Clinical trials: Sleep Disruption
Depression, Anxiety
Simulated Dawn Med Students
Medical students score higher than the general population on measures of depression, anxiety, fatigue, poor sleep and sleepiness. Data suggest that disparages in circadian phase might contribute to these problems.
- Conditions
- Depression, Anxiety, Fatigue, Sleepiness
- Trial name
- NCT02088593
- Testing
- Simulated Dawn Light Box, Sleep Hygiene instructions
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Sleep Initiation and Maintenance Disorders, Depression
Estrogen for Treating Depression in Menopausal Women With Hot Flashes and Insomnia
This study will evaluate the effectiveness of estrogen replacement therapy in treating depression in menopausal women with hot flashes and insomnia.
- Trial name
- NCT00227942
- Testing
- Estrogen Replacement Therapy, Zolpidem
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Hadine Joffe, MD
Obstructive Sleep Apnea, Sleep
Impact of Exogenous Ketones on Sleep Disruption in Vulnerable Populations
Obstructive Sleep Apnea (OSA) is a common medical disorder that is associated with reduced quality of life and higher risk of cardiovascular disease. Treatments for OSA and limited and not well tolerated.
- Trial name
- KETO-SLEEP 1 (NCT06655649)
- Testing
- Ketone-IQ (1,3 Butanediol)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Sleep Disorder, Mental Health Issue
Improving Sleep in a Psychiatric Hospital
The purpose of this study is to examine effects of sleep promotion versus treatment as usual (TAU) on subjective, self-reported sleep while in inpatient psychiatric treatment, to examine effects of sleep promotion vs.
- Trial name
- NCT07010718
- Testing
- Scented Oil, Ear Plugs, Eye Mask
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center, Houston
Sleep Disorder, Healthy
Effects of Experimental Sleep Disturbances on Receptor Function of Study Drug
The overall goal of this project is to determine whether common sleep disturbance patterns, sleep continuity disturbance (SCD) and Sleep Fragmentation (SF), alter cerebral study drug receptor availability, drug-based analgesia…
- Trial name
- Sleep-MOR (NCT04299490)
- Testing
- Sleep Fragmentation, Sleep Continuity Disruption, Undisturbed Sleep
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sleep Disruption, Sleep Hygiene
Sleep Hygiene During Ramadan
Ramadan fasting often disrupts sleep patterns, which can affect alertness and physical performance in student-athletes. This study tested whether a brief sleep education program designed for Ramadan could help improve sleep…
- Conditions
- Sleep Disruption, Sleep Hygiene, Ramadan Fasting
- Trial name
- SHIR (NCT07639229)
- Testing
- Culturally Adapted Sleep Hygiene Education Program
- Where
- Tunisia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The Higher Institute of Sport and Physical Education of Sfax
Inflammation, Sleep Deprivation
Circadian Rhythm Disruption Effects on Smoke Inhalation
Particulate matter exposure during smoke inhalation provokes inflammatory immune responses in people exposed to burning biomass including fire fighters and civilians.
- Conditions
- Inflammation, Sleep Deprivation, Circadian Rhythm Sleep Disorder, Shift Work Type, Smoke Inhalation
- Trial name
- NCT04955431
- Testing
- Sleep Restriction, Normal Sleep
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Montana
Obesity and Overweight, Type 2 Diabetes
Sleep, Glucose, and Brain Health in Obesity and Overweight Individuals
The primary aim of the NNF study is to investigate both cross-sectional and longitudinal associations between sleep patterns-measured over two consecutive weeks at baseline and again one year later-and indicators of glycemic…
- Conditions
- Obesity and Overweight, Type 2 Diabetes, Sleep, Brain Health
- Trial name
- NNF (NCT06968728)
- Volunteers
- 400 people
- Sponsor
- Uppsala University
Delirium, Sleep Disorders, Circadian Rhythm
Study of Sleep and Delirium in the Intensive Care Unit (ICU)
The investigators will perform a prospective, cohort study of 100 older intensive care unit (ICU) patients, to investigate the association between sleep disruption and ICU delirium.
