Clinical trials: Simethicone
Simethicone, Bariatric Surgery
Simethicone as Part of ERAS in Bariatric Surgery Patients
By conducting this study, we hope to assess if simethicone (also known as Gas Relief or GasX) has an effect on improving gas pain and bloating specifically in patients undergoing foregut procedures to include bariatric procedures…
- Conditions
- Simethicone, Bariatric Surgery, Post-operative Pain
- Trial name
- NCT06812832
- Testing
- Simethicone 80 MG
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Madigan Army Medical Center
Lesion of Stomach
Small Volume Simethicone Before Gastroscopy: Any Benefit?
A randomized controlled and endoscopist-blinded study which compares the efficacy of liquid simethicone (100mg) in 5 mls water, versus placebo ( 5mls of water), as premedication (given at least 30 minutes) before gastroscopy…
- Trial name
- NCT02555228
- Testing
- Simethicone, Water
- Where
- Singapore
- Volunteers
- 54 people
- Sponsor
- Changi General Hospital
Video Capsule Endoscopy
Ingestion of Simethicone After Capsule Ingestion and Its Impact on Quality of Video Capsule Endoscopy- a Pilot Study
Wireless video capsule endoscopy (VCE) is a non-invasive technology that looks into small intestine and gives images of its lumen as the wireless capsule passes through it.
- Trial name
- NCT03166605
- Testing
- Simethicone
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Albany Medical College
Gastric Disease
A Study to Evaluate Endoscopic Visibility of Stomach After a Combination Drink of N-acetylcysteine and Simethicone
Endoscopy is the diagnostic modality for most gastroduodenal diseases. During endoscopy mucus and foam may actually interfere with the visibility of the stomach mucosa.
- Trial name
- NCT05801055
- Testing
- Evaluation of gastric visibility following the combination drink of N-acetyle cysteine and simethocone
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Bubbles in Colon at Time of Colonoscopy
The Effects of Moviprep With Simethicone on Colonic Bubbles
The purpose of this study is to determine whether the administration of PEG along with simethicone will reduce the incidence of colonic bubbles that interfere with polyp detection.
- Trial name
- NCT01209806
- Testing
- simethicone
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Thomas Jefferson University
Oral Mucositis
Gelclair at Conditioning or After Oral Mucositis Diagnosed vs. Magic Mouth Wash in Stem Cell Transplant Recipients
Patients receiving high-dose chemotherapy/conditioning prior to stem cell transplantation (SCT) are at high risk for developing painful lesions in the oral cavity, known as oral mucositis (OM).
- Trial name
- NCT03490396
- Testing
- Gelclair, First® Mouthwash BLM
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Midatech Pharma US Inc.
Irritable Bowel Syndrome, Lactose Intolerance
The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION)
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease. There is no well-defined pharmacological treatment. This clinical trial is a prospective, double-blind, two-armed randomized controlled, single-center…
- Conditions
- Irritable Bowel Syndrome, Lactose Intolerance, Lactose Malabsorption
- Trial name
- LION (NCT05100719)
- Testing
- alverine-citrate + simethicone and lactase
- Where
- Hungary
- Volunteers
- 200 people
- Sponsor
- University of Pecs
Colonoscopy
Evaluation of Oral Simethicone With Low Volume Polyethylene Glycol Bowel Preparation During Colonoscopy
An adequate bowel preparation has been well established to lead to a successful colonoscopy. Research has consistently demonstrated inadequate bowel preparation with lower adenoma detection rates.
- Trial name
- NCT03410524
- Testing
- Simethicone Solution, Water
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Nevada, Reno
Otitis Media
Effect of Simethicone on Eustachian Tube Dysfunction
This study is designed to measure the effects of a chewable Simethicone tablet taken by mouth on middle-ear pressure in adults with a common cold and evidence of abnormal middle-ear pressure.
- Trial name
- NCT01312038
- Testing
- Simethicone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Pittsburgh
Colorectal Cancer Early Detection
Efficacy and Tolerability of a Simethicone-containing Evacuating Solution for Colorectal Cancer Screening Colonoscopy
Study to evaluate the efficacy and tolerability of a simethicone-containing evacuating solution for colorectal cancer screening colonoscopy.
- Trial name
- CLEAN+ (NCT07696793)
- Testing
- Clensia®, Citrafleet®
- Where
- Spain
- Volunteers
- 818 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Functional Bowel Disorder
Efficacy and Safety of Mebeverine + Simethicone in Patients With Functional Bowel Disorders
The parallel three-group study of efficacy and safety was planned to investigate the reduction in abdominal pain and bloating during treatment with the fixed-dose combination of Mebeverine + Simethicone versus Duspatalin® and…
- Trial name
- NCT05175131
- Testing
- Mebeverine+Simethicone, Mebeverine, Simethicone
- Where
- Russia
- Volunteers
- 465 people
- Sponsor
- Abbott
Infantile Colic
Effects of Vivatlac Baby on Crying Behavior of Colicky Babies
Open trial with two parallel arms, assessing the effects of Simethicone and Vivatlac Baby in babies diagnosed for infantile colic.
