Clinical trials: Sepsis-associated AKI
Acute Kidney Injury
A Safety, Tolerability, Efficacy and QoL Study of Human recAP in the Treatment of Patients With SA-AKI
The purpose of this study is to determine whether recombinant Alkaline Phosphatase (recAP) is effective and save, and to determine the most effective dose, in the treatment of patients with acute kidney injury caused by sepsis.
- Trial name
- STOP-AKI (NCT02182440)
- Testing
- recAP
- Where
- 58 sites in United States, Austria and 9 more
- Volunteers
- 301 people
- Sponsor
- AM-Pharma
AKI - Acute Kidney Injury
Renal Cell Arrest and Damage Biomarkers in Progression and Outcome of Septic AKI
The aim of the current study is to assess the predictive value of renal cell arrest biomarkers (urinary TIMP2 and IGFBP7), renal damage biomarkers (urinary KIM-1) and microscopic examination of urinary sediment in progression and…
- Trial name
- NCT06064487
- Testing
- renal cell arrest and damage biomarkers assessment
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Sepsis-Associated Organ Dysfunction, RTT
CRRT Timing in Sepsis-associated AKI in ICU
Sepsis continues to be a major global cause of both mortality and morbidity. Furthermore, the development of acute kidney injury (AKI) in sepsis increases the risk of unfavorable outcomes.
- Trial name
- CRTSAKI (NCT03175328)
- Testing
- continuous renal replacement therapies
- Where
- 2 sites in China
- Volunteers
- 460 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Primary Outcome : Compare Percent CRP Reduction, Secondary Outcome : 30-day Mortality, Renal Recovery, Length of Hospital Stay
Efficacy of Convection-based HDF Compare With Diffusion-based HD in Sepsis-associated AKI
Acute kidney injury (AKI) is a common complication among patient admitted in the hospital worldwide, with estimates of prevalence ranging from less than 1% to 66%.1, 2 In critically ill patients approximately 49% were acute…
- Trial name
- NCT06227104
- Testing
- Convection-based Hemodiafiltration
- Where
- Thailand
- Volunteers
- 28 people
- Sponsor
- Ramathibodi Hospital
Sepsis, Sepsis-associated AKI
Effect of Extracorporeal Adsorption of Plasma Neutrophil Extracellular Traps (NET) in Sepsis
This open non-randomized controlled single center study investigates to what extent the removal of circulating Neutrophil Extracellular Traps (NETs) from blood by NucleoCapture device has a positive effect on the treatment of…
- Trial name
- NCT04749238
- Testing
- NucleoCapture device
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Santersus AG
Acute Kidney Injury
Effect of CVVH on NGAL in Septic AKI
The plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in critically ill patients with AKI is not affected by continuous venovenous hemofiltration (CVVH).
- Trial name
- NCT02536027
- Testing
- continuous venovenous hemofiltration
- Volunteers
- 30 people
- Sponsor
- First People's Hospital of Chenzhou
Acute Kidney Injury Due to Sepsis
Phase 2b Study to Investigate the Safety and Efficacy of TIN816 in Sepsis-associated Acute Kidney Injury (CLEAR-AKI)
The purpose of this Ph2b study is to characterize the dose-response relationship and to evaluate the safety and efficacy of three different single doses of TIN816 in hospitalized adult participants in an intensive care setting…
- Trial name
- CLEAR-AKI (NCT05996835)
- Testing
- TIN816 70 mg lyophilisate powder
- Where
- 79 sites in United States, Argentina and 15 more
- Volunteers
- 316 people
- Sponsor
- Novartis Pharmaceuticals
Acute Kidney Injury, Sepsis
Labile Iron Removal by Adding the Iron Chelator MEX-CD1 to Dialysate in Sepsis-Associated Acute Kidney Injury
The goal of this clinical trial is to learn if adding the iron-binding drug MEX-CD1 to dialysis fluid can help remove excess iron in adults with sepsis-associated acute kidney injury (AKI) requiring dialysis who are in the…
- Trial name
- IRON-IC (NCT07236463)
- Testing
- Continuous veino-veinous dialysis with iron-chelator supplemented dialysate
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sepsis, Acute Kidney Injury
Immune Evaluation for Postoperative Sepsis-AKI
This prospective, multicenter, observational cohort study plans to enroll over 800 patients with postoperative sepsis from the ICUs of two tertiary hospitals in Beijing.
