Clinical trials: Sepsis, Severe Sepsis and Septic Shock
Severe Sepsis, Sepsis
Early Identification and Effective Management of Pediatric Sepsis
In patients diagnosed as sepsis on PICU admission, early and accurate identification of patients who will develop organ dysfunction (severe sepsis) is critical for effective management and positive outcome.
- Conditions
- Severe Sepsis, Sepsis, Septic Shock
- Trial name
- NCT03996720
- Where
- 4 sites in China
- Volunteers
- 175 people
- Sponsor
- Children's Hospital of Fudan University
Polyneuropathies, Septic Shock
Electrical Muscle Stimulation in the Development of Acquired Weakness in Patients With Severe Sepsis and Septic Shock
The aim of this study is to compare the effect of EMS and conventional physical therapy on strength and muscle mass and development in adult patients with severe sepsis and septic shock.
- Conditions
- Polyneuropathies, Septic Shock, Muscle Weakness
- Trial name
- NCT03765489
- Testing
- electrical muscle stimulation, conventional physical therapy
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Chile
Sepsis, Septic Shock
DIAGNOSis of Infection in Emergency Department
Septic pathology is an extremely frequent reason for consultation in our emergency services, with an annual incidence of severe forms between 50 to 95 cases per 100,000 inhabitants and a constant increase estimated at 9% per…
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe, Infection
- Trial name
- DIAGNOSED (NCT03708796)
- Testing
- SIRS, qSOFA, NEWS, RETTS scores evaluation
- Where
- 7 sites in France
- Volunteers
- 759 people
- Sponsor
- Association pour la Formation l'Enseignement et la Recherche du Service de l'Accueil des Urgences
Encephalopathy, Organ Dysfunction Syndrome
Prospective Analysis of Septic Associated Encephalopathy Using the Non-invasive Acoustocerebrography-ACG
The patients of the group "sepsis" are measured several times with the non-invasive multi-spectral sonography (Sonovum "ACG-Diagnosesystem") (days 1, 3, 7 and 14).
- Trial name
- SAEACG (NCT03173196)
- Testing
- Non-invasive Multispectral Sonography
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Rostock
Sepsis, Severe Sepsis
Quality Improvement in Infection COntrol and Sepsis Management in MOdel Regions
The German Quality Network Sepsis is an association trying to improve quality of care for patients with sepsis, severe sepsis and septic shock or being in risc thereof.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- icosmos (NCT02820675)
- Testing
- structured case analysis, strucured screening "every patient, every shift"
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Center for Sepsis Control and Care, Germany
Severe Septic Syndrome, Septic Shock
Community Acquired Sepsis Cohort
The aim of this project is to constitute a prospective cohort of all the patients presenting to the adult emergencies of the University Hospital Centre (CHU) of Rennes for a septic syndrome of community origin.
- Trial name
- CASC (NCT03280992)
- Where
- France
- Volunteers
- 796 people
- Sponsor
- Rennes University Hospital
Sepsis, Severe, Septic Shock
High-dose Intravenous Vitamin C in Patients With Septic Shock
Despite promising observational and phase 1 data, the therapeutic potential of vitamin C for the management of septic shock has not borne out in recent large multi-centre randomized controlled trials.
- Trial name
- HIGH-VIS (NCT04796636)
- Testing
- Sodium Ascorbate
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Melbourne Health
Acute Lung Injury, Acute Respiratory Distress Syndrome
Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients
sRAGE, the soluble form of the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury, but is also involved in acute systemic inflammation.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Severe Sepsis, Septic Shock
- Trial name
- NCT00811629
- Testing
- sRAGE
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sepsis, Septic Shock
Investigation of the Role of Brain Natriuretic Peptide and Lactate in Early Goal-directed Therapy for Patients With Severe Sepsis and Septic Shock
B-type natriuretic peptide (BNP) is a cardiac neurohormone which rapidly released by the ventricle in response to myocardial stretch.
- Trial name
- NCT01539551
- Testing
- check BNP and lactate
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Septic Shock
Effect of Dexmedetomidine on Perfusion Index and Microcirculation in Severe Sepsis and Septic Shock Patients
Septic shock is one of the major causes of death worldwide with in-hospital mortality rates varying between (11.9% to 47.2 %). Alterations in microcirculatory blood flow were associated with high risk of organ dysfunction and…
- Trial name
- NCT03151668
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Infection, Sepsis
Short-course Antimicrobial Therapy in Sepsis
The purpose of this study is to compare the effect of a short course antimicrobial therapy (5-days) versus a 10-days therapy on sepsis-related organ dysfunction.
