Clinical trials: Safety Study
Safety Issues
Safety, Tolerability and Pharmacokinetics of ETD-001 Gel
This is a single-center, randomized, double-blind, placebo-controlled Phase I clinical study, which comprises two parts: Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) in healthy subjects.Three dose groups are…
- Trial name
- ETD-001 gel (NCT07674862)
- Testing
- Dose 1, dose 2, dose 3
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Etern Therapeutics Wuxi Limited
Program Effectiveness, Program Implementation
Implementation Study With Embedded RCT of a Digital System of Parenting Support Within Government Services in South Africa
ParentText, a WhatsApp-based parenting support programme, is designed as a universal intervention to improve parent-child relationships (module 1) and promote child safety (module 2).
- Conditions
- Program Effectiveness, Program Implementation, Parent Child Relationship, Caregiver Child Relationship
- Trial name
- SWIFT (NCT07814261)
- Testing
- Module 1 - Improve My Relationship with My Teen/Child, Module 2 - Keep My Child/Teen Safe and Healthy
- Where
- South Africa
- Volunteers
- 4,961 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Accidental Fall, Patient Safety
Choosing Wisely: De-implementing Fall Prevention Alarms in Hospitals
This is a Hybrid II de-implementation study to reduce use of fall prevention alarms in hospitals. The intervention consists of tailored, site-specific approaches for three core implementation strategies: education, audit/feedback…
- Conditions
- Accidental Fall, Patient Safety, Hospital Acquired Condition, Clinical Alarms
- Trial name
- NCT06089239
- Testing
- High Intensity Coaching, Low Intensity Coaching
- Where
- 20 sites in United States
- Volunteers
- 365 people
- Sponsor
- University of Florida
Healthy, Safety
Long-Term PEA Safety Study
The goal of this clinical trial is to learn about the long term safety of PEA supplementation in healthy adults. This clinical trial will be in both males and females who are 18 years or older and are healthy volunteers.
- Trial name
- NCT06717867
- Testing
- Palmitoylethanolamide (PEA)
- Where
- Australia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RDC Clinical Pty Ltd
Medical Education, Patient Safety
Digital Microlearning for Patient-Safety Readiness in Nursing Students
This randomized controlled trial evaluated whether a seven-day, patient-safety-focused digital microlearning program improved sustained clinical error recognition and the transfer of safety learning among second-year nursing…
- Conditions
- Medical Education, Patient Safety, Nursing Education
- Trial name
- DigiM-2026 (NCT07367906)
- Testing
- Digital Microlearning Program on Patient Safety
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Agri Ibrahim Cecen University
Intracranial Venous Blood, Brain Cancers
A Study to Evaluate the Safety and Efficacy of Intracranial Venous Blood Sampling for Liquid Biopsy in the Diagnosis of Brain Cancers
To learn if drawing blood directly from veins inside the brain is safe and can effectively provide the same kind of detailed information about high-grade glioma as traditional surgical biopsy.
- Conditions
- Intracranial Venous Blood, Brain Cancers, Liquid Biopsy, Evaluate the Safety
- Trial name
- NCT07467109
- Testing
- blood sampling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Healthy Adult Participants, Asthma Exacerbation
RIG 101 Trial in Healthy Adults and Adults With Asthma
Nested Phase 1-2 Trial of RIG-101 in Healthy and Asthmatic Participants Assessing Safety, Tolerability and Viral Challenge Efficacy
- Conditions
- Healthy Adult Participants, Asthma Exacerbation, Safety and Efficacy
- Trial name
- NCT07488897
- Testing
- RIG-101
- Where
- 2 sites in United Kingdom
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- RIGImmune Inc.
Patient Transport, Respiratory Failure
HERMES: International Survey and Portable External Power Evaluation During Respiratory Support Transport
The HERMES Phase I-II study was a two-phase observational investigation designed to characterize contemporary practices and safety-related challenges associated with the transport of patients requiring advanced respiratory…
- Conditions
- Patient Transport, Respiratory Failure, Noninvasive Ventilation, High-Flow Nasal Oxygen
- Trial name
- HERMES (NCT07807189)
- Testing
- Portable External Power Supply
- Where
- 20 sites in United States, Chile and 12 more
- Volunteers
- 246 people
- Sponsor
- Medipol University
First in Man Study to Evaluate Initial Safety
Safety, Tolerability and Pharmacokinetics of RNV-166 in Healthy Male Volunteers
This Phase 1 first-in-human clinical study evaluated the safety, tolerability, and pharmacokinetics of RNV-166 following single ascending dose (SAD) and multiple ascending dose (MAD) administration in healthy participants.
