Clinical trials: Sleep Apnea, open to volunteers
Obstructive Sleep Apnea
DRonabinol Treatment of OSA
This is an open-label trial that tests the effectiveness of Dronabinol in treating obstructive sleep apnea (OSA). All participants will take oral Dronabinol for two weeks.
- Trial name
- DROSA (NCT06477952)
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
OSA - Obstructive Sleep Apnea
Comparative Study of CPAP Predictive Equations and In-laboratory Manual Titration in Thai Patients With Obstructive Sleep Apnea
The goal of this observational study is to compare predictive equations for continuous positive airway pressure (CPAP) with in-laboratory manual titration in patients with obstructive sleep apnea (OSA).
- Trial name
- NCT07376343
- Testing
- Sleep test, Predictive equations of continuous positive airway pressure (CPAP)
- Where
- 2 sites in Thailand
- Volunteers
- 150 people
- Sponsor
- Thammasat University
Obstructive Sleep Apnea, Cardiovascular (CV) Risk
Prospective Evaluation of New Metrics to Assess Cardiovascular Remodeling in Obstructive Sleep Apnea
The goal of this prospective study is to gain insight into the endophenotypic variation in OSA, with a focus on the underlying pathophysiological traits and the cardiovascular alterations associated with the condition.
- Trial name
- CARDOSA (NCT07427589)
- Testing
- Continuous positive airway pressure, Mandibular advancement device, Hypoglossal nerve stimulation
- Where
- Belgium
- Volunteers
- 270 people
- Sponsor
- University Hospital, Antwerp
Obesity, Obstructive Sleep Apnea
Changes in Body Fat and Morphologic Characteristics Associated With OSA Resolution After Bariatric Surgery
Prospective study with inclusion of bariatric surgery candidates with diagnosed Obstructive Sleep Apnea and requiring treatment with Continuous Positive Air Pressure, aiming to evaluate at 2-6-12 months after bariatric surgery…
- Trial name
- NCT05315752
- Testing
- Bariatric surgery
- Where
- 2 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Postoperative Atelectasis, Lung Ultrasonography Score
Evaluation of Recruitment Effectiveness in Patients With Obstructive Sleep Apnea Syndrome Using Lung Ultrasound
Patients with obstructive sleep apnea syndrome are at higher risk for respiratory complications after surgery. Oxygen depletion and respiratory distress are common in patients with obstructive sleep apnea syndrome.
- Conditions
- Postoperative Atelectasis, Lung Ultrasonography Score, Recruitment
- Trial name
- NCT07061002
- Testing
- Lung Recruitment Maneuver, Positional Lung Recruitment Maneuver
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Istanbul University - Cerrahpasa
Obstructive Sleep Apnea (OSA), OSA
Automated Manual Lymphatic Drainage Therapy to Improve Glymphatic Function in OSA Patients
The purpose of this research is to investigate whether enhancing systemic lymphatic drainage improves glymphatic function in patients with obstructive sleep apnea (OSA).
- Conditions
- Obstructive Sleep Apnea (OSA), OSA, Obstructive Sleep Apnea
- Trial name
- NCT07301762
- Testing
- Automated manual lymphatic drainage therapy (AMLDT) device
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Obesity, Class III, Sleep Apnea, Obstructive
High-Intensity Progressive Inspiratory Muscle Training in Class III Obesity and Obstructive Sleep Apnea
The purpose of this study is to evaluate the feasibility and effects of a 12-week high-intensity progressive Inspiratory Muscle Training (IMT) program in individuals with Class III obesity (BMI ≥ 40 kg/m²) and obstructive sleep…
- Conditions
- Obesity, Class III, Sleep Apnea, Obstructive, Inspiratory Muscle Training
- Trial name
- NCT07469280
- Testing
- High-Intensity Progressive Inspiratory Muscle Training (IMT)
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of the State of Santa Catarina
Obstructive Sleep Apnea (OSA), Syndrome, Obstructive Sleep Apnea
Implantable Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea
The objective of this study is to evaluate the safety and preliminary effectiveness of an implantable hypoglossal nerve stimulation system for moderate-to-severe obstructive sleep apnea (OSA).
- Conditions
- Obstructive Sleep Apnea (OSA), Syndrome, Obstructive Sleep Apnea, Respiration Disorders, Sleep Apnea Syndrome, Obstructive
- Trial name
- NCT07711678
- Testing
- Implantable Hypoglossal Nerve Stimulation System
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Obstructive Sleep Apnea, Down Syndrome
Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)
The overall objective of this randomized clinical trial is to test the effectiveness of a personalized approach to the surgical treatment of OSA in children with Down syndrome (DS).The estimated prevalence of obstructive sleep…
- Trial name
- TOPS-DS (NCT05508971)
- Testing
- DISE-Directed Surgery, Adenotonsillectomy
- Where
- 7 sites in United States
- Volunteers
- 304 people
- Sponsor
- Oregon Health and Science University
Obstructive Sleep Apnea (OSA)
Validation of Five Seasons Sleep Tracking Mat for the Diagnosis of Obstructive Sleep Apnea
This study will evaluate and compare the diagnostic accuracy and effectiveness of the Five Seasons Sleep Tracking Mat with the gold standard, polysomnography.
