Clinical trials: Schizophrenia, Childhood
Schizophrenia
The Danish Region Midt Schizophrenia Cohort
The objective of this study is to recruit patients at the first diagnosis with a schizophrenia spectrum disorder (SSD) and ultra-high risk patients (UHR), defined as patients with drug abuse and psychotic symptoms indicating a…
- Trial name
- RMS (NCT06431009)
- Testing
- Treatment-as-usual
- Where
- 5 sites in Denmark
- Volunteers
- 350 people
- Sponsor
- University of Aarhus
Schizophrenia, Autism Spectrum Disorder
Biological Implications of the Overlapping Phenomenon Between Childhood Schizophrenia and Autism Spectrum Disorders-Heterogeneity Approach Rather Than Diagnostic Boundary
Complex diseases such as schizophrenia and autism are heterogeneous in clinical presentation and etiology. This high heterogeneity constitutes the challenges for the clinical diagnosis and etiological research, resulting in that…
- Trial name
- NCT06063525
- Testing
- Structural anatomy
- Volunteers
- 230 people
- Sponsor
- National Taiwan University Hospital
Schizophrenia, Learning Disorders
Learning and Executive Function Disorders in Children and Psychosis Risk at Adult-age
The primary objective of the study aims to study transition toward schizophrenia in patients with learning disorders, and to compare the risk between patients with specific learning disorders, and patients with complexed learning…
- Conditions
- Schizophrenia, Learning Disorders, Executive Function Disorders
- Trial name
- DYS FUTURS UHR (NCT04280367)
- Testing
- Standardised semi-structured talk, Autistic spectre disorder screening, Anxiety measuring
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Psychosis, Complex Post-Traumatic Stress Disorder
Psychological Interventions for Complex PTSD And Schizophrenia-Spectrum Disorder: PICASSO Trial
Psychosis is a highly distressing mental health condition, affecting up to 3% of the population. Conceptually, it has much in common with complex post-traumatic stress disorder (CPTSD), a recently introduced condition in ICD-11.
- Conditions
- Psychosis, Complex Post-Traumatic Stress Disorder, Schizophrenia
- Trial name
- PICASSO (NCT05281640)
- Testing
- Affect Dysregulation intervention, Negative Self Concept intervention, Disturbed Relationships intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 57 people
- Sponsor
- Edinburgh Napier University
Psychosis of Childhood Borderline, Psychotic Disorder
Study of Self-Recognition and Self/Other Distinction Disorders in Patients With Psychological Vulnerability
The main objective of this study is to establish whether there are differences in self-recognition and self/other distinction in subjects with psychological vulnerability compared to healthy volunteer controls.
- Trial name
- ALTER-EGO (NCT04945278)
- Testing
- Double mirror device ALTER-EGO, EASE test
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Schizophrenia Prodromal, Schizophrenia, Childhood
Patientheque in Patients With a Psychosis
Establishment of a patient library for patients who have had a first psychotic episode and who have an "at risk" status for psychotic disorder (GRD, APS, BLIPS group) or a psychosis threshold during CAARMS administration.
- Conditions
- Schizophrenia Prodromal, Schizophrenia, Childhood, Schizophrenia
- Trial name
- LONGIPEP (NCT05340348)
- Testing
- Blood samples (36 mL) + fecal samples + hair sample
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Brest
Dissociative Disorder
Prevalence of Dissociative Identity Disorder in At-risk Outpatient Groups Reporting Childhood Trauma.
The investigators will study the prevalence of dissociative identity disorder (DID) in three populations at risk in cases of childhood psychotrauma : patients with a diagnosis of borderline personality, patients with a diagnosis…
- Trial name
- IDENTITY (NCT06330467)
- Testing
- psychometric assessment, semi-structured clinical interview
- Where
- 3 sites in France
- Volunteers
- 350 people
- Sponsor
- Centre Psychothérapique de Nancy
First Episode Psychosis, Schizophrenia, Childhood
Early Psychosis Intervention - Spreading Evidence-based Treatment
Implementation of 'NAVIGATE' in Ontario aims to help youth and emerging adults suffering from a first episode of psychosis. Although Ontario already has early psychosis intervention programs, the team's recent work has identified…
- Conditions
- First Episode Psychosis, Schizophrenia, Childhood, Psychosis, Schizophrenia
- Trial name
- EPI-SET (NCT03919760)
- Testing
- NAVIGATE, Treatment as Usual
- Where
- 6 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Centre for Addiction and Mental Health
Attention Deficit Disorder With Hyperactivity, Bipolar Disorder
Genetic Aspects of Neurologic and Psychiatric Disorders
The purpose of this study is to improve the understanding of the genetic causes of specific neurologic and psychiatric disorders.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Bipolar Disorder, Mental Disorder Diagnosed in Childhood, Mental Retardation
- Trial name
- NCT00001544
- Where
- United States
- Volunteers
- 1,227 people
- Sponsor
- National Institute of Mental Health (NIMH)
Childhood Onset Psychotic Disorders, Schizophrenia
Screening for Childhood-Onset Psychotic Disorders
The purpose of this study is to screen and evaluate children with psychotic disorders to establish or confirm their diagnosis and to collect data about their condition.
- Conditions
- Childhood Onset Psychotic Disorders, Schizophrenia, Psychosis, Psychotic Disorder
- Trial name
- NCT00049738
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- National Institute of Mental Health (NIMH)
Autoimmune Diseases, Mental Disorders Diagnosed in Childhood
Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg)
Recent research studies of early onset-obsessive compulsive disorder (OCD) and Tourette's syndrome have questioned whether autoimmunity could play a role in the development of these conditions.
- Conditions
- Autoimmune Diseases, Mental Disorders Diagnosed in Childhood, Schizophrenia
- Trial name
- NCT00001768
- Testing
- Intravenous immunoglobulin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Mental Health (NIMH)
Psychiatric Diagnosis, Schizophrenia Disorders
The Key to Integrated Trauma Treatment in Psychosis Trial
Schizophrenia spectrum disorders (SSDs) have a significant trauma etiology: trauma has been reported in 65 - 80% in this patient group and have a negative impact on prognosis.
- Conditions
- Psychiatric Diagnosis, Schizophrenia Disorders, Psychological Trauma, Historical
- Trial name
- KIT (NCT06608706)
- Testing
- Eye Movement Desensitization and Reprocessing (EMDR) for psychosis
- Where
- 11 sites in Norway
- Volunteers
- 187 people
- Sponsor
- Haukeland University Hospital
Schizophrenia Spectrum Disorder, PTSD
Childhood Maltreatment, Traumatic Experiences and Stress-associated Parameters in Schizophrenia Spectrum Disorders
Childhood maltreatment (CM) in psychotic disorders is associated with increased cognitive deficits, severe psychotic symptoms, and increased comorbidity.
- Trial name
- NETPSYCH (NCT03730831)
- Testing
- Narrative Exposure Therapy
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Konstanz
Childhood Onset Psychotic Disorders, Schizophrenia
Transcranial Direct Current Brain Stimulation to Treat Patients With Childhood-Onset Schizophrenia
This study will test whether transcranial direct current stimulation (TDCS) can be used safely in children with schizophrenia and if it can improve memory and attention span or auditory hallucinations in these children, at least…
- Conditions
- Childhood Onset Psychotic Disorders, Schizophrenia, Psychosis, Mental Disorders
- Trial name
- NCT00757497
- Testing
- Electrical Polarization
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Mental Health (NIMH)
Schizophrenia
Cognitive Factors Mediating the Relationship Between Childhood Trauma and Auditory Hallucinations in Schizophrenia
BACKGROUND It is demonstrated that strong associations between trauma suffered in childhood and having schizophrenia, and more specifically to experience acoustic-verbal hallucinations (AVH).
- Trial name
- HADITRYOS (NCT04481217)
- Testing
- Self-questionnaires battery, Socio-demographic screening
- Where
- 2 sites in France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Grenoble
Schizophrenia
Treating Drug-Resistant Childhood Schizophrenia
This study will compare clozapine and olanzapine (Zyprexa®) for the treatment of children and adolescents who have failed standard antipsychotic treatment for schizophrenia.
- Trial name
- NCT00048828
- Testing
- Olanzapine, Clozapine
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Northwell Health
Psychosis, Schizophrenia
Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia
A study of children and adolescents (current N=100) with very early onset by age 12 (COS) of DSM-III-R defined schizophrenia with (97-M-0126) is examining the clinical, neurobiological, early neurodevelopmental, genetic, and…
- Conditions
- Psychosis, Schizophrenia, Genetic Structure, Childhood Onset Psychotic Disorders
- Trial name
- NCT00001198
- Where
- United States
- Volunteers
- 1,556 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Schizophrenia
Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology
Childhood trauma is known as a vulnerability factor in schizophrenia. In healthy volunteers, these adversities are linked to a decrease of grey matter of the brain, similar to those observed in schizophrenia.
- Trial name
- SCHIZO'TRAUMA (NCT03355781)
- Testing
- magnetic resonance imaging (MRI), Blood sample, Clinical psychiatric evaluation
- Where
- France
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Childhood Schizophrenia, Psychotic Disorder
Comparison of Clozapine vs Olanzapine in Childhood-Onset Psychotic Disorders
The purpose of this study is to compare the effectiveness and side effects of the drugs clozapine and olanzapine in children and adolescents with schizophrenia and psychoses.
- Conditions
- Childhood Schizophrenia, Psychotic Disorder, Schizophrenia
- Trial name
- NCT00001656
- Testing
- Olanzapine, Clozapine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Mental Health (NIMH)
Psychotic Disorder, Schizoaffecitve Disorder
Glycine to Treat Psychotic Disorders in Children
This study will test the safety and effectiveness of the amino acid glycine in treating psychotic disorders in children. The drug will be given as an adjunct (in addition) to the patient's current antipsychotic medication.
- Conditions
- Psychotic Disorder, Schizoaffecitve Disorder, Schizophrenia
- Trial name
- NCT00005658
- Testing
- Glycine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Mental Health (NIMH)