- Trial name
- NCT07811544
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Beijing Chao Yang Hospital
Sepsis, Acute Kidney Injury
Nafamostat Mesylate Versus Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy in Sepsis-Associated Acute Kidney Injury
This multicenter, randomized, open-label, active-controlled, parallel-group trial will evaluate the efficacy and safety of nafamostat mesylate anticoagulation compared with regional citrate anticoagulation in adult patients with…
- Conditions
- Sepsis, Acute Kidney Injury, Continuous Renal Replacement Therapy (CRRT)
- Trial name
- NICE-AKI (NCT07518303)
- Testing
- Citrate anticoagulation, Nafamostat Mesylate
- Volunteers
- 1,162 people
- Sponsor
- Jianfeng Xie
Acute Kidney Injury Due to Sepsis
(Revival) Study to Investigate the Efficacy and Safety of Alkaline Phosphatase in Patients With Sepsis-Associated AKI
Clinical phase 3 study to investigate the effect of recAP on 28 day mortality in patients admitted to the ICU with acute kidney injury that is caused by sepsis. The study has three distinct SA-AKI trial populations: 1.
- Trial name
- NCT04411472
- Testing
- Recombinant human alkaline phosphatase
- Where
- 122 sites in United States, Australia and 13 more
- Volunteers
- 676 people
- Sponsor
- AM-Pharma
Acute Kidney Injury, Sepsis
MULTIMODAL APPROACH IN THE DIAGNOSIS OF SEPTIC AKI
In recent studies, it has been reported that the renal resistance index is effective in detecting sepsis-related acute renal failure (SA-AKI) in the early period.
- Conditions
- Acute Kidney Injury, Sepsis, Critical Illness, Renal Resistive Index
- Trial name
- SEPTIC AKI (NCT07472452)
- Testing
- Renal Resistive Index (RRI) Doppler Ultrasound, Urinary TIMP-2 and IGFBP-7 biomarkers
- Volunteers
- 130 people
- Sponsor
- Ankara Etlik City Hospital
Sepsis
Comparison of Nafamostat and Unfractionated Heparin in RRT for Sepsis Associated AKI
The goal of this clinical trial is to compare the safety and efficacy of nafamostat mesylate (NM) and unfractionated heparin (UFH) in the process of renal replacement therapy (RRT) for patients suffering from sepsis associated…
- Trial name
- NCT06375616
- Testing
- Nafamostat Mesylate, Unfractionated Heparin
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Shen Lei
Acute Kidney Injury, Peritonitis
Phase 3 Study of Reltecimod vs Placebo in Patients With Sepsis-associated Acute Kidney Injury
Phase 3 multicenter study to be conducted in up to 90 qualified participating sites globally to assess the efficacy and safety of Reltecimod vs placebo in patients with sepsis-associated Stage 2/3 AKI.
- Conditions
- Acute Kidney Injury, Peritonitis, Necrotizing Soft Tissue Infection
- Trial name
- NCT03403751
- Testing
- Reltecimod 0.5 mg/kg
- Where
- 56 sites in United States, France
- Volunteers
- 58 people
- Sponsor
- Atox Bio Ltd
Sepsis-associated AKI
Oxiris in Septic AKI
Sepsis is a leading cause of acute kidney injury (AKI) in critically ill patients, with sepsis-associated AKI accounting for approximately 50% of all AKI cases in the intensive care unit.
- Trial name
- NCT07641660
- Testing
- Oxiris, Standard CRRT
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
Sepsis, Acute Kidney Injury
NGAL and Renal Resistive Index in the Diagnosis and Prognosis of Sepsis-associated AKI
AKI develops frequently in patients hospitalized in the intensive care unit, and the biggest risk factor is sepsis. Creatine, which is traditionally used in the diagnosis of AKI, is affected by many factors, causes the diagnosis…
- Trial name
- NGAL (NCT05374759)
- Testing
- neutrophil gelatinase-associated lipocalin, renal resistive index
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Inonu University
Sepsis-associated Acute Kidney Injury
Concept Elicitation and Patient Experience Mapping in SA-AKI
This is a concept elicitation study on patient's experiences of Sepsis-associated Acute Kidney Injury (SA-AKI)
- Trial name
- NCT07180238
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Sepsis, Acute Infection
A Multicenter Prospective Observational Study to Derive and Verify the Performance of a Host-response Based Diagnostic Tool for Early Detection of Severe Infections.
The study is a multi-center, prospective, observational clinical study enrolling patients from at least 3 medical centers. Study population will include patients over the age of 18 years.
- Trial name
- NCT06665542
- Where
- 8 sites in United States, Israel
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.