Clinical trials: Sensitisation
Hysterectomy, Chronic Pain
Evaluation of Central Sensitization, Fear-Avoidance, and Pain-Pressure Threshold With Chronic Pain After Hysterectomy
Phase 1 (started in July 2019): Central Sensitization Inventory (CSI), Fear-Avoidance Components Scale (FACS), pain-pressure threshold are factors associated with chronic post-hysterectomy pain (CPHP), but a complete…
- Conditions
- Hysterectomy, Chronic Pain, Central Sensitisation, Anxiety Depression
- Trial name
- EPOCH (NCT04014829)
- Testing
- Pain-Pressure Threshold, Mechanical Temporal Summation, Hospital Anxiety and Depression Scale
- Where
- Singapore
- Volunteers
- 436 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Chronic Pain, Back Pain
Sensorial Discrimination in Chronic Low Back Pain
In this study, the effect of sensory discrimination training on cortical reorganization, pain and functionality in chronic nonspecific low back pain in which central sensitization is dominant will be investigated.
- Conditions
- Chronic Pain, Back Pain, Central Sensitisation
- Trial name
- NCT05169918
- Testing
- Core stabilization, Sensorial Discrimination Training
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Istanbul University - Cerrahpasa
Irritation/Irritant, Sensitisation
Human Skin Safety Testing of 1 Mitopure Topical Products Using a Human Repeat Insult Patch Test (HRIPT) in Healthy Volunteers
The objective of this study is to investigate the irritation and sensitization potential of 1 topically applied test article containing Mitopure in a shared panel of healthy volunteers by means of repeated cutaneous patch…
- Trial name
- GLOW-Safety-4 (NCT07517874)
- Testing
- Mitopure Topical Formula 11
- Where
- United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Chronic Pain, Central Sensitisation
Clinical Trial on Deprescribing Associated With a Psychoeducational Program Using Virtual Reality for Patients With Chronic Pain and Central Sensitization
This clinical trial evaluates the effectiveness of the REDOCVR program, an interdisciplinary, psychoeducational intervention designed to support deprescribing of chronic pain medications in primary care.
- Conditions
- Chronic Pain, Central Sensitisation, Opioid-Related Disorders, Patient Empowerment
- Trial name
- REDOCVR_AC (NCT06964360)
- Testing
- REDOCVR Psychoeducational Program, Standard Educational Materials
- Where
- 4 sites in Spain
- Volunteers
- 174 people
- Sponsor
- Badalona Serveis Assistencials
Endometriosis, Central Sensitisation
Dyspareunia and Central Sensitization
Background: Endometriosis affects 10% of reproductive aged females, and can have a negative impact on sexual quality of life. Endometriosis can cause pelvic pain with deep penetration during intercourse, as well as other sexual…
- Conditions
- Endometriosis, Central Sensitisation, Dyspareunia
- Trial name
- NCT03216330
- Testing
- No Intervention
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- BC Women's Hospital & Health Centre
Fibromyalgia, Primary, Fibromyalgia
Pain Phenotypes in Patients With Fibromyalgia Syndrome
Fibromyalgia Syndrome (FMS); is a complex syndrome characterized by many symptoms such as chronic widespread pain, fatigue and sleep disorders, cognitive dysfunctions and psychiatric disorders.
- Conditions
- Fibromyalgia, Primary, Fibromyalgia, Chronic Pain Syndrome, Pain, Neuropathic
- Trial name
- NCT05941780
- Testing
- Pain classification method
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Kutahya Health Sciences University
Food Allergy in Infants, Food Allergen Sensitisation
Human Breast Milk's Role in Food Allergy Development
The goal of this prospective cohort pilot study is to learn about food allergens being passed on in breast milk to breast feeding infants.
- Conditions
- Food Allergy in Infants, Food Allergen Sensitisation, Breast Feeding, Exclusive, Breastmilk Collection
- Trial name
- NCT06765213
- Testing
- Open Ended Oral Food Challenge, Early Introduction
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Fibromyalgia, Sedentary Behavior
Sedentary Status and Multidimensional Outcomes in Fibromyalgia
Fibromyalgia syndrome (FMS) is a chronic condition characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and functional limitations.
- Conditions
- Fibromyalgia, Sedentary Behavior, Kinesiophobia, Central Sensitisation
- Trial name
- NCT07358702
- Testing
- Assessment Only
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Izmir Democracy University
Central Sensitisation, Cervical Spine Stenosis
Comparison of Pain, Sensitisation, Function and Quality of Life According to Stenosis Degree in Chronic Neck Pain
The cervical spine is a structure that bears the weight of the head and has important functions, but is susceptible to mechanical stress and degenerative processes.
- Trial name
- NCT06967415
- Testing
- Pain, central sensitization,functional status and quality of life.
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Frozen Shoulder, Central Sensitisation
Relationship Between Central Sensitization Levels and Treatment Outcomes in Frozen Shoulder Treatment
The aim of this study was to evaluate the relationship between treatment outcomes and central sensitization levels in patients who received intra-articular injections for frozen shoulder.