- Trial name
- NCT06875479
- Testing
- Five Seasons [5S] Sleep Tracking Mat
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai 6th People's Hospital
Healthy Adult, Sleep Apnea
Oura Ring OA15 Validation
The current study intends to collect data from Oura Ring time-locked to ground truth medical sleep diagnostic gold-standard polysomnography (PSG) for product research and development, investigational algorithm validation, and…
- Trial name
- NCT07908199
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ouraring Inc.
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Cirrhosis
MASLD in Type 2 Diabetes in Primary Care - a Follow-up Study
The goal of this observational study is to understand how metabolic dysfunction-associated steatotic liver disease (MASLD) changes over time in individuals with type 2 diabetes who previously participated in the EPSONIP study.
- Conditions
- MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Cirrhosis, Advanced Fibrosis, Sarcopenia
- Trial name
- EPSOMIP2 (NCT07312136)
- Where
- Sweden
- Volunteers
- 317 people
- Sponsor
- Linkoeping University
Obstructive Sleep Apnea
Assessment of the Effect of Hypoglossal Nerve Stimulation Therapy on Upper Airway Collapsibility During Drug-induced Sleep Endoscopy
This clinical trial will evaluate the effect of treatment with hypoglossal nerve stimulation on the underlying mechanisms of obstructive sleep apnea.
- Trial name
- HNS-CoDSE (NCT07337239)
- Testing
- Additional measurements during clinical standard follow-up drug-induced sleep endoscopy (DISE)
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea (OSA)
Evaluate the Efficacy and Safety of GZR18 Injection in Obese Subjects With Obstructive Sleep Apnea Receiving Positive Airway Pressure (PAP) Therapy
The study is a multicenter, randomized, double-blind, parallel-group, placebo-controlled Phase III clinical trial to evaluate the efficacy and safety of GZR18 injection in Chinese adult obese patients with moderate-to-severe…
- Trial name
- NCT07501832
- Testing
- GZR18 injection
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Sleep Apnea, Obstructive Sleep Apnea
Continuous Positive Airway Pressure, Arousability and Links to Mechanisms in Obstructive Sleep Apnea
The study design is a randomized, controlled clinical trial to test the hypothesis that arousal threshold (ArTH) will affect how individuals with obstructive sleep apnea (OSA, Apnea-Hypopnea Index (AHI) of 10/hour of higher)…
- Trial name
- CALM-OSA (NCT07332442)
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Yale University
Obstructive Sleep Apnoea (OSA)
A Study Assessing Adult Patients Referred to an NHS Sleep Service With Suspected Obstructive Sleep Apnoea. This Study Aims to Compare the Sunrise Wearable Diagnostic Device Performance and Potential Inclusion in a NHS Diagnostic Pathway With Oximetry and WatchPAT Which Are Currently Used.
The goal of this clinical trial is to evaluate whether the Sunrise device (that measure small jaw movements) can improve the diagnosis and management of Obstructive Sleep Apnoea (OSA) in adults (≥ 18 years) referred to a Sleep…
- Trial name
- SOSA (NCT07269483)
- Testing
- WatchPAT 300, Oximetry, Sunrise
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Virginia Hawkins
Bronchial Asthma, Bronchiectasis
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
Research is being conducted into chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease, and bronchiectasis.
- Conditions
- Bronchial Asthma, Bronchiectasis, ILD, COPD
- Trial name
- NCT07060079
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
OSA - Obstructive Sleep Apnea, Dysphagia
Effects of Surgery on Oral Frailty and Dysphagia in Patients With Obstructive Sleep Apnea
Dysphagia is a commonly reported complaint among patients with obstructive sleep apnea (OSA), particularly those who have undergone upper-airway (oropharyngeal) surgery.
- Conditions
- OSA - Obstructive Sleep Apnea, Dysphagia, Oral Frailty
- Trial name
- NCT07880067
- Testing
- Upper airway surgery for OSA, Non-surgical management
- Where
- Taiwan
- Volunteers
- 450 people
- Sponsor
- National Sun Yat-sen University
Obstructive Sleep Apnea
PAP Systems External Clinical Studies (ECS)
This is a pre-market study for ongoing product development aiming to explore the usability and performance of the study PAP systems.
- Trial name
- NCT06562205
- Testing
- PAP System A (with Amalfi) then PAP System B (with CLA11), PAP System B (with CLA11) then PAP System A (with Amalfi)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ResMed
Obstructive Sleep Apnea (OSA)
The Improving Sleep in African American Couples Study (ISAAC)
The goal of this randomized study is to compare a combined behavioral intervention (remote tele-monitoring and feedback, virtual cognitive behavioral couple therapy, and couple-oriented peer support) on continuous positive airway…
- Trial name
- ISAAC (NCT07447284)
- Testing
- CPAP Training and Education, Virtual Disease Support Group Sessions, Couple CPAP Training and Education
- Where
- 2 sites in United States
- Volunteers
- 440 people
- Sponsor
- MetroHealth Medical Center