- Trial name
- SID (NCT01280097)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of California, San Francisco
Sleep Disorders
Providing "Good Sleep" for ICU Sedation
Cognitive dysfunction, either alone or as an element in the syndrome of delirium, is a common occurrence with an incidence as high as 75% in intensive care unit (ICU) patients and can independently result in serious consequences…
- Trial name
- ASRV (NCT01342328)
- Testing
- Normal saline infusion, Dexmedetomidine, Propofol
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sleep Disorder, Shift Work, Fatigue
Effect of Night Float Call on Sleep and Activity Patterns Among Anesthesia Residents
With increasing awareness about physician fatigue and its effect on patient safety, residency programs are increasingly transitioning to a night float call system.
- Conditions
- Sleep Disorder, Shift Work, Fatigue, Sleep Disturbance
- Trial name
- NCT05043038
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sleep Deprivation, Circadian Dysregulation
The Microbiome and Resilience to Sleep and Circadian Disruption
This study is about how sleep loss and being awake at night impacts the ability to think, changes molecules in the blood, and alters the bacteria that live in the gut that typically help keep people healthy.
- Conditions
- Sleep Deprivation, Circadian Dysregulation, Stress
- Trial name
- NCT03747367
- Testing
- Insufficient Sleep, Prebiotic
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Gingivitis, Circadian Rhythm Disruption
Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption
This prospective cross-sectional clinical study aims to investigate the relationship between circadian rhythm disruption and periodontal inflammation by evaluating circadian clock protein levels, inflammatory (IL-1beta) and…
- Conditions
- Gingivitis, Circadian Rhythm Disruption, Periodontal Inflammation, Circadian Rhythm Sleep Disorder, Shift Work Type
- Trial name
- Nursma-CIRC-HG (NCT07592052)
- Testing
- Standard Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Inonu University
Sleep
Effect of Asynchronies on Sleep Disruption During Mechanical Ventilation
Mechanically ventilated (MV) patients in the Intensive Care Unit (ICU) are highly susceptible to sleep disruption. Several studies in the last 15 years have demonstrated an extremely poor sleep quality and abnormal sleep pattern…
- Trial name
- SleepUCI (NCT05847374)
- Testing
- Polysomnography
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Social Jet Lag, Sleep Disturbance
Self-Acupressure and Social Jet Lag in Female Health Sciences Students
This randomized, sham-controlled trial aims to evaluate the effects of self-administered acupressure on social jet lag, sleep patterns, and sleep quality in female health sciences students.
- Conditions
- Social Jet Lag, Sleep Disturbance, Sleep Quality, Circadian Rhythm Disruption
- Trial name
- NCT07410936
- Testing
- Self-Acupressure Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Alcohol Use Disorder
The Effects of Sex Hormones and Alcohol on Sleep
Rates of heavy drinking and Alcohol Use Disorder (AUD) are increasing in women, but research on alcohol-related harms in women - including alcohol's impact on sleep - has been minimal.
- Trial name
- NCT06143059
- Testing
- Ethanol, Saline
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Sleep Disturbance
Sleep Disturbances and Delirium
Delirium is a frequent and serious problem in hospitalized patients; it is associated with multiple hospital-acquired complications.
- Trial name
- SLEEP (NCT05402280)
- Testing
- Sleep protocol
- Where
- Czechia
- Volunteers
- 3,240 people
- Sponsor
- University of Ostrava
Dementia, Alzheimer Disease
The Music, Sleep and Dementia Study
The specific aims of this studyare to examine the 1) feasibility; 2) acceptability; and 3) preliminary efficacy of a tailored music intervention in home-dwelling older adults with dementia suffering from sleep disruption.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT04157244
- Testing
- Tailored music listening intervention
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Sleep
Implementation of Digital Vital Sign Monitoring to Decrease Sleep Interruption and Enhance Recovery in Phase II of the PROmoting Sleep, Patient Engagement and Recovery (PROSPER) Project
This phase II/III trial examines how a sleep enhancement intervention, including the use of wearable digital vital sign monitoring device (ViSi), affects the quality of life of cancer patients receiving acute care.
- Trial name
- NCT05456360
- Testing
- ViSi Mobile device, Sleep enhancement intervention
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- M.D. Anderson Cancer Center
Insomnia, Spinal Cord Injury
Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia
The purpose of this study is to determine if replacing melatonin function with a melatonin agonist (ramelteon) in individuals that lack endogenous melatonin production (tetraplegia) helps to alleviate self-reported sleep…
- Conditions
- Insomnia, Spinal Cord Injury, Tetraplegia, Sleep Disorders
- Trial name
- NCT00507546
- Testing
- Ramelteon
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs