Clinical trials: Small Renal Masses
Kidney Cancer
Safety and Feasibility of IRE for SRMs
Irreversible Electroporation (IRE) is an emerging technique delivering electrical pulses to ablate tissue, with the theoretical advantage to overcome the main shortcomings of conventional thermal ablation.
- Trial name
- NCT02828709
- Testing
- Irreversible Electroporation
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Dr. Prof. M.P. Laguna Pes
Renal Cancers
Cryoablation Versus Radiofrequency Ablation for Small Renal Masses
The purpose of this study is to verify the oncological efficacy and safety of cryoablation and radiofrequency ablation for the treatment of small renal tumors.
- Trial name
- NCT00922948
- Testing
- Cryoablation, Radiofrequency ablation
- Where
- Canada
- Sponsor
- St. Joseph's Healthcare Hamilton
Patients With Newly Diagnosed Small Renal Masses(<4cm)
The Natural History of Small Renal Masses
There is a rising incidence of incidentally detected small renal tumours due to improved imaging techniques. Traditionally, patients diagnosed with these small renal masses undergo surgery and therefore there is limited data…
- Trial name
- NCT01305330
- Where
- Canada
- Volunteers
- 137 people
- Sponsor
- University Health Network, Toronto
Renal Cell Carcinoma
European Active Surveillance of Renal Cell Carcinoma Study (EASE RCC Study)
The goal of this observational, prospective, multi-national clinical study is to assess overall survival of patients who are diagnosed with incidental, histologically (biopsy) confirmed, <4 cm Renal Cell Carcinoma (RCC) and are…
- Trial name
- EASE (NCT06336187)
- Testing
- active surveillance, molecular investigation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Renal Cancer
A Feasibility Study for a Multicentre Randomised Controlled Trial to Compare Surgery With Needle Ablation Techniques in People With Small Renal Masses (4cm)
The number of people diagnosed with kidney cancer has doubled over the past 20 years, making it the eight most common cancer in the UK.
- Trial name
- CONSERVE (NCT01608165)
- Testing
- Surgical treatment for renal mass, Percutaneous Radiofrequency ablation, Laparascopic or percutaneous cryoablation
- Where
- 5 sites in United Kingdom
- Volunteers
- 17 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Renal Malignant Tumor, Renal Tumor
Normotonic Partial Nephrectomy as Novel Approach in Treating Small Renal Masses
This study evaluates novel surgical approach in treating small renal masses. Half of participants will undergo hypotonic zero-ischaemia partial nephrectomy (standard of care), while the other half will undergo normotonic…
- Trial name
- NORPN (NCT04096534)
- Testing
- Normotonic partial nephrectomy, Hypotonic partial nephrectomy
- Where
- Russia
- Volunteers
- 108 people
- Sponsor
- Saint Petersburg State University, Russia
Renal Cell Carcinoma (RCC)
Comparing Two Weight Loss Programs for the Prevention of Kidney Cancer Progression Among Patients With Small Renal Masses on Active Surveillance
This clinical trial compares two different weight-loss programs, daily continuous calorie energy reduction (CER) versus (vs.) 5:2 intermittent fasting (IF), in preventing progression of kidney (renal) cancer among patients with…
- Trial name
- NCT07714018
- Testing
- Intermittent Fasting, Continuous Energy Restriction (CER)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Roswell Park Cancer Institute
Small Renal Mass
Zero Ischemia Laparoscopic Partial Nephrectomy
Laparoscopic partial nephrectomy (LPN) is often reserved for patients with a small peripheral tumour, in the hands of an experienced surgeon since it demands a high degree of endoscopic skill.
