Clinical trials: Saline Solution, Hypertonic
Hypertonic Saline, Isotonic Saline
Activation of miRNA and Proteins After Acute Experimental Pain. (miRNA: Micro RNA)
In this experiment, the investigators would like to test the following: 1. Does acute pain induced by hypertonic injection cause changes in plasma miRNA and protein expression ? 2.
- Trial name
- miRNA (NCT04439994)
- Testing
- hypertonic saline, Saline injection, Blood sampling
- Where
- 2 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Bronchiolitis
Nasal Irrigation in Infants With Bronchiolitis.
Bronchiolitis is a leading cause of acute illness and hospitalization in the first year of life. Most children with bronchiolitis have mild disease and are managed at home with support from primary care providers, while children…
- Trial name
- NCT02162745
- Testing
- Isotonic solution (NaCl 0.9%), Hypertonic solution (NaCl 3%)
- Where
- 2 sites in Italy
- Volunteers
- 133 people
- Sponsor
- IRCCS Burlo Garofolo
Pulmonary Hypertensive Crisis
Effects of Saline on Circulation in Children
Pulmonary hypertensive crisis is a life-threatening condition, in which the blood pressure in the pulmonary artery, vein, and capillaries.
- Trial name
- NCT01668277
- Testing
- 7.2% NaCl, 0.9% NaCl
- Where
- 2 sites in Canada
- Volunteers
- 15 people
- Sponsor
- The Hospital for Sick Children
Bronchiectasis, Non-cystic Fibrosis Bronchiectasis
Hypertonic Saline in NCFB
The purpose of this single arm clinical trial is to evaluate the effects of 7% hypertonic saline (HS) delivered by nebulizer on clearance of mucus from the lungs in people with bronchiectasis (dilated airways) not due to cystic…
- Trial name
- NCT06242795
- Testing
- 7% Hypertonic Saline via nebulization
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of North Carolina, Chapel Hill
Intracranial Hypertension
Mannitol Versus Hypertonic Saline Solution in the Treatment of Elevated Intracranial Pressure
The purpose of this study is to determine whether mannitol is as effective as hypertonic saline solution in the treatment of elevated intracranial pressure in patients with brain injury.
- Trial name
- NCT00447018
- Testing
- 20% mannitol, 7.45% hypertonic saline solution
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Grenoble
Urinary Stress Incontinence
Hypertonic Saline Injection For Urinary Incontinence
The investigators aimed to evaluate the effectiveness and safety of periurethral hypertonic saline (10% NaCl) injection for the treatment of stress urinary incontinence (SUI) and stress-predominant mixed urinary incontinence…
- Trial name
- NCT04812574
- Testing
- Periurethral injection, Hypertonic (10%) saline
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Turgut Ozal University
Heart Failure，Congestive
Effects of Furosemide Plus Small HSS in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF)
The investigators sought to evaluate the effectiveness of treatment with furosemide + HSS in terms of reduction of serum levels of some chosen markers of heart failure and the response in terms of these markers at a compensated…
- Trial name
- NCT04628325
- Testing
- Furosemide
- Where
- 2 sites in Italy
- Volunteers
- 136 people
- Sponsor
- University of Palermo
Bronchiolitis
Nebulized 3% Hypertonic Saline vs. Standard of Care in Patients With Bronchiolitis
The purpose of this study is to determine whether nebulized 3% hypertonic saline is more effective than the current standard of care in the treatment of viral bronchiolitis in children.
- Trial name
- NCT02834819
- Testing
- 3% Nebulized Hypertonic Saline
- Volunteers
- 18 people
- Sponsor
- University of Colorado, Denver
Endotracheal Tube, Tracheostomy
Safety of Mechanical Insufflation-exsufflation and Hypertonic Saline
Conventional catheter suctioning of respiratory tract secretions is a mandatory procedure in intubated patients. Poor tolerance, pain and other, sometimes severe, lung and cardiovascular complications may occur during suctioning.
- Trial name
- SMASH (NCT03940118)
- Testing
- Catheter secretion suctioning, Secretion suctioning + hypertonic saline, Ins-exsufflation
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Hospital San Carlos, Madrid
Arginine Vasopressin Deficiency, Primary Polydipsia
Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome
The aim of this study is to evaluate whether a new test using mannitol infusion can diagnose the cause of polyuria-polydipsia syndrome as accurately as the current standard test (hypertonic saline infusion) and to compare which…
- Trial name
- COMPASS (NCT07569861)
- Testing
- Mannitol, Hypertonic Saline
- Where
- Switzerland
- Volunteers
- 144 people
- Sponsor
- University Hospital, Basel, Switzerland
Intracranial Hypertension, Cerebral Edema
Coagulation Activation by Hyperosmolar Agents in Intracranial Hypertension
Osmotherapy consists in the therapeutic use of osmotically active substances with the aim of reducing the volume and therefore the intracranial pressure.