- Conditions
- Frozen Shoulder, Central Sensitisation, Treatment, Intra-Articular Injection
- Trial name
- NCT07124689
- Testing
- Treatment outcome
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people
- Sponsor
- Sultan 1. Murat State Hospital
Sensitisation, Highly Sensitised Dialysis Patients
The Safety/Efficacy Of Daratumumab With Belatacept In Highly HLA-Sensitized Patients Awaiting Kidney Transplantation
While the number of kidney transplants is increasing worldwide every year, there is a clear imbalance between the high number of patients in the waiting list and those receiving a transplant and importantly, among waitlist…
- Trial name
- COMBAT (NCT05145296)
- Testing
- Each patient will undergo in the first step of the study belatacept treatment and in the second apheresis and daratumumab
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Grenoble
Irritation/Irritant, Sensitisation
Human Skin Safety Testing of 6 Mitopure Topical Products Using a Human Repeat Insult Patch Test (HRIPT) in Healthy Volunteers
The objective of this study is to investigate the irritation and sensitization potential of 6 different topically applied test articles containing Mitopure in a shared panel of healthy volunteers by means of repeated cutaneous…
- Trial name
- GLOW-Safety-3 (NCT07100912)
- Testing
- Mitopure Topical Formula 5, Mitopure Topical Formula 6, Mitopure Topical Formula 7
- Where
- United Kingdom
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Chronic Pain, Central Sensitisation
Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers
This planned study is based on a randomized, placebo-controlled cross-over design. Boswellic acids, the triterpenes found in the gum resins of Boswellia serrata (family: Burseraceae), are traditionally used in the Indian…
- Conditions
- Chronic Pain, Central Sensitisation, Peripheral Sensitization, Neuroinflammatory Response
- Trial name
- BSPP (NCT07109843)
- Testing
- Boswellia serrata extract
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Central Sensitisation, Subacromial Impingement Syndrome
Investigation of the Effect of Central Sensitization (CS) on Steroid Injection Response in Rotator Cuff Lesion
The goal of this clinical trial is to learn whether pretreatment central sensitization presence affect shoulder steroid injection resuls in patients with rotator cuff pathology. The main questions it aims to answer are: 1.
- Trial name
- CS (NCT05926895)
- Testing
- Injection of 1 CC Betamethasone Dipropionate + Betamethasone Sodium Phosphate (Diprospan) and 4 cc 2% Prilocaine (Priloc)mixture into the subacromial space
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Central Sensitisation, Carpal Tunnel Syndrome
Investigation of the Relationship Between Pain Sensitization and Diagnostic Parameters in Carpal Tunnel Syndrome
The aim of this observational, cross-sectional study is to investigate the relationship between pain sensitization and ultrasonographic and nerve conduction studies in patients diagnosed with carpal tunnel syndrome (CTS).
- Trial name
- NCT06043141
- Testing
- Nerve ultrasound, Nerve conduction studies, Pressure pain threshold
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Fibromyalgia Syndrome, Central Sensitisation
Investigation of the Relationship Between Central Sensitization and Balance in Fibromyalgia
The aim of the study is to investigate the relationship between central sensitization parameters and changes in static and dynamic balance in patients with fibromyalgia.
- Conditions
- Fibromyalgia Syndrome, Central Sensitisation, Postural Balance
- Trial name
- NCT06851091
- Testing
- Biodex Balance System, Pressure Pain Threshold (PPT) Measurement with Algometer, Conditioned Pain Modulation (CPM)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Fibromyalgia, Cognitive Dysfunction
Relationship Between Central Sensitization Symptoms and Cognitive Dysfunction in Fibromyalgia
The aim of the study is to investigate the relationship between central sensitization parameters and cognitive dysfunction in patients with fibromyalgia.The main questions it aims to answer are: Do central sensitization symptoms…
- Conditions
- Fibromyalgia, Cognitive Dysfunction, Central Sensitisation
- Trial name
- NCT06948903
- Testing
- Central Sensitization Inventory, The Montreal Cognitive Assessment, Cognitive Symptom Severity Scale-Extended
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Lipedema, Central Sensitisation
Investigation of Central Sensitization and Associated Factors in Patients With Lipedema
This study aims to investigate the presence of central sensitization and its associated parameters in patients with lipedema. Lipedema is a chronic and hereditary condition that primarily affects the lower extremities in women…
- Trial name
- NCT06770634
- Testing
- Pain-Pressure Threshold Measurement With an Algometer, Central Sensitization Inventory, Numeric Rating Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Carpal Tunnel Syndrome, Central Sensitisation
Symptom Distribution and Pain Sensitization in Carpal Tunnel Syndrome
This study aims to compare central sensitization parameters between carpal tunnel syndrome (CTS) patients with extra median symptom distribution and those with typical, median nerve-related symptoms.
- Conditions
- Carpal Tunnel Syndrome, Central Sensitisation, Pain, Radiating
- Trial name
- NCT07114913
- Testing
- Nerve ultrasound, Nerve conduction studies, Pressure pain threshold
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Chronic Pain, Central Sensitisation
The Effect of Griffonia Simplicifolia on Pain Intensity, Central and Peripheral Sensitization, Painmodulation in Healthy Volunteers
This planned study is based on a randomized, placebo-controlled cross-over design. Griffonia simplicifolia contains the serotonin-precursor 5-hydroxytryptophan (5-HTP), an endogenous amino acid.
- Conditions
- Chronic Pain, Central Sensitisation, Peripheral Sensitization, Neuroinflammatory Response
- Trial name
- NCT06893822
- Testing
- Griffonia simplicifolia
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz