Clinical trials: Sex Differences
Alcohol-Related Disorders, Substance-Related Disorders
The Women's Recovery Group Study: Stage I Trial
The purpose of this study was to develop a gender-specific 12-session, manual-based relapse prevention group for women with substance use disorders (SUDs).
- Trial name
- NCT00230100
- Testing
- The Women's Recovery Group, mixed-gender Group Drug Counseling
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Mclean Hospital
Sex Differences
Sex Differences in the Dilatory Response of Compound 21
When blood pressure changes, Angiotensin II is produced and released into the bloodstream. This substance can make blood vessels smaller (i.e., vasoconstriction) by acting through Angiotensin II type I receptors (AT1R) to…
- Trial name
- NCT05576155
- Testing
- Compound 21, Compound 21 + losartan
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Major Depressive Disorder
Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression
This study will identify the sex-dependent impact of expiratory-gated transcutaneous vagus nerve stimulation (tVNS) on the modulation of the stress response circuitry and associated physiology in major depressive disorder (MDD).
- Trial name
- tVNS_MDD_Sex (NCT04448327)
- Testing
- active tVNS
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Cerebrovascular Disorders
HYPEROXIA Responses and ROS
30 participants (15 males and 15 females) who are ≥18 - ≤ 40 years old and considered healthy will be enrolled into this study to test the role of reactive oxygen species (ROS) in regulating cerebral blood flow (CBF).
- Trial name
- NCT05958303
- Testing
- Antioxidant Cocktail
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Marijuana Dependence
Hormones and Reduction in Co-users of Marijuana and Nicotine
The purpose of this study is to examine the role of progesterone (a naturally occurring hormone found in both men and women) on reducing marijuana use.
- Trial name
- NCT02579421
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cigarette Smoking-Related Carcinoma
Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes
This early phase I trial studies potential differences between men and women when switching from the use of combustible cigarettes to the National Institute on Drug Abuse's Standard Research E-Cigarette (SREC).
- Trial name
- NCT03856515
- Testing
- Nicotine Replacement, Questionnaire Administration, Electronic Cigarette
- Where
- United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Alcohol Abuse
Sex Differences in Risk for Alcohol Abuse
This study will determine the neural and hormonal mechanisms underlying sex differences in sensitivity to the disinhibiting effects of alcohol in heavy drinkers.
- Trial name
- NCT04543942
- Testing
- Alcohol, Saline
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mark Fillmore
Tobacco Cessation
Sex Differences, Hormones & Smoking Cessation
Data suggest that progesterone may improve smoking cessation outcomes perhaps by reducing impulsive behavior. However, the clinical literature on this topic is lacking.
- Trial name
- NCT01744574
- Testing
- Progesterone, Smoking Cessation Behavioral Counseling
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- University of Minnesota
Sex, Cigarette Smoking
Mapping Brain Glutamate in Humans: Sex Differences in Cigarette Smokers
The proposed study evaluated sex differences in glutamate (Glu), with a focus on the dorsal anterior cingulate cortex (dACC), anterior insula, and thalamus, as well as how it is influenced by sex (males vs.
- Trial name
- NCT05279053
- Testing
- Abstinence and Smoking
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
PTSD
Sex/Gender Differences in Risk and Resilience to PTSD; Implication of Oxytocin
The purpose of the study is to use fMRI to investigate amygdala response to fearful faces in men and women with and without PTSD who have experienced childhood trauma.
- Trial name
- NCT01963078
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Megan Moran-Santa Maria
Aging
Sex Differences in Vascular Responses to Exercise
A key early event in cardiovascular disease development is endothelial dysfunction, characterized by impaired flow-mediated dilation.
- Trial name
- NCT04128215
- Testing
- Control Period, Exercise Period
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Florida
Myocardial Infarction
Mental Stress and Myocardial Ischemia After MI: Sex Differences, Mechanisms and Prognosis
The purpose of this study is to look at the link between emotional stress and heart disease in men and women. Taking part in this study involves one clinic visit, one week of at home monitoring, and follow up phone calls every 6…
- Trial name
- MIMS3 (NCT04123197)
- Testing
- Stress Challenge
- Where
- 3 sites in United States
- Volunteers
- 306 people
- Sponsor
- Emory University
HIV Infections
Kaletra Sex/Gender Pharmacokinetics (PK) Study
The levels of lopinavir achieved in the blood following oral ingestion of standard doses of Kaletra (lopinavir/ritonavir) in HIV-infected men was compared with those achieved in HIV-infected women receiving the same dose of the…
- Trial name
- LPVGenderPK (NCT00148759)
- Testing
- LPV/r
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Emory University
Nicotine Dependence
Gender Differences in Response to Nicotine Replacement Therapy and De-Nicotinized Cigarettes
This study will investigate the underlying neurobiology of differences between male and female smokers. Research suggests that women are less responsive to nicotine replacement therapy (NRT) than men and more responsive to the…
- Trial name
- BIRCWH (NCT00960778)
- Testing
- nicotine patch (Nicoderm Committed Quitter (CQ), Habitrol), denicotinized cigarettes (Quest 3 cigarettes)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Medical University of South Carolina
Cannabis Use
Stress-Reactivity and Cannabis Use in Cannabis-Using Older Adults
The goal of the study is to evaluate how cannabis use affects memory and thinking skills and response to stress in older adults.
- Trial name
- PUMA (NCT05072795)
- Testing
- Trier Social Stress Task (TSST)
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder
Sex Differences, Cognitive Training & Emotion Processing
This pilot project addresses two understudied questions related to neurocognitive deficits observed in treatment-seeking alcoholics.
- Trial name
- NCT03137654
- Testing
- Affective Training, Neutral Training
- Where
- 5 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Florida
Healthy
Gender Difference in Response to Caffeine in Children and Adolescents
Caffeine use is on the rise in America, and one of the most popular sources is soda. Among youth ages 8-16, caffeine consumption has increased by over 70% in the past 30 years.
- Trial name
- NCT02119416
- Testing
- Low Caffeine Administration first (1mg/kg body weight), High Caffeine Administration first (2mg/kg body weight)
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Nicotine Addiction, E-Cig Use
Sex Differences in E-cig Perception: Study 1
The primary objective is to examine the influence of sex on sensory effects, appeal, and reinforcing value of nicotine containing e-cigs in popular flavor components; sweet and cooling.
- Conditions
- Nicotine Addiction, E-Cig Use, Cigarette Smoking, Sex Differences
- Trial name
- NCT05432830
- Testing
- E-liquid Flavor 1, E-liquid Flavor 2, E-liquid Flavor 3
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Yale University
Cerebrovascular Disorders
Brain Blood Flow Responses to Stress: Sex Differences
Twenty-six otherwise healthy adults between 18-40 years of age composed of 13 males and 13 females will be enrolled in this study to determine how sex and sex hormones influence cerebral blood flow (CBF) control in healthy young…
- Trial name
- NCT06253702
- Testing
- Indomethacin, Orilissa, Testosterone gel
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Substance-Related Disorders, Alcohol-Related Disorders
Women's Recovery Group (WRG) Study - A Randomized Controlled Stage II Trial
The purpose of this Stage II randomized controlled behavioral treatment development trial was to test the effectiveness of the Women's Recovery Group (WRG) relative to mixed-gender Group Drug Counseling (GDC) and demonstrate the…
- Trial name
- NCT01318538
- Testing
- The Women's Recovery Group, Group Drug Counseling
- Where
- 2 sites in United States
- Volunteers
- 158 people
- Sponsor
- Mclean Hospital