Clinical trials: Smoking Dependence
Tobacco Use Cessation, Alcohol-related Disorders
Concurrent Alcohol and Smoking Treatment: Effects on Alcohol Relapse Risk
The majority of individuals with alcohol problems remain current smokers, and the negative health consequences of smoking among these individuals are substantial.
- Trial name
- NCT00861146
- Testing
- behavioral counseling plus contingency management
- Where
- 2 sites in United States
- Volunteers
- 151 people
- Sponsor
- Yale University
Smoking, Smoking Behaviors
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products.
- Conditions
- Smoking, Smoking Behaviors, Nicotine Dependence
- Trial name
- NCT06077240
- Testing
- E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Yale University
Nicotine Dependence Tobacco Product
Comparing SMS and E-mail Reminders in an Online Smoking Cessation Intervention
The primary purpose of the current study is to compare the effect of SMS-textmessage vs e-mail reminders on user engagement and proportion of reported quit attempts in an online smoking cessation intervention.
- Trial name
- NCT03276767
- Testing
- Endre
- Where
- 2 sites in Czechia, Norway
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Tobacco Use Disorder
Persistence-Targeted Smoking Cessation
The investigators propose to develop a theory-based smoking cessation intervention (called Persistence-targeted smoking cessation; PTSC).
- Trial name
- PTSC (NCT01654107)
- Testing
- Persistence Targeted Smoking Cessation, Clearing The Air, Nicotine lozenge
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Tobacco Dependence
Comparisons of Nicotine-free Cigarettes, Extra Low Nicotine Cigarettes vs. Medicinal Nicotine
In this study, smokers will be randomly assigned to one of three conditions for six weeks: 1) nicotine-free cigarettes (0.05mg); 2) extra low nicotine cigarettes (0.3 mg); or 3) medicinal 4 mg nicotine lozenge.
- Trial name
- NCT00777569
- Testing
- Nicotine free cigarettes, Extra-low nicotine cigarettes, Nicotine Lozenge
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking, Nicotine Dependence
Short Term Effects of Electronic Cigarettes in Tobacco Dependent Adults
This is a pilot human experimental study to evaluate whether the use of an e-cigarette affects lung function, exhaled CO levels, and quantitative tobacco cigarette consumption in active tobacco smokers.
- Trial name
- NCT02498145
- Testing
- Nicotine e-cigarette, Non-nicotine e-cigarette
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Prevention of Drug Abuse and Dependency, Alcohol Abuse and Dependency
The Whole Day First Grade Program
This five-year prevention services application is concerned with preventing substance abuse, comorbid mental and behavioral disorders, and school failure.
- Conditions
- Prevention of Drug Abuse and Dependency, Alcohol Abuse and Dependency, High Risk Sex Behavior, Smoking Tobacco
- Trial name
- NCT00257088
- Testing
- whole day first grade program
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- American Institutes for Research
Alcohol Abuse, Nicotine Dependence Tobacco Product
Reactions to E-cigs and Alcohol
The purpose of this study is to 1) examine cognitive acuity following e-cig use (as compared to no e-cig use), 2) examine motor coordination following beer and e-cig use (as compared to beer consumption only).
- Trial name
- NCT03449017
- Testing
- E-cig use
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Indiana University
Tobacco Use Disorder, Nicotine Dependence
Beta-Adrenergic Modulation of Drug Cue Reactivity
This study is designed to investigate the effects of a beta-adrenergic antagonist (Propranolol; 40 mg IR) and nicotine patch (14 mg) administered alone and in combination on neurobiological and behavioral responses to smoking…
- Conditions
- Tobacco Use Disorder, Nicotine Dependence, Cigarette Smoking
- Trial name
- NCT05587361
- Testing
- Propranolol, Nicotine Patch
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Tobacco Dependence, Alcohol Dependence
Effect of Varenicline on Reactivity to Smoking and Drinking Cues
Alcohol and nicotine dependence are often co-morbid, with 85% of alcoholics also smoking. However, very little research has been conducted into the nature of this co-occurrence.