- Trial name
- NCT07809360
- Testing
- RNV-166_200 mg
- Where
- Bangladesh
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- InVitro Research Solutions Private Limited
To Assess Extended Safety and Tolerability of Subcutaneous CAP256V2LS and VRC07-523LS Monoclonal Antibodies in HIV-negative Women
A Phase II Trial to Assess Extended Safety and Tolerability of Subcutaneous CAP256V2LS and VRC07-523LS in HIV- Negative Women
A double blinded, Randomized, Placebo- controlled phase II trial to assess extended safety and tolerability of subcutaneous CAP256V2LS and VRC07-523LS in HIV- negative women
- Trial name
- CAPRISA 012C (NCT07810062)
- Testing
- Broad band monoclonal antibodies named as CAP256V2LS and VRC07- 523LS
- Where
- Zambia
- Volunteers
- 990 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Perioperative Medication Safety
Perioperative Recommendations for Medication Safety
The purpose of the proposed research is to create and disseminate expert-based recommendations for perioperative medication safety that are tailored to country income level, using the World Bank's four country income groups…
- Trial name
- NCT04240301
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Karen C. Nanji,M.D.,M.P.H.
Firearm Injury, Safety Issues
Pediatric Trauma Centers RE-AIM at Gun Safety
Universal firearm injury and violence prevention counseling of parents and patients has been recommended by multiple national organizations for over a decade, yet clinicians rarely deliver this counseling.
- Trial name
- ACTFAST (NCT06123611)
- Testing
- Adopting Comprehensive Training for FireArm Safety in Trauma centers
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Johns Hopkins University
Healthy, Safety Evaluation of Escalating Doses
A Study to Test the Effects of Nezavist at Different Doses in Healthy Adults
The goal of this clinical trial is to determine the safety, tolerability and effects of Nezavist in healthy adults. The main questions it aims to answer are: What is the safety and maximum tolerated dose (MTD) of orally…
- Conditions
- Healthy, Safety Evaluation of Escalating Doses, Tolerability
- Trial name
- NCT06633562
- Testing
- Nezavist SDD
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Lohocla Research Corporation
Safety and Tolerability in Healthy Volunteers
Safety and Tolerability of an Ultra Absorbency Menstrual Tampon Compared to a Commercially Marketed Tampon
A Randomized, Open-Label, Evaluator-Blinded, Cross-Over Clinical Study to Confirm the Safety and Tolerability of an Ultra Absorbency Menstrual Tampon Compared to a Commercially Marketed Tampon
- Trial name
- NCT07807891
- Testing
- Tampon
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lyv Life Inc. (dba: Cora)
Enhance Patient Safety, Nurse Physician Relations
Advanced Airway Management Among Primary Care Health
Background: Advanced airway management is a critical component of advanced life support (ALS). Supraglottic airway devices (SADs) represent an effective and safe alternative to endotracheal intubation in emergency settings…
- Conditions
- Enhance Patient Safety, Nurse Physician Relations, Physician-Nurse Relations
- Trial name
- MMC26 (NCT07788690)
- Testing
- Educative Intervention
- Where
- Spain
- Volunteers
- 538 people
- Sponsor
- Universitat Jaume I
Appendicitis, Acute, Appendectomy
Video-Based Grading of Intraoperative Adverse Events in Pediatric Laparoscopic Appendectomy
Acute appendicitis is the most common surgical emergency in children, and laparoscopic appendectomy is its standard treatment. Although intraoperative adverse events (iAEs) are recognized as an important determinant of surgical…
- Conditions
- Appendicitis, Acute, Appendectomy, Intraoperative Complications, Patient Safety
- Trial name
- PedAppy-iAE (NCT07794618)
- Testing
- Laparoscopic appendectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ahmet Burak Doğan, MD
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University
PARKINSON DISEASE (Disorder), Apathy
Safety and Tolerability of IRL757 in Participants With Parkinson's Disease and Apathy
This clinical trial's goal is to evaluate if the IRL757 is safe and has a good tolerability in participants with Parkinson's disease and experiencing apathy (a lack of interest or motivation).
- Conditions
- PARKINSON DISEASE (Disorder), Apathy, Safety
- Trial name
- LIFT-PD (NCT07461220)
- Testing
- IRL757
- Where
- 14 sites in Bulgaria, Germany and 2 more
- Volunteers
- 75 people
- Sponsor
- Integrative Research Laboratories AB
Second Victim Phenomenon, Occupational Stress
RESCUE: European Certification for Second Victim Support
The "second victim" phenomenon affects healthcare professionals who experience highly stressful events in their daily practice, potentially compromising their well-being and patient safety.
- Conditions
- Second Victim Phenomenon, Occupational Stress, Healthcare Workforce Well-Being, Patient Safety
- Trial name
- NCT06888297
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Safety in Asthma Patients
Phase 1 Study Evaluating Safety and Pharmacokinetics of ASY202 in Adults With Asthma
This is a phase 1 study, randomized, double-blind, placebo-controlled, 2 treatment, 2 period crossover study to evaluate the pharmacokinetics, safety, and tolerability of a single inhaled dose of ASY202 in adults with stable…
- Trial name
- NCT07665892
- Testing
- ASY202
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Aspeya, Inc.