Clinical trials: Soil-Transmitted Helminthiasis (STH)
Trichuris Trichiura; Infection, Hookworm Infection
Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections
This study aims to assess the efficacy and safety of emodepside compared to mebendazole in adults and adolescents infected with T. trichiura, either as single infection or co-infections with hookworm and/or A. lumbricoides.
- Conditions
- Trichuris Trichiura; Infection, Hookworm Infection, Ascaris Lumbricoides Infection
- Trial name
- TREMO-Pemba (NCT06736691)
- Testing
- emodepside (BAY 44-4400), Mebendazole
- Where
- Tanzania
- Volunteers
- 315 people
- Sponsor
- Swiss Tropical & Public Health Institute
Lymphatic Filariasis, Onchocerciasis
Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia
Approximately 5,200 people will participate per year. The study population will include females and males over 5 years of age who live in filariasis and onchocerciasis endemic areas.
- Conditions
- Lymphatic Filariasis, Onchocerciasis, Soil Transmitted Helminth (STH) Infections
- Trial name
- DOLF-LIBERIA (NCT01905436)
- Testing
- Annual versus Semiannual Albendazole plus Ivermectin Mass Drug Administration
- Where
- Liberia
- Volunteers
- 21,862 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Lymphatic Filariasis, Soil Transmitted Helminth Infections
Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis
Approximately 3,500 people will participate per year. The study population will include females and males over 5 years of age who live in filariasis endemic areas. The study will be performed in Indonesia in B. timori and W.
- Trial name
- DOLF-Indo (NCT01905423)
- Testing
- Albendazole (annual), Diethylcarbamazine (annual), Albendazole (semiannual)
- Where
- Indonesia
- Volunteers
- 17,108 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Schistosomiasis in Children, Soil Transmitted Helminth (STH) Infections
Burden of Schistosomiasis and Soil-transmitted Helminth Infections in Schoolchildren in Banfora, Burkina Faso
A cross-sectional study will be conducted among 300 schoolchildren in the Banfora region, including 120 in urban and 180 in rural areas, to assess the prevalence of schistosomiasis and soil-transmitted helminth infections.
- Conditions
- Schistosomiasis in Children, Soil Transmitted Helminth (STH) Infections, Malaria Infection, Anaemia
- Trial name
- NTDs_SAC (NCT06973200)
- Testing
- Dihydroartemisin-piperaquine
- Where
- Burkina Faso
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre MURAZ/Institut National de Santé Publique
Helminthiasis, Filariasis
Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH)
Over 1.5 billion people are infected with soil-transmitted helminths (STH). Global STH guidelines recommend MDA (mass drug administration) of albendazole or mebendazole to targeted populations, including pre-school age children…
- Trial name
- NCT03014167
- Testing
- Albendazole
- Where
- 3 sites in Benin, India and 1 more
- Volunteers
- 357,716 people, healthy volunteers welcome
- Sponsor
- University of Washington
Soil Transmitted Helminth (STH) Infections
Assessing the Safety and Efficacy of a Combination Therapy for STH in PSAC in Bangladesh
Background (brief): 1. Burden: Soil-transmitted helminth (STH) infections are a major public health problem, primarily affecting children.
- Trial name
- NCT07045493
- Testing
- A single dose of Albendazole 400mg + Ivermectin (200 µg/ kg) combination therapy, A single dose of 400 mg Oral Albendazole monotherapy
- Where
- Bangladesh
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Lymphatic Filariasis, Onchocerciasis
Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast)
Approximately 4,000 people will participate per year. The study population will include females and males over 5 years of age who live in filariasis and onchocerciasis endemic areas.
- Conditions
- Lymphatic Filariasis, Onchocerciasis, Soil Transmitted Helminth (STH) Infections
- Trial name
- NCT02032043
- Testing
- Annual versus Semiannual Albendazole plus Ivermectin MDA
- Where
- Côte d’Ivoire
- Volunteers
- 14,457 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Soil-Transmitted Helminthiasis (STH)
Phase 3, Multi-center, Prospective, Randomized, Double-blind, Placebo- Controlled Study to Evaluate the Effectiveness and Safety of ZP5-9676 for the Treatment of Soil Transmitted Helminthiasis (STH)
This is a Phase 3, multi-center, prospective, randomized, double-blind, placebo-controlled study to evaluate the effectiveness, safety, and tolerability of ZP5-9676 compared to placebo for the treatment of STH infections.
