Skin AgingNCT06083402
Efficacy of a Dietary Supplement on Parameters of Skin Aging in Men and Women
A study testing HyaCera™ in people with Skin Aging, run by Natals, Inc. dba Ritual at 1 site in United States.
Trial summary
As the body ages, the skin experiences natural changes in structure and composition. These changes may manifest visibly as increased skin dryness, wrinkling, and a loss of firmness/elasticity. Read more about this study
- Who is it for?
- Ages 25 to 70 yearsHealthy volunteers can take part
- Conditions the study is for
- Skin Aging
- What is being tested?
- HyaCera™
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 63 participants
- Where
- 1 siteUnited States
- Study dates
- 12 Jun 2023to 6 Oct 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 25 to 70 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Healthy male and female volunteers, 25 - 70 years old with mild to moderate fine lines and wrinkles
- All ethnicities and skin types
- Willing to maintain current skincare regimen on face, arms, and legs and withhold all facial and body treatments throughout the course of the study
Who cannot join
- Self-reported pregnant or breastfeeding or planning to become pregnant during the course of the study
- Any conditions on the face, arms and legs that would interfere with evaluations
- Under treatment for any known health issues/medical conditions including chronic health conditions and skin diseases/conditions
Trial locations and contacts
1 site in 1 country.
United States1 site
Princeton Consumer Research
Raritan, New Jersey, 08869
About this study
Official title: Evaluating the Efficacy of a Dietary Supplement on Parameters of Skin Aging: a 12-Week, Randomized, Double-Blind, Placebo-Controlled Study
As the body ages, the skin experiences natural changes in structure and composition. These changes may manifest visibly as increased skin dryness, wrinkling, and a loss of firmness/elasticity. In this double-blind, randomized, placebo-controlled trial, the investigators will recruit healthy men and women with mild to moderate signs of skin aging and randomly assign them to either receive a HyaCera™ or placebo for 12 weeks. The investigators will perform a series of objective and subjective measurements to assess changes in skin condition. The investigators hypothesize that consumption of HyaCera™ leads to improvements in the general condition of the skin including skin hydration, crow's feet wrinkling, and other skin aging parameters.
- Conditions
- Skin Aging
- Being tested
- HyaCera™, Placebo
- Keywords
- skin aging, skin wrinkles, skin hydration, skin elasticity, skin firmness, skin smoothness, crow's feet wrinkles, dietary supplement, skin barrier function
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
HyaCera™Dietary supplement
1 Ritual HyaCera capsule once daily
PlaceboDietary supplement
1 placebo capsule once daily
| Study group | Role | What they receive |
|---|---|---|
| Active | Active comparator | Participants receive 1 HyaCera™ capsule orally once daily for 12 weeks Receives: Dietary Supplement: HyaCera™ |
| Placebo | Placebo comparator | Participants receive 1 placebo capsule orally once daily for 12 weeks Receives: Dietary Supplement: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Crow's Feet Wrinkles
Degree of crow's feet wrinkling will be measured via Visioscan®
Measured: at week 0, Week 4, Week 8, and Week 12
Skin Smoothness
Skin smoothness will be measured via Visioscan®
Measured: at week 0, Week 4, Week 8, and Week 12
Skin Hydration
Skin surface hydration will be measured via Corneometer® 825
Measured: at week 0, Week 4, Week 8, and Week 12
Secondary outcomes (3)
Skin Elasticity
Skin elasticity will be measured via Cutometer® MPA 580
Measured: at week 0, Week 4, Week 8, and Week 12
Skin Barrier Function
Skin barrier function (as transepidermal water loss) will be measured via Tewameter®
Measured: at week 0, Week 4, Week 8, and Week 12
Skin Scaliness
Skin scaliness will be measured via Visioscan®
Measured: at week 0, Week 4, Week 8, and Week 12
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Oct 2023
- Study start12 Jun 2023
- Primary completion6 Oct 2023
- Study completion6 Oct 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Skin AgingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Healthy men and women with mild to moderate signs of skin aging will be randomly assigned to either receive a Ritual HyaCera or placebo for 12 weeks
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 63 participants (actual)
Sponsor and investigators
- Lead sponsor
- Natals, Inc. dba Ritual
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06083402
- Sponsor's protocol ID
- HyaCera2023
- Status last verified
- Oct 2023
- First submitted
- 16 Aug 2023
- Last updated
- 16 Oct 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Grier-Welch AM, Vance AY, Alamdari N, Sharafi M. Efficacy of an Oral Skincare Supplement on Skin Aging: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial. Dermatol Ther (Heidelb). 2025 Dec;15(12):3689-3702. doi: 10.1007/s13555-025-01556-2. Epub 2025 Oct 10.
PubMed 41071523
Study at a glance
From the registry record, last updated by the sponsor on 16 Oct 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluating the Efficacy of a Dietary Supplement on Parameters of Skin Aging: a 12-Week, Randomized, Double-Blind, Placebo-Controlled Study
- ClinicalTrials.gov ID
- NCT06083402
- Acronym / sponsor ID
- HyaCera2023
- Conditions
- Skin Aging
- Keywords
- skin aging, skin wrinkles, skin hydration, skin elasticity, skin firmness, skin smoothness, crow's feet wrinkles, dietary supplement
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 63 participants (actual)
- Lead sponsor
- Natals, Inc. dba RitualIndustry (pharma, biotech, devices)
- Study start
- 12 Jun 2023 (actual)
- Primary completion
- 6 Oct 2023 (actual)
- Study completion
- 6 Oct 2023 (actual)
- First posted
- 16 Oct 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
As the body ages, the skin experiences natural changes in structure and composition. These changes may manifest visibly as increased skin dryness, wrinkling, and a loss of firmness/elasticity. In this double-blind, randomized, placebo-controlled trial, the investigators will recruit healthy men and women with mild to moderate signs of skin aging and randomly assign them to either receive a HyaCera™ or placebo for 12 weeks. The investigators will perform a series of objective and subjective measurements to assess changes in skin condition. The investigators hypothesize that consumption of HyaCera™ leads to improvements in the general condition of the skin including skin hydration, crow's feet wrinkling, and other skin aging parameters.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
- Model description
- Healthy men and women with mild to moderate signs of skin aging will be randomly assigned to either receive a Ritual HyaCera or placebo for 12 weeks
| Arm | Type | Receives |
|---|---|---|
| Active | Active comparator | Dietary Supplement: HyaCera™Participants receive 1 HyaCera™ capsule orally once daily for 12 weeks |
| Placebo | Placebo comparator | Dietary Supplement: PlaceboParticipants receive 1 placebo capsule orally once daily for 12 weeks |
Who may qualify
- Ages
- 25 to 70 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Healthy male and female volunteers, 25 - 70 years old with mild to moderate fine lines and wrinkles
- All ethnicities and skin types
- Willing to maintain current skincare regimen on face, arms, and legs and withhold all facial and body treatments throughout the course of the study
Key exclusion criteria (3 listed)
- Self-reported pregnant or breastfeeding or planning to become pregnant during the course of the study
- Any conditions on the face, arms and legs that would interfere with evaluations
- Under treatment for any known health issues/medical conditions including chronic health conditions and skin diseases/conditions
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| HyaCera™1 Ritual HyaCera capsule once daily | Dietary supplement | Active |
| Placebo1 placebo capsule once daily | Dietary supplement | Placebo |
Primary outcome
Crow's Feet Wrinkles
Time frame: at week 0, Week 4, Week 8, and Week 12
Degree of crow's feet wrinkling will be measured via Visioscan®
Skin Smoothness
Time frame: at week 0, Week 4, Week 8, and Week 12
Skin smoothness will be measured via Visioscan®
Skin Hydration
Time frame: at week 0, Week 4, Week 8, and Week 12
Skin surface hydration will be measured via Corneometer® 825
3 secondary outcomes
Skin Elasticity
Time frame: at week 0, Week 4, Week 8, and Week 12
Skin Barrier Function
Time frame: at week 0, Week 4, Week 8, and Week 12
Skin Scaliness
Time frame: at week 0, Week 4, Week 8, and Week 12
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Oct 2023.
- Derived from this study: PubMed 41071523Grier-Welch AM, Vance AY, Alamdari N, Sharafi M. Efficacy of an Oral Skincare Supplement on Skin Aging: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial. Dermatol Ther (Heidelb). 2025 Dec;15(12):3689-3702. doi: 10.1007/s13555-025-01556-2. Epub 2025 Oct 10.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing HyaCera™ in people with Skin Aging, run by Natals, Inc. dba Ritual at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Oct 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Crow's Feet Wrinkles (time frame: at week 0, Week 4, Week 8, and Week 12). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06083402, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Oct 2023.