Clinical trials: Skin Barrier Function
Atopic Eczema
Softened Water for Eczema Prevention Pilot Trial
An outcome assessor-blinded pilot randomised controlled trial of an ion-exchange water softener for the prevention of atopic eczema in neonates, with an embedded mechanistic study
- Trial name
- SOFTER (NCT03270566)
- Testing
- Domestic ion-exchange water softener
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- King's College London
Inflammation, Skin Inflammation
Skin Barrier Function and Inflammation in Aging: The BIA Study
This is a randomized, investigator-blinded, self-controlled pilot study of the physiologic response to topical moisturizers among older adults with dry skin.
- Conditions
- Inflammation, Skin Inflammation, Aging
- Trial name
- BIA (NCT06750653)
- Testing
- CeraVe Moisturizing Cream, Vaseline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Atopic Dermatitis
Pimecrolimus and Epidermal Barrier Function
This study seeks to investigate the role of pimecrolimus in restoring disturbed skin barrier function and reversing epidermal abnormalities found in atopic dermatitis (AD).
- Trial name
- NCT01132079
- Testing
- cream treatment
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University of Kiel
Contact Dermatitis, Type 1 Diabetes Mellitus
Exploring Skin Barrier Function, Recurrence of Diabetes Device-Related Contact Dermatitis, and Evaluation of Hydrocolloid and Silicone-Based Patches for Its Prevention in Children and Adolescents With Type 1 Diabetes
The goal of this clinical trial is to ensure that contact dermatitis does not prevent any person with diabetes from accessing optimal diabetes treatment.
- Trial name
- StenoAD1 (NCT07767461)
- Testing
- hydrocolloid patch as patch used in the Sandwich method, Silicone-based patch as patch used in the Sandwitch method
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Steno Diabetes Center Copenhagen
Atopic Dermatitis (AD), Psoriasis
A Clinical Evaluation of Marula-Derived Ceramide Cream on Skin Barrier Function Enhancement
Previously, the investigators have demonstrated in vitro the excellent efficacy of marula oil-derived ceramide NPs in enhancing skin barrier function.
- Conditions
- Atopic Dermatitis (AD), Psoriasis, Acne Vulgaris, Contact Dermatitis
- Trial name
- NCT07066150
- Testing
- Apply a cream containing 0.05% marula oil-derived ceramide NPs
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Shanghai Chicmax Cosmetic Co., Ltd.
Atopic Dermatitis Eczema
Effect of Ectoin Dermatitis Cream 7% on Skin Hydration and Skin Barrier Function
The aim of this prospective, uncontrolled clinical study is to evaluate the clinical effect of Ectoin® Dermatitis Cream-EHK02 on skin hydration and transepidermal water loss (TEWL) in subjects with atopic dermatitis after single…
- Trial name
- NCT04097327
- Testing
- Ectoin Dermatitis Cream 7% (EHK02)
- Where
- Germany
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Bitop AG
Pressure Injuries, Skin Failure
Barrier Functions oF Skin in ICU: SKIN-BAR
This study aims to investigate skin barrier function in intensive care unit (ICU) patients using biosensor-based measurements. Biophysical parameters including transepidermal water loss (TEWL), skin pH, stratum corneum hydration…
- Conditions
- Pressure Injuries, Skin Failure, Skin Abnormalities, Biophysical Parameters of Skin
- Trial name
- SKIN-BAR (NCT07560683)
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- Koç University
Healthy Volunteers
Skin Barrier Function in Women Using UV Nail Lamps
The goal of this observational study is to compare objective parameters of skin barrier function between healthy adult women who regularly use UV lamps during nail treatments and women who do not use UV lamps.
- Trial name
- NCT07700186
- Where
- Croatia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Atopic Dermatitis (AD), Non-atopic Healthy Controls
Atopic Dermatitis (AD) and Food Allergy
This is a prospective, single center, clinical mechanistic pilot clinical research study. Participants will not receive any investigational agent.
