Clinical trials: Sciatica
Lumbar Disc Herniation, Lumbar Radiculopathy
Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc Herniation
The SELDISC trial will investigate whether a selective nerve root block can reduce the need for surgery in adults with a herniated disc in the lower back.
- Conditions
- Lumbar Disc Herniation, Lumbar Radiculopathy, Lumbar Disc Herniation With Radiculopathy
- Trial name
- SELDISC (NCT07895589)
- Testing
- Selective Nerve Root Block
- Where
- 2 sites in Sweden
- Volunteers
- 262 people
- Sponsor
- Karolinska Institutet
Lumbosacral Radicular Pain, Sciatic Radiculopathy
Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy
The purpose of this study is to evaluate the safety and tolerability of C-1101 administered as a single dose, transforaminal epidural injection compared to sterile saline
- Conditions
- Lumbosacral Radicular Pain, Sciatic Radiculopathy, Sciatic Leg Pain, Sciatica
- Trial name
- NCT07264270
- Testing
- C-1101
- Where
- 6 sites in United States, Australia
- Volunteers
- 24 people
- Sponsor
- Consano Bio
Sciatica Due to Intervertebral Disc Disorder
Effect of Sensorimotor Training on Pain and Gait Performance in Patients With Discogenic Sciatica
This study aims to investigate the effect of sensorimotor training on gait performance in patients with discogenic sciatica.
- Trial name
- NCT07805265
- Testing
- Standard physical therapy, Sensorimotor Training
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Lumbar Radiculopathy, Lumbar Disc Herniation
Randomized Evaluation of Lumbar Injection Effectiveness and Function
The goal of this clinical trial is to learn whether the Triojection® System is safe and effective for treating symptomatic lumbar radiculopathy (leg pain caused by nerve irritation or compression) resulting from a contained…
- Conditions
- Lumbar Radiculopathy, Lumbar Disc Herniation, Contained Herniated Lumbar Disc
- Trial name
- RELIEF (NCT07856810)
- Testing
- Triojection® System, Selective Nerve Root Block (SNRB)
- Volunteers
- 300 people
- Sponsor
- SpinaFX Medical Inc.
Lumbar Radiculopathy
Effect of Transfer of Energy Capacitive and Resistive on Chronic Discogenic Sciatica
The goal of this clinical trial is to evaluate the effect of Transfer of Energy Capacitive and Resistive (TECAR) on pain, functional disability and electrophysiological parameters in adults with chronic discogenic sciatica .
- Trial name
- NCT07841405
- Testing
- Transfer of Energy Capacitive and Resistive (TECAR) therapy, conventional physical therapy program
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
Chronic Neuropathic Pain, Radiculopathy
Hypersound Treatment for Chronic Neuropathic and Radicular Pain
This study will evaluate whether the investigational Hypersound system reduces pain in adults with chronic neuropathic or radicular pain.
- Conditions
- Chronic Neuropathic Pain, Radiculopathy, Sciatica, Peripheral Neuropathic Pain
- Trial name
- NCT07831447
- Testing
- Hypersound RF-PNS system
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Hypersound Medical Inc
Sciatica Acute, Lumbar Spinal Stenosis
Efficacy of M640 in Acute Lumbosacral Musculoskeletal Conditions.
The goal of this clinical trial is to learn if a modification to metaxalone 640 mg can reduce low back and leg pain. The participants will be 18 to 80 years old, healthy with newly occurring back or leg pain.
- Trial name
- NCT06157177
- Testing
- Metaxalone 640 mg Oral Tablet
- Where
- 24 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Primus Pharmaceuticals
Sciatica Due to Intervertebral Disc Disorder
Two-leg Rotation and Sciatica
this study including the application of a specific technique of Mulligan mobilization calles 2 leg rotation on patients having lumbar discogenic lesion with sciatica.
- Trial name
- (MWM) (NCT07444125)
- Testing
- standard physical therapy, 2 leg rotation
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- University of Hail
Lumbosacral Radicular Pain
Corticosteroid Lumbar Epidural Analgesia for Radicular Pain 2
This is a research study of SP-102, an experimental medication designed to relieve pain in patients with moderate to severe sciatica (pain in the lower back, hips, buttocks and legs).
- Trial name
- CLEAR 2 (NCT07579351)
- Testing
- SP-102, Dexamethasone Sodium Phosphate 10 MG/ML
- Volunteers
- 755 people
- Sponsor
- Semnur Pharmaceuticals, Inc.
Lumbosacral Radiculopathy, Sciatica
A Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORE
The Move-MORE study is designed to evaluate a multicomponent mindfulness and movement program for patients with lumbosacral radiculopathy.
- Conditions
- Lumbosacral Radiculopathy, Sciatica, Chronic Low Back Pain With a Neuropathic Component, Radiculopathy Lumbar
- Trial name
- Move-MORE (NCT07125027)
- Testing
- Move-MORE
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- National University of Natural Medicine
Lumbosacral Radiculopathy
Procedural Framing and Epidural Steroid Injection Outcomes
Back pain is the leading cause of disability and military medical boards across the globe. Epidural steroid injections (ESI) are the most commonly performed pain procedure in the world.
- Trial name
- PEACE (NCT07498140)
- Testing
- Behavioral manipulation of ESI expectations, No behavioral manipulation of ESI expectations, No behavioral manipulation of pharmacotherapy expectations
- Where
- 4 sites in United States, Thailand and 1 more
- Volunteers
- 210 people
- Sponsor
- Northwestern University
Back Pain Lower Back, Neck Pain
Success Rates and Safety of Steroid Injections in Managing Spinal and Sacro-Iliac Pain (CORTisone Injection Spine Study)
This study aims to analyze the efficacy and safety of different kinds of steroid injections for back pain, comparing different steroids, dosages, locations (epidural, facet joints, nerve blocks), and also the difference between…
- Conditions
- Back Pain Lower Back, Neck Pain, Radiculopathy Multiple Sites, Spinal Stenosis Cervicothoracic Region
- Trial name
- CORTISS (NCT07762170)
- Testing
- triamcinolone acetonide (Kenalog), Celestone Soluspan 6Mg/Ml Suspension for Injection, Depo-Medrol 40Mg/Ml Suspension for Injection
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Igor Wilderman. MD
Lumbar Radiculopathy, Sciatica
Dose Dependent Steroid Injections
This study aims to evaluate the efficacy of interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, to evaluate the efficacy of interlaminar steroid injections at improving quality of life and…
- Conditions
- Lumbar Radiculopathy, Sciatica, Back Pain With Radiation
- Trial name
- NCT07494136
- Testing
- Triamcinolone 10 Mg/mL Injectable Suspension, Triamcinolone 40 Mg/mL Injectable Suspension, Triamcinolone 80 Mg/mL Injectable Suspension
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Miami
Sciatica
Effect of Somatosensory Motor Control With and Without Kinesio Tape in Patients With Sciatica
Sciatica can be defined as a radicular pain that runs through the sciatic nerve from the lower back to the lower limbs and also may be associated with weakness or numbness in the muscles.
- Trial name
- NCT07756905
- Testing
- somatosensory motor control exercises, Kinesiology taping, and conventional Treatment, somatosensory motor control and conventional Treatment
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Riphah International University
Herniated Disc, Sciatica Due to Intervertebral Disc Disorder
Effects of Neural Mobilization Combined With Manual Therapy on Infrared Thermography, Inflammatory Markers and Clinical Outcomes in Patients With Lumbar Disc Herniation: A Randomized Controlled Clinical Trial
The objective of this randomized controlled clinical trial is to evaluate whether manual therapy combined with neural mobilization can improve pain, functional impairment, quality of life, inflammatory markers, and infrared…
- Trial name
- NCT07752199
- Testing
- Neural Mobilization, Manual Therapy
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Longhua Hospital
Sciatica, Chronic Sciatica
Effects of Shockwave Therapy Versus Ultrasound Therapy Among Patients With Chronic Sciatica
Sciatica is characterized by radiating pain, functional limitations, reduced flexibility, disturbed sleep, and impaired quality of life.
- Conditions
- Sciatica, Chronic Sciatica, Lumbar Radiculopathy
- Trial name
- NCT07710924
- Testing
- Extracorporeal Shockwave Therapy, Therapeutic Ultrasound, Conventional Physiotherapy
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- University of Lahore
Sciatica, Lumbosacral Radiculopathy
Three CT Signs of Nerve-root Suffering in Low-back Sciatica: a Study of Their Frequency in Patients Referred for CT-guided Nerve-root Infiltration.
Retrospective, observational, single-centre study conducted at Nice University Hospital (Pasteur 2), Department of Diagnostic and Interventional Radiology.
- Conditions
- Sciatica, Lumbosacral Radiculopathy, Low Back Pain
- Trial name
- NCT07690449
- Testing
- Pre-infiltration lumbar planning CT scan - reading of the three nerve-root signs
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sleep Disorders, Sciatica
Intravascular Laser and Electroacupuncture for Sciatica With Insomnia: A Pilot Trial
Sciatica is a common condition worldwide, with prevalence rates ranging from 1.2% to 43%. Chronic sciatica is often associated with sleep disturbances, forming a bidirectional loop where persistent nociceptive input disrupts…
- Trial name
- NCT06755593
- Testing
- Electroacupuncture, Intravascular Low-Level Laser Therapy (ILIB)
- Where
- Vietnam
- Volunteers
- 66 people
- Sponsor
- Le Hoang Minh Quan
Piriformis Syndrome, Musculoskeletal Abnormalities
Comparing Two Soft Tissues Technique on Piriformis Syndrome Patients
Piriformis Syndrome is a neuromuscular condition with symptoms of pain, numbness and tingling tracing the route of the sciatic nerve, due to the nerve impingement by the piriformis muscle.
- Conditions
- Piriformis Syndrome, Musculoskeletal Abnormalities, Sciatica
- Trial name
- MPR-PIR (NCT07661485)
- Testing
- Myofascial Release, Post Isometric Relaxation
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- University of Faisalabad
Lumbar Disc Degeneration, Lumbar Disc Disease
Total Lumbar Disc Prosthesis and Subsequent Work Activity at at Least Five Years After Total Lumbar Disc Replacement
Lumbosciatica is a very prevalent pathology. When conservative treatments fail, surgery should be considered. The traditional surgical treatment is lumbar arthrodesis.
- Conditions
- Lumbar Disc Degeneration, Lumbar Disc Disease, Sciatica, Lumbar Disc Herniation
- Trial name
- NCT06989632
- Testing
- Total lumbar disc prosthesis (Baguera®L, Spineart, Switzerland)
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- University of Valencia