- Trial name
- ZILPAREMZ (NCT02634385)
- Testing
- Renal Artery Embolization, Partial Nephrectomy (Surgical Resection)
- Where
- Canada
- Sponsor
- St. Joseph's Healthcare Hamilton
Kidney Neoplasm
The Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) Registry
Retrospective studies indicate that active surveillance for clinically localized, small renal masses (cT1a, <=4cm) is safe. It is our hypothesis that active surveillance is safe and efficacious when compared prospectively to…
- Trial name
- DISSRM (NCT02346435)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Kidney Cancer
Protocol Active Surveillance Small Renal Masses (SRMs)
Prospective study of active surveillance, non-randomized, multicentric, in asymptomatic patients over the age of 50 years, not affected by other tumors, with occasional diagnosis of single monolateral solid renal mass equal to or…
- Trial name
- NCT03804320
- Testing
- Active Surveillance
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- IRCCS San Raffaele
Renal Carcinoma, Renal Mass
Robot-Assisted Ultrasound for Thermal Ablative Therapy in Treating Patients With Small Kidney Masses Undergoing Surgery
This clinical trial studies a type of ultrasound called robot-assisted laparoscopic high-intensity focused ultrasound for performing thermal ablative therapy, or sound wave therapy, in treating patients with small kidney masses…
- Trial name
- NCT02370342
- Testing
- Robot-Assisted Laparoscopic Surgery, High-Intensity Focused Ultrasound Ablation, Therapeutic Laparoscopic Surgery
- Where
- 2 sites in United States
- Sponsor
- University of Southern California
Small Renal Masses
A Trial Comparing - Robotic Assisted Versus Laparoscopic Partial Nephrectomy For Small Renal Masses
A prospective, randomized, controlled trial including patients who are diagnosed with a small renal mass (<4 cm) amenable to resection using either RALPN or LPN.
- Trial name
- RALPLPNNX (NCT02933398)
- Testing
- Robotic Assisted Nephrectomy, Laparoscopic Assisted Nephrectomy
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Renal Cell Carcinoma
Efficacy of Ultrasound Contrast Agent to Assess Renal Masses
Patients with an incidentally discovered small renal masses (SRM) < 4 cm in diameter are included. All patients will undergo biopsy for tissue diagnosis. Most patients will be followed by imaging.
- Trial name
- NCT01062178
- Testing
- Definity
- Where
- Canada
- Volunteers
- 167 people
- Sponsor
- University Health Network, Toronto
Small Renal Mass, Kidney Tumor
GRADE-SRM: Genomic Risk Assessment and Decisional Evaluation for Small Renal Masses
Purpose: The purpose of this study is to evaluate the role of renal mass biopsy on decision-making for patients presenting with clinical T1 kidney tumors.
- Trial name
- GRADE-SRM (NCT03819569)
- Testing
- Small Renal Mass Biopsy, No Small Renal Mass Biopsy
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Small Renal Masses (SRM)
Stereotactic Body Radiation Therapy Versus Radiofrequency Ablation for Small Renal Masses
The execution of this study is pertinent to evaluating SBRT's short- and long-term efficacy and safety in the treatment of SRMs. This study will be the first to compare RFA and SBRT in the treatment of SRMs.
- Trial name
- SBRT vs RFA (NCT03811665)
- Testing
- Radiofrequency Ablation, Stereotactive body radiation therapy
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Carcinoma, Renal Cell
Follow up After Cryoablation of Small Renal Masses.
Currently there is no consensus on post procedural follow up imaging following percutaneous cryoablation of renal tumors. Interpretation of conventional contrast enhanced imaging (CT and MRI) during follow up can be very…
- Trial name
- NCT02411968
- Testing
- 111In-Girentuximab DOTA SPECT
- Where
- Netherlands
- Volunteers
- 9 people
- Sponsor
- Radboud University Medical Center
Renal Cell Carcinoma, Renal Tumor
Non-Invasive Diagnostics of Small Renal Masses
NiSAR is a Ph.D. study and consists of three substudies. Renal cancer is one of the most deadly urologic malignancies and accounts for 900 new cases and 300 deaths per year.
- Trial name
- NISar (NCT03667885)
- Testing
- Blood sample, urine sample, Multi planar MRI
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Odense University Hospital
Carcinoma, Renal Cell
Evaluation of a Laparoscopic High Intensity Focused Ultrasound Probe for the Ablation of Small Renal Masses
The Sonatherm device provides both advanced imaging (ultrasound guidance) and high intensity focused ultrasound to target and ablate tumors.
- Trial name
- HIFU-KIDNEY (NCT02248389)
- Testing
- Sonatherm 600i ablation system
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University