Clinical trials: Skin Diseases, Parasitic
Scabies
Efficacy and Safety Study of Moxidectin in Adults With Scabies
Moxidectin is not approved to treat scabies in humans. The effective dose of moxidectin to treat scabies is not known. This study aims to assess the efficacy of a single administration of 8 mg, 16 mg, or 32 mg moxidectin per oral…
- Trial name
- NCT05875441
- Testing
- Moxidectin Oral Product
- Where
- 9 sites in United States, Dominican Republic and 2 more
- Volunteers
- 200 people
- Sponsor
- Medicines Development for Global Health
Lymphatic Filariases, Onchocerciasis
Prevalence of LF Infection in Districts Not Included in LF Control Activities
Lymphatic filariasis is a neglected tropical disease earmarked for elimination as a public health problem by the year 2020. Since the year 2000, the Global Program for the Elimination of LF has together with endemic countries…
- Trial name
- NCT03131401
- Testing
- Diagnosis of lymphatic filariasis, Diagnosis of lymphatic Filariasis and onchocerciasis, DEC Patch
- Where
- Ghana
- Volunteers
- 3,736 people
- Sponsor
- Noguchi Memorial Institute for Medical Research
Mucocutaneous Leishmaniasis
Dedicated QT Study in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis
This study is a Phase 4, open-label, single group study in which at least 40 adult patients undergoing miltefosine treatment for mucocutaneous leishmaniasis (CL and ML) will be assessed by 12-lead ECG for prolongation of the…
- Trial name
- NCT02429518
- Testing
- Miltefosine
- Where
- Bolivia
- Volunteers
- 42 people
- Sponsor
- Knight Therapeutics (USA) Inc
Old World Cutaneous Leishmaniasis
Randomised Clinical Trial in Treatment Modalities for Cutaneous Leishmaniasis Caused by Leishmania Tropica, in Pakistan
A four (4) -arm randomised control clinical trial to evaluate miltefosine, thermotherapy and the combination miltefosine-thermotherapy are effective, safe and tolerable alternative treatment options to treat cutaneous…
- Trial name
- NCT04268524
- Testing
- drug: miltefosine with thermotherapy
- Where
- 3 sites in Pakistan
- Volunteers
- 645 people
- Sponsor
- Medecins Sans Frontieres, Netherlands
Leishmaniasis, Visceral
Visceral Leishmaniasis in Emilia-Romagna (Leishmania-2019)
According to reports in the literature, from 2012 to date, there has been an increase in the number of diagnosed cases of autochthonous visceral Leishmania in the Province of Bologna.
- Trial name
- NCT06793111
- Where
- 5 sites in Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Onchocerciasis, Epilepsy
Impact of a Bi-annual CDTI on the Incidence of Epilepsy in an Onchocerciasis-endemic Area
Onchocerciasis is a neglected tropical disease associated with epilepsy, particularly in areas of high Onchocerciasis volvulus transmission.
- Trial name
- OAETanzania (NCT05749653)
- Testing
- Bi-annual CDTI
- Where
- Tanzania
- Volunteers
- 6,500 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Loiasis With Positive Blood Microfilaremia, Loiasis
21-day Double-blind Trial of Albendazole in Adults With Loa Loa Microfilaremia
Our aim is to test the hypothesis that a 3-week course of albendazole 400 mg daily is safe and can progressively reduce Loa loa microfilarial densities in subjects with microfilaremia.
- Trial name
- STOP-FiLAR-ALB (NCT06613997)
- Testing
- Albendazole 400mg
- Volunteers
- 100 people
- Sponsor
- Programme National de Lutte contre l'Onchocercose, Republic of the Congo
Pediculosis
Efficacy, Safety and Tolerability of a Novel Malathion Formulation in Patients 2 Years and Older With Head Lice
In this study, Malathion Gel 0.5% will be compared to Nix (permethrin 1%) as a treatment for head lice in patients 2 years of age and older. Malathion Gel 0.5% is a new formulation of an established head lice treatment.
- Trial name
- NCT00963508
- Testing
- Malathion gel 0.5%, Permethrin 1% rinse (Nix Crème)
- Where
- 7 sites in United States
- Volunteers
- 403 people
- Sponsor
- Sun Pharmaceutical Industries, Inc.
Scabies
Comparative Study Between Topical Permethrin 5% and Oral Ivermectin for the Treatment of Scabies
Globally, Scabies infects 300m people each year. In children of developing countries, its prevalence is expected to be about 5 to 10%.In Pakistan, Scabies accounts for 38% of dermatological diseases.