- Conditions
- Infection, Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02899143
- Testing
- Antibiotic
- Where
- 4 sites in Italy
- Volunteers
- 320 people
- Sponsor
- Ospedale Santa Maria delle Croci
Sepsis, Shock, Septic
Early Identification of Sepsis in Children
This observational nation-wide study is focused on evaluation of the new possible biomarkers for pediatric sepsis and their specificity/sensitivity in combination with usual diagnostic markers for sepsis in the terms of early…
- Conditions
- Sepsis, Shock, Septic, Sepsis, Severe, SIRS
- Trial name
- NCT03884595
- Testing
- IG, IPF, NRBC, CRP, PCT, presepsin
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Septic Shock, Endotoxemia
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study
Prospective, multicenter, randomized, open-label study of standard of care plus the PMX cartridge versus standard of care alone in patients with endotoxemic septic shock
- Trial name
- TIGRIS (NCT03901807)
- Testing
- Toraymyxin PMX 20R Extracorporeal Hemoperfusion Cartridge
- Where
- 20 sites in United States
- Volunteers
- 157 people
- Sponsor
- Spectral Diagnostics (US) Inc.
Severe Sepsis, Septic Shock
Efficacy of Mw Vaccine in Treatment of Severe Sepsis
Study Hypothesis Enhancement of Th-1 response with the help of a poly TLR agonist (Mw) is likely to increase survival in patients with severe sepsis.
- Conditions
- Severe Sepsis, Septic Shock, Immune Modulation
- Trial name
- MISS (NCT02025660)
- Testing
- Mw, 0.3ml x three days sc
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Sepsis, Septic Shock
Function of Circulating Exosomes in Sepsis-induced Immunosuppression
This is a single-center prospective bio-specimen analysis and observational study aiming to define immune pathways disrupted in bacterial sepsis and to identify clinically useful biomarkers of immune status.
- Conditions
- Sepsis, Septic Shock, Sepsis Syndrome, Sepsis Bacterial
- Trial name
- NCT04979767
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Kansas Medical Center
Septic Shock, Severe Sepsis
Lactated Ringer Versus Albumin in Early Sepsis Therapy
The use of albumin in critical ill patients is a matter of controversy. A large randomized controlled trial reported that albumin was as safe and effective as crystalloid solution for fluid replacement in intensive care unit…
- Trial name
- RASP (NCT01337934)
- Testing
- Lactated Ringer, Albumin
- Where
- Brazil
- Volunteers
- 360 people
- Sponsor
- University of Sao Paulo
Septicemia
Immunoadsorption of LPS, C5a and IL-6 in Severe Sepsis and Septic Shock (ISASS-1)
The purpose of this study is to determine whether immunoadsorption of LPS, Il-6 and C5a reduces systemic hyperinflammation, improves immune function and improves organ function in patients with severe sepsis and septic shock
- Trial name
- NCT00146432
- Testing
- Immunoadsorption of LPS, IL-6 and C5a
- Where
- Germany
- Sponsor
- Charite University, Berlin, Germany
Septic Shock, Severe Sepsis
GM-CSF to Decrease ICU Acquired Infections
The concept of acquired immunodeficiency after a first severe infection in the ICU is widely described in the literature. There is a dual risk: increased mortality and increased secondary infections.
- Trial name
- GRID (NCT02361528)
- Testing
- Sargramostim: Leukine (Genzyme USA)
- Where
- 18 sites in France
- Volunteers
- 166 people
- Sponsor
- Hospices Civils de Lyon
Sepsis, Sepsis and Septic Shock
Role of Transposable Elements in Septic Immune Aging
The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1.
- Conditions
- Sepsis, Sepsis and Septic Shock, Sepsis With Multiple Organ Dysfunction (MOD), Sepsis With Acute Organ Dysfunction
- Trial name
- SITE (NCT06809868)
- Testing
- RNA and DNA Sequencing
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Severe Sepsis
4G/5G Polymorphism of Plasminogen Activator Inhibitor-1 Gene and Disseminated Intravascular Coagulation in Severe Sepsis and Septic Shock
Data on 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene are limited in Asian patients with sepsis. Therefore, the investigators aim to prospectively investigate the incidence of 4G/5G polymorphism and its…
- Trial name
- NCT01211899
- Volunteers
- 160 people
- Sponsor
- Hallym University Medical Center