- Trial name
- NCT03409237
- Testing
- Mannitol, Hypertonic saline solution
- Where
- Italy
- Sponsor
- Neuromed IRCCS
Nontuberculous Mycobacterial Lung Disease, Bronchiectasis
Hypertonic Saline Inhalation for Nontuberculous Mycobacterial Lung Disease
This multicenter randomized controlled trial evaluates the clinical and microbiological effects of inhaled 3% hypertonic saline in treatment-naïve patients with nontuberculous mycobacterial lung disease (NTM-LD).
- Trial name
- HiNTM (NCT07647575)
- Testing
- Nebulized 3% Hypertonic Saline, Nebulized Normal Saline
- Where
- Taiwan
- Volunteers
- 262 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cystic Fibrosis
Saline Hypertonic in Preschoolers
The purpose of this study is to assess whether inhalation of 7% hypertonic saline (HS) twice daily for 48 weeks improves the lung clearance index by multiple breath nitrogen washout in comparison with inhalation of 0.9% isotonic…
- Trial name
- SHIP (NCT02378467)
- Testing
- 7% Hypertonic Saline (HS), 0.9% Isotonic Saline (IS)
- Where
- 25 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- University of Washington, the Collaborative Health Studies Coordinating Center
Cystic Fibrosis
Cell Content of Sputum Induced by Hypertonic Saline in Adolescents With Cystic Fibrosis
Cystic fibrosis requires regular monitoring of bacterial colonization of sputum. The collection is done during scheduled consultations or urgently during exacerbations during the respiratory physiotherapy session, which is…
- Trial name
- OCSI-CF (NCT06909903)
- Testing
- Autogenous drainage of sputum caused by hypertonic saline in adolescents with cystic fibrosis.
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cystic Fibrosis
The Effect of Hypertonic Saline on the Lung Clearance Index in Patients With Cystic Fibrosis
This study is examining the effect of hypertonic saline compared to placebo on the Lung Clearance Index in Cystic Fibrosis patients.
- Trial name
- NCT00635141
- Testing
- hypertonic saline (7 %) and isotonic saline (0.9%)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Elevated Intracranial Pressure
Double Blind Study of Hypertonic Saline vs Mannitol in the Management of Increased Intracranial Pressure (ICP).
The study goal is to compare the management of increased intra-cranial pressure (ICP) using 3% hypertonic saline vs. mannitol (given in same osmolar loads). Primary hypothesis: 1.
- Trial name
- NCT01108744
- Testing
- hypertonic saline, Mannitol
- Where
- United States
- Sponsor
- Beth Israel Deaconess Medical Center
Cystic Fibrosis
Tolerability of Inhaled Hypertonic Saline in Infants With Cystic Fibrosis
This is an open-label pilot study of the safety and tolerability of 7% hypertonic saline inhaled twice daily for 14 days in infants with CF, 12 to 30 months of age.
- Trial name
- ISIS Pilot (NCT00546663)
- Testing
- inhaled 7% hypertonic saline (HS)
- Where
- 3 sites in United States, Canada
- Volunteers
- 19 people
- Sponsor
- CF Therapeutics Development Network Coordinating Center
Spinal Anaesthesia
Crystalloids Versus Colloids Versus Hypertonic Saline as a Co-load During Spinal Anesthesia.
Spinal anesthesia is commonly accompanied by hypotension due to vasodilation that follows sympathetic blockade and decreased systemic vascular resistance.
- Trial name
- NCT03681847
- Testing
- Normal saline, hydroxyethyl starch, Hypertonic saline
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- National Cancer Institute, Egypt
Bronchiolitis, Respiratory Distress
Hypertonic Saline for Outpatient Bronchiolitis
We will study if small children who become ill with respiratory distress during the RSV epidemic are better relieved with salbutamol nebulizations diluted in hypertonic (3%), instead of normal (0.9%) saline.
- Trial name
- Hypertonic (NCT00696540)
- Testing
- Inhalation of salbutamol diluted in hypertonic saline, Inhalation of salbutamol diluted in normal saline
- Where
- Chile
- Volunteers
- 74 people
- Sponsor
- University Diego Portales
Acute Bronchiolitis
Nebulized 3% Hypertonic Saline Versus Normal Saline in Managing Children With Acute Bronchiolitis: A Randomized Controlled Trial
This randomized controlled trial was conducted at A-Ramadi Teaching Hospital for Maternity and Children on patients admitted with acute bronchiolitis. The study covered a duration of 6 months.
- Trial name
- NCT07138625
- Testing
- Nebulized normal saline
- Volunteers
- 300 people
- Sponsor
- University Of Anbar