- Trial name
- NCT06128447
- Testing
- ZP5-9676 600 mg dose
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Zero Point Five Therapeutics
Helminthiasis, Strongyloides Stercoralis Infection
Management of Soil-transmitted Helminthiasis and Strongyloidiasis
The general purpose of the project is to analyse soil-transmitted helminthiases (STH) in a highly endemic area in northern Argentina with a multidisciplinary approach.
- Trial name
- NCT01308268
- Testing
- Ivermectin + Albendazole
- Where
- Argentina
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Salta
Trichuris Trichiura; Infection, Hookworm Infection
Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections
This study aims to assess the efficacy and safety of emodepside compared to mebendazole in adults and adolescents infected with T. trichiura, either as single infection or co-infections with hookworm and/or A. lumbricoides.
- Conditions
- Trichuris Trichiura; Infection, Hookworm Infection, Ascaris Lumbricoides Infection
- Trial name
- TREMO-Siargao (NCT06800248)
- Testing
- emodepside (BAY 44-4400), Mebendazole 100 MG
- Where
- Philippines
- Volunteers
- 315 people
- Sponsor
- Swiss Tropical & Public Health Institute
Infections
Education Intervention to Reduce Helminth Infections and Absenteeism in Grade 5 School-children
To efficiently control soil-transmitted helminths (Ascaris, Trichuris, and hookworm), WHO, PAHO, and others recommend the inclusion of an education strategy in school-based deworming programs.
- Trial name
- NCT01085799
- Testing
- Health Education Intervention
- Where
- Peru
- Volunteers
- 1,101 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Soil-Transmitted Helminths
Real World Evaluation of an Albendazole-Ivermectin Coformulation Safety and Effectiveness
An open-label, randomized by school, two-arm pragmatic trial, will be conducted involving two study sites in Sub-Saharan-Africa (SSA), Ghana and Kenya, to evaluate safety and effectiveness of the newly developed fixed dose…
- Trial name
- NCT06282315
- Testing
- Pre-screening Phase, Screenig Phase, Randomization
- Where
- 2 sites in Ghana, Kenya
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Insud Pharma
Soil Transmitted Helminth (STH) Infections, Schistosomiasis Infection
Protocol for Integrating Mass Drug Administration Into Primary Health Care in Western Kenya
This study aims to determine whether distributing deworming drugs through routine healthcare services at the first point of contact in the health system is an effective way to prevent and treat worm infections in Western Kenya.
- Trial name
- NCT07507461
- Testing
- Primary Healthcare-Integrated Service Delivery, Standard Mass Drug Adminitsration service delivery
- Where
- Kenya
- Volunteers
- 1,229 people, healthy volunteers welcome
- Sponsor
- Amref Health Africa
Onchocerciasis (River Blindness), Schistosomiasis
Expanding Access to Preventive Chemotherapy Among Mobile and Migrant Populations
Neglected Tropical Diseases (NTDs) are among the most common groups of diseases affecting over one billion people globally and are disproportionately concentrated in remote, underserved, and marginalized communities.
- Conditions
- Onchocerciasis (River Blindness), Schistosomiasis, Soil Transmitted Helminth (STH) Infections, Lymphatic Filariasis
- Trial name
- MISSION (NCT07707817)
- Testing
- Modified Mass Administration of Medicines Strategy, Albendazole 400 mg, Praziquantel 40 mg/kg
- Where
- Nigeria
- Volunteers
- 5,760 people, healthy volunteers welcome
- Sponsor
- Uwemedimo Friday Ekpo
Ascariasis, Trichuriasis
Efficacy Albendazole and Levamisole Against STH on Unguja
Field epidemiological studies undertaken during 2005 in four village locations in Northern Unguja, Zanzibar examined mothers and their pre-school aged children for helminth infections.
- Trial name
- ALBvLEV (NCT00659997)
- Testing
- Albendazole, Levamisole
- Where
- Tanzania
- Volunteers
- 20 people
- Sponsor
- Natural History Museum, United Kingdom
Soil Transmitted Helminths, Schistosomiasis Mansoni
Evaluation of an AI-DP for STH Deworming Programs: a Study Protocol
The goal of this observational study is to test a new AI diagnostic tool for detection, specification and quantification of parasitic infections (Ascaris, Trichuris, hookworm and S.
- Trial name
- KAKADU (NCT06055530)
- Testing
- Artificial Intelligence Digital Pathology
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Enaiblers AB