteers
- 338 people
- Sponsor
- Julius-Maximilians University
Fear of Spiders
Neural Mechanisms of Imaginal and in Vivo Exposure
Imaginal exposure is a widely used and effective psychological treatment technique. Recent research suggests that neural activations and emotional responses during imaginal exposure are similar to those elicited during in vivo…
- Trial name
- NCT05193383
- Testing
- Imaginal exposure, Exposure, Approach-avoidance conflict
- Where
- Sweden
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Phobia, Specific
Virtual Reality Immersive Method for Spider (Phobia) Exposure Therapy (VIMSE)
The aim of this study is to examine the efficacy of virtual reality exposure therapy as a treatment for specific phobia (spiders).
- Trial name
- VIMSE (NCT02533310)
- Testing
- OST treatment with in-vivo spiders, VR-OST treatment with virtual spiders
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Stockholm University
One Week Follow-up Assessment, Six Weeks Follow-up Assessment
The Effect of Time on Generalization of Exposure-based Benefit
Participants will receive a pre-assessment and an exposure with a control spider. This control spider will be presented again at post-training assessments.
- Conditions
- One Week Follow-up Assessment, Six Weeks Follow-up Assessment, Three Months Follow-up Assessment
- Trial name
- NCT06255821
- Testing
- Exposure
- Where
- Germany
- Volunteers
- 59 people
- Sponsor
- Ruhr University of Bochum
Fear of Spiders
The Neural Mechanisms of Imaginal Extinction
Imaginal exposure is a widely used and effective psychological treatment technique in which patients are exposed to fearful stimuli and situations using mental imagery.
- Trial name
- NCT05168592
- Testing
- Threat conditioning, Imaginal extinction
- Where
- Sweden
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Arachnophobia, Cynophobia
Telemedicine-Based Virtual Reality Clinic for the Treatment of Phobias
The purpose of this study is to assess the feasibility of conducting a randomized controlled efficacy trial comparing the delivery of exposure therapy via a telemedicine-based virtual reality clinic (Doxy.me VR) vs.
- Conditions
- Arachnophobia, Cynophobia, Ophidiophobia
- Trial name
- NCT06302868
- Testing
- Telemedicine Exposure Therapy Using Photos and Videos, Telemedicine-Based Virtual Reality Exposure Therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of South Florida
Specific Phobia
Extinction Generalization in Exposure Therapy
Patients with anxiety disorders oftentimes express fear responses to more than only one fear-inducing object. The principal aim of this study is to examine whether the beneficial effects of exposure on fear reduction in spider…
- Trial name
- NCT03031002
- Testing
- Exposure treatment for spider fear
- Volunteers
- 77 people
- Sponsor
- Ruhr University of Bochum
Phobia, Specific
Influence of Valproic Acid on Extinction-based Therapy in Patients With Fear of Spiders.
The purpose of this study is to evaluate whether valproic acid in combination with fear memory reactivation is useful to enhance treatment stability of exposure therapy for specific phobia.
- Trial name
- VALPRO (NCT02789813)
- Testing
- Valproic Acid, Fear reactivation, No fear reactivation
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Prof. Dominique de Quervain, MD
Phobic Disorders
The Role of Treatment Expectation in Exposure Training With Spider Fearful Participants
This study evaluates the role of treatment success expectation in spider fearful individuals on the actual treatment success. Half of participants will have positive treatment success expectations, while the other half will have…
- Trial name
- NCT03012035
- Testing
- positive treatment expectations, neutral treatment expectations
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Phobias
fMRI Study Examining Effects of D-cycloserine in Specific Phobia
The research team hopes to use brain imaging and mental testing to learn more about specific phobias and the treatment of phobia.
- Trial name
- NCT00591825
- Testing
- D-cycloserine
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Phobias Snakes, Phobias Spiders
Bringing Exposure Therapy to Real-Life Context With Augmented Reality
In this patented project, U.S. Patent No. 10,839,707, the investigators will develop an augmented reality exposure therapy method for arachnophobia, and fear of snakes, to test in the clinic.
- Trial name
- ARET (NCT03649347)
- Testing
- Augmented reality exposure therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wayne State University
Specific Phobias
tDCS-Augmented Exposure Therapy for Pathological Fear
This double-blind randomized controlled clinical trial aims to test whether transcranial direct current stimulation (tDCS) can be used to modulate fear extinction learning during exposure therapy for pathological fear, including…
- Trial name
- NCT03095482
- Testing
- Transcranial Direct Current Stimulation (tDCS), In vivo exposure therapy
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Specific Phobia, Animal
A Randomized Controlled Efficacy Trial of a Telemedicine-based Virtual Reality Clinic for the Treatment of Phobias
The goal of this clinical trial is to learn if a telemedicine-based virtual reality clinic (Doxy.me VR) works to treat dog, spider, and snake phobias in adults.
- Trial name
- NCT07558824
- Testing
- Telemedicine-Based Virtual Reality Exposure Therapy, Telemedicine-Based Exposure Therapy Using Photos and Videos
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of South Florida
Specific Phobia
Spider Phobia Opposite Action Treatment Study
This study tests the effectiveness of exposure therapy for fear of spiders as enhanced by the use of antagonistic or opposite actions during treatment.
- Trial name
- NCT02905279
- Testing
- Biofeedback Relaxation Training, Exposure Therapy, Exposure with Threat-Relevant Opposite Actions
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Specific Phobia, Arachnophobia
Use of Safety Behaviors in Exposure Therapy for Arachnophobia
This study examines the impact of safety behaviors (i.e., unnecessary protective actions) on outcomes of exposure therapy for spider phobia.
- Conditions
- Specific Phobia, Arachnophobia, Spider Phobia
- Trial name
- NCT04470882
- Testing
- Exposure with faded safety behaviors, Exposure without safety behaviors, Exposure with unfaded safety behaviors
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Nevada, Reno
Spider Phobia
EMDR in Spider Phobia: Work Mechanisms and Treatment Outcome
The goal of this study is to increase the efficiency of exposure in virtual reality (VR). Based on the EMDR research the investigators would like to show that the implementation of eye movements during the VR exposure results in…
- Trial name
- NCT02973919
- Testing
- Eye Movement Desensitization and Reprocessing Therapy, Virtual Reality Exposure Therapy
- Volunteers
- 53 people
- Sponsor
- University of Regensburg
Acrophobia, Arachnophobia
3D Video Virtual Reality Exposure Therapy Study
This study seeks to examine a Virtual Reality Exposure Therapy (VRET) using the 3D Video Virtual Reality (VR) technology for the fear of spiders.
- Trial name
- 3D-VVRET (NCT02584387)
- Testing
- 3D Video Virtual Reality Exposure Therapy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin