Clinical trials: Sedated ICU Patients
Sedation
A Study Evaluating the Efficacy and Safety of HSK3486 for Sedation
This is a multi-center, open-label, randomized, propofol-controlled phase II clinical trial.A total of ICU patients undergoing mechanical ventilation are intended to be enrolled and randomly assigned to HSK3486 group and propofol…
- Trial name
- NCT04147416
- Testing
- HSK3486 0.1-0.2 /0.3 mg / kg group, Propofol 0.5-1.0/1.5 mg/kg group
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Delirium, Sleep Perception
Effect of Daily Interruption of Continuous Sedation on Delirium, Sleep Perception in Intensive Care Unit (ICU) Patients
This is an intervention study whose purpose is to determine whether daily interruption of sedative infusion contributes to the reduction of the occurrence of delirium and improves sleep perception in critically ill patients.
- Trial name
- ICUDelirium (NCT00714194)
- Testing
- Normal continuous sedation, Daily interruption of continuous sedation
- Where
- Puerto Rico
- Volunteers
- 52 people
- Sponsor
- University of California, San Francisco
Mechanically Ventilated and Intubated Subjects
A Safety and Efficacy Study of Dexmedetomidine in ICU Patients Requiring Continuous Sedation
The purpose of this study is to evaluate the safety and efficacy of dexmedetomidine in ICU subjects who are initially intubated, mechanically ventilated and require sedation for beyond 24 hours.
- Trial name
- NCT00216190
- Testing
- Dexmedetomidine HCL Injection, Midazolam Injection
- Where
- 96 sites in United States, Argentina and 3 more
- Volunteers
- 420 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Sedation and Analgesia, Pain Intensity Assessment
Prevalence of Pain in Mechanically Ventilated Patients in Intensive Care Units
Introduction: Pain is a subjective symptom, a physiological response that is difficult to assess, which affects the body physically and/or emotionally.
- Conditions
- Sedation and Analgesia, Pain Intensity Assessment, Mechanical Ventilation Complication
- Trial name
- PainICU (NCT07182851)
- Where
- 4 sites in Brazil
- Volunteers
- 370 people
- Sponsor
- Centro Universitário Augusto Motta
Critical Illness, Mechanical Ventilation Complication
Enteral Versus Intravenous Sedation in Critically Ill High-risk ICU Patients
Recent studies suggest the employment of 'conscious' sedation (1) for critically high - risk patients (2), showing more efficacy then deep sedation (3).
- Trial name
- NCT01360346
- Testing
- Enteral Sedation (EN), Control group: Intravenous Sedation (IV)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Milan
ICU Patients, Sedation
The Use of Ketamine and Dexmedetomidine in Intensive Care Sedation
The aim of the study is to compare the use of dexmedetomidine + ketamine with dexmedetomidine + placebo for sedation in ICU patients in terms of safety and efficacy
- Trial name
- NCT04096768
- Testing
- Dexmedetomidine, Ketamine
- Where
- Lebanon
- Volunteers
- 394 people
- Sponsor
- Lebanese American University Medical Center
ICU-acquired Weakness, Mechanical Ventilation
eCASH and Early Goal-Directed Mobilization to Prevent ICU-Acquired Weakness
This single-center, prospective, randomized controlled trial aims to evaluate whether an eCASH concept-based analgesia and sedation strategy combined with early goal-directed mobilization can reduce the incidence of intensive…
- Conditions
- ICU-acquired Weakness, Mechanical Ventilation, Critical Illness
- Trial name
- eCASH-EGDM (NCT07677488)
- Testing
- eCASH-Based Analgesia and Sedation Strategy Combined With Early Goal-Directed Mobilization, Routine ICU Nursing Care
- Where
- China
- Volunteers
- 70 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Respiratory Failure, Critical Illness
The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial
This clinical trial aims to assess the efficacy of sedation protocol targeting optimal respiratory drive using P0.1 and arousal level compared with conventional sedation strategy (targeting arousal level alone) in patients…
- Conditions
- Respiratory Failure, Critical Illness, Respiratory Distress Syndrome, Adult, Lung Injury
- Trial name
- NCT06203405
- Testing
- Titrating sedation targeting both optimal P0.1 and appropriate arousal level, Fentanyl, Midazolam
- Where
- Thailand
- Volunteers
- 214 people
- Sponsor
- Siriraj Hospital
Critical Illness, Mechanical Ventilation
Analysis of Weaning of Analgosedation and Kinetics of Emergence in Critically Ill Patients
The goal of this prospective multicenter observational study is to characterize early trajectories of consciousness recovery following the first valid structured awakening trial in mechanically ventilated critically ill adults, a…
- Conditions
- Critical Illness, Mechanical Ventilation, Weaning Invasive Mechanical Ventilation, Sedation and Analgesia
- Trial name
- AWAKE-ICU (NCT07710066)
- Testing
- Structured Awakening Evaluation (SAE)
- Volunteers
- 500 people
- Sponsor
- Patricia Rodriguez Villamizar
Sedation Complication, Acute Respiratory Distress Syndrome Due to COVID-19
Assessment of Sedation Depth Using Processed EEG in ICU Patients With ARDS Receiving Neuromuscular Blockade: A Prospective Observational Study"
"In intensive care units, therapeutic paralysis has been a routine treatment method for many years in a select group of patients.
- Conditions
- Sedation Complication, Acute Respiratory Distress Syndrome Due to COVID-19, Anesthesia Awareness
- Trial name
- NCT06337877
- Testing
- Depth of sedation monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Tepecik Training and Research Hospital
Pharmacokinetics
Population Pharmacokinetics of Dexmedetomidine in ICU Patients
Dexmedetomidine is a new, highly selective and potent alpha2-adrenoreceptor agonist registered for sedation of patients in intensive care units.
- Trial name
- Dex-Pop-PK (NCT00714857)
- Testing
- Dexmedetomidine
- Where
- Finland
- Volunteers
- 21 people
- Sponsor
- University of Turku
Delirium
MENDS Study: Trial in Ventilated ICU Patients Comparing an Alpha2 Agonist Versus a Gamma Aminobutyric Acid (GABA)-Agonist to Determine Delirium Rates, Efficacy of Sedation, Analgesia and Discharge Cognitive Status
Delirium has recently been shown as a predictor of death, increased cost, and longer length of stay in ventilated patients. Sedative and analgesic medications relieve anxiety and pain, but may contribute to patients'…
- Trial name
- NCT00095251
- Testing
- Dexmedetomidine, Lorazepam
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University
Deep Sedation, Ventilators, Mechanical
Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU
This study aims to examine the use of protocol directed sedation using the Duke PAD protocol with the current sedation medications of propofol or dexmedetomidine compared to the PAD protocol with midazolam, per cardiac intensive…
- Conditions
- Deep Sedation, Ventilators, Mechanical, Critical Illness
- Trial name
- NCT02903407
- Testing
- Midazolam, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
General Anesthesia
Remimazolam Phase II Cardiac Anesthesia Study
This phase II study in patients undergoing elective cardiac surgery will evaluate the efficacy, safety, and pharmacokinetics of remimazolam, compared with propofol and sevoflurane, during the induction and maintenance of general…
- Trial name
- NCT01937767
- Testing
- Remimazolam, Propofol, Sevoflurane
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Paion UK Ltd.
Conscious Sedation
Efficiency of Ventilation During Conscious Sedation in the Pediatric Intensive Care Unit
Pediatric patients admitted to the intensive care unit and requiring conscious sedation for minor surgical procedures are at risk to hypoventilate and retain CO2. The rise in CO2 levels is not well described and unpredicted.
- Trial name
- NCT01287572
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Mechanical Ventilation Complication
Sequential Use of Propofol/Midazolam and Dexmedetomidine for Sedation in Mechenical Ventialtion Patients in ICU.
For the patient who passed the screen of weaning from ventilation, the traditional sedation drug such as propofol and midazolam should be decreased or stopped, then it would induce the stress response and agitation, such as…
- Trial name
- NCT02122055
- Testing
- Fentanyl, Sedation assessment, Screen of weaning
- Volunteers
- 100 people
- Sponsor
- Tianjin Third Central Hospital
Microcirculation
Comparison Between Dexmedetomidine and Propofol for Patients in the Intensive Care Unit After Abdominal Surgery
This is a single-blind randomized clinical trial. Patients undergoing abdominal surgery will be enrolled and randomly divided into two groups: dexmedetomidine group and propofol group.
- Trial name
- NCT02874768
- Testing
- Dexmedetomidine, Propofol
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Mechanical Ventilation, Critically Ill Intensive Care Unit Patients
Ketamine Sedation in the ICU (KANINE) RCT
Sedation is given to intensive care unit (ICU) patients to treat discomfort, anxiety, agitation, and to help facilitate care, particularly when they require a breathing tube.
- Trial name
- KANINE (NCT06767358)
- Testing
- ketamine hydrochloride
- Where
- 3 sites in Canada
- Volunteers
- 54 people
- Sponsor
- McMaster University
Critical Illness
Evaluation of Pain Levels by Quantitative Pupillometry During the Placement of Deep Venous Catheters in Sedated Patients in Intensive Care Unit (PUPICAT)
Pain is common in intensive care and gives rise to multiple consequences that can impact the future of patients. The placement of deep venous catheters are painful gestures of common practice in intensive care.
- Trial name
- PUPICAT (NCT05962996)
- Testing
- Pupillometry
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Régional Universitaire de Tours
Ventilator Lung; Newborn
NIPE as an Indicator of Pain in Sedated/Ventilated Patient Under 3 Years-old Hospitalized in Intensive Care Unit
The main objective is to assess correlation between Newborn Infant Parasympathetic Index values and external evaluation by Comfort Behaviour Scale during painful medical cares in sedated intubated children admitted in pediatric…
- Trial name
- NIPE (NCT04195672)
- Testing
- NIPE (MDoloris®) and CBS values
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Lille