Clinical trials: Seriously Ill Patients
Seriously Ill Hospitalized Patients
Comparing Optimized Models of Primary And Specialist Services for Palliative Care: Pilot Feasibility Trial
Palliative care (PC) seeks to reduce suffering and improve quality of life for patients with serious illnesses and their families.
- Trial name
- NCT06629142
- Testing
- Default Order, Accountable Justification, Standardized Usual Care
- Where
- 2 sites in United States
- Volunteers
- 1,208 people
- Sponsor
- University of Pennsylvania
Clinical Decision-Making
Mixed Methods Study Web-based Life Support Decision Aid
Patients and families want to be involved in healthcare decisions. When the decision-making process does not engage older patients and their families, the care provided does not match patient preferences or meet their needs.
- Trial name
- eLSDA (NCT03271658)
- Testing
- Web based life support patient decision aid, Decision coaching
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Palliative Medicine
The Role of the Pharmacist and Pharmacogenomics in the Care of Seriously Ill Patients
Researchers are trying to learn more about how pharmacists and pharmacogenomic testing can help care providers improve control of symptoms and quality of life in seriously ill patients.
- Trial name
- NCT04251520
- Testing
- Pharmacogenomics testing, Pharmacist review
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Seriously Ill Patients, Cancer
Goals of Care Conversations Study
The long term goal is to improve quality of care in Veterans with serious illnesses by aligning medical care with Veterans' goals and values.
- Conditions
- Seriously Ill Patients, Cancer, Heart Failure, Interstitial Lung Disease
- Trial name
- LSTDI (NCT05001009)
- Testing
- Clinician Implementation Strategy Stage 1: low intensity clinician training, Clinician Implementation Strategy Stage 2: high intensity clinician training, Low patient engagement
- Where
- 3 sites in United States
- Volunteers
- 2,859 people
- Sponsor
- VA Office of Research and Development
Decision Making, Video Decision Aids
A Prospective Randomized Trial Using Video Images in Advance Care Planning in Seriously Ill Hospitalized Patients
The purpose of this study is to compare the decision making of hospitalized subjects having a verbal discussion about CPR compared to subjects using a video.
- Trial name
- NCT01325519
- Testing
- video decision aid
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Advanced Cancer
A ProspectiveTrial Using Video Images in Advance Care Planning in Hospitalized Seriously Ill Patients With Advanced Cancer
The purpose of this study is to compare the decision making of hospitalized subjects with advanced cancer having a verbal discussion about CPR compared to subjects using a video.
- Trial name
- NCT01527331
- Testing
- video decision aid
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Seriously Ill Hospitalized Patients
Comparing Optimized Models of Primary And Specialist Services for Palliative Care
Palliative care (PC) seeks to reduce suffering and improve quality of life for patients with serious illnesses and their families.
- Trial name
- COMPASS-PC (NCT07224594)
- Testing
- Default Order, Accountable Justification, Standardized Usual Care
- Where
- 2 sites in United States
- Volunteers
- 78,302 people
- Sponsor
- University of Pennsylvania
Kidney Failure, Acute, Critical Illness
Comparison of Femoral Versus Jugular Routes for Temporary Hemodialysis in Seriously Ill Patients
The purpose of this study is to determine whether a jugular route leads to a lower rate of complications as compared with a femoral route for catheterization in patients admitted in several intensive care units in France who…
- Trial name
- CATHEDIA (NCT00277888)
- Testing
- Femoral route for hemodialysis, Jugular route for hemodialysis
- Where
- 10 sites in France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Caen
Parenteral Nutrition (No Primary Condition Studied)
Dosing Study of Amino Acids in Seriously Ill Patients
The purpose of this study is to determine the best rate of infusion of amino acids (15% CLINISOL - sulfite-free (Amino Acid) Injection) for nutrition in subjects with with stages II to IVB head and neck cancer.
- Trial name
- NCT01923480
- Testing
- 15% CLINISOL - Sulfite-free (Amino Acid) Injection
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Baxter Healthcare Corporation
Palliative Care, Neoplasms
A Shared Care Approach for Seriously Ill Cancer Patients Between General Practice, Discharge Department and a Specialist Palliative Care Team
Background: Approximately one third of all deaths in Denmark are caused by cancer. Both Danish and international research shows that the majority of terminally ill cancer patients wish to die at home.
- Trial name
- NCT00594971
- Testing
- Organisational intervention, Referral to a specialist palliative care team.
- Volunteers
- 270 people
- Sponsor
- University of Aarhus
Stress Ulcer Prophylaxis
Stress Ulcer Prophylaxis of Intravenous Esomeprazole in Chinese Seriously Ill Patients
The efficacy of esomeprazole will be compared versus cimetidine (a drug that previously demonstrated prevention of bleeding events) during treatment period in proportion of patients for the prevention of upper GI bleeding.
- Trial name
- SUP (NCT02157376)
- Testing
- Esomeprazole, Cimetidine
- Where
- 15 sites in China
- Volunteers
- 343 people
- Sponsor
- AstraZeneca
CPR Decision-Making
Improving Decisions About CPR
Objective The primary objective is to evaluate the efficacy of a multi-faceted, clinical decision support intervention aimed at improving the quality of decisions about Cardio Pulmonary Resuscitation (CPR) for seriously ill…
- Trial name
- iCANACP (NCT03287895)
- Testing
- Decision Support
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Hospital Research Institute
Chemotherapy
Effects of Repeated Decision Making Among Surrogates of Seriously Ill Patients
Decision making capacity fatigues after repeated decisions similar to skeletal muscle. The result is decision fatigue, in which subsequent decisions are altered toward the status quo.
- Trial name
- NCT01723436
- Testing
- Hypothetical scenarios and related decisions
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of Pennsylvania
Covid19, Pneumonia
Clinical Use of Stem Cells for the Treatment of Covid-19
This study aims to use the regenerative and repair abilities of stem cells to fight against the harmful effects of the novel coronavirus Covid-19 and therefore develop a treatment strategy.
- Conditions
- Covid19, Pneumonia, Multiple Organ Failure, Corona Virus Infection
- Trial name
- NCT04392778
- Testing
- MSC Treatment, Saline Control
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- SBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi
COPD, ESRD
Randomized Evaluation of Default Access to Palliative Services
This is a large pragmatic, randomized controlled trial to test the real-world effectiveness of inpatient palliative care consultative services in improving a number of patient- and family-centered processes and outcomes of care…
- Conditions
- COPD, ESRD, Dementia
- Trial name
- REDAPS (NCT02505035)
- Testing
- Default ordering of palliative consult
- Where
- 11 sites in United States
- Volunteers
- 34,239 people
- Sponsor
- University of Pennsylvania