- Trial name
- NCT03168113
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Atopic Dermatitis
Assessing the Impact of Pioglitazone on Skin Barrier Function in Atopic Dermatitis Patients
Many patients with eczema (atopic dermatitis) have an inherent defect in their skin barrier as demonstrated by high water loss. In laboratory conditions, studies have shown that pioglitazone restores the skin barrier function in…
- Trial name
- NCT01695707
- Testing
- Pioglitazone
- Where
- United States
- Sponsor
- University of Rochester
Non-filarial Elephantiasis
An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis
An RCT (n=193) in two podoconiosis clinics in Ethiopia to evaluate the effectiveness of a research based skin management regimen compared to the current regimen.
- Trial name
- NCT02839772
- Testing
- Current skin care regimen plus 2% glycerine added to soaking water, Current skin care regimen
- Volunteers
- 193 people
- Sponsor
- University of Hull
Skin Barrier to Water Loss, Microbial Colonization
Oral Lactobacillus Reuteri for Skin Barrier Dysfunction in Obesity
This clinical trial aims to evaluate the safety and efficacy of oral Lactobacillus reuteri supplementation for treating obesity-induced skin barrier impairment in individuals aged 18-40 with a BMI ≥30.
- Trial name
- NCT07512050
- Testing
- Oral Lactobacillus reuteri group, Oral administration of inactive Lactobacillus reuteri group
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shenzhen People's Hospital
Skin Barrier Function, Skin Soothing Effect
Mask Instant Clinical Study
The goal of this clinical study is to evaluate the soothing effect of the test product within 2 hours after a single application by measuring changes in multiple indicators before and after product use.
- Trial name
- NCT07896993
- Testing
- Test soothing facial mask
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- ChinaNorm
Skin Aging
Efficacy of a Dietary Supplement on Parameters of Skin Aging in Men and Women
As the body ages, the skin experiences natural changes in structure and composition. These changes may manifest visibly as increased skin dryness, wrinkling, and a loss of firmness/elasticity.
- Trial name
- NCT06083402
- Testing
- HyaCera™
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Natals, Inc. dba Ritual
Atopic Dermatitis (AD)
Effect of Partially Hydrolyzed Formula With Synbiotics on Skin Barrier Function
The main purpose of this study is to assess the efficacy of a partially hydrolyzed formula with synbiotics in halting one of the first steps of the allergic march (atopic dermatitis) in infants at risk of allergy.
- Trial name
- SPHINX (NCT06943469)
- Testing
- Test formula, Control formula
- Where
- 25 sites in Belgium, France and 3 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Healthy
Natreon Healthy Skin Study - PrimaVie Supplement
This study will demonstrate the ability of the oral supplement, PrimaVie® to improve skin microperfusion, hydration, elasticity and barrier function.
- Trial name
- NCT02762032
- Testing
- PrimaVie Herbal Supplement 125, PrimaVie Herbal Supplement 250
- Where
- 3 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Acne Vulgaris
Gene Polymorphisms, Skin Barrier, and Inflammation in Acne
This study investigated the relationship between Matrix Metalloproteinase-2 (MMP-2) and Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) gene polymorphisms and acne pathogenesis.
- Trial name
- NCT07069075
- Testing
- MMP-2 Gene Polymorphism (rs243865) Analysis, TIMP-2 Gene Polymorphism (rs8179090) Analysis
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hong Zhang
Type 1 Diabetes
Investigation of the Skin Barrier in Patients With Type 1 Diabetes
This study is a case-control study comparing the skin barrier between 50 T1D patients with healthy controls in 3 age-strata including both pediatric and adult patients.
- Trial name
- NCT04280315
- Where
- 2 sites in Denmark
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Jannet Svensson
CeraVe Moisturising Lotion
Compare the Skin Barrier Repair Function of Two Ceramide Containing Moisturizers
This study aims to evaluate the improvement of CeraVe moisturising lotion on the cuticle moisture of dry skin and barrier repair function.
- Trial name
- NCT04185025
- Testing
- Ceramides
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Atopic Dermatitis
VANOS Cream and Skin Barrier Function
The purpose of this study is to determine the effect of short-term therapy using "VANOS Cream," a super-potent topical steroid cream on skin barrier function in patients with atopic dermatitis.
- Trial name
- NCT00819507
- Testing
- Fluocinonide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Oregon Health and Science University