Clinical trials: Self-harm, open to volunteers
Nonsuicidal Self Injury, Emotion Regulation
Neuro- and Biofeedback in Nonsuicidal Self-injury
Nonsuicidal self-injury (NSSI) is defined as the direct, deliberate destruction of one's own body tissue without suicidal intent, typically including behaviors such as cutting, burning, or hitting oneself.
- Trial name
- NCT05656001
- Testing
- Real-time functional magnetic resonance imaging Neurofeedback and Real-time Biofeedback
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Östergötland
Bipolar Disorder, Bipolar and Related Disorders
Targeted Alternating Current and Cognitive Training Intervention for Cognitive Control in Bipolar Disorders
This study is testing whether a type of gentle brain stimulation, combined with computer-based brain training exercises, can help improve thinking skills in Veterans with bipolar disorder.
- Conditions
- Bipolar Disorder, Bipolar and Related Disorders, Veterans, Suicide
- Trial name
- TACTIC-BD (NCT07845409)
- Testing
- Soterix 1x1 tES mini-CT
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Self Harm, Borderline Personality Disorder
Predictors of Clinical Course and Treatment Response in DBT Programmes
The project is a collaboration between The National Centre for Suicide Research and Prevention (NSSF) and clinical units with Dialectical Behaviour Therapy (DBT) programmes.
- Trial name
- NCT04318899
- Testing
- Dialectical Behaviour Therapy adapted for adolescents (DBT-A), Dialectical Behaviour Therapy - Standard version (DBT)
- Where
- 5 sites in Norway
- Volunteers
- 250 people
- Sponsor
- Oslo University Hospital
Suicidal Behaviour Disorder
Prevention of Suicidal Behavior Through the VIGILANS Protocol: the Restoration of Social Connection Hypothesis
The World Health Organization (WHO) estimates, with 800,000 annual deaths, that suicide is the second leading cause of death in people aged 10 to 44 and thus recognizes suicide prevention as a public health priority.
- Trial name
- RECONEX (NCT05227183)
- Testing
- The virtual version of the Social stress task : V-TSST
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Montpellier
Suicidal Ideation
(Cost)-Effectiveness of ABFT for Suicidal Youth.
Young adults who attempt to kill themselves is a common and serious mental health problem worldwide and certainly in Belgium and the Netherlands. Fatal suicide is the leading cause of death among young adults.
- Trial name
- REPAIR (NCT05965622)
- Testing
- Attachment Based Family Therapy (ABFT) + Treatment As Usual (TAU), Treatment As Usual (TAU)
- Where
- 13 sites in Belgium, Netherlands
- Volunteers
- 138 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Self Injurious Behavior, Self Injurious Behavior Without Suicidal Intent
Examining the Effectiveness of a Brief Therapeutic Intervention for Reducing Self-Harm Among Adolescents
Non-suicidal self-injury (NSSI), defined as deliberate self-inflicted destruction of body tissue without intent to die, is particularly prevalent during mid-adolescence, with prevalence estimated around 16-22% in community…
- Trial name
- NCT07913425
- Testing
- Cutting Down Program - a three-month cognitive-behavioral psychotherapy focused on reducing self-injury urges and behaviors in adolescents
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- University of Haifa
Obsessive-Compulsive Disorder, Tricholemmoma
Neural Mechanisms of Response Inhibition Training for OCRD
The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related disorders (OCRD) such as…
- Conditions
- Obsessive-Compulsive Disorder, Tricholemmoma, Skin-Picking
- Trial name
- OCRD (NCT05377125)
- Testing
- Computerized cognitive training
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Wisconsin, Milwaukee
Cornelia de Lange Syndrome
Use of N-Acetylcysteine in the Treatment of Repetitive and Self-Injurious Behaviors in Cornelia de Lange Syndrome
This research project is a randomized cross-over pilot trial which aims to test the efficacy of N-acetylcysteine (NAC) for the treatment of Repetitive Behaviors (RB) and self-injurious behavior (SIB) in patients with Cornelia de…
- Trial name
- NCT04381897
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Leadership, Self-Harm
Implementing Evidence-Based Nursing: Leadership and Organizational Change for Implementation
This study aims to find out whether a leadership and organizational development program called the LOCI (Leadership and Organizational Change for Implementation) strategy can help nurses and their managers use the best available…
- Conditions
- Leadership, Self-Harm, Malnutrition Elderly
- Trial name
- LOCI-FIN-P (NCT07378696)
- Testing
- Leadership and organizational change for implementation
- Where
- Finland
- Volunteers
- 300 people
- Sponsor
- Jaakko Varpula
Suicidal Thoughts and Behaviors, Social Isolation
Qnnections: Refinement and Pilot Trial of a Suicide Prevention Intervention to Increase Social Connection
Despite the high risk of suicide among LGBTQ+ Veterans, there is currently no suicide-focused intervention for this population. This study will refine and pilot Qnnections, a novel group-based suicide prevention intervention that…
- Trial name
- Qnnections (NCT06803329)
- Testing
- Qnnections, Enhanced Usual Care
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- VA Office of Research and Development
Mental Health, HIV
"Gwan Enjoy Life:" A Peer-Supported Mental Health Mentoring Intervention to Improve Engagement in Care Among Sexual Minority Men Living With HIV in Jamaica
Sexual minority men (SMM) in Jamaica face many challenges that affect their health and well-being. Although they make up a relatively small part of the population, they are much more likely to be living with HIV than the general…
- Conditions
- Mental Health, HIV, Pyschological Distress, Suicidal Ideation
- Trial name
- GwanEnjoyLife (NCT07762612)
- Testing
- Gwan Enjoy Life Interveniton
- Where
- Jamaica
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Major Depressive Disorder, Suicidal Behavior
Basal Plasma Lithium Levels and Suicidal Events
Suicidal behavior is a major public health issue and there are currently no specific treatments for it. However, lithium, the reference treatment for bipolar disorder, have been shown to be effective in preventing suicidal risk.
