Clinical trials: Sedation
Locally Advanced Cancer, Metastatic Cancer
Identification of In-hospital Patients in Need of Palliative Care Using a New Simplified Screening Tool
Every day many patients affected by chronic life-limiting illnesses are admitted into Internal Medicine wards, coming from the Emergency Department.
- Conditions
- Locally Advanced Cancer, Metastatic Cancer, Chronic Respiratory Failure, Chronic Heart Failure
- Trial name
- SST2017 (NCT04143230)
- Testing
- Screening for PC by means of two different screening tools
- Where
- Italy
- Volunteers
- 660 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Intra-abdominal Hypertension
Effect of Sedation on Intra-abdominal Pressure
The purpose of this study is to evaluate the effect of deepening of sedation on intra-abdominal pressure in mechanically ventilated adult patients with intra-abdominal hypertension.
- Trial name
- NCT02944292
- Testing
- Deepening of sedation, Propofol
- Where
- Estonia
- Volunteers
- 40 people
- Sponsor
- Tartu University Hospital
Breast Cancer
Observation of the Effect of Preoperative Use of Dexmedetomidine Hydrochloride Nasal Spray on Optimizing Awake Sedation During Breast-Conserving Surgery for Breast Cancer and Postoperative Awake Status
This clinical trial aims to evaluate the efficacy and safety of Dexmedetomidine Hydrochloride Nasal Spray for conscious sedation and anxiety relief during breast-conserving surgery.
- Trial name
- NCT07350928
- Testing
- Induction of anesthesia with dexmedetomidine nasal spray prior to surgery
- Where
- China
- Volunteers
- 394 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Anesthesia
SedLine Engineering Data Collection Study in Pediatric Patients Undergoing General Anesthesia or Sedation
The purpose of the study is to collect EEG data with the Masimo SedLine device along with vital signs, patient demographics, anesthetic record and surgical procedure during general anesthesia or sedation.
- Trial name
- NCT03128931
- Testing
- Pediatric SedLine forehead EEG sensor
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Masimo Corporation
Preoperative Anxiety, Preoperative Sedation
Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia
For pediatric patients undergoing general anesthesia, poor anesthesia induction compliance often has adverse effects on individual behavior in the early postoperative period.
- Conditions
- Preoperative Anxiety, Preoperative Sedation, Children, Dexmedetomidine
- Trial name
- NCT06853431
- Testing
- dexmedetomidine, Esketamine
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Sedation in Intensive Care Unit Patients
Comparison of Lormetazepam and Midazolam Used as Sedatives for Patients That Require Intensive Care
A goal directed , demand-driven administration of sedative drugs is an integral part of every intensive care treatment. During long-term application of sedatives, Midazolam is the most commonly used sedative in Europe.
- Trial name
- NCT02022592
- Testing
- Lormetazepam, Midazolam
- Where
- 3 sites in Germany
- Volunteers
- 84 people
- Sponsor
- Claudia Spies
Auditory Brainstem Response
Intranasal Dexmedetomidine for Sedated Hearing Testing
Auditory brainstem response testing is necessary in children who are not able to be tested by classical audiogram, because of their age or an associated retarded psycho-motor development or behavioral and cognitive troubles.
- Trial name
- NCT03530371
- Testing
- Dexmedetomidine Hydrochloride
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Lenval
Clinical Indications for Transesophageal Echocardiography
Hypnosis vs Midazolam for Sedation for TEE
Most of the reports on hypnosis in the literature have focused on pain control during minor operations. With this study we aimed to evaluate the role of hypnosis on sedation for transesophageal echocardiography and compare it…
- Trial name
- NCT01749475
- Testing
- Midazolam, hypnotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Gastrointestinal Endoscope, Endoscopic Retrograde Cholangiopancreatogram (ERCP)
Electronic Respiratory Sound Monitoring System in Gastrointestinal Endoscopic Sedation
This study aims to evaluate the application of an electronic respiratory sound monitoring system during sedation for gastrointestinal endoscopy and to determine its effectiveness in improving sedation quality.
- Trial name
- NCT06938919
- Testing
- routine care without electronic respiratory sound monitoring system, routine care with electronic respiratory sound monitoring system
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Sedation, Pediatric Anesthesia
Frequency of Adverse Events in Pediatric Patients Receiving Sedation for Magnetic Resonance Imaging
Introduction:The application of anesthesia outside the operating room for pediatric patients has increased in recent years. For diagnostic and treatment follow-up purposes, magnetic resonance imaging (MRI) requires the pediatric…
- Conditions
- Sedation, Pediatric Anesthesia, Magnetic Resonance Imaging, Adverse Effect
- Trial name
- NCT06467045
- Testing
- Pediatric patients who received sedation for magnetic resonance imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Electroencephalography, Melatonin
Sedation and Nursing Management in EEG Recording in Children
Electroencephalogram (EEG) has an important place in establishing the correct diagnosis, providing appropriate intervention, and predicting the prognosis in the long term in children.
- Conditions
- Electroencephalography, Melatonin, Chloral Hydrate, Hydroxyzine
- Trial name
- NCT05492812
- Testing
- Sedation and Nursing Management in EEG Recording in Children, Chloral Hydrate, Hydroxyzine
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Procedural Sedation, Intra-nasal Delevery Device
Intranasal Midazolam for Pediatric Pre-procedural Sedation and Pre-procedural Anti-anxiety Using sipNose Device - a Randomized Controlled Study
A Three-arm, Randomized Controlled Trial for Pediatric Pre-procedural Sedation and Pre-procedural Anti-anxiety: Intranasal Midazolam by SipNose versus MAD Versus oral administration
- Trial name
- NCT03635398
- Testing
- Sipnose device, MAD (Mucosal Atomization Device), midazolam
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Rabin Medical Center
Pediatric Procedural Sedation
Intranasal Dexmedetomidine vs. Oral Chloral Hydrate for Pediatric Orthopedic Procedural Sedation
This prospective randomized controlled study will compare the effectiveness and safety of intranasal dexmedetomidine with oral chloral hydrate for procedural sedation in children undergoing painful orthopedic manipulation.
- Trial name
- NCT07768566
- Testing
- Dexmedetomidine, Chloral Hydrate
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Childrens Hospital
Anxiety, Pain
Clonidine Versus Midazolam for Premedication
alpha2-agonists like clonidine offer several useful effects that make these drugs an interesting alternative to benzodiazepines for pharmacological premedication.
- Trial name
- NCT00638729
- Testing
- midazolam, clonidine
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Schleswig-Holstein
Children Requiring Sedation for MRI/CT
The Incidence and Nature of Adverse Events During Pediatric Sedation for MRI/CT in One Korean University Hospital: Retrospective Study
Sedation and anesthesia for diagnostic imaging represents a rapidly growing field of practice, especially in children. Propofol is the most common sedative drug administered for MRI/CT.
- Trial name
- NCT01855581
- Testing
- pediatric sedation (propofol, ketamine, etc)
- Where
- South Korea
- Volunteers
- 3,739 people
- Sponsor
- Yonsei University
Anesthesia; Reaction
Dexmedetomidine-ketamine Versus Propofol-ketamine for Sedation During Endoscopy in Hepatic Patients
We aim to compare the response to ketamine/dexmedetomidine and ketamine/propofol combinations used in hepatic patients with child-Pugh classification (class A), and early (class B) undergoing UGIE.
- Trial name
- NCT04906772
- Testing
- Dexmedetomidine, Propofol
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tamer Nabil Abdelrahman
High Flow Nasal Cannula, Body Roundness Index
High Flow Nasal Cannula and Mask Oxygenation in Patients With Visceral Obesity Undergoing Sedated Gastroscopy
During sedated gastroscopy, the insertion of the fiberscope and gastric distension required to perform the examination may induce respiratory depression, airway obstruction, and decreased chest wall compliance.
- Trial name
- NCT07159022
- Testing
- High Flow Nasal Cannula Oxygenation, Face Mask Oxygenation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Polyneuropathy
Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences.
Even 20-50% of patients under sedation and mechanical ventilation develops myopathy and / or neuropathy which difficulties both the process of extubation and the functional recovery.
- Trial name
- NCT02033057
- Testing
- Muscular electrostimulation and percutaneus muscular biopsy.
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitario La Fe
Hypercatabolism, Sedative, Hypnotic, or Anxiolytic Use Disorders
Sedation Protocols and Skeletal Muscle Metabolism in Mechanical Ventilated Patients
To investigate the effects of different sedation protocols on skeletal muscle metabolism in mechanical ventilated patients in ICU.
- Trial name
- NCT03402113
- Testing
- Dexmedetomidine, Midazolam
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Chinese Medical Association
Traumatic Brain Injury
Remifentanil for Sedation of Patients With Traumatic Brain Injury (TBI)
This is a descriptive retrospective study designed to measure the efficacy of remifentanil sedation and the ability to perform frequent neurological examinations of patients with traumatic brain injuries.
- Trial name
- NCT02049320
- Testing
- Remifentanil
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Joseph D. Tobias