Clinical trials: Self-Harm
Major Depressive Disorder, Suicide
i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial
Approximately four thousand Canadians die by suicide every year, and suicide is the second leading cause of death in youth and young adults (15-34 years).
- Conditions
- Major Depressive Disorder, Suicide, Treatment Resistant Depression
- Trial name
- Ket-CBT (NCT06480500)
- Testing
- Ketamine hydrochloride, i-CBT (Internet-based Cognitive Behavioural Therapy), Midazolam Hydrochloride
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- University Health Network, Toronto
Depression, Unipolar, Depression, Bipolar
IM Ketamine vs Midazolam for Suicidal ER Patients
Rising US suicide rates and the increased risk of suicide among persons who visit an emergency department (ED) for suicidality make the ED an important site for interventions to prevent suicide.
- Conditions
- Depression, Unipolar, Depression, Bipolar, Suicidal Ideation
- Trial name
- NCT04640636
- Testing
- Ketamine hydrochloride injection, Midazolam injection
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- New York State Psychiatric Institute
Suicide Prevention, Suicidal Ideation
Co-creation of Tools for Children and Adolescents with Suicidal Thoughts And/or Behaviour
Evidence shows that there are very few evidence-based tools or interventions specifically targeting suicidality in children and adolescents.
- Conditions
- Suicide Prevention, Suicidal Ideation, Suicidal Behaviors
- Trial name
- Co-crea K&J (NCT06776328)
- Testing
- Tools
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Ghent
Insomnia, Depression
Reducing Suicidal Ideation Through Insomnia Treatment
Epidemiologic reports have linked insomnia to suicidal ideation and suicide death. However, no studies have determined whether treating insomnia decreases the risk of suicidality.
- Conditions
- Insomnia, Depression, Suicidal Ideation
- Trial name
- REST-IT (NCT01689909)
- Testing
- Zolpidem-CR
- Where
- 4 sites in United States
- Volunteers
- 103 people
- Sponsor
- Augusta University
Depression, Suicidal Ideation
BRITEPath, Component 3 of iCHART (Integrated Care to Help At-Risk Teens)
BRITEPath (BP) aims to support co-located mental health clinicians in the development of a high quality, effective, and personalized safety plan for referred patients who screen positive for depression and/or suicidal ideation.
- Trial name
- NCT04000399
- Testing
- BRITEPath
- Where
- 6 sites in United States
- Volunteers
- 43 people
- Sponsor
- University of Pittsburgh
Sleep Disturbance, Sleep
Sleep and Circadian Interventions for College Students at High Risk of Suicide
The purpose of this study is to examine the extent to which delivering sleep and circadian focused interventions in addition to evidenced based psychiatric care for depression and suicide risk may contribute to decreasing suicide…
- Conditions
- Sleep Disturbance, Sleep, Depression, Suicide
- Trial name
- REST-UP (NCT07346014)
- Testing
- Sleep Feedback + Psychoeducation, Transdiagnostic Sleep and Circadian Intervention + Bright Light (TSC+), Triple Chronotherapy (TCT+)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Pittsburgh
Depression and Suicide
Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention
This is a rater-blinded, randomized controlled trial. All patients will receive esketamine for treatment of Major Depression with Suicidal Ideation (MDSI).
- Trial name
- ENDURE (NCT04760652)
- Testing
- Cognitive Behavioral Therapy CBT, TAU
- Where
- 3 sites in United States
- Volunteers
- 93 people
- Sponsor
- Yale University
Emergency Services, Psychiatric
Emergency Linkage to Outpatient Psychiatric Services
The purpose of this study is to compare two different kinds of follow-up care and their effects on psychiatric service use and psychological well-being.
- Trial name
- NCT00278811
- Testing
- mobile crisis team
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Rochester
Stress, Distress, Emotional
Caring for Vets and Service Members: Caring Contacts for Stressed and Distressed Veterans and Service Members
The goal of this clinical trial is to study stressed or distressed veterans and service members. Researchers will compare Caring Contacts plus best available resources to best available resources alone to see if reduces distress…
- Trial name
- COVE (NCT06136234)
- Testing
- Caring Contacts, Best Available Resources Alone
- Where
- United States
- Volunteers
- 521 people
- Sponsor
- University of Washington
Psychological Distress, Suicidal Ideation
Development and Feasibility Testing of a Suicide Prevention Intervention for Sexual and Gender Minority Youth
This study aims to develop and test a brief, digital, suicide prevention intervention for sexual and gender minority (SGM) youth who have experienced cyberbullying.