- Trial name
- NCT00873535
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation; Tobacco Dependence, E-Cig Use
BREATHE Free Curriculum
The purpose of this study is to evaluate whether BREATHE Free, an in-person faith-based smoking cessation program, can help people quit using tobacco products, including cigarettes, cigars, cigarillos, and e-cigarettes/vapes.
- Conditions
- Smoking Cessation; Tobacco Dependence, E-Cig Use, Nicotine Dependence, Other Tobacco Product
- Trial name
- NCT06862050
- Testing
- BREATHE Free Curriculum
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Augusta University
Tobacco Dependence
Bioequivalence Between Nicotine Replacement Products and Nicorette® Gum
Bioequivalence between oral nicotine replacement products and Nicorette® gum.
- Trial name
- NCT01113424
- Testing
- Nicotine, Nicorette® (Nicotine Gum)
- Where
- Sweden
- Volunteers
- 88 people
- Sponsor
- McNeil AB
Nicotine Dependence, Nicotine Addiction
A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults
Almost one in ten young adults report current e-cigarette use, putting them at risk of developing nicotine addiction and long-term health effects of exposure to inhaled toxicants.
- Conditions
- Nicotine Dependence, Nicotine Addiction, Nicotine Use Disorder, Nicotine Vaping
- Trial name
- NCT05897242
- Testing
- Smartphone app, Text Message, Survey Administration
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Tobacco Use Disorder
Chemical Dependency and Smoking Cessation: Patient's Views - 1
The purpose of this study is to asses patient views on smoking cessation and tobacco harm reduction during drug treatment.
- Trial name
- NCT00051883
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking, Nicotine Dependence
Placebo-controlled Trial of Bupropion for Smoking Cessation in Pregnant Women
Smoking during pregnancy adversely affects the health of the mother and her developing baby. Maternal smoking approximately doubles the risk of miscarriage, placental complications, preterm delivery, low birth weight and fetal…
- Trial name
- BIBS (NCT02188459)
- Testing
- Bupropion
- Where
- 3 sites in United States
- Volunteers
- 129 people
- Sponsor
- Henry Kranzler
Tobacco Use Disorder, Nicotine Addiction
Cognitive Training for Nicotine Dependence
This randomized clinical trial tested the effects of a computerized (web-based) cognitive training intervention on smoking cessation.
- Trial name
- NCT01252966
- Testing
- Cognitive Training, Control training
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- University of Pennsylvania
Cardiovascular Risk Factor, Nicotine Dependence
Vaping High vs. Low Nicotine E-Liquid
This study will examine the effects of electronic cigarette e-liquid nicotine content in a randomized, crossover clinical and behavioral pharmacology study of experienced adult e-cigarette users (N=36).
- Trial name
- NCT04047836
- Testing
- Low Nicotine E-Liquid, Medium or High Nicotine E-Liquid
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Dependence
A Study of Novel Smoking Cessation Interventions in Current and Former Injection Drug Users
Cigarette smoking is very common in current and former injection drug users and is known to cause chronic lung diseases. Quitting smoking is proven to improve the health of people addicted to cigarettes. .
- Trial name
- NCT01334736
- Testing
- Usual care, Lung age, Contingency Management
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tobacco Use Disorder, Nicotine Dependence
The MATCH (Medication Aids for Tobacco Cessation and Health) Study
Clinically proven medications such as nicotine replacement therapy, bupropion and varenicline are available to help smokers quit but there are not widely used.
- Trial name
- MATCH (NCT02146911)
- Testing
- Bupropion, Varenicline, Weekly Motivational Emails
- Where
- Canada
- Volunteers
- 968 people
- Sponsor
- Centre for Addiction and Mental Health
Drug Addiction, Nicotine Dependence
Assessing Top Down and Bottom Up Attention Mechanisms in Smokers Using Nicotine Nasal Spray
Background: Smoking is the leading cause of preventable death in the United States, and researchers are interested in gaining a better understanding of the perceived beneficial effects of nicotine to help improve treatment…
- Trial name
- NCT01136642
- Testing
- Nicotrol
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)