Clinical trials: Sex Differences
Gender Role Disorder, Male to Female Type
Gender-specific aEEGs and Outcome in Preterms
Background and objectives: Male sex is a risk factor for poor neurodevelopmental outcome following preterm birth. The investigators aimed to investigate gender-related differences in amplitude-integrated electroencephalography…
- Trial name
- NCT01562236
- Where
- Austria
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Knee Osteoarthritis
Muscle Activation in Knee Osteoarthritis
Muscle activity, as a possible fundamental cause of functional limitation, has been extensively investigated in knee osteoarthritis (KOA).
- Trial name
- NCT05870033
- Testing
- Electromyography (EMG) measurement
- Where
- Hungary
- Volunteers
- 70 people
- Sponsor
- University of Pecs
Pediatric Brain Tumor
Therapeutic Targeting of Sex Differences in Pediatric Brain Tumor Glycolysis
The investigators will develop the concept of a sex-specific therapeutic intervention for gliomas that is based upon dietary carbohydrate restriction.
- Trial name
- NCT03591861
- Testing
- Ketogenic diet, BCNU
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Washington University School of Medicine
Heart Failure, Heart Failure With Reduced Ejection Fraction
Gender-based Differences in the Outcome of Treatment With Aldosterone Antagonists in Patients With Heart Failure
Heart failure (HF) is a major healthcare problem. In patients with Heart Failure with Reduced Ejection Fraction (HFrEF), aldosterone antagonists reduce mortality and hospitalization rate.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure NYHA Class II, Heart Failure NYHA Class III
- Trial name
- GBDAL-HF (NCT06233695)
- Testing
- Potassium sparing diuretic
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Alcohol-Related Disorders, Substance-Related Disorders
The Women's Recovery Group Study: Stage I Trial
The purpose of this study was to develop a gender-specific 12-session, manual-based relapse prevention group for women with substance use disorders (SUDs).
- Trial name
- NCT00230100
- Testing
- The Women's Recovery Group, mixed-gender Group Drug Counseling
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Mclean Hospital
Sex Differences
Sex Differences in the Dilatory Response of Compound 21
When blood pressure changes, Angiotensin II is produced and released into the bloodstream. This substance can make blood vessels smaller (i.e., vasoconstriction) by acting through Angiotensin II type I receptors (AT1R) to…
- Trial name
- NCT05576155
- Testing
- Compound 21, Compound 21 + losartan
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Major Depressive Disorder
Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression
This study will identify the sex-dependent impact of expiratory-gated transcutaneous vagus nerve stimulation (tVNS) on the modulation of the stress response circuitry and associated physiology in major depressive disorder (MDD).
- Trial name
- tVNS_MDD_Sex (NCT04448327)
- Testing
- active tVNS
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Alcohol Use Disorder
Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
The goal of this clinical trial is to identify sex-specific biomarkers that confer greater susceptibility for Alcohol Use Disorder (AUD) and differentiate how treatment response varies by sex in people with Alcohol Use Disorder.
- Trial name
- ABSTAIN (NCT06426303)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Milky Kohno
Vasodilation, Hypoxia
Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia
The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.
- Trial name
- NCT05256069
- Testing
- Propranolol Pill
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Left Sided Heart Failure
Effect of Left Ventricle Diastolic Dysfunction on Outcomes in Female Cardiac Surgery Patients
The aim of this study is to evaluate the differences between males and females with LVDD, undergoing cardiac surgery. The investigators will look at perioperative factors such as body weight, body surface area, previous medical…
- Trial name
- EDISON (NCT05972356)
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Social Cognition, Healthy Aging
Immersive Group Dance in Virtual Reality and Perceived Social Cohesion in Older Adults
This is a two-arm, parallel-group randomized controlled trial designed to evaluate the effects of an immersive virtual reality (VR)-based group dance program on perceived social cohesion among community-dwelling older adults…
- Conditions
- Social Cognition, Healthy Aging, Loneliness, Social Isolation
- Trial name
- VR-GD-COHESION (NCT07850479)
- Testing
- Immersive VR Group Dance Program, Conventional Light Physical Activity Program
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Colorectal Cancer, Colorectal Adenoma
Comparison of Expression of Carcinogenesis-related Molecular Markers in the Patients With Colon Cancer and Polyp
A study of carcinogenesis-related molecular markers in the patients with colorectal cancer and colorectal adenoma.
- Trial name
- NCT05638542
- Where
- South Korea
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Thrombosis, Exercise Training
The Effect of Team Sports on the Risk of Thrombosis in Elderly Individuals in a Municipality Setting (TEAM-AGE)
Cardiovascular disease, and especially myocardial infarction, is the most common cause of death globally, and is particularly common in older individuals.
- Conditions
- Thrombosis, Exercise Training, Sex Differences
- Trial name
- TEAM-AGE (NCT04611191)
- Testing
- Team Sports, Control
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Sexual Dimorphism, Cone-beam Computed Tomography
Sexual Dimorphism of Sphenoid and Maxillary Air Sinuses Via 3D Volumetric Segmentation of CBCT
Sexual dimorphism from skeletal remains a crucial step towards biological profile reconstruction since these are some of the last structures to remain after death.
- Conditions
- Sexual Dimorphism, Cone-beam Computed Tomography, Maxillary Sinus, Sphenoid Sinus
- Trial name
- NCT05907083
- Testing
- cone beam computer tomography
- Volunteers
- 204 people
- Sponsor
- Cairo University
Gender, Early Adolescent Behavior
Gender Differences of Neuroanatomical and Neurophysiological Correlates of Risk-proneness in Early Adolescents
Risk-taking in early adolescence have has been found to be normative and even formative as it might fulfill the youth's needs to experiment different sensations, make independent decisions and learn from their consequences.
- Trial name
- NCT03534375
- Testing
- The study is an observational cross sectional study
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Heart Failure With Preserved Ejection Fraction, Diastolic Dysfunction
Sex Related Differences in Cardiac Function
The aim of the study is to investigate sex-specific differences in LV and RV function (systolic and diastolic) with regarding the development and progression of heart failure with preserved ejection fraction based on a…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Diastolic Dysfunction, Systolic Dysfunction
- Trial name
- NCT05796050
- Where
- Germany
- Volunteers
- 6,000 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Disorders of Sex Development, Hypospadias
Genetics of Differences of Sex Development and Hypospadias
This study seeks to identify genetic causes of conditions that affect the gonads and genitals, and to study the impact on families of receiving genetic results.
- Trial name
- NCT03102554
- Testing
- Return of Genetic Results
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Boston Children's Hospital
Cardiovascular Diseases, Heart Diseases
Gender Differences in Familial Risk
To develop, test, and apply comprehensive mathematical models for the interaction of genetic and environmental effect on cardiovascular risk with gender differences.
- Trial name
- NCT00005355
- Sponsor
- Virginia Commonwealth University
Functional Gastrointestinal Disorders, Overlap Syndromes
Overlap FGIDs and Genetic Polymorphism
1. To analyze the prevalence of overlap syndromes among NERD or RH, FD, and IBS patients, and to identify and to compare the differences in their characteristics and symptoms, and to determine their risk factors. 2.
- Trial name
- NCT04712617
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Asthma (Diagnosis)
Changing Lifestyle to Improve Quality of Life in Spanish Adolescents With Asthma
The goal of this clinical trial is to evaluate if a multicomponent lifestyle intervention can improve health-related quality of life in adolescents with asthma.
- Trial name
- CLiQ-Asthma (NCT07870980)
- Testing
- Lifestyle-change intervention
- Volunteers
- 96 people
- Sponsor
- Universitat Internacional de Catalunya