- Trial name
- NCT05724784
- Testing
- Flourish
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Pittsburgh
Self-Injurious Behavior, Suicidal Ideation
Brief Admission Skane: Replacing General Admission for Individuals With Self-harm and Acute Risk of Suicide
The purpose of the study is to test a standardized version of brief admission (BA) through randomized controlled trial (RCT). The main objective is to evaluate if BA can serve as a crisis management model for individuals with…
- Conditions
- Self-Injurious Behavior, Suicidal Ideation, Suicide, Attempted, Borderline Personality Disorder
- Trial name
- BAS (NCT02985047)
- Testing
- Brief Admission
- Where
- Sweden
- Volunteers
- 125 people
- Sponsor
- Region Skane
Suicide Prevention
Effectiveness Trial of Youth Suicide Prevention Delivered by Teen Peer Leaders
The purpose of this study is to evaluate the impact of the school-based Sources of Strength program in reducing suicidal behaviors in the population of high school students and determine how the program works (mechanisms of…
- Trial name
- NCT02043093
- Testing
- Sources of Strength
- Where
- United States
- Volunteers
- 17,603 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Suicide
SAFER: A Brief Intervention Involving Family Members in Suicide Safety Planning
The management of suicide risk is a pressing national public health issue especially among Veterans, and there exist no guidelines of how best to involve family members in this effort.
- Trial name
- SAFER (NCT03034863)
- Testing
- Safe Actions for Families to Encourage Recovery, Individual Safety Planning Intervention
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- VA Office of Research and Development
Suicide
Suicide Prevention for Sexual and Gender Minority Youth (Randomized Controlled Trial)
The overarching goal of this study is to evaluate a newly-developed suicide prevention program for sexual and gender minority youth and emerging adults.
- Trial name
- NCT05669976
- Testing
- Safety Planning Intervention with Navigation Services, Safety Planning Intervention
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Depression, Suicidal Ideation
A Double-Blind Study of Buprenorphine Treatment of Acute Suicidality
The acutely suicidal patient presents a complex and dangerous clinical dilemma. Many suicidal patients receive antidepressant medications, but the onset of action of these medications is at least three weeks, and despite their…
- Conditions
- Depression, Suicidal Ideation, Suicidal Action
- Trial name
- NCT00863291
- Testing
- buprenorphine
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Abarbanel Mental Health Center
Bipolar Disorder
Observation of Clozapine Treatment Safety in Bipolar Disorder.
The purpose of the registry is to record incidence of adverse events during treatment with clozapine in patients suffering from bipolar disorder.
- Trial name
- CloGD (NCT06011460)
- Testing
- Clozapine
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Gdansk
Trichotillomania, Obsessive Compulsive Disorder
Marinol in Trichotillomania or Obsessive Compulsive Disorder
The goal of the proposed study is to evaluate the efficacy and safety of dronabinol in individuals with obsessive-compulsive disorder (OCD) or the obsessive-compulsive spectrum disorders, trichotillomania (TTM) or pathological…
- Trial name
- NCT01093976
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Chicago
Suicidal Ideation
SAFETY-A for Promoting Equity in Suicide Prevention Outcomes in Schools
This study will adapt Safe Alternatives For Teens and Youth - Acute (SAFETY-A) for implementation in low-resourced school districts to reduce racial/ethnic disparities in mental health service use (MHS) following identification…
- Trial name
- NCT05834660
- Testing
- Safe Alternatives for Teens and Youth-Acute for Schools (SAFETY-A for Schools)
- Where
- United States
- Volunteers
- 347 people
- Sponsor
- University of California, Los Angeles
Sleep Disorder, Mental Health Issue
Improving Sleep in a Psychiatric Hospital
The purpose of this study is to examine effects of sleep promotion versus treatment as usual (TAU) on subjective, self-reported sleep while in inpatient psychiatric treatment, to examine effects of sleep promotion vs.
- Trial name
- NCT07010718
- Testing
- Scented Oil, Ear Plugs, Eye Mask
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center, Houston
Opioid-use Disorder, Addiction
Competitive Revision for CLARO: Collaboration Leading to Addiction Treatment and Recovery From Other Stresses
The purpose of this study is to develop and then test an enhanced version of the parent study's collaborative care intervention for co-occurring disorders (CC-COD) to reduce the risk of suicide and overdose among individuals with…
- Conditions
- Opioid-use Disorder, Addiction, Depression, Post Traumatic Stress Disorder
- Trial name
- NCT04634279
- Testing
- Collaborative care Plus
- Where
- 12 sites in United States
- Volunteers
- 68 people
- Sponsor
- RAND
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