- Trial name
- NCT05362513
- Testing
- Ivermectin Tablets, Permethrin Cream
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Combined Military Hospital Abbottabad
Lice Infestations
Ivermectin in the Treatment of Head Lice
The purpose of this study is to compare 2 single doses of ivermectin as tablets with 2 single applications of malathion 0.5% lotion (Days 1 and 8) in clearing head lice, in patients who have recently used standard head lice…
- Trial name
- NCT00819520
- Testing
- ivermectin, malathion
- Where
- 4 sites in France, Ireland and 2 more
- Volunteers
- 812 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Cutaneous Leishmaniasis, Cutaneous Leishmaniasis, American
Pilot Study: Miltefosine Gel (G-MTF) in Patients With Cutaneous Leishmaniasis
The goal of this clinical trial is to learn if the drug MILTEFOSINE, used topically in a hydrogel, works to treat non-complicated cutaneous leishmaniasis (CL) in adults.
- Conditions
- Cutaneous Leishmaniasis, Cutaneous Leishmaniasis, American, Topical Administration
- Trial name
- G-MTF01 (NCT07149753)
- Testing
- MILTEFOSINE gel
- Where
- Colombia
- Volunteers
- 15 people
- Sponsor
- Universidad Industrial de Santander
Pediculus Humanus Capitis, Head Lice
A Study Evaluating the Safety and Efficacy of BGC20-0582 Lice Treatment Gel for Head Lice Infestation
The main purpose of this study is to investigate the safety and efficacy of an investigational treatment for head lice infestation against a placebo.
- Trial name
- NCT00528021
- Testing
- BGC20-0582
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Boston Scientific Corporation
Leishmaniasis, Leptospirosis
Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-borne Diseases
Zoonoses and arboviroses refer to a group of diseases transmitted from animals to humans, either directly or indirectly (via mosquitoes, ticks or contact with contaminated environments).
- Conditions
- Leishmaniasis, Leptospirosis, Brucellosis, Q Fever
- Trial name
- SEZAM (NCT06859619)
- Testing
- Peripheral venous blood sample
- Where
- France
- Volunteers
- 183 people
- Sponsor
- University Hospital, Montpellier
Cutaneous Manifestations, Skin Manifestations
Cutaneous Manifestations of Coronavirus Disease 2019(COVID-19).
An outbreak of Corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-coV-2) occurred in Wuhan city, Hubei province, China in December 2019.
- Conditions
- Cutaneous Manifestations, Skin Manifestations, COVID-19, COVID-19 Pneumonia
- Trial name
- NCT05094687
- Where
- Pakistan
- Volunteers
- 1,206 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Leishmaniasis, Cutaneous
Investigation of an Outbreak Situation of Cutaneous Leishmaniasis Among Military Personnel in French Guiana (CEFELEISH)
Clinical, epidemiological, therapeutic and microbiological investigation of an outbreak of cutaneous Leishmaniasis that occurred among military personnel in French Guiana in 2020.
- Trial name
- CEFELEISH (NCT04888130)
- Testing
- Phylogenetic Analysis, Data collection
- Where
- French Guiana
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cayenne
Pediculosis
Pharmacokinetic (PK) and Tolerance Study of Natroba Topical Suspension in Pediatrics With an Active Head Lice Infestation
A pharmacokinetic and tolerance study of Natroba (spinosad) Topical Suspension, 0.9% in pediatric subjects 6 months to 4 years of age with an active head lice infestation.
- Trial name
- NCT01660321
- Testing
- spinosad
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- ParaPRO LLC
Leishmaniasis
Safety and Drug Absorption of Orally Administered Oleylphosphocholine (OlPC) in Healthy Adults
The goal of this interventional study is to assess the safety and tolerability of OlPC and to characterize the pharmacokinetics (PK) of OlPC following single, ascending doses administered orally in healthy-fed subjects.
- Trial name
- NCT06124144
- Testing
- Oleylphosphocholine
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Pediculosis
Control of Head Lice Infestations in Children and Adults
The goal of this study is to see if heated air will kill head lice and their eggs. The treatment visit is approximately 1 hour long with a follow up phone call.
- Trial name
- NCT00731718
- Testing
- lousebuster
- Where
- United States
- Volunteers
- 543 people
- Sponsor
- Larada Sciences, Inc.
Scabies
Comparison of the Efficacy and Safety of Ivermectin to Permethrin
Comparison of the efficacy and safety of a single administration of ivermectin to a single administration of permethrin for the treatment of scabies
- Trial name
- NCT00262418
- Testing
- Administration of ivermectin or permethrin
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- University Ghent
Scabies
Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies
To assess the safety and efficacy of Natroba (spinosad) topical suspension versus placebo for the clinical cure of scabies after a single treatment.
- Trial name
- NCT02485717
- Testing
- spinosad topical suspension, 0.9%
- Where
- 5 sites in United States
- Volunteers
- 291 people
- Sponsor
- ParaPRO LLC