Clinical trials: Serotonin Transporter
Healthy
Effects of SERT Inhibition on the Subjective Response to Psilocybin in Healthy Subjects
Psilocybin is a classic serotonergic hallucinogen acting on the 5-HT2A receptor. It is used recreationally and in psychiatric research.
- Trial name
- NCT03912974
- Testing
- Escitalopram
- Where
- Switzerland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Premature Ejaculation
Therapeutic Outcomes of Selective Serotonin Reuptake Inhibitors and Phosphodiesterase-5 Inhibitors Combination Therapy Versus Monotherapy
Premature ejaculation (PE) is a prevalent male sexual dysfunction that affects as many as 20-30% of men regardless of age and ethnicity.The International Society for Sexual Medicine defines premature ejaculation as a male sexual…
- Trial name
- NCT07057011
- Testing
- Paroxetine 20 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- South Valley University
Healthy, Serotonin Transporter
Brain Imaging of Serotonin Transporters in the Brain
Serotonin is a chemical involved in the regulation of emotions, anxiety, sleep, stress, and other body functions. The purpose of this study is to use brain imaging technology to study how serotonin works in the brain.
- Trial name
- NCT00059046
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder and Anxiety Disorders
First Study in Humans With GSK424887
This is the first study in Humans with GSK424887 to evaluate what effects, good or bad, the drug has on human health (safety and tolerability) and the amount of drug which gets into the bloodstream and is eliminated from the body…
- Trial name
- NCT01059591
- Testing
- GSK424887, PET
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Major Depressive Disorder
A Study to Assess Serotonin Transporter Occupancy of Healthy Adults Using 11C-DASB PET
This study was a non-randomized, open-label clinical study to assess Serotonin transporter occupancy in the brain of healthy adults using 11C-DASB positron emission tomography (PET)
- Trial name
- NCT06476509
- Testing
- LV232 40mg, Escitalopram 20 mg, LV232 60mg
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Depression, Traumatic Brain Injury
Depression and Traumatic Brain Injury
Problem: Depressive symptoms are a common mental health problem following traumatic brain injury (TBI), occurring in up to 87% of patients.
- Trial name
- NCT00254007
- Testing
- citalopram (celexa)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Depressive Disorder and Anxiety Disorders
First Study in Humans With GSK206136
This is the first study in humans with GSK206136 to evaluate what effects: good or bad, the drug has on human health (safety and tolerability) and the amount of drug which gets into the bloodstream and is eliminated from the body…
- Trial name
- NSB101909 (NCT01059578)
- Testing
- GSK206136, PET
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Transsexualism
Sex Steroids and the Serotonin Transporter
The aim of this study is to prove the influence of the sex steroid hormones estrogen, progesterone and testosterone on the serotonin transporter (5-HTT) binding using positron emission tomography (PET) and the selective…
- Trial name
- NCT01065220
- Testing
- Testolactone undecanoate, Lynestrenol, Cyproterone Acetate
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Medical University of Vienna
Depression
Clinical Pharmacogenomics of Antidepressant Response
The purpose of this study is to understand how genetic polymorphisms influence the efficacy and side effect profiles of Paroxetine and Escitalopram for major depression treatment.
- Trial name
- NCT00384020
- Testing
- Paroxetine (Seroxat), Escitalopram (Lexapro)
- Where
- 4 sites in Taiwan
- Volunteers
- 402 people
- Sponsor
- National Health Research Institutes, Taiwan
Major Depressive Disorder
Pilot Study of Duloxetine in Psychological Resilience
The purpose of this study is to explore benefits of duloxetine in enhancing psychological resilience and to understand the relevance of inhibiting of both serotonin (5HT) and norepinephrine (NE)to therapeutic responses.
- Trial name
- NCT00331799
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Obsessive-Compulsive Disorder
Serotonin Transporters in Obsessive-Compulsive-Related Disorders
This study will compare serotonin transporters in patients with obsessive-compulsive disorder (OCD) and healthy volunteers in order to better understand the role of serotonin in OCD.
- Trial name
- NCT00082550
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) Activity: Serotonin Transporter (SERT), Cytokines and Depression (CASCADE Study)
The goal of the study is to look at how genes and certain chemicals in the body are related to depression and chronic obstructive pulmonary disease.
- Trial name
- CASCADE (NCT01074515)
- Where
- 4 sites in United States
- Volunteers
- 350 people
- Sponsor
- University of Washington
Obesity, Diabetes Mellitus Type 2
Diet, Insulin Sensitivity And the Brain
Obesity and insulin resistance may be in part explained by an altered reward system with changes in the serotonin/dopamine system.
- Trial name
- DISAB (NCT01297738)
- Testing
- Meal size increase with HFHS, Meal size increase with HS, Meal frequency increase with HFHS
- Where
- Netherlands
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hot Flashes
Study of PET Scans and Serotonin in Hot Flashes Treatment
The purpose of this study is to determine in a preliminary manner whether successful therapy of hot flashes can be associated with changes in the serotonin transporter in the brain.
- Trial name
- NCT00249847
- Testing
- Paroxetine controlled-release, Conjugated equine estrogen
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Alcoholism
Serotonin Transporters in Alcoholism
This study will compare serotonin transporter proteins in people with alcoholism and healthy volunteers to examine how these proteins may be related to the inability of people with alcoholism to appropriately regulate their…
- Trial name
- NCT00085865
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder, Bipolar Depression
PET and MRI Brain Imaging of Bipolar Disorder
The primary aims of this study are to: 1. Quantify serotonin transporter (5-HTT) binding potential (BP) in vivo in bipolar disorder patients (BPD) during a major depressive episode (MDE). 2.
- Conditions
- Bipolar Disorder, Bipolar Depression, Unipolar Depression
- Trial name
- NCT01880957
- Testing
- Lithium, Lamotrigine
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Treatment Resistant Depression
Antidepressant Discontinuation in Treatment Resistant Depression
The purpose of this study is to compare the effects on depressive symptoms of subjects who discontinue serotonergic antidepressants (a certain type of antidepressant, such as Prozac, that works on serotonin receptors in the…
- Trial name
- NCT03786614
- Testing
- Discontinuation of serotonergic antidepressants, Continuation of serotonergic medications
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Louisville
Depression
Childhood Adversity, Genetic Polymorphisms and Stress in First Onset Major Depression
The Blue Sky Project, a 5-year study funded by the Canadian Institutes of Health Research, seeks to examine how genetics and early life experiences work together to cause a person's very first onset of depression by increasing…
- Trial name
- NCT00517764
- Testing
- escitalopram
- Where
- 2 sites in Canada
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Melancholia
Serotonin Transporter Density in Late-life Depression With and Without Dementia
This study will recruit a total of 40 evaluable subjects (20 cognitively depressive, and 20 AD depressive); each evaluable subject involved in this study must fulfill all the inclusion and exclusion criteria according the subject…
- Trial name
- NCT01548937
- Testing
- I-123 ADAM
- Volunteers
- 39 people
- Sponsor
- Chang Gung Memorial Hospital
Depression
Beta-CIT-SPECT and Neurophysiology in Depression
Aim of this project is to investigate the effects of escitalopram on monoamine transporter (SERT, DAT) availabilities as assessed by b-CIT and SPECT, and on neurophysiological parameters such as the loudness dependence of…
- Trial name
- NCT00145132
- Testing
- β-CIT-SPECT, Neurophysiology
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Ludwig-Maximilians - University of Munich