Clinical trials: Solitary Pulmonary Nodules
Peripheral Pulmonary Lesion
Evaluate the Diagnostic Value of BTPNA for PPL: a Real-world Study
The study is designed as a multicenter prospective trial of BTPNA for the diagnosis of peripheral pulmonary lesions in the real world.
- Trial name
- NCT04597346
- Testing
- Bronchoscopic Transparenchymal Nodule Access
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Lung Diseases, Interstitial, Pulmonary Nodule, Solitary
Chest Tube After a Video-assisted Thoracoscopic Surgery Pulmonary Wedge Resection
After performing VATS pulmonary wedge resections, a chest tube is routinely left in the pleural cavity to drain possible air leaks and fluid accumulations.
- Trial name
- NOTUBE (NCT00841750)
- Testing
- Do not leave a chest tube in the pleural cavity., Do leave a chest tube in the pleural cavity.
- Where
- 3 sites in Colombia
- Volunteers
- 100 people
- Sponsor
- Fundación Oftalmológica de Santander Clínica Carlos Ardila Lulle
Lung Cancer, Lung Cancer Metastatic
Needlescopic-assisted Uniportal vs Uniportal VATS
The investigators' study aims is to evaluate the safety and efficacy of uniportal VATS under assistance of needlescopic instruments through additional 2-3 mm ports compared to conventional uniportal VATS in patients with lung…
- Conditions
- Lung Cancer, Lung Cancer Metastatic, Bullous Disease Lung, Nodule Solitary Pulmonary
- Trial name
- UNeed (NCT03439696)
- Testing
- Thoracoscopic surgery
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- IRB of NTUH Hsin-Chu Branch
Lung Nodules
Bronchoscopic Navigation Robot-guided Dye Marking-assisted Thoracoscopic Pulmonary Nodule Resection
With the widespread use of low-dose spiral CT screening for the lungs, an increasing number of small nodules are being detected, and surgical resection is the preferred method for clinical intervention of pulmonary nodules.
- Trial name
- NCT06821451
- Testing
- Bronchoscopic navigation robot, Conventional electromagnetic navigation bronchoscope
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Ruijin Hospital
Progression
A Prospective, Two-center, Single Arm Phase II Clinical Study to Evaluate Safety and Effectiveness of Ablation Therapy in the Treatment of Lung Cancer Presenting as Ground-glass Nodules
A prospective, two-center, single arm phase II clinical study to evaluate safety and effectiveness of ablation therapy in the treatment of lung cancer presenting as ground-glass nodules
- Trial name
- NCT04905056
- Testing
- Ablation therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Zhongshan Hospital
Lung Cancer, Secondary Lung Cancer
Conventional Bronchoscopy Plus Rose Versus Electromagnetic Navigation (EMN) Plus Rose in Small Peripheral Lesions
The aim of this study is to evaluate if Electromagnetic navigation (ENB) in combination with rapid on site evaluation (ROSE) can improve diagnostic accuracy in those patients who fail to be diagnosed with conventional…
- Conditions
- Lung Cancer, Secondary Lung Cancer, Benign Lung Lesions
- Trial name
- NCT00880945
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Suture, Nodule, Solitary Pulmonary
Semi-barbed Suture for Pulmonary Small Nodules Localization
Hookwire and microcoil are currently the most widely used localization instruments. Although their success rate is relatively high in preoperative localization attempts, they may lead to consequences that negatively affect…
- Conditions
- Suture, Nodule, Solitary Pulmonary, Video-Assisted Thoracoscopic Surgery
- Trial name
- NCT04168359
- Testing
- absorbable semi-barbed suture
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Aerospace General Hospital
Pulmonary Nodule, Solitary, Whole-genome Methylation Sequencing
Benign/Malignant Pulmonary Nodule Classification Based on High-throughput Whole-genome Methylation Sequencing(GM-seq)
Lung cancer is the first cancer in China in terms of morbidity and mortality. The problem of early diagnosis/treatment has always been concerned.
- Trial name
- NCT05415670
- Testing
- Whole-genome Methylation Sequencing(GM-seq)
- Where
- 2 sites in China
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Geneplus-Beijing Co. Ltd.
Pulmonary Nodule, Solitary, Multiple Pulmonary Nodules
GE Healthcare VolumeRAD Lung Nodule Detection Study
To perform a multiple reader, multiple case (MRMC) observer study assessing the detection performance of VolumeRAD tomosynthesis of the chest in detecting lung nodules.
- Trial name
- NCT00963651
- Testing
- Chest tomosynthesis and X-ray
- Where
- 4 sites in United States, Sweden
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- American College of Radiology - Image Metrix
Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple
Nitrous Oxide for Identifying the Intersegmental Plane in Segmentectomy: A Randomized Controlled Trial
Lung cancer is currently one of the most common malignant tumors in the world. In recent years, with the popularity of high-resolution CT, more and more early-stage lung cancers have been found.
- Conditions
- Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple, Lung Cancer
- Trial name
- NCT04302350
- Testing
- nitrous oxide
- Where
- 2 sites in China
- Volunteers
- 81 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pulmonary Nodule, Solitary, Peripheral Pulmonary Nodules
Intraoperative Longitude-Latitude-Depth Localization Versus Preoperative CT-Guided Percutaneous Lung Puncture Localization for 0.8-2 cm Peripheral Pulmonary Nodules
The goal of this clinical trial is to learn whether intraoperative longitude-latitude-depth three-dimensional localization (LLD localization) is non-inferior to preoperative CT-guided percutaneous lung puncture localization for…
- Conditions
- Pulmonary Nodule, Solitary, Peripheral Pulmonary Nodules, Pulmonary Nodules
- Trial name
- NCT07675889
- Testing
- Longitude-Latitude-Depth Localization, CT-Guided Percutaneous Lung Puncture Localization
- Where
- 4 sites in China
- Volunteers
- 274 people
- Sponsor
- Qilu Hospital of Shandong University
Pulmonary Nodule, Solitary, Lung Cancer (NSCLC)
Comprehensive Prospective Comparison Of Two Robotic Platforms In Anatomical Lung Resections: Clinical Outcomes And Cost-utility Analysis
The goal is to compare clinical outcomes, hospital costs, and cost-utility in patients undergoing anatomical lung resections with DaVinci Xi vs Versius platforms The main questions it aims to answer are: Do patients that undergo…
- Conditions
- Pulmonary Nodule, Solitary, Lung Cancer (NSCLC), Pulmonary Metastases
- Trial name
- RATS_RYC (NCT07537556)
- Testing
- da Vinci Xi Surgical System, Versius Surgical System
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Solitary Pulmonary Nodules, Lung Cancer
Plasma Metabolomics as a Tool to Distinguish PET-positive Malignant From PET-positive Benign Nodules
Positron emission tomography-computed tomography (PET-CT) is an important technique in lung cancer staging, where almost no lung lesion goes undetected.
- Trial name
- NCT07087080
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 350 people
- Sponsor
- Hasselt University
Solitary Pulmonary Nodule, Oncology
18F-2-fluoro-2-deoxy-D-glucose in Positron Emission Tomography Computed Tomography
The study objectives are as follows: To determine the safety of trial 18F-2-fluoro-2-deoxy-D-glucose, produced by a new manufacturer, by surveillance for adverse events in patients having Positron Emission Tomography Computed…
- Conditions
- Solitary Pulmonary Nodule, Oncology, 18F-2-fluoro-2-deoxy-D-glucose, Adverse Event
- Trial name
- NCT04615156
- Testing
- 18F-2-fluoro-2-deoxy-D-glucose
- Volunteers
- 10,000 people
- Sponsor
- Eastern Health, Canada
Lung Cancer
ENB-GS-TBLB for the Diagnosis of PPLs
The purpose of this study is to evaluate the efficacy and safety of electromagnetic navigation bronchoscopy with a Guide Sheath(ENB-GS) for the diagnosis of peripheral pulmonary lesions (PPLs) .
- Trial name
- NCT02207478
- Testing
- ENB, GS-TBLB-X-ray
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer, Multiple Pulmonary Nodules
Real World Registry for Use of the Ion Endoluminal System
The primary objective of this study is to evaluate the performance of the Ion Endoluminal System with real-world use for pulmonary lesion localization or biopsy.
- Conditions
- Lung Cancer, Multiple Pulmonary Nodules, Lung Neoplasms, Respiratory Tract Neoplasms
- Trial name
- NCT06004440
- Testing
- Ion Endoluminal System
- Where
- 16 sites in United States
- Volunteers
- 1,301 people
- Sponsor
- Intuitive Surgical
High Risk Cancer, Lung Cancer
Retrospective Clinical Trial Comparing Radiologists' Diagnosis Accuracy in Lung Cancer Screening Population With and Without the Help of an AI/ML Tech-based SaMD
This is a two arm, randomized, controlled, blinded, multi-case multi reader (MRMC), retrospective study for the evaluation of the efficacy and safety of an AI/ML technology-based CADe/x developed to detect, localize and…
- Trial name
- RELIVE (NCT06751576)
- Testing
- Median LCS
- Where
- 5 sites in United States, Spain
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Median Technologies
Pulmonary Nodule, Solitary
ICG Fluorescence Versus CO₂ Inflation-Deflation for Intersegmental Plane Identification During Thoracoscopic Segmentectomy
Intersegmental plane identification is a critical step in thoracoscopic anatomical segmentectomy because it helps ensure adequate surgical margins while preserving healthy lung tissue.
- Trial name
- NCT07745738
- Testing
- Indocyanine Green Fluorescence Imaging, Carbon Dioxide Inflation-Deflation
- Volunteers
- 50 people
- Sponsor
- Tongji Hospital
Lung Nodules, Lung Cancer (Diagnosis)
Robotic-Assisted Navigation for Lung Nodule Localization: A Non-Inferiority Study
This study compares robotic-assisted navigation and manual CT-guided needle localization for lung nodules under 20 mm. It aims to evaluate localization success, procedure duration, CT scans, and complication rates.
- Conditions
- Lung Nodules, Lung Cancer (Diagnosis), Robotic-Assisted Navigation System
- Trial name
- NCT07055997
- Testing
- Robotic-assisted needle localization, Manual needle localization
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Malignant Neoplasm of Lung
Single Pulmonary Nodule Investigation
A small proportion of patients with lung cancer present with a solitary pulmonary nodule (SPN). This is an important group of patients because if it is lung cancer, presentation as a SPN represents early disease, which following…
- Trial name
- SPUtNIk (NCT02013063)
- Where
- 9 sites in United Kingdom
- Volunteers
- 375 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust