Clinical trials: Severe Mental Illness
Severe Mental Illness
Supporting Older Adults Remotely
The Supporting Older Adults Remotely (SOAR) study is a randomized controlled trial evaluating a 12-week, telephone-delivered peer support intervention for adults age 50 and older with serious mental illness who live in supportive…
- Trial name
- SOAR (NCT07878169)
- Testing
- Supporting Older Adults Remotely (SOAR), Peer support as usual
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Severe Mental Illness, Hospitalizations Psychiatric
Community-Based Intensive Treatment (CBIT): Meeting the Complex Needs of Rural Adults With Serious Mental Illness
The purpose for this research project is to successfully achieve the primary systems intervention outcome, maintaining fidelity to the intervention model and time to rehospitalization.
- Conditions
- Severe Mental Illness, Hospitalizations Psychiatric, Rural Healthcare-seeking Behaviour, Rural Health
- Trial name
- CBIT (NCT07887113)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Schizophenia Disorder, Severe Mental Illness
Effect of Occupational Therapy on Psychosocial Parameters and Functioning in Individuals With Severe Mental Illness
Severe mental illness (SMI), including schizophrenia spectrum disorders and bipolar disorder, is associated with significant impairments in psychosocial functioning, daily life participation, self-efficacy, and social…
- Conditions
- Schizophenia Disorder, Severe Mental Illness, Bipolar Disorder, Nonorganic Psychosis
- Trial name
- OT-SMI (NCT07879118)
- Testing
- Occupational Therapy Group Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Biruni University
Severe Mental Illness, Bipolar Disorder
A Mobile App to Support Mood, Daily Routines and Medication Adherence in Adults With Severe Mental Illness
The goal of this clinical trial is to learn whether MoodSync, a mobile application for patients and their family caregivers, improves mood stability, medication adherence, daily functioning and early detection of relapse warning…
- Conditions
- Severe Mental Illness, Bipolar Disorder, Schizophrenia, Schizoaffective Disorder
- Trial name
- MoodSync (NCT07879131)
- Testing
- MoodSync, Standard care
- Where
- Bahrain
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Severe Mental Illness
Use of AI Chatbots for Mental Health
The goal of this observational study is to learn how patients with mental disorders use, perceive, and evaluate generative artificial intelligence (AI) chatbots for mental health-related purposes.
- Trial name
- NUKI-PSY (NCT07658547)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Medizinische Hochschule Brandenburg Theodor Fontane
Severe Mental Illness
Ultra-Processed Foods, DASH Diet, and Well-Being in Severe Mental Illness
This study aimed to investigate the associations of ultra-processed food (UPF) consumption and DASH diet adherence with psychological well-being, emotional eating, and inflammatory markers in individuals with severe mental…
- Trial name
- NCT07844837
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Abant Izzet Baysal University
Severe Mental Illness
Care Coordination and Passive Mobile Data Monitoring to Improve Mental Health Care
Providing care to individuals with serious mental illness can be challenging, requiring ongoing monitoring, treatment adjustments, and coordination of various medical and social services.
- Trial name
- CCM (NCT07549178)
- Testing
- Care Coordination Mobile
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- VA Office of Research and Development
Severe Mental Illness, Health Professionals
The Design and Evaluation of a Digital Physical Activity Intervention for Individuals With Severe Mental Illness in an Irish Mental Health Residential Setting
The goal of this clinical trial is to collaboratively develop and evaluate Active Ease, a co-designed, web-based digital physical activity application, to promote and maintain physical activity levels among individuals with…
- Trial name
- NCT07746609
- Testing
- Active Ease Digital Physical Activity Intervention
- Where
- Ireland
- Volunteers
- 18 people
- Sponsor
- Munster Technological University
Severe Mental Illness, Severe Mental Disorder
Outcome of Patients With Severe Mental Illness in the Intensive Care Unit
Severe mental illnesses (SMIs), such as major depression, schizophrenia, and bipolar disorder, carry a significant prevalence among patients admitted to the intensive care unit (ICU), estimated at an average of 19%.
- Trial name
- REPSYRE (NCT07705802)
- Testing
- Observational follow-up
- Where
- 30 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Severe Mental Illness
Cognitive Remediation and Transcranial Direct Current Stimulation in Severe Mental Illness (SMI)
Seven per cent of patients suffering from severe mental illness (SMI) need long-term intensive treatment and support in a clinical setting or sheltered living.
- Trial name
- HEADDSET+ (NCT06378463)
- Testing
- Cognitive remediation + active tDCS
- Where
- 3 sites in Netherlands
- Volunteers
- 126 people
- Sponsor
- University of Groningen
Severe Mental Illness, Substance Use Disorder (SUD)
A Study to Investigate Health Related Quality of Life With a Pharmacist Intervention Compared to Treatment as Usual in Participants With Severe Mental Illness and Substance Use Disorder Receiving Treatment From FACT Teams.
The study aims to evaluate the impact of integrating a clinical pharmacist into Flexible Assertive Community (FACT) teams on health-related quality of life and pharmacotherapy for individuals with severe mental illness and…
- Trial name
- pharmaFACT (NCT07597863)
- Testing
- Clinical Pharmacist Intervention
- Where
- Norway
- Volunteers
- 160 people
- Sponsor
- Sykehuset Innlandet HF
Severe Mental Illness, Depression / Major Depressive Disorder
Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN)
This randomized, rater-blind, multicenter clinical trial will evaluate whether a personalized pharmaco-lifestyle intervention improves mental functioning in adults with severe mental illness, including schizophrenia, bipolar…
- Conditions
- Severe Mental Illness, Depression / Major Depressive Disorder, Bipolar Disorder (BD), Schizophrenia
- Trial name
- LIFETRAIN (NCT07586150)
- Testing
- Semaglutide (SEMA), Exercise module, Anti-inflammatory diet module
- Where
- 5 sites in Austria, Germany and 1 more
- Volunteers
- 140 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Severe Mental Illness, Schizophrenia Spectrum &Amp; Other Psychotic Disorders
Validation and Impact of Cardiorespiratory Fitness in Severe Mental Illness - the Heart in Mind Project
This project aims to evaluate feasibility, validity and clinically applicability to systematically measure fitness in patients with severe mental illness. The research project is a validation study using a cross-sectional design.
- Conditions
- Severe Mental Illness, Schizophrenia Spectrum &Amp; Other Psychotic Disorders, Bipolar Affective Disorder
- Trial name
- NCT06743711
- Where
- Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Bjorn H. Ebdrup
Psychotic Disorders, Schizophrenia Spectrum Disorders (SSD)
Multimodal Physical Exercise Program (Physical Exercise for Psychosis) for People With Psychosis Treated With Long-Acting Injectable Antipsychotics
People with psychotic disorders, such as schizophrenia, often experience significant difficulties in daily functioning, physical health, and quality of life.
- Conditions
- Psychotic Disorders, Schizophrenia Spectrum Disorders (SSD), Severe Mental Illness
- Trial name
- PEP (NCT07360665)
- Testing
- Physical Exercise
- Where
- Portugal
- Volunteers
- 44 people
- Sponsor
- University of Trás-os-Montes and Alto Douro
Severe Mental Disorder, Severe Mental Illness
Musical Intervention for the Management of Anxiety and Stress in People With Severe Mental Disorder in a Medium-stay Unit.
The aim of this study is to analyze the influence of music therapy on perceived anxiety and stress, as well as its effect on the recovery process in individuals with Severe Mental Disorder who are admitted to a Regional…
- Trial name
- NCT07470346
- Testing
- Combined music therapy intervention (active and receptive)
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Alejando Vargas Rubio
Patients With Severe Mental Illness
Cognitive Impairment Characteristics and Biological Mechanisms in Untreated Severe Mental Illness
Patients with Severe Mental Illness (SMI) frequently exhibit cognitive impairment of varying degrees, involving multiple cognitive domains.
- Trial name
- NCT07448675
- Where
- China
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Tianjin Anding Hospital
Severe and Persistent Mental Illness
Evaluating the Feasibility, Acceptability, and Initial Clinical Effectiveness of Implementing a Cognitive Remediation Program Within Psychiatric Services.
Severe and persistent mental health disorders are associated with impairments in cognitive, emotional, and social functioning. Some of these disorders involve cognitive challenges that are likely to negatively affect quality of…
- Trial name
- NCT07446140
- Testing
- Cognitive remediation
- Volunteers
- 87 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Severe Mental Disorder, Severe Mental Illness
"Pilot Study of Music Intervention for Recovery of People With Severe Mental Disorder in the Community"
The aim of this study was to analyze the effect of music therapy on hope, quality of life, and social functioning in individuals with Severe Mental Disorder in the community.
- Trial name
- NCT07379996
- Testing
- Passive music therapy in an individual format
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Alejando Vargas Rubio
Severe Mental Illness, Schizophrenia
Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness
This study evaluates a group-based intervention designed to improve romantic and social relationship skills in adults living with a severe mental illness (SMI), such as schizophrenia, bipolar disorder, or major depressive…
- Conditions
- Severe Mental Illness, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- A2C'estMieuxVE (NCT07316803)
- Testing
- À deux, c'est mieux (Better Together) Group Intervention
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre hospitalier de Ville-Evrard, France
Severe Mental Disorder, Severe Mental Illness
Real-time Experiences, Physical Activity and Biological Outcomes in Personal Recovery Residents (EMPOWER-RES)
The project focuses on patients with severe mental disorders (SMD) residing in Italian mental health supported accommodation (SA).
- Trial name
- EMPOWER-RES (NCT06914622)
- Testing
- Mental Health Recovery Star (MHRS)
- Where
- 3 sites in Italy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli