Clinical trials: Spastic Quadriplegia
Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE)
Intranasal AAV9-PHP.eB Gene Therapy in Cerebral Palsy (CP) & Hypoxic Ischemic Encephalopathy (HIE)
This international study, organized by Healing Hope International, is an observational registry designed to collect real-world data on participants living with chronic hypoxic ischemic encephalopathy (HIE) who receive an emerging…
- Conditions
- Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE), Hypoxic Ischaemic Encephalopathy Due to Cardiac Arrest, Hypoxic Ischemic Encephalopathy of Newborn
- Trial name
- GEN-HOPE (NCT07264166)
- Where
- Mexico
- Volunteers
- 25 people
- Sponsor
- Healing Hope International
Spinal Cord Injuries, Tetraplegia
Influence of Upper Extremity Vibration on Spasticity and Function in Persons With Tetraplegia
Vibration therapy is a possible alternative to drug-based treatments for spasticity following SCI. Research indicates that it may provide temporary relief from spasticity, but many interventions under investigation are not…
- Trial name
- NCT04020770
- Testing
- Vibrating ball
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Shepherd Center, Atlanta GA
Cerebral Palsy
Effects of Proprioceptive Training With Routine PT on Gross Motor Function in Spastic Quadriplegic CP
The proprioceptive training with a therapy regime enhances the body's somatosensory input that in result changes the body to be more functional in different types of interactions.
- Trial name
- NCT05436847
- Testing
- Proprioceptive Training, Routine Physical Therapy
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- University of Lahore
Hemiparesis, Paraparesis
Immediate Effects On Gait and Spasticity After The Use Of Passive Kinesiotherapy Equipment In The Lower Limbs Of Neurological Patients
Undergo assessment of muscle tone (Ashworth Scale), gait (BAIOBIT) and risk of falling (Timed Up and Go) before using the device; Use the device on the spastic lower limb(s) for 30 minutes; Go through the same assessment carried…
- Conditions
- Hemiparesis, Paraparesis, Tetraparesis, Cerebral Palsy
- Trial name
- NCT06696040
- Testing
- Passive mobilization using a device
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Fernanda Trubian
Cerebral Palsy, Spastic Diplegia
Evaluation of Brain MRI Changes in Cerebral Palsy Patients
Cerebral palsy (CP) is a neurodevelopmental syndrome characterized by sensorimotor impairment that arises during early childhood defined as a static insult to the developing brain.
- Conditions
- Cerebral Palsy, Spastic Diplegia, Spastic Quadriplegia, Spastic Hemiplegia
- Trial name
- NCT07433647
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Columbia University
Incomplete Spinal Cord Injury, Spastic Tetraplegia
Correlation Between Clinical Assessment and Neurophysiological Assessment in Spinal Cord Injury
This study is a cross-sectional study that aims to explore the correlation between clinical assessment and neurophysiological assessment in SCI.
- Conditions
- Incomplete Spinal Cord Injury, Spastic Tetraplegia, Spastic Paraplegia, Spinal Cord Injury
- Trial name
- NCT06680063
- Where
- Thailand
- Volunteers
- 22 people
- Sponsor
- Mahidol University
Physical Therapy
Feasibility Of Oral Sensorimotor Stimulation On Oropharyngeal Dysphagia In Children With Spastic Cerebral Palsy
Children with CP encounter swallow and feeding impairments, especially in infancy and childhood with long meal times with late development of oral motor skills resulting in poor growth.
- Trial name
- NCT04524559
- Testing
- conventional physical therapy training, oral motor training.
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Cairo University
Spastic Cerebral Palsy
Therapeutic Potential of Myofascial Structural Integration in Children With Cerebral Palsy
The investigators hypothesize that children with spastic cerebral palsy will show greater improvements in gross motor function, associated developmental skills and growth after the 3 months of myofascial structural integration…
- Trial name
- NCT01815814
- Testing
- Rolfing / Myofascial Structural Integration
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Stanford University
Cerebral Palsy
Does Oral Baclofen Improve Care and Comfort in Spastic Children in Nursing Homes?
Baclofen is a drug that reduces the muscle stiffness. In disabled children that have very stiff muscles, the stiffness and secondary changes in the joints may cause discomfort and pain.
- Trial name
- NCT00752934
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Shaare Zedek Medical Center
Spinal Cord Injuries, Paraplegia, Spinal
Transspinal Stimulation Plus Locomotor Training for SCI
Locomotor training is often used with the aim to improve corticospinal function and walking ability in individuals with Spinal Cord Injury.