- Conditions
- Major Depressive Disorder, Suicidal Behavior, Bipolar Disorder
- Trial name
- LIPS (NCT05409794)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 158 people
- Sponsor
- University Hospital, Montpellier
Self Injurious Behavior, Suicide
Real-time Examination of Skills and Coping Use in Teen's Everyday Lives
The goal of this clinical trial is to compare two core intervention skills among adolescents with a history of engaging in at least 3 lifetime incidents of self-inflicted injury (SII), at least one of which was a suicide attempt…
- Trial name
- RESCUE (NCT06720753)
- Testing
- Opposite to emotion action, GIVE
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Utah
Suicide Prevention, Ketamine
Esketamine Versus Crisis Response Planning Versus Enhanced Treatment as Usual for Suicide Prevention: A Pragmatic Randomized Trial in a Brazilian Municipality (SAVE)
The SAVE study will test whether a single esketamine infusion or a single Crisis Response Planning session, each added to enhanced treatment as usual, reduces future suicide-related events compared with enhanced treatment as…
- Conditions
- Suicide Prevention, Ketamine, Crisis Response Plan
- Trial name
- SAVE (NCT07120477)
- Testing
- Intravenous Esketamine, Crisis Response Planning (CRP), Enhanced Treatment as Usual (eTAU)
- Where
- Brazil
- Volunteers
- 478 people
- Sponsor
- University of Sao Paulo
Depression
A Study on the Intervention Effect of Therapeutic Horticulture Based on the Healing System on Non-suicidal Self-injury in Adolescent Patients With Depression
Non-suicidal self-harm is a serious issue. Adolescents with depression are among the high-risk groups for non-suicidal self-harm behavior.
- Trial name
- NCT07115381
- Testing
- Therapeutic Horticulture, Routine treatment and nursing
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Lei Huang
Suicidal Ideation, Suicidal and Self-injurious Behavior
A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum
Rates of suicide have increased significantly over the past two decades, particularly among youth. Compared to the general population, autistic people are significantly more likely to think about suicide, attempt suicide, and die…
- Conditions
- Suicidal Ideation, Suicidal and Self-injurious Behavior, Suicide, Autism Spectrum Disorder
- Trial name
- NCT05398250
- Testing
- Safety Planning Intervention tailored for Autistic Individuals, Safety Planning Intervention Tailored for Autistic Individuals Plus Structured Follow-Up Contacts
- Where
- 5 sites in United States
- Volunteers
- 1,665 people
- Sponsor
- University of North Carolina, Chapel Hill
Suicide, Mental Health Issue
Proximal Risk for Suicide in Adolescents
The central hypothesis is that biometric data can continuously monitor and allow for early identification/intervention of escalating suicidal symptoms.
- Trial name
- NCT06400810
- Testing
- Analog Devices Inc.
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Oregon Health and Science University
Suicide Attempt
Brief Cognitive Behaviour Therapy to Prevent Suicide Reattempts: A Feasibility Study in Swedish Psychiatric Inpatient Care
The goal of this study is to determine whether Brief Cognitive Behaviour Therapy (BCBT), a four-session psychological treatment aimed at reducing suicide attempts, is acceptable and feasible to deliver during psychiatric…
- Trial name
- BCBT (NCT07567885)
- Testing
- Brief Cognitive Behaviour Therapy
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Karolinska Institutet
Depression, Post Traumatic Stress Disorder
The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Registry
While effective interventions for depression exist, their success rates are unsatisfactory and their provision is haphazard. The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Depression Hub will improve…
- Conditions
- Depression, Post Traumatic Stress Disorder, Bipolar Disorder, Mood Disorder
- Trial name
- NCT02443636
- Where
- Canada
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Suicide, Suicide Attempt
Efficacy of a Smartphone Suicide Prevention App
It is an interventional research, single-blind, randomized, controlled, multicenter, which involves only minimal risks and constraints.
- Trial name
- PreventS (NCT07160465)
- Testing
- emma application
- Where
- France
- Volunteers
- 632 people
- Sponsor
- University Hospital, Montpellier