- Trial name
- NCT04487834
- Testing
- Simethicone Solution, Vivatlac Baby
- Where
- 2 sites in Poland
- Volunteers
- 87 people
- Sponsor
- The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz
Colo-rectal Cancer, Colonic Neoplasms
Effect of Adding Simethicone to Split-dose Polyethylene Glycol for Bowel Preparation in a Screening Colonoscopy Setting
Colonoscopy is currently accepted as the gold standard in screening, surveillance and prevention for colorectal cancer (CRC), and therefore, its quality is a major priority.
- Trial name
- NCT03816774
- Testing
- PEG split-dose and simethicone
- Where
- Portugal
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- Portuguese Oncology Institute, Coimbra
Simethicone
Simethicone: Does it Improve Operative Field and Postoperative Pain?
Simethicone is an oral anti-foaming agent that reduces bloating, abdominal discomfort, and abdominal pain by promoting the clearance of excessive gas along the gastrointestinal tract.
- Trial name
- NCT02984176
- Testing
- Simethicone Tab 40 mg
- Volunteers
- 100 people
- Sponsor
- Woman's Health University Hospital, Egypt
Colonoscopy
Evaluation of Two Different Regimens of Colon Preparations for Advanced Cleaning.
Multicenter, prospective, randomized, checked, open label, with blind evaluation, for compare the intestinal cleansing effectiveness of the regimen full-dose delayed (A) of Clensia vs split regimen (B) of Clensia, in patients…
- Trial name
- ERACLES (NCT05570669)
- Testing
- (Macrogol 4000 52,500 g + Sodium sulphate anhydrous 3,750 g + Simethicone 0,080 g) full dose, (Macrogol 4000 52,500 g + Sodium sulphate anhydrous 3,750 g + Simethicone 0,080 g) split dose
- Where
- 10 sites in Italy
- Volunteers
- 321 people
- Sponsor
- Societa Italiana di Endoscopia Digestiva
Diarrhea
Study to Determine the Best Way to Measure How Quickly the Drug Can Give Relief From Sudden Diarrhea
For six hours following drug administration, subjects will rate the severity of specific symptoms. At the end of the six hour study, subjects will rate the overall effectiveness of the product.
- Trial name
- NCT00685607
- Testing
- loperamide-simethicone
- Where
- Mexico
- Volunteers
- 45 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Infant Colic
EFFICACY OF A MIXTURE OF SIMETHICONE AND TYNDALLIZED BACILLUS COAGULANS IN INFANT COLIC: A PILOT STUDY
: A pilot study was conducted on a group of 41 infants with diagnosis of Infant Colic according to Rome IV criteria. We administered to all the enrolled infants a mixture of Tyndallized bacillus coagulans and Simethicone for 28…
- Trial name
- NCT06458881
- Testing
- Mixture of Simethicone and Tyndallized Bacillus Coagulans
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Federico II University
Dyspepsia
Efficacy of Bromopride and Simethicone Versus Bromopride in Functional Dyspepsia
Multi-center, randomized, superiority, double blind clinical trial to asses the efficacy of fixed-dose combination of bromopride and simethicone versus isolated bromopride on research participants diagnosed with functional…
- Trial name
- NCT02604576
- Testing
- FDC Bromopride 10 mg and Simethicone 80 mg, Bromopride 10 mg
- Where
- 10 sites in Brazil
- Volunteers
- 339 people
- Sponsor
- EMS
Colonoscopy Preparation
4-L Split-dose Polyethylene Glycol and Bisacodyl and Docusate Sodium Regimen Versus 2-L Split-dose Polyethylene Glycol Plus Oral Simethicone Regimen for Bowel Preparation Before Colonoscopy
The goal of this randomized controlled trial is to compare the safety, compliance, and efficacy of different bowel preparation methods prior to colonoscopy.
- Trial name
- NCT07328880
- Testing
- 4-L split-dose polyethylene glycol and Bisacodyl + Docusate sodium., 2-L split-dose polyethylene glycol plus Oral Simethicone regimen ., 2-L split-dose polyethylene glycol regimen
- Where
- Egypt
- Volunteers
- 450 people
- Sponsor
- Tanta University
Postoperative Ileus, Ileus
Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery
Post-operative ileus is a common complication following abdominal surgery. It results in abdominal distension, nausea and vomiting as well as abdominal pain.
- Trial name
- NCT02161367
- Testing
- Simethicone, Oral Suspending Vehicle
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University