- Conditions
- Spinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis, Paraplegia, Spastic
- Trial name
- NCT04807764
- Testing
- Standing transspinal stimulation followed by robotic gait training, Lying transspinal stimulation followed by robotic gait training
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- City University of New York
Cerebral Palsy, Spasticity
Exopulse Mollii Suit, Motor Functions & CP Children With Cerebral Palsy
Cerebral Palsy (CP) is is estimated to be around 1.5-3 per live birth, with prenatal factors accounting for 75% of cases. CP appears in early childhood and persists with age and is characterized by permanent lesions or…
- Conditions
- Cerebral Palsy, Spasticity, Muscle, Pain Syndrome
- Trial name
- EXOCEP2GER (NCT05885139)
- Testing
- Exopulse Mollii Suit
- Where
- 2 sites in Germany
- Volunteers
- 34 people
- Sponsor
- Exoneural Network AB
Motor Complete Spinal Cord Injury
The Effects of Passive Gait Training in Complete Motor Spinal Cord Injury (SCI)
The purpose of this study is to determine whether a three times per week, 2 month robotic assisted treadmill gait training program, will beneficially affect the fitness, physical and psychological well-being, and the vascular and…
- Trial name
- NCT01349478
- Testing
- LOKOMAT
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Dr. Gabriel Zeilig
Cerebral Palsy (CP), Spastic Quadriplegia
Impact of Task-Specific Electrical Stimulation on Upper Limb Functional Motor Skills in Children With Spastic Quadriplegia
Cerebral palsy is a non-progressive lesion of the brain occurring before 2 years of age resulting in disorders of posture and movement.( Ostensjo S, 2004)( Keles MN, 2018) .
- Conditions
- Cerebral Palsy (CP), Spastic Quadriplegia, Upper Limb Function, Functional Motor Disorder
- Trial name
- NCT07631390
- Testing
- The Chattanooga Continuum™, Designed Physical therapy program
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kafrelsheikh University
Spinal Cord Injuries
Assessment of the Effects of Early Proprioceptive Stimulations in Patients With Spinal Cord Injury
"Spinal cord injury (SCI) is a dramatic event resulting in a long-term handicap. Appropriate care from admission to the intensive care unit (ICU) is a key element not only for the survival of these patients but also to promote…
- Trial name
- Tetra-Mouv (NCT05094752)
- Testing
- Proprioceptive stimulations
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spastic Quadriplegia, Cerebral Palsy (CP)
Focused Versus Radial Extracorporeal Shock Wave Therapy on Gastrocnemius Spasticity in Children With Spastic Quadriplegic Cerebral Palsy
The goal of this pilot randomized controlled trial is to compare the effectiveness of focused extracorporeal shockwave therapy (ESWT) versus radial ESWT on gastrocnemius spasticity in children with spastic quadriplegic cerebral…
- Conditions
- Spastic Quadriplegia, Cerebral Palsy (CP), Gastrocnemius Muscle
- Trial name
- NCT07894003
- Testing
- Focused Extracorporeal Shock Wave Therapy, Radial Extracorporeal Shock Wave Therapy
- Where
- Indonesia
- Volunteers
- 16 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Spastic/Dystonic Quadriplegia, Cerebral Palsy (CP)
Outcomes of Neurosurgical Tone Management
Patients with spastic/dystonic quadriplegia (GMFCS IV/V) are often severely disabled by their tone, and require surgical tone management to improve quality of life, allow for better function, improve comfort, and range of motion.
- Trial name
- NCT07817745
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Cerebral Palsy (CP), Spastic Cerebral Palsy
Effect of Task Specific Electrical Stimulation on Upper Limb Gross Motor Skills in Children With Spastic Quadriplegia
Cerebral palsy is a non-progressive lesion of the brain occurring before 2 years of age resulting in disorders of posture and movement.( Ostensjo S, 2004)( Keles MN, 2018).
- Conditions
- Cerebral Palsy (CP), Spastic Cerebral Palsy, Quadriplegic Cerebral Palsy, Upper Limb Function
- Trial name
- NCT06925425
- Testing
- Task specific electrical stimulation ( TASES ), Designed Physical therapy program
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kafrelsheikh University
Cerebral Palsy, Spastic Diplegia
MEOPA to Improve Physical Therapy Results After Multilevel Surgery
Children with cerebral palsy commonly undergo "multilevel surgery", meaning several lower limb combined procedures performed during the same surgical intervention.
- Conditions
- Cerebral Palsy, Spastic Diplegia, Quadriplegia, Hemiplegia
- Trial name
- KINOPA (NCT00632528)
- Testing
- MEOPA, Medicinal air
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spastic Tetraplegia, Pain
ESWT for UE Pain in Patients With Cervical Spinal Cord Injury
This study aimed to investigate the efficacy and safety of extracorporeal shockwave therapy (ESWT) for upper extremity pain related to spasticity in patients with spinal cord injury.
- Conditions
- Spastic Tetraplegia, Pain, Myelopathy Cervical
- Trial name
- NCT04319679
- Testing
- Extracorporeal shockwave therapy
- Where
- South Korea
- Volunteers
- 4 people
- Sponsor
- Bundang CHA Hospital
Spinal Cord Injuries, Spasticity, Muscle
Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury
People with spinal cord injury (SCI) experience a host of secondary complications that can impact their quality of life and functional independence.
- Conditions
- Spinal Cord Injuries, Spasticity, Muscle, Spastic Paraplegia, Spastic Quadriplegia
- Trial name
- NCT05432999
- Testing
- Extracorporeal Shockwave Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Kessler Foundation